MX9704587A - Sulfonamidas novedosas. - Google Patents

Sulfonamidas novedosas.

Info

Publication number
MX9704587A
MX9704587A MX9704587A MX9704587A MX9704587A MX 9704587 A MX9704587 A MX 9704587A MX 9704587 A MX9704587 A MX 9704587A MX 9704587 A MX9704587 A MX 9704587A MX 9704587 A MX9704587 A MX 9704587A
Authority
MX
Mexico
Prior art keywords
novel sulfonamides
endothelin
sulfonamides
novel
disorders
Prior art date
Application number
MX9704587A
Other languages
English (en)
Other versions
MXPA97004587A (es
Inventor
Volker Breu
Kaspar Burri
Jean-Marie Cassal
Martine Clozel
Georges Hirth
Bernd-Michael Loffler
Marcel Muller
Werner Neidhart
Henri Ramuz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX9704587A publication Critical patent/MX9704587A/es
Publication of MXPA97004587A publication Critical patent/MXPA97004587A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69Benzenesulfonamido-pyrimidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Bipolar Transistors (AREA)
  • Surgical Instruments (AREA)
  • Steroid Compounds (AREA)
  • Lubricants (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Los compuestos de formula (I) en la cual R1-R8, A y B tienen el significado dado en la descripcion, son inhibidores de la endotelina y pueden usarse para el tratamiento de padecimientos asociados con las actividades de la endotelina, tales como la presion sanguínea alta.
MXPA/A/1997/004587A 1994-12-20 1997-06-19 Sulfonamidas novedosas MXPA97004587A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH383794 1994-12-20
CH3837/94-6 1994-12-20
CH2419/95-1 1995-08-24
CH241995 1995-08-24

Publications (2)

Publication Number Publication Date
MX9704587A true MX9704587A (es) 1998-07-31
MXPA97004587A MXPA97004587A (es) 1998-11-09

Family

ID=

Also Published As

Publication number Publication date
DE69531457D1 (en) 2003-09-11
FI972628A0 (fi) 1997-06-18
HK1001973A1 (en) 1998-07-24
MA23744A1 (fr) 1996-07-01
ES2203649T3 (es) 2004-04-16
CN1170407A (zh) 1998-01-14
US6004965A (en) 1999-12-21
IL116385A (en) 2000-07-16
EP0799209A1 (en) 1997-10-08
FI972628A (fi) 1997-06-18
NO972538L (no) 1997-06-04
MY131126A (en) 2007-07-31
CA2208018A1 (en) 1996-06-27
NO972538D0 (no) 1997-06-04
CZ187497A3 (en) 1997-10-15
ATE246681T1 (de) 2003-08-15
AU701767B2 (en) 1999-02-04
JPH10509182A (ja) 1998-09-08
CY2495B1 (en) 2005-09-02
KR100445085B1 (ko) 2004-10-14
NZ297797A (en) 1999-10-28
HU228619B1 (en) 2013-04-29
CN1098254C (zh) 2003-01-08
WO1996019459A1 (en) 1996-06-27
EP0799209B1 (en) 2003-08-06
CA2208018C (en) 2007-03-27
PT799209E (pt) 2003-12-31
SA95160421B1 (ar) 2006-05-01
JP2989014B2 (ja) 1999-12-13
BR9510104A (pt) 1997-11-25
HUT77884A (hu) 1998-09-28
FI120397B (fi) 2009-10-15
IL116385A0 (en) 1996-03-31
DE69531457T2 (de) 2004-06-24
DK0799209T3 (da) 2003-11-24
AU4304196A (en) 1996-07-10
CZ287916B6 (cs) 2001-03-14
TW313568B (es) 1997-08-21
NO316645B1 (no) 2004-03-22

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