ID20717A - Proses yang diperbaiki untuk memperoleh prekursor-prekursor insulin yang mempunyai jembatan-jembatan sistin yang terikat dengan tepat - Google Patents

Proses yang diperbaiki untuk memperoleh prekursor-prekursor insulin yang mempunyai jembatan-jembatan sistin yang terikat dengan tepat

Info

Publication number
ID20717A
ID20717A IDP981136A ID981136A ID20717A ID 20717 A ID20717 A ID 20717A ID P981136 A IDP981136 A ID P981136A ID 981136 A ID981136 A ID 981136A ID 20717 A ID20717 A ID 20717A
Authority
ID
Indonesia
Prior art keywords
improved process
right bridge
insulin precursors
bridge systems
obtain insulin
Prior art date
Application number
IDP981136A
Other languages
English (en)
Indonesian (id)
Inventor
Franz-Josef Rubroder
Reinhold Keller
Original Assignee
Hoechst Marion Roussel De Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel De Gmbh filed Critical Hoechst Marion Roussel De Gmbh
Publication of ID20717A publication Critical patent/ID20717A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IDP981136A 1997-08-18 1998-08-14 Proses yang diperbaiki untuk memperoleh prekursor-prekursor insulin yang mempunyai jembatan-jembatan sistin yang terikat dengan tepat ID20717A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19735711A DE19735711C2 (de) 1997-08-18 1997-08-18 Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken

Publications (1)

Publication Number Publication Date
ID20717A true ID20717A (id) 1999-02-18

Family

ID=7839275

Family Applications (1)

Application Number Title Priority Date Filing Date
IDP981136A ID20717A (id) 1997-08-18 1998-08-14 Proses yang diperbaiki untuk memperoleh prekursor-prekursor insulin yang mempunyai jembatan-jembatan sistin yang terikat dengan tepat

Country Status (20)

Country Link
US (3) US5986048A (cs)
EP (2) EP0980874B1 (cs)
JP (1) JP4291900B2 (cs)
KR (2) KR100537842B1 (cs)
CN (3) CN101186940B (cs)
AR (1) AR016821A1 (cs)
AT (2) ATE217636T1 (cs)
AU (1) AU744824B2 (cs)
BR (2) BR9803755A (cs)
CA (1) CA2245151C (cs)
CZ (1) CZ295679B6 (cs)
DE (3) DE19735711C2 (cs)
DK (2) DK0906918T3 (cs)
ES (2) ES2176870T3 (cs)
HU (2) HU228161B1 (cs)
ID (1) ID20717A (cs)
PL (1) PL191901B1 (cs)
PT (2) PT906918E (cs)
RU (2) RU2205836C2 (cs)
TR (1) TR199801587A2 (cs)

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DE19735711C2 (de) * 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
JP2003530316A (ja) 1999-12-22 2003-10-14 ノボ ノルディスク アクティーゼルスカブ スクランブルした一本鎖ポリペプチドの抽出的再生法
WO2002004481A2 (en) * 2000-07-12 2002-01-17 Eli Lilly And Company Process to increase protein stability
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
DE102004015965A1 (de) * 2004-04-01 2005-10-20 Aventis Pharma Gmbh Verfahren zur Gewinnung von Insulinen durch verbesserte Luftbegasung der Faltung
BRPI0621124A2 (pt) 2005-12-22 2011-11-29 Genentech Inc métodos para recuperação de uma proteìna de ligação à heparina
AR062069A1 (es) * 2006-07-14 2008-10-15 Genentech Inc Replegado de proteinas recombinantes
CN101815944A (zh) * 2007-07-03 2010-08-25 安姆根有限公司 利用包含体干重的蛋白测量
RU2451750C2 (ru) * 2007-09-24 2012-05-27 Общество С Ограниченной Ответственностью "Герофарм" Способ получения рекомбинантного с-пептида проинсулина человека
JP5694779B2 (ja) 2008-01-09 2015-04-01 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 極度に遅延した時間作用プロファイルを有する新規なインスリン誘導体
CA2724510C (en) * 2008-04-30 2015-10-27 Wockhardt Research Centre Processes for refolding of insulin
KR101820024B1 (ko) 2008-10-17 2018-01-18 사노피-아벤티스 도이칠란트 게엠베하 인슐린과 ｇｌｐ－1 효능제의 병용물
SI2554183T1 (en) 2009-11-13 2018-08-31 Sanofi-Aventis Deutschland Gmbh A pharmaceutical composition comprising the GLP-1 agonist and insulin and methionine
PT2498801T (pt) 2009-11-13 2018-05-02 Sanofi Aventis Deutschland Composição farmacêutica compreendendo despro36exendin-4(1-39)-lys6-nh2 e metionina
KR101823320B1 (ko) 2010-08-30 2018-01-31 사노피-아벤티스 도이칠란트 게엠베하 제２형 진성 당뇨병 치료용 약제를 제조하기 위한 ａｖｅ００１０의 용도
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
US12157766B2 (en) * 2012-08-05 2024-12-03 Absci Corporation Cytoplasmic expression system
US10421795B2 (en) 2012-12-17 2019-09-24 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
PT2963056T (pt) * 2013-02-26 2020-02-19 Hanmi Pharm Ind Co Ltd Análogo de insulina e utilização do mesmo
CN103694339B (zh) * 2013-12-04 2017-10-13 珠海联邦制药股份有限公司 一种甘精胰岛素前体的复性方法
EP3116531B1 (en) 2014-03-14 2021-10-20 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
CN107206058A (zh) 2014-12-12 2017-09-26 赛诺菲-安万特德国有限公司 甘精胰岛素/利西拉来固定比率配制剂
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN104911203A (zh) * 2015-06-30 2015-09-16 成都易胜科生物科技有限公司 一种重组人胰岛素的工业制备方法
WO2017040363A1 (en) 2015-09-02 2017-03-09 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds
WO2017205309A1 (en) * 2016-05-25 2017-11-30 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
WO2018018613A1 (zh) 2016-07-29 2018-02-01 广东东阳光药业有限公司 一种提高抗体纯度的细胞培养基和培养方法
CN113773391B (zh) * 2020-06-09 2023-10-20 宁波鲲鹏生物科技有限公司 一种门冬胰岛素的制备方法
CN113773400B (zh) * 2020-06-09 2023-08-18 宁波鲲鹏生物科技有限公司 一种门冬胰岛素衍生物及其应用
CN113773396A (zh) * 2020-06-10 2021-12-10 宁波鲲鹏生物科技有限公司 一种地特胰岛素衍生物及其应用
JP7749397B2 (ja) * 2021-09-30 2025-10-06 キヤノン株式会社 超音波ファントム及び超音波ファントムの製造方法

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Publication number Priority date Publication date Assignee Title
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
GR1005153B (el) * 1989-08-29 2006-03-13 The General Hospital Corporation Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους.
RU2045535C1 (ru) * 1991-06-18 1995-10-10 Институт биоорганической химии им.М.М.Шемякина и Ю.А.Овчинникова РАН Способ получения проинсулина человека
SG46612A1 (en) * 1992-12-02 1998-02-20 Hoechst Ag Process for obtaining proinsulin in processing correctly linked cystine bridges
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
RU2081122C1 (ru) * 1994-06-16 1997-06-10 Институт биоорганической химии им.М.М.Шемякина и Ю.А.Овчинникова РАН Способ выделения и очистки инсулина или его биотехнологических предшественников
ATE350053T1 (de) * 1994-12-29 2007-01-15 Ferring Int Ct Sa Herstellung von humaninsulin
DE19735711C2 (de) 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken

Also Published As

Publication number Publication date
HUP9801886A2 (hu) 1999-01-28
HU228161B1 (en) 2013-01-28
HK1018464A1 (en) 1999-12-24
EP0906918A2 (de) 1999-04-07
TR199801587A3 (tr) 1999-03-22
BR9803755A (pt) 2000-03-28
RU2302882C2 (ru) 2007-07-20
ATE217636T1 (de) 2002-06-15
DE19735711C2 (de) 2001-04-26
JP4291900B2 (ja) 2009-07-08
US5986048A (en) 1999-11-16
ES2176870T3 (es) 2002-12-01
CA2245151A1 (en) 1999-02-18
HU0600287D0 (en) 2006-05-29
CN101186940B (zh) 2012-02-08
HUP9801886A3 (en) 1999-06-28
BRPI9816233B8 (pt) 2021-05-25
EP0980874A1 (de) 2000-02-23
EP0980874B1 (de) 2002-05-02
AU8076398A (en) 1999-02-25
DE19735711A1 (de) 1999-02-25
BRPI9816233B1 (pt) 2016-09-27
AU744824B2 (en) 2002-03-07
TR199801587A2 (xx) 1999-03-22
ES2177178T3 (es) 2002-12-01
CN1209437A (zh) 1999-03-03
HU9801886D0 (en) 1998-10-28
PL191901B1 (pl) 2006-07-31
HK1061870A1 (en) 2004-10-08
CZ295679B6 (cs) 2005-09-14
ATE217012T1 (de) 2002-05-15
KR100574580B1 (ko) 2006-04-28
HU228203B1 (en) 2013-01-28
KR20050067371A (ko) 2005-07-01
JPH11130798A (ja) 1999-05-18
CZ259898A3 (cs) 1999-03-17
CN1483831A (zh) 2004-03-24
PL328108A1 (en) 1999-03-01
DE59803985D1 (de) 2002-06-06
PT980874E (pt) 2002-10-31
KR100537842B1 (ko) 2006-03-23
KR19990023651A (ko) 1999-03-25
EP0906918A3 (de) 1999-08-11
US20020156234A1 (en) 2002-10-24
HK1119449A1 (en) 2009-03-06
CN101186940A (zh) 2008-05-28
CN1132845C (zh) 2003-12-31
DK0906918T3 (da) 2002-09-09
CA2245151C (en) 2009-10-06
RU2205836C2 (ru) 2003-06-10
AR016821A1 (es) 2001-08-01
DE59804121D1 (de) 2002-06-20
DK0980874T3 (da) 2002-08-19
CN1483831B (zh) 2012-06-13
PT906918E (pt) 2002-10-31
US6727346B2 (en) 2004-04-27
US6380355B1 (en) 2002-04-30
EP0906918B1 (de) 2002-05-15

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