IE42395B1 - Production of long acting insulin preparations - Google Patents

Production of long acting insulin preparations

Info

Publication number
IE42395B1
IE42395B1 IE62/76A IE6276A IE42395B1 IE 42395 B1 IE42395 B1 IE 42395B1 IE 62/76 A IE62/76 A IE 62/76A IE 6276 A IE6276 A IE 6276A IE 42395 B1 IE42395 B1 IE 42395B1
Authority
IE
Ireland
Prior art keywords
insulin
process according
stabiliser
preparation
production
Prior art date
Application number
IE62/76A
Other languages
English (en)
Other versions
IE42395L (en
Original Assignee
Nordisk Insulinlab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordisk Insulinlab filed Critical Nordisk Insulinlab
Publication of IE42395L publication Critical patent/IE42395L/xx
Publication of IE42395B1 publication Critical patent/IE42395B1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • C07K14/625Extraction from natural sources
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IE62/76A 1975-01-15 1976-01-13 Production of long acting insulin preparations IE42395B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK8375AA DK140801B (da) 1975-01-15 1975-01-15 Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.

Publications (2)

Publication Number Publication Date
IE42395L IE42395L (en) 1976-07-15
IE42395B1 true IE42395B1 (en) 1980-07-30

Family

ID=8089535

Family Applications (1)

Application Number Title Priority Date Filing Date
IE62/76A IE42395B1 (en) 1975-01-15 1976-01-13 Production of long acting insulin preparations

Country Status (36)

Country Link
JP (1) JPS5946939B2 (forum.php)
AR (1) AR213088A1 (forum.php)
AT (1) AT362492B (forum.php)
BE (1) BE837600A (forum.php)
BR (1) BR7600206A (forum.php)
CA (1) CA1094549A (forum.php)
CH (1) CH631625A5 (forum.php)
CS (1) CS208147B2 (forum.php)
DD (1) DD124379A5 (forum.php)
DE (1) DE2600971C2 (forum.php)
DK (1) DK140801B (forum.php)
EG (1) EG11988A (forum.php)
ES (1) ES444558A1 (forum.php)
FI (1) FI66751C (forum.php)
FR (1) FR2297634A1 (forum.php)
GB (1) GB1524431A (forum.php)
GR (1) GR58608B (forum.php)
HU (1) HU175142B (forum.php)
IE (1) IE42395B1 (forum.php)
IL (1) IL48845A (forum.php)
IN (1) IN143279B (forum.php)
IT (1) IT1054211B (forum.php)
KE (1) KE2919A (forum.php)
LU (1) LU74175A1 (forum.php)
MX (1) MX4052E (forum.php)
MY (1) MY7900169A (forum.php)
NL (1) NL166464C (forum.php)
NO (1) NO146698C (forum.php)
NZ (1) NZ179733A (forum.php)
OA (1) OA05209A (forum.php)
PL (1) PL99927B1 (forum.php)
PT (1) PT64696B (forum.php)
RO (1) RO71576A (forum.php)
SE (1) SE437219B (forum.php)
YU (1) YU8376A (forum.php)
ZA (1) ZA7658B (forum.php)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK374579A (da) * 1979-09-07 1981-03-08 Nordisk Insulinlab Fremgangsmaade til fremstilling af et injucerbart insulinpraeparat
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
US4801575A (en) * 1986-07-30 1989-01-31 The Regents Of The University Of California Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4878892A (en) * 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
AU609769B2 (en) * 1987-02-10 1991-05-09 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5447728A (en) 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
EP2662472B1 (de) 2009-03-31 2019-02-27 Boehringer Ingelheim International Gmbh Verfahren zur Beschichtung einer Oberfläche eines Bauteils
WO2010133294A2 (de) 2009-05-18 2010-11-25 Boehringer Ingelheim International Gmbh Adapter, inhalationseinrichtung und zerstäuber
EP2504051B1 (en) 2009-11-25 2019-09-04 Boehringer Ingelheim International GmbH Nebulizer
WO2011064164A1 (en) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
JP5874724B2 (ja) 2010-06-24 2016-03-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
WO2012130757A1 (de) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
EP2835146B1 (en) 2013-08-09 2020-09-30 Boehringer Ingelheim International GmbH Nebulizer
EP3030298B1 (en) 2013-08-09 2017-10-11 Boehringer Ingelheim International GmbH Nebulizer
PL3139979T3 (pl) 2014-05-07 2023-12-27 Boehringer Ingelheim International Gmbh Jednostka, nebulizator i sposób
US10716907B2 (en) 2014-05-07 2020-07-21 Boehringer Ingelheim International Gmbh Nebulizer
JP6559157B2 (ja) 2014-05-07 2019-08-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3758683A (en) * 1971-04-30 1973-09-11 R Jackson Insulin product

Also Published As

Publication number Publication date
IE42395L (en) 1976-07-15
EG11988A (en) 1978-06-30
BR7600206A (pt) 1976-08-31
LU74175A1 (forum.php) 1977-03-18
MX4052E (es) 1981-11-24
ATA21376A (de) 1980-10-15
JPS5946939B2 (ja) 1984-11-15
DK140801B (da) 1979-11-19
CH631625A5 (en) 1982-08-31
DE2600971C2 (de) 1985-12-12
MY7900169A (en) 1979-12-31
SE437219B (sv) 1985-02-18
FR2297634B1 (forum.php) 1979-03-30
NO146698B (no) 1982-08-16
PT64696A (fr) 1976-02-01
FI760058A7 (forum.php) 1976-07-16
DK8375A (forum.php) 1976-07-16
NO146698C (no) 1982-11-24
GR58608B (en) 1977-11-10
CA1094549A (en) 1981-01-27
BE837600A (fr) 1976-07-15
DD124379A5 (forum.php) 1977-02-16
PL99927B1 (pl) 1978-08-31
NL7600338A (nl) 1976-07-19
FI66751C (fi) 1984-12-10
FI66751B (fi) 1984-08-31
JPS51125299A (en) 1976-11-01
AU1030776A (en) 1977-07-21
YU8376A (en) 1982-06-30
FR2297634A1 (fr) 1976-08-13
PT64696B (fr) 1977-08-10
HU175142B (hu) 1980-05-28
DK140801C (forum.php) 1980-04-21
SE7600284L (sv) 1976-07-16
DE2600971A1 (de) 1976-07-22
NL166464C (nl) 1981-08-17
IL48845A (en) 1981-06-29
AR213088A1 (es) 1978-12-15
NL166464B (nl) 1981-03-16
NZ179733A (en) 1978-04-28
CS208147B2 (en) 1981-08-31
AT362492B (de) 1981-05-25
ZA7658B (en) 1976-12-29
IL48845A0 (en) 1976-03-31
OA05209A (fr) 1981-02-28
KE2919A (en) 1979-03-30
IT1054211B (it) 1981-11-10
ES444558A1 (es) 1977-05-16
GB1524431A (en) 1978-09-13
IN143279B (forum.php) 1977-10-29
RO71576A (ro) 1980-12-30
NO760118L (forum.php) 1976-07-16

Similar Documents

Publication Publication Date Title
IE42395B1 (en) Production of long acting insulin preparations
US4183849A (en) Therapeutic insulin preparation and a process for the production of a stable insulin preparation with protracted effect
KR100546225B1 (ko) 신속한 작용개시를 나타내는 인슐린 유도체
FI79786C (fi) Foerfarande foer framstaellning ett farmaceutiskt medel foer behandling av diabetes.
AU612324B2 (en) Novel peptides and injectable solutions having prolonged insulin action
EP0216832B1 (en) Novel insulin derivatives and pharmaceutical preparations containing these derivatives
Brange et al. Chemical stability of insulin. 2. Formation of higher molecular weight transformation products during storage of pharmaceutical preparations
US3869437A (en) Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
EP0194864A2 (en) Novel peptides
EP0032655B2 (en) A process in purification and concentration of the factor viii-complex
NZ224715A (en) Mixed crystals of insulin and insulin derivatives, pharmaceutical compositions and methods of preparation
CA2330183C (en) Novel insulin analogs with enhanced zinc binding
JPH06511471A (ja) インスリンの燐酸化の方法およびそれによって製造された物
CA1243972A (en) Anti-diabetic compounds
US2343625A (en) Insulin preparation and method of making same
US4430326A (en) Method of diminishing glucose levels resulting from endogenous glucagon
US5153308A (en) S-sulfonated calcitonin derivatives
US3897551A (en) Iodoglucagons and process for prolonging the biological activity of glucagon
Covelli et al. Carboxymethylation of the histidyl residues of insulin
Smrcka et al. Modulation of the tight binding of carboxyarabinitol 1, 5-bisphosphate to the large subunit of ribulose 1, 5-bisphosphate carboxylase/oxygenase
EP0464549A1 (en) Calcitonin analogues and use thereof
SU1108737A1 (ru) Бромид 2-амино-3-(1-адамантилкарбонилметил)-1-метилбензимидазоли , про вл ющий психостимулирующую, антикаталептическую активность и обладающий способностью укорачивать снотворное действие барбитуратов
MARGOLIASH et al. DF STEINER,* JL CLARK,* C. NOLAN,† AH RUBENSTEIN
DK160880B (da) Insulinderivater samt injicerbare oploesninger indeholdende disse
TRY-THRALA-THR et al. TMV-PROTEIN (A-PROTEIN) 158 AMINO ACIDS 17 52 152 158 N-AC-SER-TYR TRY TRY··· TRY... THR