ES8507490A1 - 1-Phenoxy-3-hydroxyindolyl-alkylamino-3-propanols and preparation - Google Patents

1-Phenoxy-3-hydroxyindolyl-alkylamino-3-propanols and preparation

Info

Publication number
ES8507490A1
ES8507490A1 ES533185A ES533185A ES8507490A1 ES 8507490 A1 ES8507490 A1 ES 8507490A1 ES 533185 A ES533185 A ES 533185A ES 533185 A ES533185 A ES 533185A ES 8507490 A1 ES8507490 A1 ES 8507490A1
Authority
ES
Spain
Prior art keywords
hydrogen
propanols
hydroxyindolyl
alkylamino
phenoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES533185A
Other languages
Spanish (es)
Other versions
ES533185A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8507490A1 publication Critical patent/ES8507490A1/en
Publication of ES533185A0 publication Critical patent/ES533185A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Abstract

1-(2-Cyanophenyloxy)-3-(hydroxyindolylalkylamino)-2-propanols and their salts are cardiovascular agents having promise as antihypertensive agents by virtue of their vasodilating and adrenergic receptor blocking actions. Preferred compounds contain the 3-indolyl-tertiary-butylamino moiety. The compounds have the formula < IMAGE > wherein one of R<1> and R<2> is hydrogen and the other is hydrogen or C1-4 alkyl R<3> and R<4> are independently selected from hydrogen or C1-4 alkyl R<5> is halogen, hydrogen, hydroxy, or C1-4 alkylo
ES533185A 1983-06-10 1984-06-06 PROCEDURE FOR THE PREPARATION OF NEW 2-PROPANOL DERIVATIVES. Granted ES533185A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50290183A 1983-06-10 1983-06-10

Publications (2)

Publication Number Publication Date
ES8507490A1 true ES8507490A1 (en) 1985-09-16
ES533185A0 ES533185A0 (en) 1985-09-16

Family

ID=23999880

Family Applications (1)

Application Number Title Priority Date Filing Date
ES533185A Granted ES533185A0 (en) 1983-06-10 1984-06-06 PROCEDURE FOR THE PREPARATION OF NEW 2-PROPANOL DERIVATIVES.

Country Status (29)

Country Link
JP (1) JPS608262A (en)
KR (1) KR900005021B1 (en)
AT (1) AT381492B (en)
AU (1) AU569303B2 (en)
BE (1) BE899875A (en)
CA (1) CA1217496A (en)
CH (1) CH662561A5 (en)
CY (1) CY1518A (en)
DE (1) DE3421252A1 (en)
DK (1) DK162089C (en)
ES (1) ES533185A0 (en)
FI (1) FI78291C (en)
FR (1) FR2549054B1 (en)
GB (1) GB2141121B (en)
GR (1) GR82208B (en)
HK (1) HK14690A (en)
HU (1) HU191670B (en)
IE (1) IE57682B1 (en)
IL (1) IL72008A (en)
IT (1) IT1206705B (en)
LU (1) LU85410A1 (en)
MY (1) MY102077A (en)
NL (1) NL8401840A (en)
NO (1) NO164471C (en)
NZ (1) NZ208337A (en)
SE (1) SE455865B (en)
SG (1) SG1090G (en)
YU (1) YU44873B (en)
ZA (1) ZA844277B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601008B1 (en) * 1986-07-03 1990-03-30 Sanofi Sa PROCESS FOR THE STEREOSPECIFIC SYNTHESIS OF INDOLE DERIVATIVES
KR101986648B1 (en) 2018-04-06 2019-06-07 (유)로뎀건설 Excavating device for steel pipe access hole

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES259580A1 (en) * 1959-07-13 1961-01-16 Philips Nv Improvements in or relating to pharmacologically active compounds being substituted tryptamines
NL300886A (en) * 1962-11-23
US4234595A (en) * 1977-07-13 1980-11-18 Mead Johnson & Company 3-Indolyl-tertiary butylaminopropanols
CA1116598A (en) * 1977-07-13 1982-01-19 William T. Comer 3-indolyl-tertiary butylaminopropanols
US4314943A (en) * 1977-07-13 1982-02-09 Mead Johnson & Company Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
FR2463765A1 (en) * 1979-08-17 1981-02-27 Clin Midy NEW ACTIVE INDOLE DERIVATIVES ON THE CARDIOVASCULAR SYSTEM

Also Published As

Publication number Publication date
FI78291C (en) 1989-07-10
IE841441L (en) 1984-12-10
GB2141121A (en) 1984-12-12
NO164471B (en) 1990-07-02
FI78291B (en) 1989-03-31
JPS608262A (en) 1985-01-17
CY1518A (en) 1990-11-16
IT8421330A0 (en) 1984-06-08
DK162089B (en) 1991-09-16
IL72008A (en) 1988-05-31
IE57682B1 (en) 1993-02-24
IL72008A0 (en) 1984-10-31
KR850000396A (en) 1985-02-27
GR82208B (en) 1984-12-13
SE455865B (en) 1988-08-15
NL8401840A (en) 1985-01-02
FR2549054B1 (en) 1988-03-04
LU85410A1 (en) 1985-03-26
NO842279L (en) 1984-12-11
SG1090G (en) 1990-07-06
DK162089C (en) 1992-02-24
HK14690A (en) 1990-03-02
AU2923884A (en) 1984-12-13
ZA844277B (en) 1985-03-27
AU569303B2 (en) 1988-01-28
GB2141121B (en) 1987-01-07
GB8414652D0 (en) 1984-07-11
KR900005021B1 (en) 1990-07-18
BE899875A (en) 1984-12-10
FI842316A (en) 1984-12-11
SE8403112L (en) 1984-12-11
HU191670B (en) 1987-03-30
DE3421252A1 (en) 1984-12-13
CH662561A5 (en) 1987-10-15
HUT34445A (en) 1985-03-28
DK284184D0 (en) 1984-06-08
NZ208337A (en) 1988-10-28
ATA186784A (en) 1986-03-15
JPH0587503B2 (en) 1993-12-16
NO164471C (en) 1990-10-10
FR2549054A1 (en) 1985-01-18
CA1217496A (en) 1987-02-03
YU44873B (en) 1991-04-30
AT381492B (en) 1986-10-27
IT1206705B (en) 1989-04-27
DK284184A (en) 1984-12-11
MY102077A (en) 1992-03-31
YU99784A (en) 1986-10-31
ES533185A0 (en) 1985-09-16
SE8403112D0 (en) 1984-06-08
FI842316A0 (en) 1984-06-07

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