JPS56104866A - Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt - Google Patents

Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt

Info

Publication number
JPS56104866A
JPS56104866A JP705880A JP705880A JPS56104866A JP S56104866 A JPS56104866 A JP S56104866A JP 705880 A JP705880 A JP 705880A JP 705880 A JP705880 A JP 705880A JP S56104866 A JPS56104866 A JP S56104866A
Authority
JP
Japan
Prior art keywords
alkyl
acid
tartaric acid
piperidinecarboxylic acid
released
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP705880A
Other languages
Japanese (ja)
Other versions
JPS6234035B2 (en
Inventor
Ryoji Kikumoto
Kunihiro Ninomiya
Mamoru Kanno
Akira Maruyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11655459&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS56104866(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP705880A priority Critical patent/JPS56104866A/en
Publication of JPS56104866A publication Critical patent/JPS56104866A/en
Publication of JPS6234035B2 publication Critical patent/JPS6234035B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: L-tartaric acid is used as an agent for optical resolution to come into contact with 4-alkyl-2-piperidinecarboxylic acid and, when necessary, L-tartaric acid is released to produced the high-purity titled compound as an intermediate for an anticoagulant.
CONSTITUTION: L-tartaric acid is used to come into contact with a 4-alkyl-2- piperidinecarboxylic acid in water or an aqueous solvent to form (2R,4R)-4-alkyl-2- piperidinecarboxylic acid L-tartarate salt. When necessary, the L-tartaric acid is released from the resultant salt to give (2R,4R)-4-alkyl-2-piperidine-carboxylic acid. The tartaric acid is released preferably using a strong acid type ion exchange resin. The product is led to N2-arylsulfonyl-L-alginineamides, anticoagulants, preferably the compound of the formula.
COPYRIGHT: (C)1981,JPO&Japio
JP705880A 1980-01-24 1980-01-24 Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt Granted JPS56104866A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP705880A JPS56104866A (en) 1980-01-24 1980-01-24 Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP705880A JPS56104866A (en) 1980-01-24 1980-01-24 Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt

Publications (2)

Publication Number Publication Date
JPS56104866A true JPS56104866A (en) 1981-08-20
JPS6234035B2 JPS6234035B2 (en) 1987-07-24

Family

ID=11655459

Family Applications (1)

Application Number Title Priority Date Filing Date
JP705880A Granted JPS56104866A (en) 1980-01-24 1980-01-24 Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt

Country Status (1)

Country Link
JP (1) JPS56104866A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02212473A (en) * 1989-02-13 1990-08-23 Mitsubishi Kasei Corp L-tartaric acid salt of (2r,4r)-4-methyl-2-piperidine-carboxylic acid ethyl ester and its desalted substance
JP2008247922A (en) * 1995-06-30 2008-10-16 Astrazeneca Ab Method of producing enantiomerically pure azetidine-2-carboxylic acid
JP2009120611A (en) * 1996-04-26 2009-06-04 Astrazeneca Ab Improved method for producing enantiomerically-pure azetidine-2-carboxylic acid
US20140088310A1 (en) * 2011-04-04 2014-03-27 Lundbeck Pharmaceuticals Italy S.P.A. Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02212473A (en) * 1989-02-13 1990-08-23 Mitsubishi Kasei Corp L-tartaric acid salt of (2r,4r)-4-methyl-2-piperidine-carboxylic acid ethyl ester and its desalted substance
JP2008247922A (en) * 1995-06-30 2008-10-16 Astrazeneca Ab Method of producing enantiomerically pure azetidine-2-carboxylic acid
JP2009120611A (en) * 1996-04-26 2009-06-04 Astrazeneca Ab Improved method for producing enantiomerically-pure azetidine-2-carboxylic acid
US20140088310A1 (en) * 2011-04-04 2014-03-27 Lundbeck Pharmaceuticals Italy S.P.A. Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate
JP2014510117A (en) * 2011-04-04 2014-04-24 ルンドベック ファーマシューティカルズ イタリー ソシエタ ペル アチオニ Process for the preparation of process intermediates for the synthesis of argatroban monohydrate
JP2017186350A (en) * 2011-04-04 2017-10-12 ルンドベック ファーマシューティカルズ イタリー ソシエタ ペル アチオニ Manufacturing method of process intermediate for synthesizing argatroban monohydrate
US9994526B2 (en) 2011-04-04 2018-06-12 Lundbeck Pharmaceuticals Italy S.P.A. Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate
US10385020B2 (en) 2011-04-04 2019-08-20 Lundbeck Pharmaceuticals Italy S.P.A. Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate

Also Published As

Publication number Publication date
JPS6234035B2 (en) 1987-07-24

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