JPS56104866A - Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt - Google Patents
Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate saltInfo
- Publication number
- JPS56104866A JPS56104866A JP705880A JP705880A JPS56104866A JP S56104866 A JPS56104866 A JP S56104866A JP 705880 A JP705880 A JP 705880A JP 705880 A JP705880 A JP 705880A JP S56104866 A JPS56104866 A JP S56104866A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- acid
- tartaric acid
- piperidinecarboxylic acid
- released
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: L-tartaric acid is used as an agent for optical resolution to come into contact with 4-alkyl-2-piperidinecarboxylic acid and, when necessary, L-tartaric acid is released to produced the high-purity titled compound as an intermediate for an anticoagulant.
CONSTITUTION: L-tartaric acid is used to come into contact with a 4-alkyl-2- piperidinecarboxylic acid in water or an aqueous solvent to form (2R,4R)-4-alkyl-2- piperidinecarboxylic acid L-tartarate salt. When necessary, the L-tartaric acid is released from the resultant salt to give (2R,4R)-4-alkyl-2-piperidine-carboxylic acid. The tartaric acid is released preferably using a strong acid type ion exchange resin. The product is led to N2-arylsulfonyl-L-alginineamides, anticoagulants, preferably the compound of the formula.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP705880A JPS56104866A (en) | 1980-01-24 | 1980-01-24 | Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP705880A JPS56104866A (en) | 1980-01-24 | 1980-01-24 | Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56104866A true JPS56104866A (en) | 1981-08-20 |
JPS6234035B2 JPS6234035B2 (en) | 1987-07-24 |
Family
ID=11655459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP705880A Granted JPS56104866A (en) | 1980-01-24 | 1980-01-24 | Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56104866A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02212473A (en) * | 1989-02-13 | 1990-08-23 | Mitsubishi Kasei Corp | L-tartaric acid salt of (2r,4r)-4-methyl-2-piperidine-carboxylic acid ethyl ester and its desalted substance |
JP2008247922A (en) * | 1995-06-30 | 2008-10-16 | Astrazeneca Ab | Method of producing enantiomerically pure azetidine-2-carboxylic acid |
JP2009120611A (en) * | 1996-04-26 | 2009-06-04 | Astrazeneca Ab | Improved method for producing enantiomerically-pure azetidine-2-carboxylic acid |
US20140088310A1 (en) * | 2011-04-04 | 2014-03-27 | Lundbeck Pharmaceuticals Italy S.P.A. | Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate |
-
1980
- 1980-01-24 JP JP705880A patent/JPS56104866A/en active Granted
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02212473A (en) * | 1989-02-13 | 1990-08-23 | Mitsubishi Kasei Corp | L-tartaric acid salt of (2r,4r)-4-methyl-2-piperidine-carboxylic acid ethyl ester and its desalted substance |
JP2008247922A (en) * | 1995-06-30 | 2008-10-16 | Astrazeneca Ab | Method of producing enantiomerically pure azetidine-2-carboxylic acid |
JP2009120611A (en) * | 1996-04-26 | 2009-06-04 | Astrazeneca Ab | Improved method for producing enantiomerically-pure azetidine-2-carboxylic acid |
US20140088310A1 (en) * | 2011-04-04 | 2014-03-27 | Lundbeck Pharmaceuticals Italy S.P.A. | Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate |
JP2014510117A (en) * | 2011-04-04 | 2014-04-24 | ルンドベック ファーマシューティカルズ イタリー ソシエタ ペル アチオニ | Process for the preparation of process intermediates for the synthesis of argatroban monohydrate |
JP2017186350A (en) * | 2011-04-04 | 2017-10-12 | ルンドベック ファーマシューティカルズ イタリー ソシエタ ペル アチオニ | Manufacturing method of process intermediate for synthesizing argatroban monohydrate |
US9994526B2 (en) | 2011-04-04 | 2018-06-12 | Lundbeck Pharmaceuticals Italy S.P.A. | Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate |
US10385020B2 (en) | 2011-04-04 | 2019-08-20 | Lundbeck Pharmaceuticals Italy S.P.A. | Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate |
Also Published As
Publication number | Publication date |
---|---|
JPS6234035B2 (en) | 1987-07-24 |
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