IL100631A - History of acridi, their preparation and pharmaceutical preparations containing them - Google Patents
History of acridi, their preparation and pharmaceutical preparations containing themInfo
- Publication number
- IL100631A IL100631A IL10063192A IL10063192A IL100631A IL 100631 A IL100631 A IL 100631A IL 10063192 A IL10063192 A IL 10063192A IL 10063192 A IL10063192 A IL 10063192A IL 100631 A IL100631 A IL 100631A
- Authority
- IL
- Israel
- Prior art keywords
- oxo
- dihydro
- acridinecarboxamide
- methyl
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/26—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups and being further substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Plural Heterocyclic Compounds (AREA)
- Soft Magnetic Materials (AREA)
- Paper (AREA)
- Laminated Bodies (AREA)
- Dry Shavers And Clippers (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919100637A GB9100637D0 (en) | 1991-01-11 | 1991-01-11 | Chemical compounds |
GB919100628A GB9100628D0 (en) | 1991-01-11 | 1991-01-11 | Chemical compounds |
GB919115956A GB9115956D0 (en) | 1991-07-24 | 1991-07-24 | Chemical compounds |
GB919115981A GB9115981D0 (en) | 1991-07-24 | 1991-07-24 | Chemical compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
IL100631A0 IL100631A0 (en) | 1992-09-06 |
IL100631A true IL100631A (en) | 1996-09-12 |
Family
ID=27450605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10063192A IL100631A (en) | 1991-01-11 | 1992-01-10 | History of acridi, their preparation and pharmaceutical preparations containing them |
Country Status (25)
Country | Link |
---|---|
US (1) | US5604237A (fr) |
EP (2) | EP0494623A1 (fr) |
JP (1) | JP2783680B2 (fr) |
KR (1) | KR100220538B1 (fr) |
AT (1) | ATE153660T1 (fr) |
AU (1) | AU652996B2 (fr) |
CA (1) | CA2100258C (fr) |
CZ (1) | CZ283038B6 (fr) |
DE (1) | DE69220037T2 (fr) |
DK (1) | DK0569380T3 (fr) |
ES (1) | ES2104887T3 (fr) |
FI (1) | FI103888B1 (fr) |
GE (1) | GEP20002210B (fr) |
GR (1) | GR3024525T3 (fr) |
HU (2) | HUT68856A (fr) |
IE (1) | IE920083A1 (fr) |
IL (1) | IL100631A (fr) |
MX (1) | MX9200109A (fr) |
NO (1) | NO300267B1 (fr) |
NZ (1) | NZ241278A (fr) |
PL (1) | PL168202B1 (fr) |
RU (1) | RU2119482C1 (fr) |
SG (1) | SG45403A1 (fr) |
SK (1) | SK280864B6 (fr) |
WO (1) | WO1992012132A1 (fr) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ283038B6 (cs) * | 1991-01-11 | 1997-12-17 | Laboratoires Glaxo Sa | Akridinové deriváty, způsob výroby a farmaceutické prostředky s jejich obsahem |
TR28930A (tr) * | 1992-05-07 | 1997-07-21 | Zeneca Ltd | Alkil sübstitüentli nitrotoluen türevleri |
GB9209872D0 (en) * | 1992-05-07 | 1992-06-24 | Ici Plc | Alkyl substituted nitrotoluene derivatives |
ATE152443T1 (de) * | 1992-07-10 | 1997-05-15 | Glaxo Lab Sa | Anilide-derivate |
RU2036198C1 (ru) * | 1993-04-01 | 1995-05-27 | Товарищество с ограниченной ответственностью "Полисан" | N-МЕТИЛ-N-( α,D -ГЛЮКОПИРАНОЗИЛ) АММОНИЯ-2-(АКРИДОН-9-ОН-10-ИЛ)АЦЕТАТ(ЦИКЛОФЕРОН), ОБЛАДАЮЩИЙ ИНТЕРФЕРОНОГЕННОЙ, ПРОТИВОВИРУСНОЙ, В ТОМ ЧИСЛЕ АНТИВИЧ, АНТИПАРАЗИТАРНОЙ, АНТИПРОМОТОРНОЙ И РАДИОПРОТЕКТИВНОЙ АКТИВНОСТЬЮ |
US5387685A (en) * | 1993-07-16 | 1995-02-07 | American Cyanamid Co | MDR reversal agents |
DE4422517A1 (de) * | 1994-06-28 | 1996-01-04 | Dresden Arzneimittel | Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
ES2206508T3 (es) * | 1994-08-04 | 2004-05-16 | C & C RESEARCH LABS. | Nuevo derivado aminado, procedimiento de obtencion de este derivado y su utilizacion como antiarritmico. |
WO1996011007A1 (fr) * | 1994-10-05 | 1996-04-18 | Glaxo Wellcome Inc. | Compositions pharmaceutiques parenterales contenant gf120918a |
FR2726267B1 (fr) * | 1994-10-26 | 1998-01-02 | Smithkline Beecham Lab | Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer |
US6395770B1 (en) | 1995-10-26 | 2002-05-28 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for administering taxanes orally to human patients |
US6245805B1 (en) | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
AU1597197A (en) * | 1996-02-01 | 1997-08-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thienoquinolines |
US6713517B1 (en) | 1996-03-08 | 2004-03-30 | Oxigene, Inc. | Use of aryl N-substituted carboxamides directly and as radio-and chemosensitizers for killing tumor and cancer cells and novel compounds for such use |
RU2118532C1 (ru) * | 1996-04-10 | 1998-09-10 | Олег Викторович Травкин | Противоинфекционное, противовоспалительное и противоопухолевое лекарственное средство |
GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
GB9710612D0 (en) * | 1997-05-23 | 1997-07-16 | Glaxo Group Ltd | Synthesis of acridine derivatives |
UA74767C2 (en) * | 1997-05-27 | 2006-02-15 | Baker Norton Pharma | Method and composition for oral use of taxanes in patients |
GB9718903D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
GB9812189D0 (en) * | 1998-06-05 | 1998-08-05 | Glaxo Group Ltd | Methods and compositions for increasing penetration of HIV protease inhibitors |
WO2000000472A1 (fr) * | 1998-06-30 | 2000-01-06 | Du Pont Pharmaceuticals Company | Antagonistes du recepteur 5-ht¿7? |
CO5140073A1 (es) | 1998-10-08 | 2002-03-22 | Smithkline Beecham Plc | Derivados de 2,3,4,5-tetrahidro-1h-3-benzapina |
WO2000069390A2 (fr) | 1999-05-17 | 2000-11-23 | Cancer Research Ventures Limited | Procede pour ameliorer la biodisponibilite de medicaments administres par voie orale, procede pour selectionner des activateurs d'une telle biodisponibilite et nouvelles compositions pharmaceutiques pour medicaments a administration par voie orale |
EP1229934B1 (fr) | 1999-10-01 | 2014-03-05 | Immunogen, Inc. | Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques |
US6521635B1 (en) | 2000-01-20 | 2003-02-18 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of MXR transport by acridine derivatives |
ATE480237T1 (de) * | 2000-02-18 | 2010-09-15 | New York Medical College | Tumorhemmende nitroacridin-zusammensetzungen |
MXPA02008797A (es) | 2000-03-14 | 2005-09-08 | Actelion Pharmaceuticals Ltd | Derivados de 1,2,3,4-tetrahidroisoquinolina. |
WO2001085693A1 (fr) | 2000-05-11 | 2001-11-15 | Banyu Pharmaceutical Co., Ltd. | Dérivés n-acyltétrahydroisoquinoline |
HUP0303719A2 (hu) * | 2000-10-16 | 2004-03-01 | Neopharm, Inc. | Mitoxantron hatóanyag-tartalmú liposzómás gyógyszerkészítmények és eljárás az előállításukra |
BR0309990A (pt) * | 2002-05-14 | 2005-02-22 | Xenova Ltd | Processo para produzir um hidrato de um sal de adição de ácido de um composto, hidrato de um sal de adição de ácido de um composto, composição farmacêutica ou veterinária, uso de um hidrato agente para o uso como um inibidor ou p-glicoproteìna, e, métodos para modular a mdr modulada pela p-gp no tratamento de tumores, para potencializar a citotoxicidade de um agente citotóxico para uma célula de tumor, para tratar uma doença em que o patógeno responsável exibe resistência a múltiplos medicamentos, e para realçar uma caracterìstica de um agente terapêutico |
WO2004039795A2 (fr) * | 2002-10-29 | 2004-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Composes amide |
CA2557163C (fr) | 2004-03-01 | 2011-08-16 | Actelion Pharmaceuticals Ltd | Derives de 1,2,3,4-tetrahydroisoquinoleine substitues |
RU2346692C2 (ru) * | 2007-03-29 | 2009-02-20 | Ефаг АО | Применение 9-оксоакридин-10-уксусной кислоты, ее солей и сложных эфиров в комбинированной терапии рака яичников, способ лечения и наборы |
SE531698C2 (sv) * | 2007-07-12 | 2009-07-07 | Respiratorius Ab | Nya bronkdilaterande a,b-omättade amider |
WO2015142670A1 (fr) * | 2014-03-15 | 2015-09-24 | Medisyn Technologies, Inc. | Composés anti-diabétiques, compositions pharmaceutiques les contenant et méthode de traitement du diabète |
CN104434808A (zh) | 2014-07-03 | 2015-03-25 | 石药集团中奇制药技术(石家庄)有限公司 | 一种治疗性纳米粒子及其制备方法 |
IL277335B2 (en) * | 2018-03-21 | 2024-03-01 | Izumi Tech Llc | Analogues of alcridar with deuterium |
CN113387873B (zh) * | 2021-06-15 | 2022-09-20 | 山东第一医科大学(山东省医学科学院) | 取代二芳基类化合物其制备方法和用途 |
CN117414367A (zh) * | 2022-08-09 | 2024-01-19 | 北京清华长庚医院 | 一种逆转仑伐替尼耐药的药物组合物及其用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4250182A (en) * | 1972-02-24 | 1981-02-10 | Burroughs Wellcome Co. | Pharmaceutical composition containing acridone compounds and method of using same |
US4021551A (en) * | 1972-06-07 | 1977-05-03 | Boehringer Ingelheim Gmbh | 3,6-Bis-(heterocyclic aminoacyl-amino)-acridines and salts thereof |
US4127573A (en) * | 1972-09-06 | 1978-11-28 | Burroughs Wellcome Co. | Ditetrazole substituted acridone compounds |
ATE12779T1 (de) * | 1980-09-30 | 1985-05-15 | Bayer Ag | Verfahren zur herstellung eines antithrombinheparin-komplexes sowie diesen komplex enthaltende pharmazeutische mischungen. |
NZ198115A (en) * | 1981-08-21 | 1985-05-31 | New Zealand Dev Finance | 9-anilinoacridines;pharmaceutical compositions |
NZ201084A (en) * | 1982-06-25 | 1985-10-11 | New Zealand Dev Finance | 4-carboxamidoacridine derivatives and pharmaceutical compositions containing such |
IN164921B (fr) * | 1986-07-22 | 1989-07-08 | Hoechst India | |
US5104858A (en) * | 1988-09-29 | 1992-04-14 | Yale University | Sensitizing multidrug resistant cells to antitumor agents |
CA1340821C (fr) * | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Composes heterocycliques, ainsi que des adjuvants de produits anti-cancereux les comprenant |
DK0409406T3 (da) * | 1989-06-19 | 1994-02-07 | Wellcome Found | Arylsubstituerede aminderivater, der er anvendelige ved cancerterapi |
CZ283038B6 (cs) * | 1991-01-11 | 1997-12-17 | Laboratoires Glaxo Sa | Akridinové deriváty, způsob výroby a farmaceutické prostředky s jejich obsahem |
US5296602A (en) * | 1991-03-18 | 1994-03-22 | Sloan-Kettering Institute For Cancer Research | Multisubstituted 1-hydroxy-9-acridones with anticancer activity |
US5240936A (en) * | 1992-05-14 | 1993-08-31 | Texas A&M University System | Treating or preventing ocular inflammation or systemic imflammatory disease |
-
1992
- 1992-01-07 CZ CS931378A patent/CZ283038B6/cs not_active IP Right Cessation
- 1992-01-07 PL PL92299989A patent/PL168202B1/pl unknown
- 1992-01-07 WO PCT/EP1992/000020 patent/WO1992012132A1/fr active IP Right Grant
- 1992-01-07 DE DE69220037T patent/DE69220037T2/de not_active Expired - Lifetime
- 1992-01-07 EP EP92100123A patent/EP0494623A1/fr active Pending
- 1992-01-07 AU AU11543/92A patent/AU652996B2/en not_active Expired
- 1992-01-07 HU HU9301989A patent/HUT68856A/hu unknown
- 1992-01-07 RU RU93051543A patent/RU2119482C1/ru active
- 1992-01-07 SK SK730-93A patent/SK280864B6/sk not_active IP Right Cessation
- 1992-01-07 AT AT92901861T patent/ATE153660T1/de not_active IP Right Cessation
- 1992-01-07 GE GEAP19922653A patent/GEP20002210B/en unknown
- 1992-01-07 ES ES92901861T patent/ES2104887T3/es not_active Expired - Lifetime
- 1992-01-07 EP EP92901861A patent/EP0569380B1/fr not_active Expired - Lifetime
- 1992-01-07 DK DK92901861.2T patent/DK0569380T3/da active
- 1992-01-07 CA CA002100258A patent/CA2100258C/fr not_active Expired - Lifetime
- 1992-01-07 JP JP4501671A patent/JP2783680B2/ja not_active Expired - Lifetime
- 1992-01-07 KR KR1019930702079A patent/KR100220538B1/ko not_active IP Right Cessation
- 1992-01-07 SG SG1996006197A patent/SG45403A1/en unknown
- 1992-01-10 IL IL10063192A patent/IL100631A/en not_active IP Right Cessation
- 1992-01-10 MX MX9200109A patent/MX9200109A/es unknown
- 1992-01-10 IE IE008392A patent/IE920083A1/en not_active IP Right Cessation
- 1992-01-10 NZ NZ241278A patent/NZ241278A/en not_active IP Right Cessation
-
1993
- 1993-07-09 FI FI933149A patent/FI103888B1/fi active
- 1993-07-09 NO NO932512A patent/NO300267B1/no not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/468,620 patent/US5604237A/en not_active Expired - Lifetime
- 1995-06-29 HU HU95P/P00524P patent/HU211623A9/hu unknown
-
1997
- 1997-08-22 GR GR970402168T patent/GR3024525T3/el unknown
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Legal Events
Date | Code | Title | Description |
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FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |