IL103329A - Noble preparations of imidazole-5-carboxylic acids in their preparation and pharmaceutical preparations containing them - Google Patents

Noble preparations of imidazole-5-carboxylic acids in their preparation and pharmaceutical preparations containing them

Info

Publication number
IL103329A
IL103329A IL10332992A IL10332992A IL103329A IL 103329 A IL103329 A IL 103329A IL 10332992 A IL10332992 A IL 10332992A IL 10332992 A IL10332992 A IL 10332992A IL 103329 A IL103329 A IL 103329A
Authority
IL
Israel
Prior art keywords
compound
denotes
imidazole
formula
butyl
Prior art date
Application number
IL10332992A
Other languages
English (en)
Hebrew (he)
Other versions
IL103329A0 (en
Original Assignee
Chem Pharm Forsch Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Pharm Forsch Gmbh filed Critical Chem Pharm Forsch Gmbh
Publication of IL103329A0 publication Critical patent/IL103329A0/xx
Publication of IL103329A publication Critical patent/IL103329A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL10332992A 1991-10-04 1992-10-02 Noble preparations of imidazole-5-carboxylic acids in their preparation and pharmaceutical preparations containing them IL103329A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0198791A AT398202B (de) 1991-10-04 1991-10-04 Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
IL103329A0 IL103329A0 (en) 1993-03-15
IL103329A true IL103329A (en) 1996-10-31

Family

ID=3525398

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10332992A IL103329A (en) 1991-10-04 1992-10-02 Noble preparations of imidazole-5-carboxylic acids in their preparation and pharmaceutical preparations containing them

Country Status (22)

Country Link
US (1) US5298519A (sh)
EP (1) EP0535420A1 (sh)
JP (1) JP2544565B2 (sh)
CN (1) CN1032856C (sh)
AT (1) AT398202B (sh)
AU (1) AU649357B2 (sh)
CA (1) CA2079735A1 (sh)
CZ (1) CZ301992A3 (sh)
FI (1) FI924353A (sh)
HR (1) HRP920817A2 (sh)
HU (1) HUT62291A (sh)
IL (1) IL103329A (sh)
LV (1) LV10256B (sh)
MY (1) MY108350A (sh)
NO (1) NO923798L (sh)
NZ (1) NZ244320A (sh)
RU (1) RU2105764C1 (sh)
SI (1) SI9200240A (sh)
SK (1) SK301992A3 (sh)
TW (1) TW223073B (sh)
YU (1) YU48290B (sh)
ZA (1) ZA927205B (sh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2105939B1 (es) * 1994-08-02 1998-07-01 Uriach & Cia Sa J Nuevos pirazoles con actividad antagonista de la angiotensina ii.
CN101024643A (zh) * 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
CN101195615B (zh) * 2006-12-06 2013-03-27 深圳市信立泰资产管理有限公司 咪唑-5-羧酸衍生物的盐、制备方法及其药物组合物
EP2103610B1 (en) * 2006-12-06 2011-09-21 Shanghai Allist Pharmaceutical., Inc. Salts of imidazol-5-carboxylic acid derivatives, preparation methods and use thereof
CN101214242A (zh) * 2007-01-05 2008-07-09 上海艾力斯医药科技有限公司 新的药用组合物
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA3089569C (en) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
CN101317842A (zh) 2007-06-07 2008-12-10 上海艾力斯医药科技有限公司 一种咪唑-5-羧酸衍生物的治疗用途
CN101367795B (zh) * 2007-08-17 2012-05-02 上海艾力斯生物医药有限公司 一种咪唑-5-羧酸衍生物及其制备方法
CN101407511B (zh) * 2007-10-11 2013-01-09 上海艾力斯生物医药有限公司 一种结晶型的咪唑-5-羧酸衍生物
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103012377A (zh) * 2011-09-27 2013-04-03 江苏艾力斯生物医药有限公司 一种咪唑-5-羧酸酯的重结晶方法
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
RS65632B1 (sr) 2013-06-05 2024-07-31 Bausch Health Ireland Ltd Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
SG50669A1 (en) * 1989-06-30 1998-07-20 Du Pont Fused-ring aryl subtituted imidazoles
EP0411507B1 (en) * 1989-08-02 1994-10-26 Takeda Chemical Industries, Ltd. Pyrazole derivatives, their production and use
DE4132631A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Imidazolyl-propensaeurederivate
DE4132632A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Substituierte imidazolyl-propensaeurederivate
DE69329982T2 (de) * 1992-06-02 2001-09-27 Sankyo Co., Ltd. 4-Carboxyimidazolderivate als Angiotensin-II-Antagonisten und ihre therapeutische Verwendung

Also Published As

Publication number Publication date
RU2105764C1 (ru) 1998-02-27
AU2617692A (en) 1993-04-08
LV10256A (lv) 1994-10-20
HUT62291A (en) 1993-04-28
JP2544565B2 (ja) 1996-10-16
IL103329A0 (en) 1993-03-15
EP0535420A1 (de) 1993-04-07
CN1032856C (zh) 1996-09-25
JPH05310731A (ja) 1993-11-22
CZ301992A3 (en) 1993-08-11
FI924353A0 (fi) 1992-09-29
YU48290B (sh) 1998-05-15
NO923798L (no) 1993-04-05
US5298519A (en) 1994-03-29
SI9200240A (en) 1993-06-30
CN1071426A (zh) 1993-04-28
MY108350A (en) 1996-09-30
TW223073B (sh) 1994-05-01
NO923798D0 (no) 1992-09-30
SK301992A3 (en) 1995-10-11
YU87592A (sh) 1995-10-03
NZ244320A (en) 1995-01-27
LV10256B (en) 1995-04-20
AT398202B (de) 1994-10-25
CA2079735A1 (en) 1993-04-05
ZA927205B (en) 1993-03-23
AU649357B2 (en) 1994-05-19
ATA198791A (de) 1994-02-15
HU9203149D0 (en) 1992-12-28
HRP920817A2 (en) 1996-08-31
FI924353A (fi) 1993-04-05

Similar Documents

Publication Publication Date Title
US5298519A (en) Acylals of imidazole-5-carboxylic acid derivatives, and their use as angiotensin (II) inhibitors
DE69123784T2 (de) Benzimidazolderivate, Verfahren zu deren Herstellung und Anwendung
CH642357A5 (de) 4-((3,4-dialkoxyphenyl)-alkyl)-2-imidazolidinon-derivate und verfahren zu ihrer herstellung.
US4518712A (en) Piperazine derivative and analgesic composition containing the same
US5254574A (en) New tetrazole derivatives, process for their preparation and their use
EP0087810A1 (en) Antiphlogistic/antipyretic/analgesic pharmaceutical compositions containing theophylline derivatives as active ingredient
US4330472A (en) Meta-sulfonamido-benzamide derivatives
US3740401A (en) 2-(n-cycloalkyl-phenylamino)-2-imidazolines-(2) and salts thereof
US4361575A (en) Substituted 2-phenylamino-2-imidazolines and salts thereof
JPS6323191B2 (sh)
GB1563887A (en) Oxadiazolopyrimidine derivatives
US3974285A (en) 10,11-Furo-derivatives of cyproheptadine
US4103018A (en) 2-[4-(Polyhalo-2-hydroxy-2-propyl)anilino]-2-oxazolin-4-ones and thiazolin-4-ones corresponding thereto
US4093627A (en) 3-[(4-Chromanylidene)amino]-2-oxazolidinones
US4703055A (en) Benzamides and therapeutic use thereof
DE69324794T2 (de) Phenyl imidazolinon-derivate, verfahren zu ihrer herstellung und ihre verwendung als 5-ht3-rezeptor-antagonisten
US4323576A (en) Derivatives of pyrazole for use in therapy
US4614743A (en) Methods of treating pain and inflammation with 4,7-dimethyl-2-(4-pyridinyl)-1,2,4,-triazolo[1,5-a]pyrimidin-5(4H)-one or the pharmaceutically acceptable salts or solvates thereof
DE69431820T2 (de) Bicyclische Imidazolverbindungen, Verfahren zu ihrer Herstellung, Zwischenverbindungen, ihre Anwendung als Medikamente und sie enthaltende pharmazeutische Zusammensetzungen
KR810000631B1 (ko) 치환된 2-페닐아미노-이미다졸린-(2)유도체의 제조방법
DK151885B (da) Fremgangsmaade til fremstilling af pyridooe1,2aaapyrimidin-3-carboxamider eller optisk aktive isomere eller farmaceutisk acceptable salte deraf
EP0182271B1 (de) Neue Nb-quartäre Dibromderivate von Ajmalin, Isoajmalin, Sandwicin und Isosandwicin sowie diese Derivate enthaltende pharmazeutische Zubereitungen und Zwischenprodukte und Verfahren zu ihrer Herstellung
US4182890A (en) Ethyl 2-oxo-3-phenylethylaminopiperidine-4-carboxylate hydrochloride
JPS6312870B2 (sh)
US4176120A (en) 2-[4-(Polyhalo-2-hydroxy-2-propyl)anilino]thiazolin-4-ones

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH Patent void