IE57682B1 - 1-phenoxy-3-hydroxyindolyl-alkylamino-2-propanols and preparation - Google Patents
1-phenoxy-3-hydroxyindolyl-alkylamino-2-propanols and preparationInfo
- Publication number
- IE57682B1 IE57682B1 IE1441/84A IE144184A IE57682B1 IE 57682 B1 IE57682 B1 IE 57682B1 IE 1441/84 A IE1441/84 A IE 1441/84A IE 144184 A IE144184 A IE 144184A IE 57682 B1 IE57682 B1 IE 57682B1
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- formula
- hydrogen
- hydroxy
- img
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title description 6
- 150000001875 compounds Chemical class 0.000 claims abstract description 67
- -1 3-indolyl-tertiary-butylamino moiety Chemical group 0.000 claims abstract description 31
- 239000001257 hydrogen Substances 0.000 claims abstract description 27
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 27
- 150000003839 salts Chemical class 0.000 claims abstract description 21
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 12
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- 229910052736 halogen Inorganic materials 0.000 claims abstract description 6
- 150000002367 halogens Chemical class 0.000 claims abstract description 6
- 150000002431 hydrogen Chemical class 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 34
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 24
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- 239000002253 acid Substances 0.000 claims description 21
- 238000006243 chemical reaction Methods 0.000 claims description 15
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 11
- ILAHWRKJUDSMFH-UHFFFAOYSA-N boron tribromide Chemical compound BrB(Br)Br ILAHWRKJUDSMFH-UHFFFAOYSA-N 0.000 claims description 10
- 125000001041 indolyl group Chemical group 0.000 claims description 10
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- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims description 5
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- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50290183A | 1983-06-10 | 1983-06-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE841441L IE841441L (en) | 1984-12-10 |
| IE57682B1 true IE57682B1 (en) | 1993-02-24 |
Family
ID=23999880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1441/84A IE57682B1 (en) | 1983-06-10 | 1984-06-08 | 1-phenoxy-3-hydroxyindolyl-alkylamino-2-propanols and preparation |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS608262A (nl) |
| KR (1) | KR900005021B1 (nl) |
| AT (1) | AT381492B (nl) |
| AU (1) | AU569303B2 (nl) |
| BE (1) | BE899875A (nl) |
| CA (1) | CA1217496A (nl) |
| CH (1) | CH662561A5 (nl) |
| CY (1) | CY1518A (nl) |
| DE (1) | DE3421252A1 (nl) |
| DK (1) | DK162089C (nl) |
| ES (1) | ES8507490A1 (nl) |
| FI (1) | FI78291C (nl) |
| FR (1) | FR2549054B1 (nl) |
| GB (1) | GB2141121B (nl) |
| GR (1) | GR82208B (nl) |
| HK (1) | HK14690A (nl) |
| HU (1) | HU191670B (nl) |
| IE (1) | IE57682B1 (nl) |
| IL (1) | IL72008A (nl) |
| IT (1) | IT1206705B (nl) |
| LU (1) | LU85410A1 (nl) |
| MY (1) | MY102077A (nl) |
| NL (1) | NL8401840A (nl) |
| NO (1) | NO164471C (nl) |
| NZ (1) | NZ208337A (nl) |
| SE (1) | SE455865B (nl) |
| SG (1) | SG1090G (nl) |
| YU (1) | YU44873B (nl) |
| ZA (1) | ZA844277B (nl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601008B1 (fr) * | 1986-07-03 | 1990-03-30 | Sanofi Sa | Procede de synthese stereospecifique de derives de l'indole |
| KR101986648B1 (ko) | 2018-04-06 | 2019-06-07 | (유)로뎀건설 | 강관작업구 굴착장치 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB962793A (en) * | 1959-07-13 | 1964-07-01 | Philips Nv | Improvements in or relating to pharmacologically active compounds being substituted tryptamines |
| NL300886A (nl) * | 1962-11-23 | |||
| US4314943A (en) * | 1977-07-13 | 1982-02-09 | Mead Johnson & Company | Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols |
| CA1116598A (en) * | 1977-07-13 | 1982-01-19 | William T. Comer | 3-indolyl-tertiary butylaminopropanols |
| US4234595A (en) * | 1977-07-13 | 1980-11-18 | Mead Johnson & Company | 3-Indolyl-tertiary butylaminopropanols |
| FR2463765A1 (fr) * | 1979-08-17 | 1981-02-27 | Clin Midy | Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire |
-
1984
- 1984-05-31 NZ NZ208337A patent/NZ208337A/xx unknown
- 1984-06-04 IL IL72008A patent/IL72008A/xx unknown
- 1984-06-06 FR FR8408858A patent/FR2549054B1/fr not_active Expired
- 1984-06-06 AT AT0186784A patent/AT381492B/de not_active IP Right Cessation
- 1984-06-06 ES ES533185A patent/ES8507490A1/es not_active Expired
- 1984-06-06 ZA ZA844277A patent/ZA844277B/xx unknown
- 1984-06-06 NO NO842279A patent/NO164471C/no unknown
- 1984-06-07 YU YU997/84A patent/YU44873B/xx unknown
- 1984-06-07 GR GR74949A patent/GR82208B/el unknown
- 1984-06-07 FI FI842316A patent/FI78291C/fi not_active IP Right Cessation
- 1984-06-07 DE DE19843421252 patent/DE3421252A1/de not_active Ceased
- 1984-06-08 BE BE0/213109A patent/BE899875A/fr not_active IP Right Cessation
- 1984-06-08 SE SE8403112A patent/SE455865B/sv not_active IP Right Cessation
- 1984-06-08 DK DK284184A patent/DK162089C/da not_active IP Right Cessation
- 1984-06-08 NL NL8401840A patent/NL8401840A/nl active Search and Examination
- 1984-06-08 IE IE1441/84A patent/IE57682B1/en not_active IP Right Cessation
- 1984-06-08 IT IT8421330A patent/IT1206705B/it active
- 1984-06-08 AU AU29238/84A patent/AU569303B2/en not_active Ceased
- 1984-06-08 CA CA000456154A patent/CA1217496A/en not_active Expired
- 1984-06-08 CH CH2814/84A patent/CH662561A5/de not_active IP Right Cessation
- 1984-06-08 LU LU85410A patent/LU85410A1/fr unknown
- 1984-06-08 GB GB08414652A patent/GB2141121B/en not_active Expired
- 1984-06-08 JP JP59116767A patent/JPS608262A/ja active Granted
- 1984-06-08 HU HU842215A patent/HU191670B/hu not_active IP Right Cessation
- 1984-06-09 KR KR1019840003251A patent/KR900005021B1/ko not_active IP Right Cessation
-
1987
- 1987-09-29 MY MYPI87002203A patent/MY102077A/en unknown
-
1990
- 1990-01-08 SG SG10/90A patent/SG1090G/en unknown
- 1990-02-22 HK HK146/90A patent/HK14690A/xx not_active IP Right Cessation
- 1990-11-16 CY CY1518A patent/CY1518A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |