IL116208A0 - Metal complexes of diethylenetriaminepentaacetic acid derivatives and pharmaceutical and diagnostic agents containing the same - Google Patents

Metal complexes of diethylenetriaminepentaacetic acid derivatives and pharmaceutical and diagnostic agents containing the same

Info

Publication number
IL116208A0
IL116208A0 IL11620895A IL11620895A IL116208A0 IL 116208 A0 IL116208 A0 IL 116208A0 IL 11620895 A IL11620895 A IL 11620895A IL 11620895 A IL11620895 A IL 11620895A IL 116208 A0 IL116208 A0 IL 116208A0
Authority
IL
Israel
Prior art keywords
pharmaceutical
same
acid derivatives
metal complexes
diagnostic agents
Prior art date
Application number
IL11620895A
Other languages
English (en)
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL116208A0 publication Critical patent/IL116208A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
IL11620895A 1994-11-30 1995-11-30 Metal complexes of diethylenetriaminepentaacetic acid derivatives and pharmaceutical and diagnostic agents containing the same IL116208A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35108694A 1994-11-30 1994-11-30
US38740895A 1995-02-13 1995-02-13

Publications (1)

Publication Number Publication Date
IL116208A0 true IL116208A0 (en) 1996-01-31

Family

ID=26996938

Family Applications (3)

Application Number Title Priority Date Filing Date
IL11620895A IL116208A0 (en) 1994-11-30 1995-11-30 Metal complexes of diethylenetriaminepentaacetic acid derivatives and pharmaceutical and diagnostic agents containing the same
IL11620995A IL116209A0 (en) 1994-11-30 1995-11-30 Metal complexes and complexing agents as x-ray contrast media
IL11620695A IL116206A0 (en) 1994-11-30 1995-11-30 Metal complexes of diethylenetriaminepentaacetic acid derivatives and pharmaceutical and diagnostic compositions containing the same

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL11620995A IL116209A0 (en) 1994-11-30 1995-11-30 Metal complexes and complexing agents as x-ray contrast media
IL11620695A IL116206A0 (en) 1994-11-30 1995-11-30 Metal complexes of diethylenetriaminepentaacetic acid derivatives and pharmaceutical and diagnostic compositions containing the same

Country Status (15)

Country Link
US (4) US5672335A (fi)
EP (3) EP0794799A2 (fi)
JP (3) JPH10509961A (fi)
CN (1) CN1167444A (fi)
AU (3) AU3922795A (fi)
CA (3) CA2206522A1 (fi)
CZ (1) CZ166897A3 (fi)
FI (3) FI972288A0 (fi)
HU (1) HUT77284A (fi)
IL (3) IL116208A0 (fi)
MX (1) MX9703880A (fi)
NO (3) NO972459L (fi)
PL (1) PL320462A1 (fi)
SK (1) SK68997A3 (fi)
WO (3) WO1996016928A1 (fi)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501560D0 (en) 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
HUP9900428A2 (hu) * 1995-01-26 1999-06-28 Nycomed Imaging A/S Bizmutvegyületek, ezeket tartalmazó diagnosztikai kontrasztanyag, ennek alkalmazása és ezt tartalmazó gyógyászati készítmény
IT1290417B1 (it) * 1996-08-02 1998-12-03 Bracco Spa Composti chelanti derivati di acidi poliamminopolicarbossilici, loro chelati con ioni metallici paramagnetici, loro preparazione ed
US6403055B1 (en) 1996-08-02 2002-06-11 Dibra S.P.A. Diagnostic imaging contrast agent with improved in serum relaxivity
IT1283650B1 (it) * 1996-08-02 1998-04-23 Bracco Spa Chelati paramagnetici ad alta relassivita' in siero
US6458337B1 (en) 1996-08-02 2002-10-01 Dibra S.P.A Diagnostic imaging contrast agent with improved in serum relaxivity
US6558669B1 (en) 1996-08-28 2003-05-06 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US7521531B2 (en) 1996-08-28 2009-04-21 Immunomedics, Inc. Methods for the purification of stable radioiodine conjugates
WO1998028258A1 (en) 1996-12-23 1998-07-02 Bracco Research S.A. Compositions for increasing the mri contrast in visualising the digestive tract of patients
DE19719033C1 (de) * 1997-04-29 1999-01-28 Schering Ag Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6767741B1 (en) 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
CA2437989A1 (en) * 2001-02-20 2002-08-29 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
DE10127126A1 (de) * 2001-06-05 2002-12-19 Forschungszentrum Juelich Gmbh Geschützte Tyrosinderivate, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von O-(2-[·18·F]-Fluorethyl)-L-tyrosin
US6627394B2 (en) 2001-07-19 2003-09-30 Common Sense Ltd. Diagnostic pad
EP1805188A4 (en) 2004-09-30 2010-03-03 Mds Analytical Technologies Us COMPLEXES OF LUMINESCENT LANTHANIDES
GB0423506D0 (en) * 2004-10-22 2004-11-24 Univ Belfast Light emitting complex salts
EP2717934A4 (en) * 2011-06-06 2015-01-14 Oregon State X-RAY CONTRACTS FROM WISMUT PARTICLES
WO2013171048A1 (en) * 2012-05-18 2013-11-21 Bayer Pharma Aktiengesellschaft Bis azainositol heavy metal complexes for x-ray imaging
BR102013023479B1 (pt) * 2013-09-12 2022-07-26 Uniao Brasileira De Educação E Assistência Processo de síntese de compostos de coordenação à base de lantanídeo
CN105277656B (zh) 2014-07-01 2018-12-25 科蒙森斯公司 用于鉴定羊水的诊断组合物
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CN110035996B (zh) 2016-11-28 2022-08-09 拜耳医药股份公司 用于磁共振成像的新型高弛豫性钆螯合物
JP7120802B2 (ja) 2017-07-20 2022-08-17 株式会社神戸製鋼所 流体流通装置及びその流通異常検知方法
JP6836471B2 (ja) 2017-07-20 2021-03-03 株式会社神戸製鋼所 流体流通装置
CN107573291A (zh) * 2017-10-27 2018-01-12 上海司太立制药有限公司 一种钆塞酸二钠配体杂质的制备方法和用途
KR20210095168A (ko) 2018-11-23 2021-07-30 바이엘 악티엔게젤샤프트 조영 매체의 제형 및 그의 제조 방법
EP4059925A1 (en) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft New contrast agent for use in magnetic resonance imaging
EP4335840A1 (en) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft New contrast agents for use in diagnostic imaging
EP4335462A1 (en) 2022-09-09 2024-03-13 Bayer AG Contrast agents for use in diagnostic computed tomography imaging

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1374979A (en) * 1970-12-21 1974-11-20 Nat Res Dev 3,5-dioxopiperazine derivatives
US3994966A (en) * 1972-09-28 1976-11-30 The Board Of Trustees Of The Leland Stanford Junior University Chelating agents
US4622420A (en) * 1980-03-18 1986-11-11 The Regents Of The University Of California Chelating agents and method
US4339426A (en) * 1980-03-18 1982-07-13 Regents Of The University Of California Bleomycin analog
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
US4672028A (en) * 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
US4824986A (en) * 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
IL83966A (en) * 1986-09-26 1992-03-29 Schering Ag Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
IT1224416B (it) * 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US5482700A (en) * 1987-03-31 1996-01-09 Schering Aktiengesellschaft Substituted polyamino, polycarboxy complexing agent dimers for MRI and X-ray contrast
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5198208A (en) * 1987-07-16 1993-03-30 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5399340A (en) * 1987-09-24 1995-03-21 Schering Aktiengesellschaft Use of amide complex compounds
US5137711A (en) * 1988-07-19 1992-08-11 Mallickrodt Medical, Inc. Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents
US5334371A (en) * 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
US5342604A (en) * 1988-10-31 1994-08-30 The Dow Chemical Company Complexes possessing ortho ligating functionality
NZ231180A (en) * 1988-10-31 1994-11-25 Dow Chemical Co Bifunctional chelants;complexes,conjugates and pharmaceutical compositions thereof
US5101041A (en) * 1989-04-26 1992-03-31 The Curators Of The University Of Missouri Triamines and their derivatives as bifunctional chelating agents
US5695739A (en) * 1989-06-30 1997-12-09 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
DE3922005A1 (de) * 1989-06-30 1991-01-10 Schering Ag Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
GB9122984D0 (en) * 1991-10-30 1991-12-18 Salutar Inc Contrast media
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
AU6996594A (en) * 1993-06-02 1994-12-20 Bracco S.P.A. Iodinated paramagnetic chelates, and their use as contrast agents
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
JPH09505819A (ja) * 1993-12-03 1997-06-10 ブラッコ エッセ．ピ．ア． 核磁気共鳴診断用常磁性キレート

Also Published As

Publication number Publication date
CN1167444A (zh) 1997-12-10
US5853699A (en) 1998-12-29
FI972286A0 (fi) 1997-05-29
JPH10511934A (ja) 1998-11-17
FI972288A (fi) 1997-05-29
FI972288A0 (fi) 1997-05-29
IL116206A0 (en) 1996-01-31
WO1996016928A1 (de) 1996-06-06
US5885548A (en) 1999-03-23
EP0794939A1 (de) 1997-09-17
JPH10509961A (ja) 1998-09-29
AU4254696A (en) 1996-06-19
WO1996016677A3 (de) 1996-09-12
NO972460D0 (no) 1997-05-29
AU4299496A (en) 1996-06-19
EP0794799A2 (de) 1997-09-17
FI972286A (fi) 1997-05-29
CA2206522A1 (en) 1996-06-06
US5746995A (en) 1998-05-05
FI972287A0 (fi) 1997-05-29
WO1996016929A1 (de) 1996-06-06
NO972457L (no) 1997-07-30
HUT77284A (hu) 1998-03-30
MX9703880A (es) 1997-08-30
NO972457D0 (no) 1997-05-29
CZ166897A3 (en) 1997-09-17
SK68997A3 (en) 1997-11-05
NO972459L (no) 1997-07-29
JPH11503405A (ja) 1999-03-26
CA2206397A1 (en) 1996-06-06
CA2206576A1 (en) 1996-06-06
PL320462A1 (en) 1997-09-29
FI972287A (fi) 1997-05-29
AU3922795A (en) 1996-06-19
NO972459D0 (no) 1997-05-29
NO972460L (no) 1997-05-29
EP0794938A1 (de) 1997-09-17
US5672335A (en) 1997-09-30
IL116209A0 (en) 1996-01-31
WO1996016677A2 (de) 1996-06-06

Similar Documents

Publication Publication Date Title
IL116208A0 (en) Metal complexes of diethylenetriaminepentaacetic acid derivatives and pharmaceutical and diagnostic agents containing the same
IL115483A0 (en) Urea derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
HUT75089A (en) Compositions containing hyaluronic acid or it's derivatives and pharmaceutical active agent
NZ250762A (en) Five-membered-heterocyclic carboxylic acid derivatives and pharmaceutical compositions
IL113196A0 (en) Imidazole derivatives and pharmaceutical compositions containing the same
HUP9903916A3 (en) Phosphinic acid amides and pharmaceutical compositions containing the same
IL135177A0 (en) Amidocarboxylic acid derivatives and pharmaceutical compositions containing the same
IL106431A0 (en) Aminediol derivatives and pharmaceutical compositions containing the same
IL115685A0 (en) Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
IL114759A (en) Benzoxazole derivatives and pharmaceutical compositions containing them
HU9501561D0 (en) Fatty acid derivatives and pharmaceutical compositions containing them
IL115563A0 (en) Benzoxazole derivatives and pharmaceutical compositions containing the same
HU9502520D0 (en) Pharmaceutical use of substituted 4-phenyl-6-amino-nicotinic acid derivatives
HU9502918D0 (en) Pharmaceutical composition of antihypertriglyceridemic activity
IL95394A0 (en) Amide complexes and diagnostic agents containing the same
HUP0102646A3 (en) Phthalazine derivatives phosphodiesterase 4 inhibitors and pharmaceutical compositions containing the same
IL136612A0 (en) Phenylaminoalkylcarboxylic acid derivatives and medical compositions containing the same
HU9300078D0 (en) Benzofuranyl-methyl-thio-alkane-carboxylic acid derivatives and thiophenyl ones
IL116207A0 (en) Diagnostic agents containing metal complexes of benzyl-substituted diethylenetriaminepentaacetic acid derivatives
IL108920A0 (en) Acyloxyhexanoic acid derivatives and pharmaceutical compositions containing them
IL115982A0 (en) Cyclolignan derivatives and pharmaceutical compositions containing the same
IL115981A (en) Cyclolignan derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
IL115294A0 (en) Steroid esters and amides processes for the preparation thereof and pharmaceutical compositions containing the same
ZA955896B (en) Technetium-sulfonamide complexes their use pharmaceutical agents containing the latter as well as process for the production of the complexes and agents
IL94970A0 (en) Fusidic acid derivatives and pharmaceutical compositions containing the same