HUT64584A - Modified biological material - Google Patents

Modified biological material

Info

Publication number
HUT64584A
HUT64584A HU9201240A HU124092A HUT64584A HU T64584 A HUT64584 A HU T64584A HU 9201240 A HU9201240 A HU 9201240A HU 124092 A HU124092 A HU 124092A HU T64584 A HUT64584 A HU T64584A
Authority
HU
Hungary
Prior art keywords
species
rejection
complement
biological material
modified biological
Prior art date
Application number
HU9201240A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9201240D0 (en
Inventor
David James White
Alan Frederick Williams
Original Assignee
Imutran Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26296038&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUT64584(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB898922987A external-priority patent/GB8922987D0/en
Priority claimed from GB909017198A external-priority patent/GB9017198D0/en
Application filed by Imutran Ltd filed Critical Imutran Ltd
Publication of HU9201240D0 publication Critical patent/HU9201240D0/hu
Publication of HUT64584A publication Critical patent/HUT64584A/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
HU9201240A 1989-10-12 1990-10-12 Modified biological material HUT64584A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898922987A GB8922987D0 (en) 1989-10-12 1989-10-12 Modified biological material
GB909017198A GB9017198D0 (en) 1990-08-06 1990-08-06 Modified biological material

Publications (2)

Publication Number Publication Date
HU9201240D0 HU9201240D0 (en) 1992-06-29
HUT64584A true HUT64584A (en) 1994-01-28

Family

ID=26296038

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9201240A HUT64584A (en) 1989-10-12 1990-10-12 Modified biological material

Country Status (27)

Country Link
US (1) US6495735B1 (en:Method)
EP (2) EP0495852B1 (en:Method)
JP (1) JP3302358B2 (en:Method)
KR (2) KR100317106B1 (en:Method)
CN (2) CN1491624A (en:Method)
AT (1) ATE139562T1 (en:Method)
AU (1) AU654116B2 (en:Method)
BG (1) BG61080B1 (en:Method)
CA (1) CA2067235A1 (en:Method)
CY (1) CY1996A (en:Method)
DE (2) DE69027535T2 (en:Method)
DK (1) DK0495852T3 (en:Method)
ES (1) ES2060561T3 (en:Method)
FI (1) FI921618A0 (en:Method)
GR (2) GR940300004T1 (en:Method)
HK (1) HK48497A (en:Method)
HU (1) HUT64584A (en:Method)
IE (1) IE75345B1 (en:Method)
IL (2) IL95970A0 (en:Method)
IN (1) IN171948B (en:Method)
MY (1) MY107433A (en:Method)
NO (2) NO303502B1 (en:Method)
NZ (2) NZ248153A (en:Method)
PT (2) PT95580B (en:Method)
RO (1) RO109863B1 (en:Method)
SG (1) SG72614A1 (en:Method)
WO (1) WO1991005855A1 (en:Method)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705732A (en) * 1989-06-12 1998-01-06 Oklahoma Medical Research Foundation Universal donor cells
WO1991002002A1 (en) * 1989-07-21 1991-02-21 Washington University Recombinantly produced human membrane cofactor protein (mcp)
CA2082277A1 (en) * 1990-05-11 1991-11-12 Damien F. J. Purcell Cd46 variants
US5846715A (en) * 1990-05-11 1998-12-08 The Austin Research Institute CD46 variants
EP1041142A3 (en) * 1991-07-15 2007-10-24 Oklahoma Medical Research Foundation Universal donor cells
US6916654B1 (en) * 1992-06-29 2005-07-12 Oklahoma Medical Research Foundation Universal donor cells
AU671158B2 (en) * 1992-09-22 1996-08-15 Dnx Biotherapeutics, Inc. Delivery of proteins by intermembrane transfer for preaccommodation of xenogeneic organ transplants and other purposes
US5627264A (en) * 1994-03-03 1997-05-06 Alexion Pharmaceuticals, Inc. Chimeric complement inhibitor proteins
CA2196311A1 (en) * 1994-08-19 1996-02-29 David H. Sachs Genetically engineered swine cells
CA2227584A1 (en) * 1995-08-04 1997-02-20 The General Hospital Corporation Transgenic swine and swine cells having human hla genes
US6166288A (en) * 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
WO1997035886A1 (en) * 1996-03-22 1997-10-02 Imutran Limited Surfaces which prevent or reduce complement activation
JP4243355B2 (ja) 1997-03-26 2009-03-25 インペリアル カレッジ イノベイションズ リミテッド 細胞膜に固定された抗凝固性融合タンパク質
EP1004238B1 (en) 1997-07-14 2005-12-21 Nippon Meat Packers, Inc. Transgenic pigs
CA2298475A1 (en) * 1997-10-31 1999-05-14 Walter Reed Army Institute Of Research Method of inhibiting side effects of pharmaceutical compositions containing amphiphilic vehicles or drug carrier molecules
SE523817C2 (sv) 1999-02-05 2004-05-18 Corline Systems Ab Användning av ett koagulationsförebyggande ämne i samband med transplantation av insulinproducerande celler
GB9905503D0 (en) 1999-03-10 1999-05-05 Adprotech Plc Novel compound formulations and methods of delivery
WO2005009134A1 (en) 2003-07-21 2005-02-03 Lifecell Corporation ACELLULAR TISSUE MATRICES MADE FROM GALACTOSE α-1,3-GALACTOSE-DEFICIENT TISSUE
WO2011020120A2 (en) 2009-08-14 2011-02-17 Revivicor, Inc. Multi-transgenic pigs for diabetes treatment
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
WO2012031273A2 (en) 2010-09-03 2012-03-08 Stem Centrx, Inc. Novel modulators and methods of use
NZ759163A (en) 2011-02-14 2023-03-31 Revivicor Inc Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
ES2846758T3 (es) 2013-11-04 2021-07-29 Lifecell Corp Métodos para eliminar la alfa-galactosa
CN114686427B (zh) * 2022-05-23 2022-07-29 中国人民解放军总医院第一医学中心 一种脾脏调节型b淋巴细胞及其制备方法与应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0081570A4 (en) * 1981-06-12 1985-09-02 Univ Ohio GENETIC TRANSFORMATION OF ZYGOTS.
US4431636A (en) 1982-05-24 1984-02-14 American Cyanamid Company Bis(4-O-polyhexaose-thio)-phenyl ureas and method of use
US5109113A (en) * 1986-05-02 1992-04-28 Genentech, Inc. Membrane anchor fusion polypeptides
JPS62104594A (ja) * 1985-10-31 1987-05-15 Terumo Corp クエン酸塩利用能検査用培地組成物
JPH0742235B2 (ja) * 1985-11-08 1995-05-10 三共株式会社 自己免疫性疾病の予防・治療剤
IL82390A0 (en) * 1986-05-02 1987-10-30 Genentech Inc Nucleic acid and methods for the synthesis of novel daf compositions
GB8615942D0 (en) * 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
IL89790A (en) * 1988-04-01 2002-05-23 Johns Hopking University Nucleic acid sequences that encode and cells that produce cr1 protein and methods of production and purification
DE3830271A1 (de) 1988-09-06 1990-03-15 Goetze Otto Mittel mit immunsuppressiver wirkung
US5573940A (en) * 1989-06-12 1996-11-12 Oklahoma Medical Research Foundation Cells expressing high levels of CD59

Also Published As

Publication number Publication date
US6495735B1 (en) 2002-12-17
HK48497A (en) 1997-04-25
CN1491624A (zh) 2004-04-28
CY1996A (en) 1997-09-05
PT95580A (pt) 1991-09-13
RO109863B1 (ro) 1995-06-30
NO921438L (no) 1992-04-10
NO982131D0 (no) 1998-05-11
ES2060561T1 (es) 1994-12-01
IN171948B (en:Method) 1993-02-13
NO303502B1 (no) 1998-07-20
HU9201240D0 (en) 1992-06-29
PT101896B (pt) 2003-01-31
KR100317106B1 (ko) 2001-12-22
FI921618A7 (fi) 1992-04-10
DE69027535T2 (de) 1996-11-28
SG72614A1 (en) 2000-05-23
NZ248153A (en) 1997-07-27
IL120795A0 (en) 1997-09-30
DK0495852T3 (da) 1996-07-15
FI921618L (fi) 1992-04-10
NZ235657A (en) 1994-05-26
CN1122719C (zh) 2003-10-01
IE903649A1 (en) 1991-04-24
GR940300004T1 (en) 1994-02-28
PT95580B (pt) 1999-05-31
AU6539290A (en) 1991-05-16
KR920702410A (ko) 1992-09-04
IL95970A0 (en) 1992-05-25
EP0495852B1 (en) 1996-06-19
NO921438D0 (no) 1992-04-10
BG96329A (bg) 1993-12-24
WO1991005855A1 (en) 1991-05-02
PT101896A (pt) 1998-02-27
MY107433A (en) 1995-12-30
AU654116B2 (en) 1994-10-27
EP0709459A2 (en) 1996-05-01
GR3020741T3 (en) 1996-11-30
NO982131L (no) 1992-04-10
ATE139562T1 (de) 1996-07-15
JPH05503074A (ja) 1993-05-27
FI921618A0 (fi) 1992-04-10
EP0495852A1 (en) 1992-07-29
EP0709459A3 (en) 1999-01-07
IE75345B1 (en) 1997-08-27
BG61080B1 (bg) 1996-10-31
DE495852T1 (de) 1994-03-31
DE69027535D1 (de) 1996-07-25
ES2060561T3 (es) 1996-08-01
CA2067235A1 (en) 1991-04-13
CN1051199A (zh) 1991-05-08
JP3302358B2 (ja) 2002-07-15

Similar Documents

Publication Publication Date Title
CY1996A (en) Modified biological material
MD970009A (en) Methods for inducing T cells tolerance to donor tissues or organs
MXPA98002434A (es) Animales transgenicos para xenotrasplante con rechazo reducido de anticuerpos mediados.
DK720488D0 (da) Immunokompromitterede kimaerepattedyr og anvendelse heraf til fremstilling af celler og stoffer
AU667530B2 (en) Removal of antibodies from blood-derived compositions while retaining coagulation factors
NO171634C (no) Analogifremgangsmaate for fremstilling av alfa-aryl-4-(4,5-dihydro-3,5-diokso-1,2,4-triazin-2(3h)-yl)-benzenacetonitriler
ES2055415T3 (es) S-adenosil-metionina para el tratamiento de pancreatitis y del inmunorechazo del trasplante de pancreas.
AR018489A1 (es) Uso de una celula realizada geneticamente que comprende dna que codifica una proteina de gen de activacion de linfocito 3 (lag-3) transmembrana y de dicha proteina para la fabricacion de un medicamento util para inducir la proteccion del rechazo de injerto y uso de moleculas antisentido de las misma
DK0410319T3 (da) Middel til spirogyrabekæmpelse og desodorisering
AU7608687A (en) Improved mammal immunization
NZ209467A (en) Herbicidal composition derived from phomopsis cirsii and septoria cirsii
ES2098353T3 (es) Aparato y metodo para criar nematodos, hongos, cultivos tisulares y similares, y para recoger nematodos.
DE59308555D1 (de) Vorrichtung für eine Entalkoholisierungsanlage
Tanveer The effects of temperature on survival, growth and reproduction of Bellamaya bengalensis Lamarck, in the laboratory.
ES2087885T3 (es) Soporte de desodorante, particularmente para tazas de wc.
Pilat et al. Hematopoietic repopulation, in vivo, with genetically defined clones derived from HOXB4 expressing ES-cells
Bertschinger [Contribution to the ethical appraisal of xenotransplantation with respect to protection of the dignity of the animals][Article in German]
TR26704A (tr) Muamele edilmis kullanim disi tohumun kullanilir hale getirilmesi.
UA12061A1 (uk) Засіб для лікуваhhя цукрового діабету