IE50646B1 - Novel 4-aroylimidazol-2-ones - Google Patents

Novel 4-aroylimidazol-2-ones

Info

Publication number
IE50646B1
IE50646B1 IE1162/80A IE116280A IE50646B1 IE 50646 B1 IE50646 B1 IE 50646B1 IE 1162/80 A IE1162/80 A IE 1162/80A IE 116280 A IE116280 A IE 116280A IE 50646 B1 IE50646 B1 IE 50646B1
Authority
IE
Ireland
Prior art keywords
alkyl
hydrogen
methyl
phenyl
pharmaceutical composition
Prior art date
Application number
IE1162/80A
Other languages
English (en)
Other versions
IE801162L (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26727558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE50646(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IE801162L publication Critical patent/IE801162L/xx
Publication of IE50646B1 publication Critical patent/IE50646B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IE1162/80A 1979-06-18 1980-06-05 Novel 4-aroylimidazol-2-ones IE50646B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4980879A 1979-06-18 1979-06-18
US11920780A 1980-02-07 1980-02-07

Publications (2)

Publication Number Publication Date
IE801162L IE801162L (en) 1980-12-18
IE50646B1 true IE50646B1 (en) 1986-06-11

Family

ID=26727558

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1162/80A IE50646B1 (en) 1979-06-18 1980-06-05 Novel 4-aroylimidazol-2-ones

Country Status (20)

Country Link
AT (1) AT375349B (ja)
AU (1) AU532783B2 (ja)
CA (1) CA1132554A (ja)
CH (1) CH646155A5 (ja)
DE (1) DE3021792A1 (ja)
DK (1) DK160269C (ja)
ES (1) ES492255A0 (ja)
FR (1) FR2459233A1 (ja)
GB (1) GB2055364B (ja)
HK (1) HK61486A (ja)
HU (1) HU186736B (ja)
IE (1) IE50646B1 (ja)
IL (1) IL60243A (ja)
IT (1) IT1143922B (ja)
MY (1) MY8600709A (ja)
NL (2) NL193752C (ja)
NO (1) NO152841C (ja)
NZ (1) NZ193935A (ja)
PH (1) PH18683A (ja)
SE (2) SE447107B (ja)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones
US4405628A (en) * 1981-03-05 1983-09-20 Merrell Dow Pharmaceuticals Inc. 4-Pyridylimidazolones and method of use
US4526981A (en) * 1981-05-04 1985-07-02 Merrell Dow Pharmaceuticals Inc. [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates
US4329470A (en) * 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4329471A (en) * 1981-05-04 1982-05-11 Merrell Dow Pharmaceuticals Inc. 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
US4371737A (en) * 1981-05-04 1983-02-01 Merrell Dow Pharmaceuticals Inc. 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives
US4381393A (en) * 1981-05-04 1983-04-26 Merrell Dow Pharmaceuticals Inc. 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones
JPS57185266A (en) * 1981-05-04 1982-11-15 Merrell Dow Pharma 4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazole- 2-one
US4367236A (en) 1981-11-04 1983-01-04 Merrell Dow Pharmaceuticals Inc. Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
US4410540A (en) * 1981-11-04 1983-10-18 Merrell Dow Pharmaceuticals Inc. Cardiotonic 4-aroylimidazolidin-2-ones
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20060025463A1 (en) * 2004-03-22 2006-02-02 Michael Bristow Enoximone sulfoxide enantiomers and their use in the treatment of PDE-III mediated diseases
US20060030611A1 (en) * 2004-03-22 2006-02-09 Myogen, Inc. Enoximone sulfoxide enantiomers and their use in the treatment of PDE-III mediated diseases
KR20080065704A (ko) 2005-11-09 2008-07-14 콤비네이토릭스, 인코포레이티드 의학적 이상의 치료 방법들, 조성물들, 및 키트들
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
CN105979959B (zh) 2013-08-09 2021-11-30 阿德利克斯公司 用于抑制磷酸盐转运的化合物和方法
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
CN114539157B (zh) * 2022-03-03 2023-12-22 曲靖师范学院 一种碘促进氧化法制备4-碘代n-芳基吡唑类化合物的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441933A (en) * 1945-07-30 1948-05-18 Hoffmann La Roche Substituted imidazolones and process of making them

Also Published As

Publication number Publication date
DE3021792C2 (ja) 1989-08-10
NL300015I2 (nl) 2000-10-02
IT8048997A0 (it) 1980-06-17
SE447107B (sv) 1986-10-27
SE8004253L (sv) 1980-12-19
NL193752B (nl) 2000-05-01
NO152841C (no) 1985-11-27
NO801796L (no) 1980-12-19
PH18683A (en) 1985-08-29
ATA314280A (de) 1983-12-15
ES8105299A1 (es) 1981-06-01
ES492255A0 (es) 1981-06-01
IL60243A (en) 1987-01-30
CA1132554A (en) 1982-09-28
SE464559B (sv) 1991-05-13
IE801162L (en) 1980-12-18
NO152841B (no) 1985-08-19
AT375349B (de) 1984-07-25
IL60243A0 (en) 1980-09-16
CH646155A5 (de) 1984-11-15
HU186736B (en) 1985-09-30
FR2459233B1 (ja) 1983-09-23
SE8501452D0 (sv) 1985-03-25
DE3021792A1 (de) 1981-01-22
DK160269B (da) 1991-02-18
FR2459233A1 (fr) 1981-01-09
MY8600709A (en) 1986-12-31
GB2055364A (en) 1981-03-04
AU5911880A (en) 1981-01-08
AU532783B2 (en) 1983-10-13
GB2055364B (en) 1983-06-08
DK259080A (da) 1980-12-19
DK160269C (da) 1991-07-22
NZ193935A (en) 1985-05-31
NL8003498A (nl) 1980-12-22
NL193752C (nl) 2000-09-04
IT1143922B (it) 1986-10-29
HK61486A (en) 1986-08-29
NL300015I1 (nl) 2000-11-01
SE8501452L (sv) 1985-03-25

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