ZA919932B - A method of constructing synthetic leader sequences - Google Patents

A method of constructing synthetic leader sequences

Info

Publication number
ZA919932B
ZA919932B ZA919932A ZA919932A ZA919932B ZA 919932 B ZA919932 B ZA 919932B ZA 919932 A ZA919932 A ZA 919932A ZA 919932 A ZA919932 A ZA 919932A ZA 919932 B ZA919932 B ZA 919932B
Authority
ZA
South Africa
Prior art keywords
leader sequences
synthetic leader
constructing synthetic
constructing
sequences
Prior art date
Application number
ZA919932A
Inventor
Lars Christiansen
Christiansen Lars
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of ZA919932B publication Critical patent/ZA919932B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
ZA919932A 1990-12-19 1991-12-18 A method of constructing synthetic leader sequences ZA919932B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK300090A DK300090D0 (en) 1990-12-19 1990-12-19 PROCEDURE FOR PREPARING LEADER SEQUENCES

Publications (1)

Publication Number Publication Date
ZA919932B true ZA919932B (en) 1992-08-26

Family

ID=8118017

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA919932A ZA919932B (en) 1990-12-19 1991-12-18 A method of constructing synthetic leader sequences

Country Status (17)

Country Link
EP (1) EP0563175A1 (en)
JP (1) JPH06503957A (en)
KR (1) KR930703450A (en)
AU (1) AU660161B2 (en)
CA (1) CA2098731A1 (en)
CZ (1) CZ119293A3 (en)
DK (1) DK300090D0 (en)
FI (1) FI932831A (en)
HU (1) HUT68751A (en)
IE (1) IE914433A1 (en)
IL (1) IL100408A0 (en)
MX (1) MX9102684A (en)
NZ (1) NZ241011A (en)
PT (1) PT99848A (en)
SK (1) SK62593A3 (en)
WO (1) WO1992011378A1 (en)
ZA (1) ZA919932B (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI92601C (en) * 1992-03-11 1994-12-12 Marja Makarow Procedure for secretion of yeast beneficial proteins
US5538863A (en) * 1993-07-01 1996-07-23 Immunex Corporation Expression system comprising mutant yeast strain and expression vector encoding synthetic signal peptide
US5639642A (en) * 1994-06-16 1997-06-17 Novo Nordisk A/S Synthetic leader peptide sequences
IL114160A (en) * 1994-06-17 2006-12-31 Novo Nordisk As Dna constructs encoding heterologous proteins and processes for the heterologous protein production in yeast
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
HRP940432B1 (en) * 1994-08-05 2003-10-31 Pliva Pharm & Chem Works Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin
NZ303162A (en) 1995-03-17 2000-01-28 Novo Nordisk As Enzyme preparations comprising an enzyme exhibiting endoglucanase activity appropriate for laundry compositions for textiles
BR9707807A (en) 1996-03-01 1999-07-27 Novo Nordisk As Use of a pharmaceutical composition pharmaceutical composition process of treating diseases or disorders associated with the regulation of impaired appetite and use of a peptide
DE69739319D1 (en) 1996-12-13 2009-04-30 Novartis Vaccines & Diagnostic Method for expression of PDGF or IGR proteins in yeast
JP2003525570A (en) 1998-01-23 2003-09-02 ノボ ノルディスク アクティーゼルスカブ Method for producing desired polypeptide in yeast
DE60044728D1 (en) 1999-12-29 2010-09-02 Novo Nordisk As METHOD FOR THE PRODUCTION OF INSULIN FORECASTS AND ANALOGS OF INSULIN PROCESSORS WITH IMPROVED FERMENTATION EXPORTS IN YEAST
AT410217B (en) * 2000-06-15 2003-03-25 Cistem Biotechnologies Gmbh VECTOR AND A METHOD FOR THE EXPRESSION AND SELECTION OF RANDOMIZED PEPTIDE SEQUENCES
ES2432967T3 (en) 2001-03-22 2013-12-05 Novo Nordisk Health Care Ag Coagulation Factor VII derivatives
ATE532858T1 (en) 2001-09-27 2011-11-15 Novo Nordisk Healthcare Ag HUMAN CLOTTING FACTOR VII POLYPEPTIDES
ES2381110T3 (en) 2003-09-09 2012-05-23 Novo Nordisk Health Care Ag Coagulation Factor VII Polypeptides
JP2007532096A (en) 2003-11-14 2007-11-15 ノボ　ノルディスク　アクティーゼルスカブ Method for producing acylated insulin
ES2369895T3 (en) 2003-12-03 2011-12-07 Novo Nordisk A/S MONOCATENARY INSULIN.
WO2005078116A1 (en) * 2004-01-16 2005-08-25 Qiuyun Liu A method of isolating antibacterial peptides and the isolated peptides thereof
ES2357550T3 (en) 2005-04-18 2011-04-27 Novo Nordisk A/S VARIANTS OF IL-21.
CN102660614A (en) 2005-08-16 2012-09-12 诺沃-诺迪斯克有限公司 Method for making mature insulin polypeptides
US20090055942A1 (en) 2005-09-14 2009-02-26 Novo Nordisk Healthcare A/G Human Coagulation Factor VII Polypeptides
ATE482977T1 (en) 2006-02-27 2010-10-15 Novo Nordisk As INSULIN DERIVATIVES
EP2069502B1 (en) 2006-09-27 2014-02-26 Novo Nordisk A/S Method for making maturated insulin polypeptides
WO2009021955A1 (en) 2007-08-13 2009-02-19 Novo Nordisk A/S Rapid acting insulin analogues
ES2526924T3 (en) 2007-08-15 2015-01-16 Novo Nordisk A/S Insulins with an acyl fraction comprising repetitive amino acid units containing alkylene glycol
EP2178912B1 (en) 2007-08-15 2015-07-08 Novo Nordisk A/S Insulin analogues with an acyl and aklylene glycol moiety
EP2406282A1 (en) 2009-03-11 2012-01-18 Novo Nordisk A/S Interleukin-21 variants having antagonistic binding to the il-21 receptor
AU2010272483B2 (en) 2009-07-17 2016-07-21 Omeros Corporation MASP isoforms as inhibitors of complement activation
EP2504355B1 (en) 2009-11-25 2015-07-22 Novo Nordisk A/S Method for making polypeptides
WO2011067283A1 (en) 2009-12-01 2011-06-09 Novo Nordisk A/S Novel peptidyl alpha-hydroxyglycine alpha-amidating lyases
ES2543634T3 (en) 2010-01-22 2015-08-20 Novo Nordisk A/S Process for preparing FGF-21 with low O-glycosylation grade
JP6148013B2 (en) 2010-03-05 2017-06-14 リグショスピタレト Chimera inhibitor molecule of complement activation
AU2011282988A1 (en) * 2010-07-28 2013-01-31 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
US11787844B2 (en) 2012-02-09 2023-10-17 Var2 Pharmaceuticals Aps Targeting of chondroitin sulfate glycans
JP2015532307A (en) 2012-10-15 2015-11-09 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー Coagulation factor VII polypeptide
EP3004156A1 (en) 2013-06-07 2016-04-13 Novo Nordisk A/S Method for making mature insulin polypeptides
US20160376330A1 (en) * 2014-02-28 2016-12-29 Novo Nordisk A/S Mating factor alpha pro-peptide variants
CN112789504A (en) 2018-07-13 2021-05-11 瓦克特诊断有限责任公司 Isolation of fetal-derived circulating cells using the recombinant malaria protein VAR2CSA

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK463887D0 (en) * 1987-09-07 1987-09-07 Novo Industri As GAERLEADER
CA1340772C (en) * 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
JP3092811B2 (en) * 1988-07-23 2000-09-25 デルタ バイオテクノロジー リミテッド Peptide and DNA sequences
DK105489D0 (en) * 1989-03-03 1989-03-03 Novo Nordisk As POLYPEPTIDE

Also Published As

Publication number Publication date
AU660161B2 (en) 1995-06-15
CZ119293A3 (en) 1994-02-16
FI932831A0 (en) 1993-06-18
WO1992011378A1 (en) 1992-07-09
CA2098731A1 (en) 1992-06-19
PT99848A (en) 1993-06-30
IE914433A1 (en) 1992-07-01
HUT68751A (en) 1995-07-28
NZ241011A (en) 1993-04-28
SK62593A3 (en) 1993-10-06
DK300090D0 (en) 1990-12-19
AU9134891A (en) 1992-07-22
MX9102684A (en) 1992-06-01
FI932831A (en) 1993-06-18
EP0563175A1 (en) 1993-10-06
IL100408A0 (en) 1992-09-06
JPH06503957A (en) 1994-05-12
HU9301801D0 (en) 1993-10-28
KR930703450A (en) 1993-11-30

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