IL115972A - One-step process for selective acylation of epsilon-amino groups of proinsulin insulin or an insulin analog under basic conditions - Google Patents

One-step process for selective acylation of epsilon-amino groups of proinsulin insulin or an insulin analog under basic conditions

Info

Publication number
IL115972A
IL115972A IL11597295A IL11597295A IL115972A IL 115972 A IL115972 A IL 115972A IL 11597295 A IL11597295 A IL 11597295A IL 11597295 A IL11597295 A IL 11597295A IL 115972 A IL115972 A IL 115972A
Authority
IL
Israel
Prior art keywords
insulin
epsilon
amino groups
step process
basic conditions
Prior art date
Application number
IL11597295A
Other languages
English (en)
Other versions
IL115972A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL115972A0 publication Critical patent/IL115972A0/xx
Publication of IL115972A publication Critical patent/IL115972A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL11597295A 1994-11-17 1995-11-14 One-step process for selective acylation of epsilon-amino groups of proinsulin insulin or an insulin analog under basic conditions IL115972A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups

Publications (2)

Publication Number Publication Date
IL115972A0 IL115972A0 (en) 1996-01-31
IL115972A true IL115972A (en) 2000-09-28

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11597295A IL115972A (en) 1994-11-17 1995-11-14 One-step process for selective acylation of epsilon-amino groups of proinsulin insulin or an insulin analog under basic conditions

Country Status (28)

Country Link
US (2) US5646242A (ja)
EP (2) EP1227107A1 (ja)
JP (1) JP4312828B2 (ja)
CN (1) CN1171742A (ja)
AR (1) AR003915A1 (ja)
AT (1) ATE328902T1 (ja)
AU (2) AU691066B2 (ja)
BR (1) BR9509652A (ja)
CA (1) CA2205061A1 (ja)
CO (1) CO4520285A1 (ja)
CZ (1) CZ287731B6 (ja)
DE (1) DE69535031T2 (ja)
DK (1) DK0712862T3 (ja)
ES (1) ES2264124T3 (ja)
HK (1) HK1014007A1 (ja)
HU (2) HU217585B (ja)
IL (1) IL115972A (ja)
IN (1) IN179820B (ja)
NO (1) NO972185L (ja)
NZ (1) NZ297256A (ja)
PL (1) PL320556A1 (ja)
PT (1) PT712862E (ja)
RU (1) RU2155773C2 (ja)
SI (1) SI0712862T1 (ja)
TR (1) TR199501421A2 (ja)
WO (1) WO1996015803A1 (ja)
YU (1) YU71495A (ja)
ZA (1) ZA959680B (ja)

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US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
CA2306905A1 (en) * 1997-10-24 1999-05-06 Eli Lilly And Company Fatty acid-acylated insulin analogs
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
US5981709A (en) * 1997-12-19 1999-11-09 Enzon, Inc. α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
US5985263A (en) * 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US6451974B1 (en) 1999-03-17 2002-09-17 Novo Nordisk A/S Method of acylating peptides and novel acylating agents
US7181349B1 (en) 1999-05-27 2007-02-20 Cecil Yip Identification of compounds for modulating dimeric receptors
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US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
CN1406131A (zh) * 2000-12-25 2003-03-26 株式会社资生堂 活化交感神经的香料组合物
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7595172B2 (en) * 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
IL159623A0 (en) * 2001-07-24 2004-06-01 Novo Nordisk As Method for making acylated polypeptides
AU2002355160A1 (en) * 2001-07-24 2003-02-17 Novo Nordisk A/S Method for making acylated polypeptides
US20030082671A1 (en) 2001-07-24 2003-05-01 Thomas Hoeg-Jensen Method for making acylated polypeptides
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
EP1430082B1 (en) 2001-09-07 2009-10-28 Biocon Limited Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
PL210455B1 (pl) * 2002-09-25 2012-01-31 Novo Nordisk As Sposób otrzymywania acylowanych peptydów
PL2107069T3 (pl) * 2003-08-05 2013-06-28 Novo Nordisk As Nowe pochodne insuliny
JP2007532096A (ja) 2003-11-14 2007-11-15 ノボ　ノルディスク　アクティーゼルスカブ アシル化されたインスリンの製造方法
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ES2371361T3 (es) 2005-12-28 2011-12-30 Novo Nordisk A/S Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones.
US8722620B2 (en) 2006-02-27 2014-05-13 Novo Nordisk A/S Insulin derivatives
WO2007121318A2 (en) * 2006-04-12 2007-10-25 Emisphere Technologies, Inc. Formulations for delivering insulin
EP2049149B1 (en) 2006-07-31 2015-04-15 Novo Nordisk A/S Pegylated extended insulins
HUE029512T2 (en) 2006-09-22 2017-03-28 Novo Nordisk As Protease Resistant Insulin Analogs
JP5503968B2 (ja) 2006-09-27 2014-05-28 ノボ・ノルデイスク・エー／エス 成熟インスリンポリペプチドの作製方法
JP5496082B2 (ja) 2007-04-30 2014-05-21 ノボ・ノルデイスク・エー／エス タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
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PT2203181T (pt) 2007-10-16 2018-05-10 Biocon Ltd Uma composição farmacêutica sólida para administração por via oral e o seu processo de fabrico
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DK2632478T3 (da) 2010-10-27 2019-10-07 Novo Nordisk As Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
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JP2016519127A (ja) 2013-04-30 2016-06-30 ノヴォ ノルディスク アー／エス 新規投与レジメン
WO2015052088A1 (en) 2013-10-07 2015-04-16 Novo Nordisk A/S Novel derivative of an insulin analogue
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
CN109715793A (zh) 2016-05-05 2019-05-03 科德克希思公司 青霉素-g 酰化酶
EP3534962B1 (en) 2016-11-07 2020-08-19 Novo Nordisk A/S Dchbs-active esters of peg compounds and their use
HRP20221324T1 (hr) 2016-12-16 2022-12-23 Novo Nordisk A/S Farmaceutski pripravci koji sadrže inzulin
CN107602437A (zh) * 2017-08-09 2018-01-19 上海昂德生物科技有限公司 活化酯的制备方法
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Also Published As

Publication number Publication date
DE69535031T2 (de) 2006-12-28
DK0712862T3 (da) 2006-09-25
JP4312828B2 (ja) 2009-08-12
RU2155773C2 (ru) 2000-09-10
EP0712862A3 (en) 1998-03-04
CO4520285A1 (es) 1997-10-15
ZA959680B (en) 1997-05-14
NO972185D0 (no) 1997-05-13
EP1227107A1 (en) 2002-07-31
YU71495A (sh) 1998-09-18
ES2264124T3 (es) 2006-12-16
PL320556A1 (en) 1997-10-13
CZ145697A3 (en) 1997-12-17
MX9703506A (es) 1997-07-31
CZ287731B6 (en) 2001-01-17
NZ297256A (en) 2000-01-28
IL115972A0 (en) 1996-01-31
CA2205061A1 (en) 1996-05-30
ATE328902T1 (de) 2006-06-15
HU9903007D0 (en) 1999-11-29
PT712862E (pt) 2006-08-31
EP0712862B1 (en) 2006-06-07
HK1014007A1 (en) 1999-09-17
NO972185L (no) 1997-05-13
BR9509652A (pt) 1997-09-16
IN179820B (ja) 1997-12-13
AR003915A1 (es) 1998-09-30
AU4237296A (en) 1996-06-17
AU720820B2 (en) 2000-06-15
TR199501421A2 (tr) 1996-06-21
USRE37971E1 (en) 2003-01-28
DE69535031D1 (de) 2006-07-20
HUT77737A (hu) 1998-07-28
AU7885498A (en) 1998-11-05
JPH10509176A (ja) 1998-09-08
CN1171742A (zh) 1998-01-28
US5646242A (en) 1997-07-08
HU217585B (hu) 2000-02-28
SI0712862T1 (sl) 2006-10-31
AU691066B2 (en) 1998-05-07
EP0712862A2 (en) 1996-05-22
WO1996015803A1 (en) 1996-05-30

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