IL100861A - 8-(aryloxyalkyl)-3-heteroaryl-8- azabicyclo [3,2,1] octanes a process for the preparation thereof pharmaceutical compositions containing them and some intermediates therefor - Google Patents

8-(aryloxyalkyl)-3-heteroaryl-8- azabicyclo [3,2,1] octanes a process for the preparation thereof pharmaceutical compositions containing them and some intermediates therefor

Info

Publication number
IL100861A
IL100861A IL10086192A IL10086192A IL100861A IL 100861 A IL100861 A IL 100861A IL 10086192 A IL10086192 A IL 10086192A IL 10086192 A IL10086192 A IL 10086192A IL 100861 A IL100861 A IL 100861A
Authority
IL
Israel
Prior art keywords
octanes
aryloxyalkyl
azabicyclo
heteroaryl
preparation
Prior art date
Application number
IL10086192A
Other languages
English (en)
Other versions
IL100861A0 (en
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of IL100861A0 publication Critical patent/IL100861A0/xx
Publication of IL100861A publication Critical patent/IL100861A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
IL10086192A 1991-02-04 1992-02-03 8-(aryloxyalkyl)-3-heteroaryl-8- azabicyclo [3,2,1] octanes a process for the preparation thereof pharmaceutical compositions containing them and some intermediates therefor IL100861A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65014491A 1991-02-04 1991-02-04

Publications (2)

Publication Number Publication Date
IL100861A0 IL100861A0 (en) 1992-11-15
IL100861A true IL100861A (en) 1997-02-18

Family

ID=24607667

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10086192A IL100861A (en) 1991-02-04 1992-02-03 8-(aryloxyalkyl)-3-heteroaryl-8- azabicyclo [3,2,1] octanes a process for the preparation thereof pharmaceutical compositions containing them and some intermediates therefor

Country Status (21)

Country Link
EP (1) EP0498331B1 (ja)
JP (1) JPH089613B2 (ja)
KR (1) KR100222774B1 (ja)
AT (1) ATE138377T1 (ja)
AU (1) AU641842B2 (ja)
CA (1) CA2060573C (ja)
CZ (1) CZ284754B6 (ja)
DE (1) DE69210849T2 (ja)
DK (1) DK0498331T3 (ja)
ES (1) ES2089255T3 (ja)
FI (1) FI111367B (ja)
GR (1) GR3020094T3 (ja)
HU (2) HU207863B (ja)
IE (1) IE74905B1 (ja)
IL (1) IL100861A (ja)
MX (1) MX9200471A (ja)
NO (1) NO300040B1 (ja)
NZ (1) NZ241481A (ja)
PL (1) PL169092B1 (ja)
RU (1) RU2075479C1 (ja)
ZA (1) ZA92753B (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
ATE362931T1 (de) * 1995-10-13 2007-06-15 Neurosearch As 8-azabicyclo(3.2.1)oct-2en-derivate, deren herstellung und anwendung
IL126882A0 (en) * 1996-05-13 1999-09-22 Zeneca Ltd Bicyclic amines as insecticides
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
DE69727694T2 (de) 1996-11-26 2004-07-29 Syngenta Ltd., Guildford 8-azabicyclo 3.2.1]octan-, 8-azabicyclo 3.2.1]oct-6-en-, 9-azabicyclo 3.3.1]nonan-, 9-aza-3-oxabicyclo 3.3.1]nonan- und 9-aza-3-thiabicyclo 3.3.1]nonan-derivate, ihre herstellung und ihre verwendung als insektizide
GB9624611D0 (en) 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
CN1157392C (zh) 1997-05-30 2004-07-14 神经研究公司 在尼古丁ach受体上作为胆碱能配体的8-氮杂双环(3,2,1)辛-2-烯以及辛烷衍生物
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
US6835733B2 (en) 1999-12-20 2004-12-28 Eli Lilly And Company Tropane linked benzofuran derivatives
EP1242419A1 (en) * 1999-12-20 2002-09-25 Eli Lilly And Company Azabicyclo 3.2.1]octane derivatives
MXPA03006524A (es) * 2001-02-16 2003-09-25 Aventis Pharma Inc Derivados heterociclicos novedosos de amidas y su uso como ligandos para receptor d3 de dopamina.
EP1594868B1 (en) * 2003-02-12 2009-11-11 Neurosearch A/S 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2548666A1 (fr) * 1983-07-08 1985-01-11 Delalande Sa Nouveaux derives du nor-tropane et du granatane, leur procede de preparation et leur application en therapeutique
ATE108791T1 (de) * 1987-11-04 1994-08-15 Beecham Group Plc Neue 4-oxobenzotriazine und 4-oxochinazoline.

Also Published As

Publication number Publication date
CA2060573A1 (en) 1992-08-05
ATE138377T1 (de) 1996-06-15
CS29792A3 (en) 1992-08-12
KR920016452A (ko) 1992-09-24
JPH089613B2 (ja) 1996-01-31
HU9200321D0 (en) 1992-04-28
HU9203977D0 (en) 1993-04-28
IE920349A1 (en) 1992-08-12
HUT62295A (en) 1993-04-28
ZA92753B (en) 1992-10-28
AU641842B2 (en) 1993-09-30
AU1060592A (en) 1992-08-06
RU2075479C1 (ru) 1997-03-20
CZ284754B6 (cs) 1999-02-17
KR100222774B1 (ko) 1999-10-01
DE69210849T2 (de) 1996-12-05
JPH0559049A (ja) 1993-03-09
IL100861A0 (en) 1992-11-15
EP0498331B1 (en) 1996-05-22
FI920435A (fi) 1992-08-05
DK0498331T3 (da) 1996-09-09
NO920438L (no) 1992-08-05
EP0498331A1 (en) 1992-08-12
NO300040B1 (no) 1997-03-24
ES2089255T3 (es) 1996-10-01
CA2060573C (en) 2002-08-13
FI920435A0 (fi) 1992-01-31
GR3020094T3 (en) 1996-08-31
HUT60494A (en) 1992-09-28
FI111367B (fi) 2003-07-15
MX9200471A (es) 1992-08-01
DE69210849D1 (de) 1996-06-27
PL169092B1 (pl) 1996-05-31
HU217616B (hu) 2000-03-28
HU207863B (en) 1993-06-28
NO920438D0 (no) 1992-02-03
IE74905B1 (en) 1997-08-13
NZ241481A (en) 1994-06-27
PL293363A1 (en) 1993-03-08

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Legal Events

Date Code Title Description
FF Patent granted
HC Change of name of proprietor(s)
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees