HUP9901789A2 - Eljárás tiolmentesítésre - Google Patents

Eljárás tiolmentesítésre

Info

Publication number
HUP9901789A2
HUP9901789A2 HU9901789A HUP9901789A HUP9901789A2 HU P9901789 A2 HUP9901789 A2 HU P9901789A2 HU 9901789 A HU9901789 A HU 9901789A HU P9901789 A HUP9901789 A HU P9901789A HU P9901789 A2 HUP9901789 A2 HU P9901789A2
Authority
HU
Hungary
Prior art keywords
compounds
thiol
thiadiazole
thiols
scavenging
Prior art date
Application number
HU9901789A
Other languages
English (en)
Inventor
Tullio Cappelletto
Denis Desilets
Khashayar Karimian
Sue Lee
Wanren Li
Tim F. Tam
Original Assignee
Apotex Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Inc. filed Critical Apotex Inc.
Publication of HUP9901789A2 publication Critical patent/HUP9901789A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
    • C07C335/28—Y being a hetero atom, e.g. thiobiuret

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya eljárás tiőlvegyületek megkötésére ésdiszűlfidvegyületté történő átalakítására, őly módőn, hőgy a tiőlőkategy (I) általánős képletű 1,2,4-tiadiazől gyűrűrendszert tartalmazóvegyülettel reagáltatják, amely a tiadiazől-gyűrű 3-as helyzetébenszűbsztitűálva van, és az N-2 helyzetben szűbsztitűálatlan. Az eljárástöbbek között gyógyászati célőkra alkalmazható tiőltartalmú enzimek,példáűl H+/K+-ATPáz (a prőtőnpűmpa) gátlására, vagy ipari célőkratiőlvegyületek eltávőlítására gáz- vagy főlyadékelegyekből. Atalálmány szerinti eljárásban alkalmazőtt tiadiazőlvegyületek részbenújak, a találmány ezekre a vegyületekre is vőnatkőzik. ŕ
HU9901789A 1996-02-26 1997-02-26 Eljárás tiolmentesítésre HUP9901789A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60670596A 1996-02-26 1996-02-26

Publications (1)

Publication Number Publication Date
HUP9901789A2 true HUP9901789A2 (hu) 1999-08-30

Family

ID=24429112

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901789A HUP9901789A2 (hu) 1996-02-26 1997-02-26 Eljárás tiolmentesítésre

Country Status (15)

Country Link
US (1) US6114537A (hu)
EP (1) EP0883606A1 (hu)
JP (1) JPH11513994A (hu)
KR (1) KR19990087409A (hu)
CN (1) CN1216527A (hu)
AU (1) AU1762997A (hu)
BR (1) BR9707745A (hu)
CA (1) CA2247899A1 (hu)
CZ (1) CZ271398A3 (hu)
HU (1) HUP9901789A2 (hu)
IL (1) IL125931A0 (hu)
NO (1) NO983913L (hu)
PL (1) PL328629A1 (hu)
TR (1) TR199801671T2 (hu)
WO (1) WO1997031893A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6468977B1 (en) * 1998-03-02 2002-10-22 Apotex Inc. Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes
US6060472A (en) * 1998-04-06 2000-05-09 Apotex Inc. Thiadiazole compounds useful as inhibitors of H+ /K+ atpase
DE10061137B4 (de) * 2000-12-07 2016-10-06 Takeda Gmbh Neue pharmazeutische Zubereitung
UA80393C2 (uk) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
CA2379375A1 (en) * 2002-03-28 2003-09-28 Apotex Inc. Sulfonamide derivatives of 3-substituted imidazol[1,2-d]-1,2,4-thiadiazoles and 3-substituted-[1,2,4] thiadiazolo[4,5-a] benzimidazole as inhibitors of fibrin cross-linking and transglutaminases
JP4742026B2 (ja) 2003-03-10 2011-08-10 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング ロフルミラストの新規の製造方法
US7232820B2 (en) * 2004-04-01 2007-06-19 Pfizer Inc Thiadiazole-amine compounds for the treatment of neurodegenerative disorders
EP2258350B1 (en) * 2005-03-16 2014-12-24 Takeda GmbH Taste masked dosage form containing roflumilast
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
WO2011133920A1 (en) 2010-04-23 2011-10-27 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
WO2012060848A1 (en) 2010-11-05 2012-05-10 Haemonetics Corporation System and method for automated platelet wash
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
CN112457272B (zh) * 2020-12-02 2022-04-19 上海再启生物技术有限公司 (3-甲氧基-1,2,4-噻二唑-5-氨基)甲酸苯酯的制备方法
CN113880864A (zh) * 2021-11-22 2022-01-04 吉首大学 含苯并咪唑骈杂硒咪唑亚胺的化合物及其制法和应用

Also Published As

Publication number Publication date
NO983913D0 (no) 1998-08-26
CZ271398A3 (cs) 1999-01-13
WO1997031893A1 (en) 1997-09-04
CN1216527A (zh) 1999-05-12
US6114537A (en) 2000-09-05
IL125931A0 (en) 1999-04-11
TR199801671T2 (xx) 1998-11-23
NO983913L (no) 1998-10-23
AU1762997A (en) 1997-09-16
CA2247899A1 (en) 1997-09-04
JPH11513994A (ja) 1999-11-30
KR19990087409A (ko) 1999-12-27
BR9707745A (pt) 2000-10-24
PL328629A1 (en) 1999-02-15
EP0883606A1 (en) 1998-12-16

Similar Documents

Publication Publication Date Title
HUP9901789A2 (hu) Eljárás tiolmentesítésre
ATE88338T1 (de) Vernetzungsmittel zur haarbehandlung.
JPS57179142A (en) Reformed d-retro cyclic hexapeptide somatostatin analogue
ATE69239T1 (de) Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung.
ATE49957T1 (de) Adamantanamin-derivate, verfahren zur herstellung und diese enthaltende heilmittel.
ATE19063T1 (de) Verfahren zur herstellung von trithiocarbonsaeurediestern.
EP0587188A3 (en) Aryl and heterocyclic substituted propenamide derivatives
KR860008174A (ko) 항정신질환성 벤지소티아졸 s-산화물의 제조방법
ES8707160A1 (es) Un procedimiento para separar uno o mas contaminantes de la formula ticl3or
KR850001204A (ko) 1,4-디하이드로피리딘 유도체의 제조방법
DK19885D0 (da) 3-alkoxy-2-(n-pyrrolidino)-n-pyridyl-n-furyl (eller thienyl)-methyl-propylaminer, fremgangsmaade til fremstilling deraf, samt farmaceutiske midler indeholdende disse
KR870006070A (ko) 스피로디포스페이트-함유 작용성 조성물
KR870002093A (ko) 설포닐이소(티오) 우레아의 제조방법
KR870006069A (ko) 스피로디포스포아미데이트-타입 화합물 및 그의 제조방법
KR850006390A (ko) 이소시아네이트의 제조방법
SE8302084L (sv) Nya bensimidazolderivat
KR870010062A (ko) 세파로스포린 유도체의 제조방법
KR870006836A (ko) 브라시노 라이드 유사체의 제조방법
RO92447B1 (ro) Compozitie de decapant lichid pentru vopsele pulbere
KR890002176A (ko) 신규한 세펨 화합물
KR890003721A (ko) 벤조티아졸린 살진균제
KR840004112A (ko) 세팔로스포린 유도체의 제조방법
KR870008913A (ko) 브라시노라이드 유사체의 제조방법
KR860006437A (ko) 아실우레아의 제조방법
RU93019809A (ru) Тетрофтортетраазапорфин