IL100408A0 - Construction of synthetic leader peptide sequences - Google Patents

Construction of synthetic leader peptide sequences

Info

Publication number
IL100408A0
IL100408A0 IL100408A IL10040891A IL100408A0 IL 100408 A0 IL100408 A0 IL 100408A0 IL 100408 A IL100408 A IL 100408A IL 10040891 A IL10040891 A IL 10040891A IL 100408 A0 IL100408 A0 IL 100408A0
Authority
IL
Israel
Prior art keywords
construction
peptide sequences
leader peptide
synthetic leader
synthetic
Prior art date
Application number
IL100408A
Other languages
English (en)
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL100408A0 publication Critical patent/IL100408A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
IL100408A 1990-12-19 1991-12-18 Construction of synthetic leader peptide sequences IL100408A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK300090A DK300090D0 (da) 1990-12-19 1990-12-19 Fremgangsmaade til fremstilling af leadersekvenser

Publications (1)

Publication Number Publication Date
IL100408A0 true IL100408A0 (en) 1992-09-06

Family

ID=8118017

Family Applications (1)

Application Number Title Priority Date Filing Date
IL100408A IL100408A0 (en) 1990-12-19 1991-12-18 Construction of synthetic leader peptide sequences

Country Status (17)

Country Link
EP (1) EP0563175A1 (fr)
JP (1) JPH06503957A (fr)
KR (1) KR930703450A (fr)
AU (1) AU660161B2 (fr)
CA (1) CA2098731A1 (fr)
CZ (1) CZ119293A3 (fr)
DK (1) DK300090D0 (fr)
FI (1) FI932831A0 (fr)
HU (1) HUT68751A (fr)
IE (1) IE914433A1 (fr)
IL (1) IL100408A0 (fr)
MX (1) MX9102684A (fr)
NZ (1) NZ241011A (fr)
PT (1) PT99848A (fr)
SK (1) SK62593A3 (fr)
WO (1) WO1992011378A1 (fr)
ZA (1) ZA919932B (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI92601C (fi) * 1992-03-11 1994-12-12 Marja Makarow Menetelmä hyötyproteiinien erittämiseksi hiivoista
US5538863A (en) * 1993-07-01 1996-07-23 Immunex Corporation Expression system comprising mutant yeast strain and expression vector encoding synthetic signal peptide
US5639642A (en) * 1994-06-16 1997-06-17 Novo Nordisk A/S Synthetic leader peptide sequences
ZA954983B (en) * 1994-06-17 1996-02-14 Novo Nordisk As N-terminally extended proteins expressed in yeast
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
HRP940432B1 (en) * 1994-08-05 2003-10-31 Pliva Pharm & Chem Works Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin
CN101173263A (zh) 1995-03-17 2008-05-07 诺沃奇梅兹有限公司 新的内切葡聚糖酶
KR100611130B1 (ko) 1996-03-01 2006-11-30 노보 노르디스크 에이/에스 식욕억제펩티드로이루어진약학적조성물의사용
EP1365028B1 (fr) 1996-12-13 2009-03-18 Novartis Vaccines and Diagnostics, Inc. Procédés permettant d'exprimer des protéines PDGF ou IGF dans la levure
WO1999037793A1 (fr) 1998-01-23 1999-07-29 Novo Nordisk A/S Procede servant a preparer des polypeptides souhaites dans de la levure
EP1246933B1 (fr) 1999-12-29 2010-07-21 Novo Nordisk A/S Procede de fabrication de precurseurs d'insuline et analogues des precurseurs d'insuline presentant un meilleur rendement de fermentation dans la levure
AT410217B (de) * 2000-06-15 2003-03-25 Cistem Biotechnologies Gmbh Vektor und ein verfahren zur expression und selektion randomisierter peptid-sequenzen
MXPA03008590A (es) 2001-03-22 2003-12-08 Novo Nordisk Healthcare Ag Derivados del factor vii de coagulacion.
IL160897A0 (en) 2001-09-27 2004-08-31 Novo Nordisk Healthcare Ag Human coagulation factor vii polypeptides
EP2392655A3 (fr) 2003-09-09 2012-02-29 Novo Nordisk Health Care AG Polypeptides de facteur VII à coagulation
EP1687428A1 (fr) 2003-11-14 2006-08-09 Novo Nordisk A/S Procede de fabrication d'insuline acylee
CN1902226A (zh) 2003-12-03 2007-01-24 诺和诺德公司 单链胰岛素
WO2005078116A1 (fr) * 2004-01-16 2005-08-25 Qiuyun Liu Methode permettant d'isoler de peptides antibacteriens et peptides isoles
MX2007012887A (es) 2005-04-18 2007-12-10 Novo Nordisk As Variantes il-21.
EP1917363B1 (fr) 2005-08-16 2011-06-22 Novo Nordisk A/S Procede permettant de realiser des polypeptides d'insuline matures
EP2316930A1 (fr) 2005-09-14 2011-05-04 Novo Nordisk Health Care AG Polypéptides humains du facteur de coagulation VII
DE602007009496D1 (de) 2006-02-27 2010-11-11 Novo Nordisk As Insulinderivate
US8518668B2 (en) 2006-09-27 2013-08-27 Novo Nordisk A/S Method for making maturated insulin polypeptides in a fungal cell
CN101778862B (zh) 2007-08-13 2014-12-17 诺沃-诺迪斯克有限公司 快速作用的胰岛素类似物
US8962794B2 (en) 2007-08-15 2015-02-24 Novo Nordisk A/S Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids
WO2009022013A1 (fr) 2007-08-15 2009-02-19 Novo Nordisk A/S Analogues de l'insuline comprenant un fragment acyle et alkylène glycol
EP2406282A1 (fr) 2009-03-11 2012-01-18 Novo Nordisk A/S Variants de l'interleukine 21 se liant de manière antagoniste au récepteur de l'il-21
BR112012001070B1 (pt) 2009-07-17 2022-05-03 Omeros Corporation Composição de polipeptídeo associado à ficolina e uso da mesma
US8815541B2 (en) 2009-11-25 2014-08-26 Novo Nordisk A/S Method for making polypeptides
US9096843B2 (en) 2009-12-01 2015-08-04 Novo Nordisk A/S Peptidyl α-hydroxyglycine α-amidating lyases
EP2526117B1 (fr) 2010-01-22 2015-05-06 Novo Nordisk A/S Procédé de préparation de fgf-21 présentant un faible degré de o-glycosylation
AU2011222883B2 (en) 2010-03-05 2016-05-26 Omeros Corporation Chimeric inhibitor molecules of complement activation
AU2011282988A1 (en) * 2010-07-28 2013-01-31 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
JP6517018B2 (ja) 2012-02-09 2019-05-22 ヴァー２・ファーマシューティカルズ・アンパルトセルスカブＶＡＲ２ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＡｐＳ コンドロイチン硫酸グリカンのターゲティング
EP2906693A1 (fr) 2012-10-15 2015-08-19 Novo Nordisk Health Care AG Polypeptides de facteur vii de coagulation
US20160115216A1 (en) 2013-06-07 2016-04-28 Novo Nordisk A/S Method for Making Mature Insulin Polypeptides
WO2015128507A1 (fr) * 2014-02-28 2015-09-03 Novo Nordisk A/S Variants pro-peptidiques alpha du facteur d'appariement
CN112789504A (zh) 2018-07-13 2021-05-11 瓦克特诊断有限责任公司 使用重组疟疾蛋白var2csa分离胎儿来源的循环细胞

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK463887D0 (da) * 1987-09-07 1987-09-07 Novo Industri As Gaerleader
CA1340772C (fr) * 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression et secretion de proteines heterologues dans une levure au moyen de sequences leader tronquees du facteur alpha
AU633020B2 (en) * 1988-07-23 1993-01-21 Novozymes Delta Limited New secretory leader sequences
DK105489D0 (da) * 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid

Also Published As

Publication number Publication date
DK300090D0 (da) 1990-12-19
JPH06503957A (ja) 1994-05-12
IE914433A1 (en) 1992-07-01
CA2098731A1 (fr) 1992-06-19
FI932831A (fi) 1993-06-18
KR930703450A (ko) 1993-11-30
FI932831A0 (fi) 1993-06-18
WO1992011378A1 (fr) 1992-07-09
MX9102684A (es) 1992-06-01
AU660161B2 (en) 1995-06-15
HUT68751A (en) 1995-07-28
SK62593A3 (en) 1993-10-06
NZ241011A (en) 1993-04-28
EP0563175A1 (fr) 1993-10-06
PT99848A (pt) 1993-06-30
AU9134891A (en) 1992-07-22
ZA919932B (en) 1992-08-26
CZ119293A3 (en) 1994-02-16
HU9301801D0 (en) 1993-10-28

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