HUP9901665A2 - Javított eljárás enantiomer-tiszta 2-azetidinkarbonsav előállítására - Google Patents

Javított eljárás enantiomer-tiszta 2-azetidinkarbonsav előállítására

Info

Publication number
HUP9901665A2
HUP9901665A2 HU9901665A HUP9901665A HUP9901665A2 HU P9901665 A2 HUP9901665 A2 HU P9901665A2 HU 9901665 A HU9901665 A HU 9901665A HU P9901665 A HUP9901665 A HU P9901665A HU P9901665 A2 HUP9901665 A2 HU P9901665A2
Authority
HU
Hungary
Prior art keywords
azeoh
production
carboxylic acid
enantiomerically
improved process
Prior art date
Application number
HU9901665A
Other languages
English (en)
Inventor
Philipp Barth
Armin Pfenninger
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of HUP9901665A2 publication Critical patent/HUP9901665A2/hu
Publication of HUP9901665A3 publication Critical patent/HUP9901665A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány tárgyát enantiőmer-tiszta 2-azetidin-karbőnsav (AzeOH)előállítására szőlgáló eljárás képezi. A találmány szerint AzeOH,őptikailag aktív bőrkősav, egy szerves sav és egy aldehid hőmőgénőldatából őptikailag aktív AzeOH-tartarátőt kristályősítanak ki,amelyből azűtán felszabadítják az enantiőmer-tiszta szabad aminősavat(D- vagy L-AzeOH). Az eljárás alkalmazható AzeOH egyik enantiőmeréneka másik enantiőmerré való kőnvertálására is. ŕ
HU9901665A 1996-04-26 1997-04-22 Improved process for the production of enantiomerically-pure azetidine-2-carboxylic acid HUP9901665A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9601600A SE9601600D0 (sv) 1996-04-26 1996-04-26 Improved process

Publications (2)

Publication Number Publication Date
HUP9901665A2 true HUP9901665A2 (hu) 1999-09-28
HUP9901665A3 HUP9901665A3 (en) 1999-11-29

Family

ID=20402360

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901665A HUP9901665A3 (en) 1996-04-26 1997-04-22 Improved process for the production of enantiomerically-pure azetidine-2-carboxylic acid

Country Status (32)

Country Link
US (1) US6143903A (hu)
EP (1) EP0906255B1 (hu)
JP (2) JP2000509068A (hu)
KR (1) KR100447072B1 (hu)
CN (1) CN1071292C (hu)
AR (1) AR006639A1 (hu)
AT (1) ATE200889T1 (hu)
AU (1) AU713519B2 (hu)
BR (1) BR9708872A (hu)
CA (1) CA2253711C (hu)
CZ (1) CZ339998A3 (hu)
DE (1) DE69704708T2 (hu)
DK (1) DK0906255T3 (hu)
EE (1) EE9800365A (hu)
EG (1) EG20975A (hu)
ES (1) ES2158557T3 (hu)
GR (1) GR3036303T3 (hu)
HU (1) HUP9901665A3 (hu)
ID (1) ID16840A (hu)
IL (1) IL126717A (hu)
IN (1) IN186439B (hu)
IS (1) IS4860A (hu)
MY (1) MY132450A (hu)
NO (1) NO310404B1 (hu)
NZ (1) NZ332155A (hu)
PL (1) PL329685A1 (hu)
PT (1) PT906255E (hu)
SE (1) SE9601600D0 (hu)
SK (1) SK140898A3 (hu)
TR (1) TR199802146T2 (hu)
WO (1) WO1997041084A1 (hu)
ZA (1) ZA973156B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69834276T2 (de) * 1997-01-24 2007-04-12 Sumitomo Chemical Co. Ltd. Verfahren zur Verbesserung der optischen Reinheit von Azetidin-2-carbonsäure
SE9802939D0 (sv) 1998-09-01 1998-09-01 Astra Ab New process
SE9901712D0 (sv) * 1999-05-11 1999-05-11 Astra Ab New process
WO2005103005A1 (ja) * 2004-04-26 2005-11-03 Astellas Pharma Inc. β－ピリジルアラニンの光学活性体の選択的製造方法
WO2010025968A2 (en) * 2008-09-05 2010-03-11 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. Process for enantioseparation of chiral systems with compound formation using two subsequent crystallization steps
JP2013241339A (ja) * 2010-09-09 2013-12-05 Mitsubishi Gas Chemical Co Inc 光学活性アミノ酸の製造方法
JP2013241338A (ja) * 2010-09-09 2013-12-05 Mitsubishi Gas Chemical Co Inc 光学活性２−アミノ酪酸の製造方法
CN103204783B (zh) * 2013-04-18 2015-09-02 张家港市华昌药业有限公司 一种d-赖氨酸盐酸盐的制备方法
WO2016021711A1 (ja) * 2014-08-07 2016-02-11 株式会社エーピーアイ コーポレーション アミノ酸誘導体の製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795874A (fr) * 1972-02-25 1973-08-23 Glaxo Lab Ltd Procede de preparation d'esters optiquement actifs d'alpha-amino-acides
JPS5139219B2 (hu) * 1972-06-08 1976-10-26
US4072698A (en) * 1976-12-02 1978-02-07 The Upjohn Company Resolution of aminonitriles
JPS56104866A (en) * 1980-01-24 1981-08-20 Mitsubishi Chem Ind Ltd Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt
DE3303112A1 (de) * 1983-01-31 1984-08-09 Hoechst Ag, 6230 Frankfurt Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren
US4923983A (en) * 1989-07-31 1990-05-08 Eli Lilly And Company Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2-one
EP0499376A1 (en) * 1991-01-31 1992-08-19 Hoechst Celanese Corporation Precipitation-induced asymmetric transformation of chiral alpha-amino acids and salts thereof
GB9420246D0 (en) * 1994-10-07 1994-11-23 Chiroscience Ltd Asymmetric crystallisation
IN187238B (hu) * 1995-06-30 2002-03-09 Astra Ab
EP0827954B1 (en) * 1996-09-06 2003-06-04 Sumitomo Chemical Company Limited Process for producing optically active azetidine-2-carboxylic acid

Also Published As

Publication number Publication date
CZ339998A3 (cs) 1999-03-17
AU2719497A (en) 1997-11-19
AU713519B2 (en) 1999-12-02
CN1216972A (zh) 1999-05-19
KR20000065019A (ko) 2000-11-06
IN186439B (hu) 2001-09-01
DK0906255T3 (da) 2001-08-13
PL329685A1 (en) 1999-04-12
TR199802146T2 (xx) 1999-01-18
NO984681L (no) 1998-10-07
ID16840A (id) 1997-11-13
BR9708872A (pt) 1999-08-03
KR100447072B1 (ko) 2004-10-14
EE9800365A (et) 1999-04-15
IS4860A (is) 1998-10-06
ES2158557T3 (es) 2001-09-01
IL126717A (en) 2002-11-10
WO1997041084A1 (en) 1997-11-06
CA2253711A1 (en) 1997-11-06
CN1071292C (zh) 2001-09-19
HUP9901665A3 (en) 1999-11-29
EG20975A (en) 2000-08-30
NZ332155A (en) 2000-07-28
US6143903A (en) 2000-11-07
IL126717A0 (en) 1999-08-17
JP2009120611A (ja) 2009-06-04
MY132450A (en) 2007-10-31
ATE200889T1 (de) 2001-05-15
AR006639A1 (es) 1999-09-08
JP2000509068A (ja) 2000-07-18
GR3036303T3 (en) 2001-10-31
NO310404B1 (no) 2001-07-02
SE9601600D0 (sv) 1996-04-26
EP0906255A1 (en) 1999-04-07
ZA973156B (en) 1997-11-06
DE69704708T2 (de) 2001-12-06
PT906255E (pt) 2001-10-30
EP0906255B1 (en) 2001-05-02
NO984681D0 (no) 1998-10-07
CA2253711C (en) 2005-08-23
SK140898A3 (en) 1999-05-07
DE69704708D1 (de) 2001-06-07

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