MY102077A - 1-phenoxy-3-hydroxyindolyl-alkylamino-3-propanols and preparation - Google Patents

1-phenoxy-3-hydroxyindolyl-alkylamino-3-propanols and preparation

Info

Publication number
MY102077A
MY102077A MYPI87002203A MYPI19872203A MY102077A MY 102077 A MY102077 A MY 102077A MY PI87002203 A MYPI87002203 A MY PI87002203A MY PI19872203 A MYPI19872203 A MY PI19872203A MY 102077 A MY102077 A MY 102077A
Authority
MY
Malaysia
Prior art keywords
propanols
hydroxyindolyl
alkylamino
phenoxy
preparation
Prior art date
Application number
MYPI87002203A
Inventor
E Kreighbaum William
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MY102077A publication Critical patent/MY102077A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Abstract

1-(2-CYANOPHENYLOXY) -3-(HYDROXYINDOLYLALKYLAMINO) 2-PROPANOLS ARE CARDIOVASCULAR AGENTS HAVING PROMISE AS ANTIHYPERTENSIVE AGENTS BY VIRTUE OF THEIR VASODILATING AND ADRENERGIC RECEPTOR BLOCKING ACTIONS. PREFERRED COMPOUNDS CONTAIN THE 3-INDOLYL-TERTIARY- BUTYLAMINO MOIETY.
MYPI87002203A 1983-06-10 1987-09-29 1-phenoxy-3-hydroxyindolyl-alkylamino-3-propanols and preparation MY102077A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50290183A 1983-06-10 1983-06-10
GB08414652A GB2141121B (en) 1983-06-10 1984-06-08 1-phenoxy-3-hydroxyindolyl-alkylamino-3-propanols and preparation

Publications (1)

Publication Number Publication Date
MY102077A true MY102077A (en) 1992-03-31

Family

ID=23999880

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI87002203A MY102077A (en) 1983-06-10 1987-09-29 1-phenoxy-3-hydroxyindolyl-alkylamino-3-propanols and preparation

Country Status (29)

Country Link
JP (1) JPS608262A (en)
KR (1) KR900005021B1 (en)
AT (1) AT381492B (en)
AU (1) AU569303B2 (en)
BE (1) BE899875A (en)
CA (1) CA1217496A (en)
CH (1) CH662561A5 (en)
CY (1) CY1518A (en)
DE (1) DE3421252A1 (en)
DK (1) DK162089C (en)
ES (1) ES8507490A1 (en)
FI (1) FI78291C (en)
FR (1) FR2549054B1 (en)
GB (1) GB2141121B (en)
GR (1) GR82208B (en)
HK (1) HK14690A (en)
HU (1) HU191670B (en)
IE (1) IE57682B1 (en)
IL (1) IL72008A (en)
IT (1) IT1206705B (en)
LU (1) LU85410A1 (en)
MY (1) MY102077A (en)
NL (1) NL8401840A (en)
NO (1) NO164471C (en)
NZ (1) NZ208337A (en)
SE (1) SE455865B (en)
SG (1) SG1090G (en)
YU (1) YU44873B (en)
ZA (1) ZA844277B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601008B1 (en) * 1986-07-03 1990-03-30 Sanofi Sa PROCESS FOR THE STEREOSPECIFIC SYNTHESIS OF INDOLE DERIVATIVES
KR101986648B1 (en) 2018-04-06 2019-06-07 (유)로뎀건설 Excavating device for steel pipe access hole

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB962793A (en) * 1959-07-13 1964-07-01 Philips Nv Improvements in or relating to pharmacologically active compounds being substituted tryptamines
NL300886A (en) * 1962-11-23
US4234595A (en) * 1977-07-13 1980-11-18 Mead Johnson & Company 3-Indolyl-tertiary butylaminopropanols
CA1116598A (en) * 1977-07-13 1982-01-19 William T. Comer 3-indolyl-tertiary butylaminopropanols
US4314943A (en) * 1977-07-13 1982-02-09 Mead Johnson & Company Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
FR2463765A1 (en) * 1979-08-17 1981-02-27 Clin Midy NEW ACTIVE INDOLE DERIVATIVES ON THE CARDIOVASCULAR SYSTEM

Also Published As

Publication number Publication date
FI842316A0 (en) 1984-06-07
DK162089C (en) 1992-02-24
AU569303B2 (en) 1988-01-28
DK284184A (en) 1984-12-11
GB8414652D0 (en) 1984-07-11
NO842279L (en) 1984-12-11
SE8403112L (en) 1984-12-11
KR850000396A (en) 1985-02-27
JPH0587503B2 (en) 1993-12-16
NO164471C (en) 1990-10-10
NZ208337A (en) 1988-10-28
FI78291C (en) 1989-07-10
AT381492B (en) 1986-10-27
DE3421252A1 (en) 1984-12-13
YU44873B (en) 1991-04-30
ATA186784A (en) 1986-03-15
BE899875A (en) 1984-12-10
ES533185A0 (en) 1985-09-16
CY1518A (en) 1990-11-16
AU2923884A (en) 1984-12-13
HK14690A (en) 1990-03-02
FR2549054A1 (en) 1985-01-18
YU99784A (en) 1986-10-31
IT1206705B (en) 1989-04-27
NO164471B (en) 1990-07-02
IE57682B1 (en) 1993-02-24
HUT34445A (en) 1985-03-28
JPS608262A (en) 1985-01-17
ES8507490A1 (en) 1985-09-16
FR2549054B1 (en) 1988-03-04
GB2141121A (en) 1984-12-12
FI78291B (en) 1989-03-31
GR82208B (en) 1984-12-13
KR900005021B1 (en) 1990-07-18
GB2141121B (en) 1987-01-07
IE841441L (en) 1984-12-10
IL72008A (en) 1988-05-31
CH662561A5 (en) 1987-10-15
DK162089B (en) 1991-09-16
CA1217496A (en) 1987-02-03
ZA844277B (en) 1985-03-27
LU85410A1 (en) 1985-03-26
SE8403112D0 (en) 1984-06-08
NL8401840A (en) 1985-01-02
HU191670B (en) 1987-03-30
IT8421330A0 (en) 1984-06-08
SE455865B (en) 1988-08-15
FI842316A (en) 1984-12-11
DK284184D0 (en) 1984-06-08
IL72008A0 (en) 1984-10-31
SG1090G (en) 1990-07-06

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