NO983913L - FremgangsmÕte for oppfanging av tioler - Google Patents

FremgangsmÕte for oppfanging av tioler

Info

Publication number
NO983913L
NO983913L NO983913A NO983913A NO983913L NO 983913 L NO983913 L NO 983913L NO 983913 A NO983913 A NO 983913A NO 983913 A NO983913 A NO 983913A NO 983913 L NO983913 L NO 983913L
Authority
NO
Norway
Prior art keywords
thiols
compounds
capturing
procedure
thiadiazole ring
Prior art date
Application number
NO983913A
Other languages
English (en)
Other versions
NO983913D0 (no
Inventor
Khashayar Karimian
Tim F Tam
Denis Desilets
Sue Lee
Tullio Cappelletto
Wanren Li
Original Assignee
Apotex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Inc filed Critical Apotex Inc
Publication of NO983913D0 publication Critical patent/NO983913D0/no
Publication of NO983913L publication Critical patent/NO983913L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
    • C07C335/28—Y being a hetero atom, e.g. thiobiuret

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Tioler oppfanges og omdannes til disulfid-forbindelser ved en frem- gangsmåte hvor de reageres med forbindelser inneholdende en 1,2,4-tiadiazol- ringstruktur som bærer en substituent i stilling 3 på tiadiazolringen og som er usubstituert i stilling N-2. Fremgangsmåten er farmakologisk nyttig for inhibering av visse tiol-inneholdende enzymer så som HVrC-ATPase (proton-pumpen) og industrielt for selektiv fjerning av tiol-forbindelser fra gassformige eller flytende blandinger.
NO983913A 1996-02-26 1998-08-26 FremgangsmÕte for oppfanging av tioler NO983913L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60670596A 1996-02-26 1996-02-26
PCT/CA1997/000137 WO1997031893A1 (en) 1996-02-26 1997-02-26 Process for scavenging thiols

Publications (2)

Publication Number Publication Date
NO983913D0 NO983913D0 (no) 1998-08-26
NO983913L true NO983913L (no) 1998-10-23

Family

ID=24429112

Family Applications (1)

Application Number Title Priority Date Filing Date
NO983913A NO983913L (no) 1996-02-26 1998-08-26 FremgangsmÕte for oppfanging av tioler

Country Status (15)

Country Link
US (1) US6114537A (no)
EP (1) EP0883606A1 (no)
JP (1) JPH11513994A (no)
KR (1) KR19990087409A (no)
CN (1) CN1216527A (no)
AU (1) AU1762997A (no)
BR (1) BR9707745A (no)
CA (1) CA2247899A1 (no)
CZ (1) CZ271398A3 (no)
HU (1) HUP9901789A2 (no)
IL (1) IL125931A0 (no)
NO (1) NO983913L (no)
PL (1) PL328629A1 (no)
TR (1) TR199801671T2 (no)
WO (1) WO1997031893A1 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6468977B1 (en) * 1998-03-02 2002-10-22 Apotex Inc. Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes
US6060472A (en) * 1998-04-06 2000-05-09 Apotex Inc. Thiadiazole compounds useful as inhibitors of H+ /K+ atpase
DE10061137B4 (de) * 2000-12-07 2016-10-06 Takeda Gmbh Neue pharmazeutische Zubereitung
UA80393C2 (uk) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
CA2379375A1 (en) * 2002-03-28 2003-09-28 Apotex Inc. Sulfonamide derivatives of 3-substituted imidazol[1,2-d]-1,2,4-thiadiazoles and 3-substituted-[1,2,4] thiadiazolo[4,5-a] benzimidazole as inhibitors of fibrin cross-linking and transglutaminases
KR101179012B1 (ko) 2003-03-10 2012-09-03 니코메드 게엠베하 로플루미라스트 신규한 제조 방법
US7232820B2 (en) 2004-04-01 2007-06-19 Pfizer Inc Thiadiazole-amine compounds for the treatment of neurodegenerative disorders
AU2006224619B2 (en) * 2005-03-16 2012-06-07 Takeda Gmbh Taste masked dosage form containing roflumilast
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
EP2881127B1 (en) 2010-11-05 2017-01-04 Haemonetics Corporation System and method for automated platelet wash
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
CN112457272B (zh) * 2020-12-02 2022-04-19 上海再启生物技术有限公司 (3-甲氧基-1,2,4-噻二唑-5-氨基)甲酸苯酯的制备方法
CN113880864A (zh) * 2021-11-22 2022-01-04 吉首大学 含苯并咪唑骈杂硒咪唑亚胺的化合物及其制法和应用

Also Published As

Publication number Publication date
CN1216527A (zh) 1999-05-12
PL328629A1 (en) 1999-02-15
AU1762997A (en) 1997-09-16
KR19990087409A (ko) 1999-12-27
TR199801671T2 (xx) 1998-11-23
WO1997031893A1 (en) 1997-09-04
HUP9901789A2 (hu) 1999-08-30
EP0883606A1 (en) 1998-12-16
NO983913D0 (no) 1998-08-26
US6114537A (en) 2000-09-05
IL125931A0 (en) 1999-04-11
JPH11513994A (ja) 1999-11-30
CZ271398A3 (cs) 1999-01-13
BR9707745A (pt) 2000-10-24
CA2247899A1 (en) 1997-09-04

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