CO5140073A1 - Derivados de 2,3,4,5-tetrahidro-1h-3-benzapina - Google Patents
Derivados de 2,3,4,5-tetrahidro-1h-3-benzapinaInfo
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- CO5140073A1 CO5140073A1 CO99063348A CO99063348A CO5140073A1 CO 5140073 A1 CO5140073 A1 CO 5140073A1 CO 99063348 A CO99063348 A CO 99063348A CO 99063348 A CO99063348 A CO 99063348A CO 5140073 A1 CO5140073 A1 CO 5140073A1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de fórmula (I)<EMI FILE="99063348_1" ID="1" IMF=JPEG >en la que:R1 representa un sustituyente seleccionado entre: un átomo de hidrógeno o de halógeno; un grupo hidroxi, ciano, nitro, trifluorometilo, trifluorometoxi, trifluorometanosul- foniloxi, pentafluoroetilo, alquilo de C1-4, alcoxi de C1-4, aril-alcoxi de C1-4, alquil(C1-4)-tio, alcoxi de C1-4-alquilo de C1-4, cicloalquilo de C3-6-alcoxi de C1-4, alcanoilo de C1-4, alcoxi de C1-4-carbonilo, alquil(C1-4)sulfonilo, alquil(C1-4)sulfoniloxi, alquil(C1-4)sulfonilo-alquilo de C1-4, arilsulfonilo, arilsulfoniloxi, arilsulfonil-alquilo de C1-4, alquil(C1-4)sulfonamido, alquil(C1-4)amido, alquil (C1-4)sulfonamido-alquilo de C1-4, alquil (C1-4)amido-alquilo de C1-4, arilsulfonamido, arilcarboxamido, arilsulfonamido- alquilo de C1-4, arilcarboxamido-alquilo de C1-4, aroilo, aroil-alquilo de C1-4, o aril-alcanoilo de C1-4; un grupo R3OCO(CH2)p, R3CON(R4)(CH2)p, R3R4NCO(CH2)p ó R3R4NSO2(CH2)p, en cada una de cuyas fórmulas R3 y R4, independientemente, representa un átomo de hidrógeno o un grupo alquilo de C1-4 ó R3R4 forma parte de un anillo de azacicloalcano de C3-6 o (2-oxo)azacicloalcano de C3-6 y p representa cero o un número entero desde 1 a 4; o un grupo Ar3-Z, en el que Ar3 representa un anillo de fenilo opcionalmente sustituido o un anillo heterocíclico aromáticos de 5 o 6 miembros opcionalmente sustituido, y Z representa un enlace, O, S ó CH2; R2 representa un átomo de hidrógeno o un grupo alquilo de C1-4; q es 1 ó 2; A representa un grupo de la fórmula (a), (b) (c) o (d):-Ar -Ar1-Y-Ar2 <EMI FILE="99063348_2" ID="2" IMF=JPEG > (CH2)r-V-(CH2)sSr(a) (b) (c) (d) en las que: Ar representa un anillo de fenilo opcionalmente sustituido o un anillo heterocíclico aromático de 5 ó 6 miembros opcionalmente sustituido; o un sistema de anillos bicíclico opcionalmente sustituido; Ar1 y Ar2, cada uno independientemente, representan un anillo de fenilo opcionalmente sustituido o un anillo heterocíclico aromático de 5 ó 6 miembros opcionalmente sustituido; e Y representa un enlace, -NHCO-, -CONH-, -CH2- o -(CH2)mY1(CH2)n-, en cuyas fórmulas Y1 representa O, S, S02 o CO, y m y n representan cada uno cero ó 1, de tal modo que Ia suma de m+n es cero ó 1; con tal que cuando A representa un grupo de fórmula (a), cualquier sustituyente presente en Ar en posición orto respecto al resto de carboxamida es necesariamente un grupo hidrógeno o un grupo metoxi; r y s independientemente, representan un número entero desde cero a 3, de tal modo que la suma de r y s es igual a un número entero desde 1 a 4; V representa un enlace, 0 o S; y sus sales. - 2 -Un procedimiento de preparación de compuestos defórmula (I) cuyo procedimiento comprende:(a) hacer reaccionar un compuesto de fórmula (II)<EMI FILE="99063348_3" ID="3" IMF=JPEG >en la que R1, R2 y q son como se ha definido anteriormente, con un compuesto de fórmula (III):<EMI FILE="99063348_4" ID="4" IMF=JPEG >en la que A es como se ha definido anteriormente y X es un átomo de halógeno o el resto de un éster activado;(b) preparar un compuesto de fórmula (I) haciendo reaccionar un compuesto de fórmula (II) con un compuesto A-Br, o A-l, o A-OSO2CF3 en presencia de monóxido de carbono y un catalizador tal como bromuro de trans-bis-trifenilfosfinapaladio (II); (c) preparar un compuesto de fórmula (I) en la que R1 es Ar3-Z y Z es un enlace, haciendo reaccionar un compuesto de fórmula (IV);<EMI FILE="99063348_5" ID="5" IMF=JPEG >en la que R2 y A son como se ha definido anteriormente y un R1a representa un grupo W, en el que W es un átomo de halógeno o un grupo trifluorometilsulfoniloxi, o W es un grupo M seleccionado entre un derivado de boro, por ejemplo una función de ácido borónico B(OH)2 o una función metálica tal como trialquilestannilo, por ejemplo, SnBu3, haluro de cinc o haluro de magnesio, y cuando q es 2 el otro R1a es R1; con un compuesto Ar3-W1, en el que W1 es un átomo de halógeno o un grupo trifluorometilsulfoniloxi cuando W es un grupo M o W1 es un grupo M cuando W es un átomo de halógeno o un grupo trifluorometilsulfoniloxi;(d) preparar un compuesto de fórmula (I) en la que R1 es Ar3-Z y Z es O ó S, haciendo reaccionar un compuesto de fórmula (V):<EMI FILE="99063348_6" ID="6" IMF=JPEG >en la que R2 y A son como se ha definido anteriormente, y un R1b representa un grupo ZH, y cuando q es 2 el otro R1brepresenta R1; con un reactivo que sirve para introducir elgrupo Ar3;(e) preparar un compuesto de fórmula (I) en la que Y es un enlace, haciendo reaccionar un compuesto de fórmula (VI):<EMI FILE="99063348_7" ID="7" IMF=JPEG >en la que R1, R2, Ar1, W y q son como se ha definido anteriormente, con un compuesto Ar2-W1, en el que W1 es un átomo de halógeno o un grupo trifluorometilsulfoniloxi cuando W es un grupo M, o W1 es un grupo M cuando W es un átomo de halógeno o un grupo trifluorometilsulfoniloxi. (f) interconversión de un compuesto de fórmula (I) en un compuesto diferente de fórmula (I), por ejemplo, (i) alquilación de un compuesto (I) en el que R2 representa hidrógeno, (ii) conversión de un R1 desde alcoxi (por ejemplo, metoxi) a hidroxi, o (iii) conversión de R1 desde hidroxi a sulfoniloxi, por ejemplo, alquilsulfoniloxi o trifluorometanosulfoniloxi; (iv) conversión de un compuesto en el que Y representa S, en un compuesto en el que Y es S02 o (v) conversión de Y desde CO a CH2;(g) separación de los isómeros cis y trans de compuestos de fórmula (I) mediante métodos convencionales, por ejemplo, cromatografía o recristalización;y opcionalmente, después de esto, formar una sal de fórmula (I) .
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9821976.9A GB9821976D0 (en) | 1998-10-08 | 1998-10-08 | Compounds |
GBGB9824340.5A GB9824340D0 (en) | 1998-11-06 | 1998-11-06 | Compounds |
GBGB9910711.2A GB9910711D0 (en) | 1999-05-07 | 1999-05-07 | Compounds |
GBGB9918032.5A GB9918032D0 (en) | 1999-07-30 | 1999-07-30 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5140073A1 true CO5140073A1 (es) | 2002-03-22 |
Family
ID=27451837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO99063348A CO5140073A1 (es) | 1998-10-08 | 1999-10-06 | Derivados de 2,3,4,5-tetrahidro-1h-3-benzapina |
Country Status (30)
Country | Link |
---|---|
US (1) | US6605607B1 (es) |
EP (1) | EP1119563B1 (es) |
JP (1) | JP2002527433A (es) |
KR (1) | KR20010085898A (es) |
CN (1) | CN1329609A (es) |
AP (1) | AP2001002114A0 (es) |
AR (1) | AR023681A1 (es) |
AT (1) | ATE316969T1 (es) |
AU (1) | AU761018B2 (es) |
BG (1) | BG105467A (es) |
BR (1) | BR9914370A (es) |
CA (1) | CA2346689A1 (es) |
CO (1) | CO5140073A1 (es) |
CZ (1) | CZ20011270A3 (es) |
DE (1) | DE69929704T2 (es) |
EA (1) | EA200100428A1 (es) |
ES (1) | ES2255311T3 (es) |
HK (1) | HK1038745A1 (es) |
HU (1) | HUP0104280A3 (es) |
ID (1) | ID28385A (es) |
IL (1) | IL142388A0 (es) |
MA (1) | MA26696A1 (es) |
NO (1) | NO20011745L (es) |
NZ (1) | NZ511018A (es) |
OA (1) | OA11663A (es) |
PE (1) | PE20001088A1 (es) |
PL (1) | PL347237A1 (es) |
SK (1) | SK4782001A3 (es) |
TR (1) | TR200101025T2 (es) |
WO (1) | WO2000021951A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
IL142388A0 (en) | 1998-10-08 | 2002-03-10 | Smithkline Beecham Plc | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
US7229986B2 (en) * | 2000-05-16 | 2007-06-12 | Takeda Pharmaceutical Company Ltd. | Melanin-concentrating hormone antagonist |
CZ20031311A3 (cs) | 2000-11-14 | 2004-04-14 | Smithkline Beecham P. L. C. | Deriváty tetrahydroazepinu, užitečné jako modulátory receptorů dopaminu D3 (antipsychotická činidla) |
WO2002051232A2 (en) * | 2000-12-27 | 2002-07-04 | Actelion Pharmaceuticals Ltd. | Novel benzazepines and related heterocyclic derivatives |
HU227543B1 (en) * | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
WO2003062205A1 (en) * | 2001-12-21 | 2003-07-31 | Smithkline Beecham P.L.C. | 7-sulfonyl-3-benzazepine derivatives as modulators of the dopamine receptor and their use for the treatment of cns disorders |
JP2005517705A (ja) * | 2002-02-13 | 2005-06-16 | グラクソ グループ リミテッド | ベンゼンスルホンアミド誘導体ならびにドーパミンd3およびd2受容体リガンドとしてのその使用 |
ES2316777T3 (es) | 2002-02-15 | 2009-04-16 | Glaxo Group Limited | Moduladores de receptores vainilloides. |
GB0224083D0 (en) * | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
BR0317483A (pt) | 2002-12-20 | 2005-11-16 | Glaxo Group Ltd | Derivados de benzodiazepina para o tratamento de desordens neurológicas |
ES2624610T3 (es) | 2003-04-11 | 2017-07-17 | Ptc Therapeutics, Inc. | Compuestos de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades |
US20050137186A1 (en) | 2003-12-18 | 2005-06-23 | Abbott Gmbh & Co. Kg. | Tetrahydrobenzazepines and their use |
ATE529114T1 (de) | 2003-12-18 | 2011-11-15 | Abbott Gmbh & Co Kg | Tetrahydrobenzazepine und ihre verwendung in der modulation des dopamin-d3-rezeptors |
GB0330042D0 (en) | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them |
GB0330043D0 (en) | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them |
EP1725240A4 (en) * | 2004-03-17 | 2009-03-25 | Glaxo Group Ltd | ANTAGONISTS OF THE ACETYLCHOLINE MUSCARINIC RECEPTOR |
US20070185148A1 (en) * | 2004-03-17 | 2007-08-09 | Glaxo Group Limited | M3 muscarinic acetylchoine receptor antagonists |
JP2007529514A (ja) * | 2004-03-17 | 2007-10-25 | グラクソ グループ リミテッド | M3ムスカリン性アセチルコリン受容体アンタゴニスト |
BRPI0617376A2 (pt) * | 2005-10-13 | 2011-07-26 | Morphochem Ag | derivados de 5-quinolina tendo uma atividade antibacteriana |
HUE036035T2 (hu) * | 2013-12-13 | 2018-06-28 | Pf Medicament | Kromon-származék mint dopamin-D3 receptor antagonista autizmus spektrum betegség kezelésében történõ alkalmazásra |
CN106455571A (zh) | 2014-03-06 | 2017-02-22 | Ptc医疗公司 | 1,2,4‑噁二唑苯甲酸的药物组合物和盐 |
AR106530A1 (es) | 2015-10-30 | 2018-01-24 | Ptc Therapeutics Inc | Métodos para tratar epilepsia |
US10870660B2 (en) | 2016-07-28 | 2020-12-22 | Shionogi & Co., Ltd. | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect |
RS60209B1 (sr) | 2017-03-20 | 2020-06-30 | Forma Therapeutics Inc | Kompozicije pirolopirola kao aktivatori piruvat kinaze (pkr) |
CN111433201B (zh) * | 2017-12-21 | 2022-05-27 | 江苏恒瑞医药股份有限公司 | 苯并氮杂䓬衍生物、其制备方法及其在医药上的应用 |
CN111801330B (zh) * | 2018-01-26 | 2024-04-05 | 盐野义制药株式会社 | 具有多巴胺d3受体拮抗作用的稠环化合物 |
CN110498768A (zh) * | 2018-05-17 | 2019-11-26 | 上海中泽医药科技有限公司 | 庚嗪类化合物及其在制备抗精神分裂症药物中的应用 |
US20220031671A1 (en) | 2018-09-19 | 2022-02-03 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA792785B (en) * | 1978-07-07 | 1980-08-27 | Smithkline Corp | Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines |
US4220778A (en) | 1978-10-30 | 1980-09-02 | G. D. Searle & Co. | 8-Aryl-1,2,3,4-tetrahydroisoquinoline and derivatives thereof |
IL63918A0 (en) | 1980-10-17 | 1981-12-31 | Pennwalt Corp | N-(amino(or hydroxy)phenethyl)-1,2,3,4-tetrahydroisoquinolines,their preparation and pharmaceutical compositions containing them |
ZA816903B (en) | 1980-10-17 | 1983-02-23 | Pennwalt Corp | N-(amino(or hydroxy)-1,2,3,4,-tetrahydroisoquinolines, precursors thereof, and methods of preparation |
FR2618149B1 (fr) | 1987-07-16 | 1989-09-22 | Synthelabo | Derives de n-aminoalkyl n-phenyl arylamides, leur preparation et leur application en therapeutique |
IL89156A (en) | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
US5217977A (en) | 1989-02-28 | 1993-06-08 | Imperial Chemical Industries Plc | Heterocyclic cycloalkanes |
US5047406A (en) * | 1989-12-06 | 1991-09-10 | Warner-Lambert Co. | Substituted cyclohexanols as central nervous system agents |
US5633376A (en) | 1990-12-28 | 1997-05-27 | Neurogen Corporation | Certain aminomethyl phenylimidazole derivatives; and 4-aryl substituted piperazinyl and piperidinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype ligands |
US5681956A (en) | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
CZ283038B6 (cs) | 1991-01-11 | 1997-12-17 | Laboratoires Glaxo Sa | Akridinové deriváty, způsob výroby a farmaceutické prostředky s jejich obsahem |
WO1993003025A1 (fr) | 1991-08-09 | 1993-02-18 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose de thiophene |
US5532240A (en) | 1991-12-26 | 1996-07-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Condensed thiophene compound and pharmaceutical use thereof |
KR930703327A (ko) | 1991-12-26 | 1993-11-29 | 고야 다다시 | 축합형 티오펜 화합물 및 그의 의약용도 |
GB9206757D0 (en) | 1992-03-27 | 1992-05-13 | Ferring Bv | Novel peptide receptor ligands |
DE69310367T2 (de) | 1992-07-10 | 1997-08-14 | Glaxo Lab Sa | Anilide-derivate |
AU4704593A (en) | 1992-08-06 | 1994-03-03 | Smithkline Beecham Plc | 5-(2-oxyphenyl)-pyrrole derivatives as dopamine d3 receptor antagonists |
US5294621A (en) | 1992-10-07 | 1994-03-15 | Ortho Pharmaceutical Corporation | Thieno tetrahydropyridines useful as class III antiarrhythmic agents |
GB9305644D0 (en) | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
GB9307400D0 (en) | 1993-04-08 | 1993-06-02 | Smithkline Beecham Plc | Compounds |
FR2706895A1 (en) | 1993-06-22 | 1994-12-30 | Synthelabo | Tetrahydroisoquinoline derivatives, their preparation and their application in therapeutics |
JP2959615B2 (ja) | 1993-06-24 | 1999-10-06 | 吉富製薬株式会社 | 縮合型チオフェン化合物およびその医薬用途 |
AU7186994A (en) | 1993-06-25 | 1995-01-17 | Smithkline Beecham Plc | Phenyrrole derivatives and their use as dopamine d3 antagonists |
GB9315801D0 (en) | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
GB9315800D0 (en) | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
ATE231126T1 (de) | 1993-08-12 | 2003-02-15 | Astrazeneca Ab | Amidin-derivate mit stickstoffoxid-synthease- aktivität |
AU7665694A (en) | 1993-09-21 | 1995-04-10 | Yamanouchi Pharmaceutical Co., Ltd. | N-(3-pyrrolidinyl)benzamide derivative |
GB9320855D0 (en) | 1993-10-09 | 1993-12-01 | Smithkline Beecham Plc | Compounds |
US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
GB9325827D0 (en) | 1993-12-17 | 1994-02-23 | Smithkline Beecham Plc | Compounds |
GB9402197D0 (en) | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Compounds |
GB9402807D0 (en) | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
GB9403199D0 (en) | 1994-02-19 | 1994-04-13 | Smithkline Beecham Plc | Compounds |
WO1995029891A1 (fr) | 1994-04-28 | 1995-11-09 | Yamanouchi Pharmaceutical Co., Ltd. | Derive de n-(3-pyrrolidinyl)benzamide |
US5414010A (en) | 1994-05-10 | 1995-05-09 | Warner-Lambert Company | Dimeric benzimidazoles as central nervous system agents |
DE4425143A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
DE4425146A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
DE4425144A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Triazolverbindungen und deren Verwendung |
DE4425145A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung von Thiazol- und Thiadiazolverbindungen |
GB9418912D0 (en) | 1994-09-20 | 1994-11-09 | Fisons Corp | Pharmaceutically active compounds |
PL319511A1 (en) | 1994-10-05 | 1997-08-18 | Glaxo Wellcome Inc | Parenteral pharmaceutic compositions containing gf120918a |
AU4368996A (en) | 1994-11-23 | 1996-06-17 | Neurogen Corporation | Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands |
US5478934A (en) | 1994-11-23 | 1995-12-26 | Yuan; Jun | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands |
GB9426071D0 (en) | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
GB9426090D0 (en) | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
GB9426224D0 (en) | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
US5891877A (en) | 1995-02-14 | 1999-04-06 | Xenova Limited | Pharmaceutical compounds |
JP3332929B2 (ja) | 1995-02-15 | 2002-10-07 | ニューロゲン コーポレイション | ある種の架橋4−フェニル−2−アミノメチルイミダゾール:新しいドパミン受容体サブタイプ特異的リガンド |
JPH11503116A (ja) | 1995-03-27 | 1999-03-23 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 二環式アミン誘導体および抗精神病薬としてのそれらの使用 |
GB9512129D0 (en) | 1995-06-15 | 1995-08-16 | Smithkline Beecham Plc | Compounds |
WO1997011070A1 (en) | 1995-09-22 | 1997-03-27 | Warner-Lambert Company | Substituted cyclohexylamines as central nervous system agents |
FR2741074B1 (fr) | 1995-11-09 | 1997-12-19 | Adir | Nouveaux composes tetracycliques de la 1,4-oxazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
DE19600934A1 (de) | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
WO1997028166A1 (de) | 1996-02-01 | 1997-08-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thienochinoline |
WO1997029079A1 (fr) | 1996-02-06 | 1997-08-14 | Japan Tobacco Inc. | Composes chimiques et utilisation pharmaceutique |
JPH09291034A (ja) | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
US5710274A (en) | 1996-02-28 | 1998-01-20 | Neurogen Corporation | N-aminoalkyldibenzofurancarboxamides; new dopamine receptor subtype specific ligands |
US5763609A (en) | 1996-03-21 | 1998-06-09 | Neurogen Corporation | Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands |
US5703237A (en) | 1996-04-18 | 1997-12-30 | Neurogen Corporation | N-Aminoalkyl-2-anthraquinonecarboxamides; new dopamine receptor subtype specific ligands |
US5688950A (en) | 1996-04-23 | 1997-11-18 | Neurogen Corporation | Tricyclic aminoalkylcarboxamides; novel dopamine D3 receptor subtype specific ligands |
CA2253927A1 (en) * | 1996-05-11 | 1997-11-20 | Smithkline Beecham P.L.C. | Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors |
GB9612153D0 (en) | 1996-06-11 | 1996-08-14 | Smithkline Beecham Plc | Compounds |
JP2000517301A (ja) * | 1996-08-14 | 2000-12-26 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | テトラヒドロイソキノリン誘導体およびそれらの薬理学的使用 |
WO1998007421A1 (fr) | 1996-08-16 | 1998-02-26 | Ishihara Sangyo Kaisha, Ltd. | Composition medicinale |
SK65499A3 (en) | 1996-11-27 | 2001-05-10 | Pfizer | Apo b-secretion/mtp inhibitory amides |
FR2761985B1 (fr) | 1997-04-10 | 1999-05-21 | Adir | Nouveaux composes amines du 6,7,8,9-tetrahydro-cyclopenta[a] naphtalene et du 2,3-dihydro-cyclopenta[e]indene, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
AU7260398A (en) | 1997-04-28 | 1998-11-24 | University Of British Columbia, The | Method and composition for modulating amyloidosis |
GB9708694D0 (en) | 1997-04-30 | 1997-06-18 | Smithkline Beecham Plc | Compounds |
GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
WO1998050364A1 (en) * | 1997-05-03 | 1998-11-12 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors |
GB9709303D0 (en) | 1997-05-09 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
GB9710612D0 (en) | 1997-05-23 | 1997-07-16 | Glaxo Group Ltd | Synthesis of acridine derivatives |
DE19728996A1 (de) | 1997-07-07 | 1999-01-14 | Basf Ag | Triazolverbindungen und deren Verwendung |
GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
IL142388A0 (en) | 1998-10-08 | 2002-03-10 | Smithkline Beecham Plc | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
GB9821977D0 (en) | 1998-10-08 | 1998-12-02 | Smithkline Beecham Plc | Compounds |
AR022230A1 (es) | 1999-01-12 | 2002-09-04 | Abbott Gmbh & Co Kg | Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion |
-
1999
- 1999-10-06 IL IL14238899A patent/IL142388A0/xx unknown
- 1999-10-06 SK SK478-2001A patent/SK4782001A3/sk unknown
- 1999-10-06 WO PCT/EP1999/007763 patent/WO2000021951A1/en not_active Application Discontinuation
- 1999-10-06 CN CN99814062A patent/CN1329609A/zh active Pending
- 1999-10-06 NZ NZ511018A patent/NZ511018A/en unknown
- 1999-10-06 ID IDW20010785A patent/ID28385A/id unknown
- 1999-10-06 AU AU10381/00A patent/AU761018B2/en not_active Ceased
- 1999-10-06 EP EP99953833A patent/EP1119563B1/en not_active Expired - Lifetime
- 1999-10-06 BR BR9914370-4A patent/BR9914370A/pt not_active IP Right Cessation
- 1999-10-06 DE DE69929704T patent/DE69929704T2/de not_active Expired - Fee Related
- 1999-10-06 MA MA25809A patent/MA26696A1/fr unknown
- 1999-10-06 AR ARP990105055A patent/AR023681A1/es not_active Application Discontinuation
- 1999-10-06 PE PE1999001015A patent/PE20001088A1/es not_active Application Discontinuation
- 1999-10-06 PL PL99347237A patent/PL347237A1/xx not_active Application Discontinuation
- 1999-10-06 AT AT99953833T patent/ATE316969T1/de not_active IP Right Cessation
- 1999-10-06 EA EA200100428A patent/EA200100428A1/ru unknown
- 1999-10-06 KR KR1020017004442A patent/KR20010085898A/ko not_active Application Discontinuation
- 1999-10-06 OA OA1200100090A patent/OA11663A/en unknown
- 1999-10-06 AP APAP/P/2001/002114A patent/AP2001002114A0/en unknown
- 1999-10-06 JP JP2000575857A patent/JP2002527433A/ja not_active Withdrawn
- 1999-10-06 CO CO99063348A patent/CO5140073A1/es unknown
- 1999-10-06 TR TR2001/01025T patent/TR200101025T2/xx unknown
- 1999-10-06 ES ES99953833T patent/ES2255311T3/es not_active Expired - Lifetime
- 1999-10-06 US US09/806,902 patent/US6605607B1/en not_active Expired - Fee Related
- 1999-10-06 HU HU0104280A patent/HUP0104280A3/hu unknown
- 1999-10-06 CA CA002346689A patent/CA2346689A1/en not_active Abandoned
- 1999-10-06 CZ CZ20011270A patent/CZ20011270A3/cs unknown
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2001
- 2001-04-06 NO NO20011745A patent/NO20011745L/no not_active Application Discontinuation
- 2001-04-24 BG BG105467A patent/BG105467A/xx unknown
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KR20010085898A (ko) | 2001-09-07 |
MA26696A1 (fr) | 2004-12-20 |
ATE316969T1 (de) | 2006-02-15 |
WO2000021951A1 (en) | 2000-04-20 |
DE69929704T2 (de) | 2006-07-20 |
HUP0104280A3 (en) | 2002-07-29 |
IL142388A0 (en) | 2002-03-10 |
PL347237A1 (en) | 2002-03-25 |
PE20001088A1 (es) | 2000-12-02 |
CN1329609A (zh) | 2002-01-02 |
EP1119563A1 (en) | 2001-08-01 |
ES2255311T3 (es) | 2006-06-16 |
AP2001002114A0 (en) | 2001-06-30 |
NO20011745D0 (no) | 2001-04-06 |
AU1038100A (en) | 2000-05-01 |
SK4782001A3 (en) | 2001-11-06 |
JP2002527433A (ja) | 2002-08-27 |
BG105467A (en) | 2001-11-30 |
EP1119563B1 (en) | 2006-02-01 |
CA2346689A1 (en) | 2000-04-20 |
CZ20011270A3 (cs) | 2001-09-12 |
NZ511018A (en) | 2003-09-26 |
TR200101025T2 (tr) | 2001-09-21 |
DE69929704D1 (de) | 2006-04-13 |
BR9914370A (pt) | 2001-11-27 |
NO20011745L (no) | 2001-06-06 |
AU761018B2 (en) | 2003-05-29 |
EA200100428A1 (ru) | 2001-10-22 |
ID28385A (id) | 2001-05-17 |
US6605607B1 (en) | 2003-08-12 |
HK1038745A1 (zh) | 2002-03-28 |
OA11663A (en) | 2004-12-08 |
AR023681A1 (es) | 2002-09-04 |
HUP0104280A2 (hu) | 2002-03-28 |
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