IE841441L - 1-phenoxy-3-hydroxyindolyl-alkylamino-3-propanols. - Google Patents

1-phenoxy-3-hydroxyindolyl-alkylamino-3-propanols.

Info

Publication number
IE841441L
IE841441L IE841441A IE144184A IE841441L IE 841441 L IE841441 L IE 841441L IE 841441 A IE841441 A IE 841441A IE 144184 A IE144184 A IE 144184A IE 841441 L IE841441 L IE 841441L
Authority
IE
Ireland
Prior art keywords
hydrogen
propanols
alkyl
hydroxyindolyl
alkylamino
Prior art date
Application number
IE841441A
Other versions
IE57682B1 (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IE841441L publication Critical patent/IE841441L/en
Publication of IE57682B1 publication Critical patent/IE57682B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1-(2-Cyanophenyloxy)-3-(hydroxyindolylalkylamino)-2-propanols and their salts are cardiovascular agents having promise as antihypertensive agents by virtue of their vasodilating and adrenergic receptor blocking actions. Preferred compounds contain the 3-indolyl-tertiary-butylamino moiety. The compounds have the formula <IMAGE> wherein one of R<1> and R<2> is hydrogen and the other is hydrogen or C1-4 alkyl; R<3> and R<4> are independently selected from hydrogen or C1-4 alkyl; R<5> is halogen, hydrogen, hydroxy, or C1-4 alkyl;o [GB2141121A]
IE1441/84A 1983-06-10 1984-06-08 1-phenoxy-3-hydroxyindolyl-alkylamino-2-propanols and preparation IE57682B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50290183A 1983-06-10 1983-06-10

Publications (2)

Publication Number Publication Date
IE841441L true IE841441L (en) 1984-12-10
IE57682B1 IE57682B1 (en) 1993-02-24

Family

ID=23999880

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1441/84A IE57682B1 (en) 1983-06-10 1984-06-08 1-phenoxy-3-hydroxyindolyl-alkylamino-2-propanols and preparation

Country Status (29)

Country Link
JP (1) JPS608262A (en)
KR (1) KR900005021B1 (en)
AT (1) AT381492B (en)
AU (1) AU569303B2 (en)
BE (1) BE899875A (en)
CA (1) CA1217496A (en)
CH (1) CH662561A5 (en)
CY (1) CY1518A (en)
DE (1) DE3421252A1 (en)
DK (1) DK162089C (en)
ES (1) ES8507490A1 (en)
FI (1) FI78291C (en)
FR (1) FR2549054B1 (en)
GB (1) GB2141121B (en)
GR (1) GR82208B (en)
HK (1) HK14690A (en)
HU (1) HU191670B (en)
IE (1) IE57682B1 (en)
IL (1) IL72008A (en)
IT (1) IT1206705B (en)
LU (1) LU85410A1 (en)
MY (1) MY102077A (en)
NL (1) NL8401840A (en)
NO (1) NO164471C (en)
NZ (1) NZ208337A (en)
SE (1) SE455865B (en)
SG (1) SG1090G (en)
YU (1) YU44873B (en)
ZA (1) ZA844277B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601008B1 (en) * 1986-07-03 1990-03-30 Sanofi Sa PROCESS FOR THE STEREOSPECIFIC SYNTHESIS OF INDOLE DERIVATIVES
KR101986648B1 (en) 2018-04-06 2019-06-07 (유)로뎀건설 Excavating device for steel pipe access hole

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB962793A (en) * 1959-07-13 1964-07-01 Philips Nv Improvements in or relating to pharmacologically active compounds being substituted tryptamines
NL300886A (en) * 1962-11-23
US4314943A (en) * 1977-07-13 1982-02-09 Mead Johnson & Company Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
CA1116598A (en) * 1977-07-13 1982-01-19 William T. Comer 3-indolyl-tertiary butylaminopropanols
US4234595A (en) * 1977-07-13 1980-11-18 Mead Johnson & Company 3-Indolyl-tertiary butylaminopropanols
FR2463765A1 (en) * 1979-08-17 1981-02-27 Clin Midy NEW ACTIVE INDOLE DERIVATIVES ON THE CARDIOVASCULAR SYSTEM

Also Published As

Publication number Publication date
YU44873B (en) 1991-04-30
SG1090G (en) 1990-07-06
SE455865B (en) 1988-08-15
YU99784A (en) 1986-10-31
GB2141121A (en) 1984-12-12
FR2549054A1 (en) 1985-01-18
GB2141121B (en) 1987-01-07
SE8403112D0 (en) 1984-06-08
KR900005021B1 (en) 1990-07-18
IE57682B1 (en) 1993-02-24
HUT34445A (en) 1985-03-28
SE8403112L (en) 1984-12-11
LU85410A1 (en) 1985-03-26
DK284184A (en) 1984-12-11
HU191670B (en) 1987-03-30
HK14690A (en) 1990-03-02
CH662561A5 (en) 1987-10-15
FI842316A0 (en) 1984-06-07
FI78291B (en) 1989-03-31
MY102077A (en) 1992-03-31
DK284184D0 (en) 1984-06-08
ATA186784A (en) 1986-03-15
NO164471B (en) 1990-07-02
JPH0587503B2 (en) 1993-12-16
NO164471C (en) 1990-10-10
NL8401840A (en) 1985-01-02
IT1206705B (en) 1989-04-27
DE3421252A1 (en) 1984-12-13
NO842279L (en) 1984-12-11
KR850000396A (en) 1985-02-27
AT381492B (en) 1986-10-27
FI78291C (en) 1989-07-10
ZA844277B (en) 1985-03-27
IL72008A (en) 1988-05-31
ES533185A0 (en) 1985-09-16
CY1518A (en) 1990-11-16
DK162089B (en) 1991-09-16
DK162089C (en) 1992-02-24
ES8507490A1 (en) 1985-09-16
GR82208B (en) 1984-12-13
IT8421330A0 (en) 1984-06-08
NZ208337A (en) 1988-10-28
AU2923884A (en) 1984-12-13
CA1217496A (en) 1987-02-03
JPS608262A (en) 1985-01-17
AU569303B2 (en) 1988-01-28
IL72008A0 (en) 1984-10-31
FI842316A (en) 1984-12-11
GB8414652D0 (en) 1984-07-11
FR2549054B1 (en) 1988-03-04
BE899875A (en) 1984-12-10

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Legal Events

Date Code Title Description
MM4A Patent lapsed