SK280864B6 - Acridine derivatives, process for their preparation, and pharmaceutical compositions based thereon - Google Patents

Acridine derivatives, process for their preparation, and pharmaceutical compositions based thereon Download PDF

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Publication number
SK280864B6
SK280864B6 SK730-93A SK73093A SK280864B6 SK 280864 B6 SK280864 B6 SK 280864B6 SK 73093 A SK73093 A SK 73093A SK 280864 B6 SK280864 B6 SK 280864B6
Authority
SK
Slovakia
Prior art keywords
dihydro
oxo
methyl
phenyl
acridinecarboxamide
Prior art date
Application number
SK730-93A
Other languages
English (en)
Slovak (sk)
Other versions
SK73093A3 (en
Inventor
Bernard Andr Dumaitre
Nerina Dodic
Original Assignee
Laboratoires Glaxo Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919100628A external-priority patent/GB9100628D0/en
Priority claimed from GB919100637A external-priority patent/GB9100637D0/en
Priority claimed from GB919115956A external-priority patent/GB9115956D0/en
Priority claimed from GB919115981A external-priority patent/GB9115981D0/en
Application filed by Laboratoires Glaxo Sa filed Critical Laboratoires Glaxo Sa
Publication of SK73093A3 publication Critical patent/SK73093A3/sk
Publication of SK280864B6 publication Critical patent/SK280864B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/26—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups and being further substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Laminated Bodies (AREA)
  • Soft Magnetic Materials (AREA)
  • Paper (AREA)
  • Dry Shavers And Clippers (AREA)
SK730-93A 1991-01-11 1992-01-07 Acridine derivatives, process for their preparation, and pharmaceutical compositions based thereon SK280864B6 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB919100628A GB9100628D0 (en) 1991-01-11 1991-01-11 Chemical compounds
GB919100637A GB9100637D0 (en) 1991-01-11 1991-01-11 Chemical compounds
GB919115956A GB9115956D0 (en) 1991-07-24 1991-07-24 Chemical compounds
GB919115981A GB9115981D0 (en) 1991-07-24 1991-07-24 Chemical compounds
PCT/EP1992/000020 WO1992012132A1 (fr) 1991-01-11 1992-01-07 Derives d'acridine

Publications (2)

Publication Number Publication Date
SK73093A3 SK73093A3 (en) 1994-01-12
SK280864B6 true SK280864B6 (en) 2000-08-14

Family

ID=27450605

Family Applications (1)

Application Number Title Priority Date Filing Date
SK730-93A SK280864B6 (en) 1991-01-11 1992-01-07 Acridine derivatives, process for their preparation, and pharmaceutical compositions based thereon

Country Status (25)

Country Link
US (1) US5604237A (fr)
EP (2) EP0569380B1 (fr)
JP (1) JP2783680B2 (fr)
KR (1) KR100220538B1 (fr)
AT (1) ATE153660T1 (fr)
AU (1) AU652996B2 (fr)
CA (1) CA2100258C (fr)
CZ (1) CZ283038B6 (fr)
DE (1) DE69220037T2 (fr)
DK (1) DK0569380T3 (fr)
ES (1) ES2104887T3 (fr)
FI (1) FI103888B1 (fr)
GE (1) GEP20002210B (fr)
GR (1) GR3024525T3 (fr)
HU (2) HUT68856A (fr)
IE (1) IE920083A1 (fr)
IL (1) IL100631A (fr)
MX (1) MX9200109A (fr)
NO (1) NO300267B1 (fr)
NZ (1) NZ241278A (fr)
PL (1) PL168202B1 (fr)
RU (1) RU2119482C1 (fr)
SG (1) SG45403A1 (fr)
SK (1) SK280864B6 (fr)
WO (1) WO1992012132A1 (fr)

Families Citing this family (40)

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RU2119482C1 (ru) * 1991-01-11 1998-09-27 Лаборатуар Глаксо С.А. Производные акридина, способ получения, фармацевтическая композиция и способ лечения злокачественных опухолей
GB9209872D0 (en) * 1992-05-07 1992-06-24 Ici Plc Alkyl substituted nitrotoluene derivatives
TR28930A (tr) * 1992-05-07 1997-07-21 Zeneca Ltd Alkil sübstitüentli nitrotoluen türevleri
ATE152443T1 (de) * 1992-07-10 1997-05-15 Glaxo Lab Sa Anilide-derivate
RU2036198C1 (ru) * 1993-04-01 1995-05-27 Товарищество с ограниченной ответственностью "Полисан" N-МЕТИЛ-N-( α,D -ГЛЮКОПИРАНОЗИЛ) АММОНИЯ-2-(АКРИДОН-9-ОН-10-ИЛ)АЦЕТАТ(ЦИКЛОФЕРОН), ОБЛАДАЮЩИЙ ИНТЕРФЕРОНОГЕННОЙ, ПРОТИВОВИРУСНОЙ, В ТОМ ЧИСЛЕ АНТИВИЧ, АНТИПАРАЗИТАРНОЙ, АНТИПРОМОТОРНОЙ И РАДИОПРОТЕКТИВНОЙ АКТИВНОСТЬЮ
US5387685A (en) * 1993-07-16 1995-02-07 American Cyanamid Co MDR reversal agents
DE4422517A1 (de) * 1994-06-28 1996-01-04 Dresden Arzneimittel Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE69531691T2 (de) * 1994-08-04 2004-07-08 C & C Research Labs Neues amin-derivat, verfahren zur herstellung und dessen verwendung als anti-arrhythmisches mittel
PL319511A1 (en) * 1994-10-05 1997-08-18 Glaxo Wellcome Inc Parenteral pharmaceutic compositions containing gf120918a
FR2726267B1 (fr) * 1994-10-26 1998-01-02 Smithkline Beecham Lab Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer
US6395770B1 (en) 1995-10-26 2002-05-28 Baker Norton Pharmaceuticals, Inc. Method and compositions for administering taxanes orally to human patients
US6245805B1 (en) 1995-10-26 2001-06-12 Baker Norton Pharmaceuticals, Inc. Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
WO1997028166A1 (fr) * 1996-02-01 1997-08-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Thienoquinoleines
US6713517B1 (en) 1996-03-08 2004-03-30 Oxigene, Inc. Use of aryl N-substituted carboxamides directly and as radio-and chemosensitizers for killing tumor and cancer cells and novel compounds for such use
RU2118532C1 (ru) * 1996-04-10 1998-09-10 Олег Викторович Травкин Противоинфекционное, противовоспалительное и противоопухолевое лекарственное средство
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9710612D0 (en) * 1997-05-23 1997-07-16 Glaxo Group Ltd Synthesis of acridine derivatives
DE69832173T2 (de) * 1997-05-27 2006-08-03 IVAX RESEARCH, INC., Miami Zusammensetzungen zur oralen verabreichung von taxanen und deren verwendung
GB9718903D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
GB9812189D0 (en) * 1998-06-05 1998-08-05 Glaxo Group Ltd Methods and compositions for increasing penetration of HIV protease inhibitors
WO2000000472A1 (fr) * 1998-06-30 2000-01-06 Du Pont Pharmaceuticals Company Antagonistes du recepteur 5-ht¿7?
CO5140073A1 (es) 1998-10-08 2002-03-22 Smithkline Beecham Plc Derivados de 2,3,4,5-tetrahidro-1h-3-benzapina
DE60045114D1 (de) 1999-05-17 2010-11-25 Cancer Res Ventures Ltd Zubereitungen zur Erhöhung der Bioverfügbarkeit von oral verabreichten pharmazeutischen Verbindungen
EP2266607A3 (fr) 1999-10-01 2011-04-20 Immunogen, Inc. Des immunoconjugués pour le traitement des cancers.
US6521635B1 (en) 2000-01-20 2003-02-18 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of MXR transport by acridine derivatives
CA2400403C (fr) * 2000-02-18 2011-07-19 New York Medical College Compositions inhibitrices de tumeurs a base de 1-nitroacridine
CN100393703C (zh) * 2000-03-14 2008-06-11 埃科特莱茵药品有限公司 1,2,3,4-四氢异喹啉的衍生物
WO2001085693A1 (fr) 2000-05-11 2001-11-15 Banyu Pharmaceutical Co., Ltd. Dérivés n-acyltétrahydroisoquinoline
MXPA03003401A (es) * 2000-10-16 2004-06-30 Neopharm Inc Formulacion liposomica de mitoxantrona.
DE60326341D1 (de) * 2002-05-14 2009-04-09 Xenova Ltd Verfahren zur herstellung von anthranilsäurederivat-hydrat
WO2004039795A2 (fr) * 2002-10-29 2004-05-13 Fujisawa Pharmaceutical Co., Ltd. Composes amide
KR100848747B1 (ko) 2004-03-01 2008-07-25 액테리온 파마슈티칼 리미티드 치환된 1,2,3,4-테트라하이드로이소퀴놀린 유도체
RU2346692C2 (ru) * 2007-03-29 2009-02-20 Ефаг АО Применение 9-оксоакридин-10-уксусной кислоты, ее солей и сложных эфиров в комбинированной терапии рака яичников, способ лечения и наборы
SE531698C2 (sv) * 2007-07-12 2009-07-07 Respiratorius Ab Nya bronkdilaterande a,b-omättade amider
WO2015142670A1 (fr) * 2014-03-15 2015-09-24 Medisyn Technologies, Inc. Composés anti-diabétiques, compositions pharmaceutiques les contenant et méthode de traitement du diabète
CN104434808A (zh) 2014-07-03 2015-03-25 石药集团中奇制药技术（石家庄）有限公司 一种治疗性纳米粒子及其制备方法
BR112020018669A2 (pt) * 2018-03-21 2020-12-29 Izumi Technology, Llc Análogos deuterados de elacridar
CN115385847B (zh) * 2021-06-15 2023-09-29 山东第一医科大学(山东省医学科学院) 多取代二芳基类化合物及其制备方法和应用
CN117414367A (zh) * 2022-08-09 2024-01-19 北京清华长庚医院 一种逆转仑伐替尼耐药的药物组合物及其用途

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US4250182A (en) * 1972-02-24 1981-02-10 Burroughs Wellcome Co. Pharmaceutical composition containing acridone compounds and method of using same
US4021551A (en) * 1972-06-07 1977-05-03 Boehringer Ingelheim Gmbh 3,6-Bis-(heterocyclic aminoacyl-amino)-acridines and salts thereof
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EP0048898B1 (fr) * 1980-09-30 1985-04-17 Bayer Ag Procédé de preparation d'un complexe antithrombine-héparine et compositions pharmaceutiques le contenant
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CA1340821C (fr) * 1988-10-06 1999-11-16 Nobuyuki Fukazawa Composes heterocycliques, ainsi que des adjuvants de produits anti-cancereux les comprenant
DE69003200T2 (de) * 1989-06-19 1994-01-20 Wellcome Found Arylsubstituierte Aminderivate verwendbar in der Krebstherapie.
RU2119482C1 (ru) * 1991-01-11 1998-09-27 Лаборатуар Глаксо С.А. Производные акридина, способ получения, фармацевтическая композиция и способ лечения злокачественных опухолей
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Also Published As

Publication number Publication date
CZ137893A3 (en) 1994-02-16
FI933149A (fi) 1993-07-09
NO300267B1 (no) 1997-05-05
ATE153660T1 (de) 1997-06-15
CZ283038B6 (cs) 1997-12-17
FI103888B (fi) 1999-10-15
JPH06506440A (ja) 1994-07-21
NO932512D0 (no) 1993-07-09
DE69220037T2 (de) 1997-11-06
JP2783680B2 (ja) 1998-08-06
SG45403A1 (en) 1998-01-16
AU1154392A (en) 1992-08-17
IL100631A (en) 1996-09-12
HUT68856A (en) 1995-08-28
HU211623A9 (en) 1995-12-28
NO932512L (no) 1993-09-09
GEP20002210B (en) 2000-08-25
SK73093A3 (en) 1994-01-12
PL168202B1 (pl) 1996-01-31
FI933149A0 (fi) 1993-07-09
KR100220538B1 (ko) 1999-09-15
NZ241278A (en) 1994-05-26
EP0569380B1 (fr) 1997-05-28
ES2104887T3 (es) 1997-10-16
DK0569380T3 (da) 1997-12-22
EP0494623A1 (fr) 1992-07-15
MX9200109A (es) 1992-09-01
HU9301989D0 (en) 1993-10-28
AU652996B2 (en) 1994-09-15
IE920083A1 (en) 1992-07-15
RU2119482C1 (ru) 1998-09-27
IL100631A0 (en) 1992-09-06
US5604237A (en) 1997-02-18
CA2100258C (fr) 1999-12-14
GR3024525T3 (en) 1997-11-28
CA2100258A1 (fr) 1992-07-12
DE69220037D1 (de) 1997-07-03
EP0569380A1 (fr) 1993-11-18
FI103888B1 (fi) 1999-10-15
WO1992012132A1 (fr) 1992-07-23

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MK4A Patent expired

Expiry date: 20120107