ID28210A - Turunan-turunan epotilon dan sintesa serta penggunaannya - Google Patents

Turunan-turunan epotilon dan sintesa serta penggunaannya

Info

Publication number
ID28210A
ID28210A IDW20002739A ID20002739A ID28210A ID 28210 A ID28210 A ID 28210A ID W20002739 A IDW20002739 A ID W20002739A ID 20002739 A ID20002739 A ID 20002739A ID 28210 A ID28210 A ID 28210A
Authority
ID
Indonesia
Prior art keywords
absent
single bond
alkyl
double bond
bond
Prior art date
Application number
IDW20002739A
Other languages
English (en)
Indonesian (id)
Inventor
Maurice Raymond Verscho Finlay
Kyriacos Costa Nicolaou
Nigel Paul King
Yun He
Frank Roschangar
Dionisios Vourloumis
Hans Vallberg
Antony Bigot
Original Assignee
Novartis Ag Cs
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag Cs, Scripps Research Inst filed Critical Novartis Ag Cs
Publication of ID28210A publication Critical patent/ID28210A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Silicon Polymers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
IDW20002739A 1998-06-22 1999-06-21 Turunan-turunan epotilon dan sintesa serta penggunaannya ID28210A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/102,602 US6380394B1 (en) 1996-12-13 1998-06-22 Epothilone analogs

Publications (1)

Publication Number Publication Date
ID28210A true ID28210A (id) 2001-05-10

Family

ID=22290705

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20002739A ID28210A (id) 1998-06-22 1999-06-21 Turunan-turunan epotilon dan sintesa serta penggunaannya

Country Status (28)

Country Link
US (3) US6380394B1 (de)
EP (2) EP1089998B1 (de)
JP (1) JP4681732B2 (de)
KR (3) KR20090066332A (de)
CN (1) CN1192031C (de)
AT (1) ATE343573T1 (de)
AU (1) AU757854B2 (de)
BR (1) BR9911420A (de)
CA (1) CA2334342C (de)
CY (1) CY1105863T1 (de)
CZ (1) CZ301783B6 (de)
DE (1) DE69933767T2 (de)
DK (1) DK1089998T3 (de)
ES (1) ES2273502T3 (de)
HK (1) HK1038358A1 (de)
HU (1) HUP0102711A3 (de)
ID (1) ID28210A (de)
IL (3) IL139784A0 (de)
MX (1) MXPA00012443A (de)
NO (1) NO328417B1 (de)
NZ (1) NZ508622A (de)
PL (1) PL197648B1 (de)
PT (1) PT1089998E (de)
RU (1) RU2227142C2 (de)
SK (2) SK285647B6 (de)
TR (1) TR200003844T2 (de)
WO (1) WO1999067252A2 (de)
ZA (1) ZA200007059B (de)

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US6660758B1 (en) * 1996-12-13 2003-12-09 The Scripps Research Institute Epothilone analogs
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IL154986A0 (en) * 2000-09-22 2003-10-31 Biotechnolog Forschung Gmbh Triazolo-epothilone derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
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BRPI0718360A2 (pt) 2006-12-04 2013-11-12 Univ Illinois "composições e métodos para o tratamento do câncer com cupredoxinas e dna rico em cpg"
JP2010518123A (ja) 2007-02-08 2010-05-27 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 癌をキュプレドキシンで予防するための組成物および方法
US8435983B2 (en) * 2007-03-23 2013-05-07 The University Of Toledo Conformationally restrained epothilone analogues as anti-leukemic agents
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EP2070521A1 (de) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Nanopartikel mit modifizierter Oberfläche
KR20110043653A (ko) * 2008-07-03 2011-04-27 파르마 마르 에스.에이. 항종양 마크롤라이드
US8802394B2 (en) 2008-11-13 2014-08-12 Radu O. Minea Method of expressing proteins with disulfide bridges with enhanced yields and activity
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EP3566719A1 (de) 2010-05-18 2019-11-13 Cerulean Pharma Inc. Zusammensetzungen und verfahren zur behandlung von autoimmun- und anderen erkrankungen
AU2012207142B2 (en) 2011-01-20 2017-04-27 Board Of Regents, The University Of Texas System MRI markers, delivery and extraction systems, and methods of manufacture and use thereof
CN102863474A (zh) 2011-07-09 2013-01-09 陈小平 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用
CN102993239A (zh) 2011-09-19 2013-03-27 陈小平 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物
EP2793949B1 (de) 2011-12-23 2018-08-22 Innate Pharma Enzymatische konjugation von antikörpern
EP2872894B1 (de) 2012-07-13 2019-04-17 Innate Pharma Screening von konjugierten antikörpern
EP2916872B1 (de) 2012-11-09 2019-02-27 Innate Pharma Kennungen für tgase-vermittelte konjugation
CN104768962B (zh) 2012-11-17 2017-04-05 北京市丰硕维康技术开发有限责任公司 离去基团是含氨基或烷氨基的丙二酸衍生物的铂类化合物
US9862692B2 (en) * 2013-01-23 2018-01-09 The University Of Toledo Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer
EP2968582B1 (de) 2013-03-15 2020-07-01 Innate Pharma Festphasen-tgase-vermittelte konjugation von antikörpern
EP3010547B1 (de) 2013-06-20 2021-04-21 Innate Pharma Enzymatische konjugation von polypeptiden
CN105517577A (zh) 2013-06-21 2016-04-20 先天制药公司 多肽的酶促偶联
JP2018534283A (ja) * 2015-10-16 2018-11-22 ウィリアム マーシュ ライス ユニバーシティＷｉｌｌｉａｍ Ｍａｒｓｈ Ｒｉｃｅ Ｕｎｉｖｅｒｓｉｔｙ エポシロン類似体、合成方法、処置方法、およびその薬物結合体
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Also Published As

Publication number Publication date
PL345327A1 (en) 2001-12-17
AU4774899A (en) 2000-01-10
WO1999067252A3 (en) 2000-03-16
DE69933767D1 (de) 2006-12-07
SK285647B6 (sk) 2007-05-03
CA2334342A1 (en) 1999-12-29
PL197648B1 (pl) 2008-04-30
NO20006378L (no) 2001-02-21
CZ20004769A3 (cs) 2001-07-11
NO20006378D0 (no) 2000-12-14
CA2334342C (en) 2012-07-17
KR20080045298A (ko) 2008-05-22
NZ508622A (en) 2003-07-25
KR20010083060A (ko) 2001-08-31
CN1192031C (zh) 2005-03-09
IL182744A0 (en) 2007-07-24
US7579366B2 (en) 2009-08-25
JP4681732B2 (ja) 2011-05-11
TR200003844T2 (tr) 2001-04-20
HUP0102711A2 (hu) 2001-12-28
WO1999067252A2 (en) 1999-12-29
MXPA00012443A (es) 2004-12-03
SK287864B6 (sk) 2012-02-03
IL139784A (en) 2010-05-17
EP1089998A2 (de) 2001-04-11
KR20090066332A (ko) 2009-06-23
CZ301783B6 (cs) 2010-06-23
CN1306531A (zh) 2001-08-01
HK1038358A1 (en) 2002-03-15
EP1741715A1 (de) 2007-01-10
PT1089998E (pt) 2007-01-31
SK19712000A3 (sk) 2001-09-11
HUP0102711A3 (en) 2002-09-30
KR100864742B1 (ko) 2008-10-22
BR9911420A (pt) 2001-03-20
RU2227142C2 (ru) 2004-04-20
US6531497B1 (en) 2003-03-11
AU757854B2 (en) 2003-03-06
US20030203938A1 (en) 2003-10-30
NO328417B1 (no) 2010-02-15
CY1105863T1 (el) 2011-02-02
US6380394B1 (en) 2002-04-30
IL139784A0 (en) 2002-02-10
EP1089998B1 (de) 2006-10-25
DK1089998T3 (da) 2007-01-15
JP2002518504A (ja) 2002-06-25
ES2273502T3 (es) 2007-05-01
DE69933767T2 (de) 2007-09-13
IL182744A (en) 2010-05-17
ZA200007059B (en) 2002-01-30
ATE343573T1 (de) 2006-11-15

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