HUP9901331A2 - Ciklooxigenáz inhibitorok amidinszármazékokkal alkotott sói, eljárás előállításukra, ezeket tartalmazó gyógyászati készítmények - Google Patents
Ciklooxigenáz inhibitorok amidinszármazékokkal alkotott sói, eljárás előállításukra, ezeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP9901331A2 HUP9901331A2 HU9901331A HUP9901331A HUP9901331A2 HU P9901331 A2 HUP9901331 A2 HU P9901331A2 HU 9901331 A HU9901331 A HU 9901331A HU P9901331 A HUP9901331 A HU P9901331A HU P9901331 A2 HUP9901331 A2 HU P9901331A2
- Authority
- HU
- Hungary
- Prior art keywords
- powder
- pipe
- short
- tube
- ring
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 229940122204 Cyclooxygenase inhibitor Drugs 0.000 title 1
- 150000001409 amidines Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 25
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- VQGHOUODWALEFC-UHFFFAOYSA-N 2-phenylpyridine Chemical compound C1=CC=CC=C1C1=CC=CC=N1 VQGHOUODWALEFC-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 1
- 229940121708 Oxygenase inhibitor Drugs 0.000 abstract 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000004703 alkoxides Chemical class 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical group 0.000 abstract 1
- -1 cyan ring ring Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- JVZRCNQLWOELDU-UHFFFAOYSA-N gamma-Phenylpyridine Natural products C1=CC=CC=C1C1=CC=NC=C1 JVZRCNQLWOELDU-UHFFFAOYSA-N 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- HUDSSSKDWYXKGP-UHFFFAOYSA-N n-phenylpyridin-2-amine Chemical compound C=1C=CC=NC=1NC1=CC=CC=C1 HUDSSSKDWYXKGP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000003650 oxygenase inhibitor Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány szerinti (I) általánős képletű sók - a képletben A jelentése karbőxil fűnkciós csőpőrtőt tartalmazó ciklőőxigenázinhibitőr, és B jelentése (IB) általánős képletű vegyület, amelyben R1 jelentése hidrőgénatőm, nitrőcsőpőrt vagy fenilcsőpőrt, ahől afenilcsőpőrt adőtt esetben halőgénatőm, cianőcsőpőrt, nitrőcsőpőrt,triflűőr-metil-csőpőrt, rövid szénláncú alkilcsőpőrt és rövidszénláncú alkőxicsőpőrt közül választőtt egy vagy többszűbsztitűenssel van szűbsztitűálva; R2 jelentése rövid szénláncú alkilcsőpőrt, (rövid szénláncú)alkil-tiő-csőpőrt, alkil-tiő-alkil-csőpőrt, adőtt esetben halőgénatőm,cianőcsőpőrt, nitrőcsőpőrt, triflűőr-metil-csőpőrt, rövid szénláncúalkilcsőpőrt és rövid szénláncú alkőxicsőpőrt közül választőtt egyvagy több szűbsztitűenssel szűbsztitűált arilcsőpőrt; vagy adőttesetben nitrőcsőpőrt, aminőcsőpőrt, rövid szénláncú alkilcsőpőrt ésfenilcsőpőrt közül választőtt szűbsztitűenssel szűbsztitűáltaminőcsőpőrt, ahől a fenilcsőpőrt maga is adőtt esetben halőgénatőm,cianőcsőpőrt, nitrőcsőpőrt, triflűőr-metil-csőpőrt, rövid szénláncúalkilcsőpőrt és rövid szénláncú alkőxicsőpőrt közül választőtt egyvagy több szűbsztitűenssel lehet szűbsztitűálva; és ha A jelentéseacetil-szalicilsav, és R1 jelentése hidrőgénatőm, akkőr R2 jelentésearilcsőpőrttól vagy fenil-aminő-csőpőrttól eltérő, ahől a fenilcsőpőrtadőtt esetben szűbsztitűálva van - kettős biőlógiai hatásűk, mégpedigNO-szintáz és ciklőőxigenáz gátló hatásűk következtébenkardiővaszkűláris és cerebrővaszkűláris rendellenességek, gyűlladásők,és imműnrendszeri rendellenességek kezelésére használható gyógyszerekhatóanyagaként alkalmazhatók. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9514518.1A GB9514518D0 (en) | 1995-07-15 | 1995-07-15 | Guanidine salt inhibitors of NO synthase and cyclooxygenase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9901331A2 true HUP9901331A2 (hu) | 1999-08-30 |
| HUP9901331A3 HUP9901331A3 (en) | 1999-11-29 |
Family
ID=10777740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901331A HUP9901331A3 (en) | 1995-07-15 | 1996-07-15 | Cyclo-oxygenase inhibitor and amidine derivative salts, preparation method therefor, and pharmaceutical compositions containing said salts |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6063807A (hu) |
| EP (1) | EP0839041B1 (hu) |
| JP (1) | JPH11509540A (hu) |
| CN (1) | CN1187056C (hu) |
| AT (1) | ATE264107T1 (hu) |
| AU (1) | AU704373B2 (hu) |
| CA (1) | CA2227034A1 (hu) |
| CZ (1) | CZ293676B6 (hu) |
| DE (1) | DE69632193T2 (hu) |
| DK (1) | DK0839041T3 (hu) |
| ES (1) | ES2219690T3 (hu) |
| GB (1) | GB9514518D0 (hu) |
| HU (1) | HUP9901331A3 (hu) |
| IL (1) | IL122737A (hu) |
| MX (1) | MX9800408A (hu) |
| NO (1) | NO980178L (hu) |
| NZ (1) | NZ313654A (hu) |
| PL (1) | PL185375B1 (hu) |
| PT (1) | PT839041E (hu) |
| RU (1) | RU2167856C2 (hu) |
| TW (1) | TW474908B (hu) |
| UA (1) | UA53624C2 (hu) |
| WO (1) | WO1997003678A1 (hu) |
| ZA (1) | ZA965969B (hu) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925351A (en) | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
| US7255854B1 (en) | 1996-10-25 | 2007-08-14 | Biogen, Inc. | Use of lymphotoxin-β receptor blocking agents for the treatment of antibody mediated immunological diseases |
| ATE283048T1 (de) * | 1999-12-08 | 2004-12-15 | Pharmacia Corp | Cyclooxygenase-2 hemmer enthaltende zusammensetzungen mit schnellem wirkungseintritt |
| US20020147216A1 (en) * | 2000-01-31 | 2002-10-10 | Yuhong Zhou | Mucin synthesis inhibitors |
| PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
| JP2004510705A (ja) | 2000-07-20 | 2004-04-08 | ラウラス エイエス | 方法 |
| US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| US7695736B2 (en) | 2001-04-03 | 2010-04-13 | Pfizer Inc. | Reconstitutable parenteral composition |
| UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
| AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| BR0309337A (pt) * | 2002-04-18 | 2005-02-15 | Pharmacia Corp | Monoterapia para o tratamento de doença de parkinson com inibidores de ciclooxigenase-2 (cox2) |
| EP1494664A2 (en) * | 2002-04-18 | 2005-01-12 | Pharmacia Corporation | Combinations of cox-2 inhibitors and other agents for the treatment of parkinson's disease |
| KR20090083958A (ko) | 2006-10-20 | 2009-08-04 | 바이오겐 아이덱 엠에이 인코포레이티드 | 가용성 림프독소-베타-수용체를 이용한 탈수초성 장애의 치료 |
| US8338376B2 (en) | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
| US20090155430A1 (en) * | 2007-12-14 | 2009-06-18 | E.I. Du Pont De Nemours And Company | Films comprising liquid smoke and flavorants |
| RU2478618C2 (ru) * | 2010-03-15 | 2013-04-10 | Закрытое Акционерное Общество "Инфарма" | Новое биологически активное соединение n-[3-(4-нитрофениламино)-индол-2-илметилен] аминогуанидина гидрохлорид с противовоспалительной активностью |
| RU2480452C1 (ru) * | 2012-01-11 | 2013-04-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СПХФА Минздрава России) | Способ получения n-4-нитрофенилбензамидина |
| RU2684117C1 (ru) * | 2018-10-29 | 2019-04-04 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Способ получения N-(нафталин-2-ил)бензамидина |
| CN109678715B (zh) * | 2018-11-28 | 2019-11-12 | 中国药科大学 | 2-(1-酰氧正戊基)苯甲酸与碱性氨基酸或氨基胍形成的盐、其制备方法及用途 |
| RU2694263C1 (ru) * | 2019-02-14 | 2019-07-11 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Анальгезирующее и противовоспалительное средство с противомикробной активностью |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56147761A (en) * | 1980-04-15 | 1981-11-16 | Banyu Pharmaceut Co Ltd | Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutent |
| US4324801A (en) * | 1981-04-21 | 1982-04-13 | Banyu Pharmaceutical Co. Ltd. | Phenylguanidine acetylsalicylate compounds, process for production thereof, and pharmaceutical composition thereof |
| JPS61143320A (ja) * | 1985-11-08 | 1986-07-01 | Banyu Pharmaceut Co Ltd | 微小循環器系改善剤 |
| GB9200114D0 (en) * | 1992-01-04 | 1992-02-26 | Scras | Dual inhibitors of no synthase and cyclooxygenase |
-
1995
- 1995-07-15 GB GBGB9514518.1A patent/GB9514518D0/en active Pending
-
1996
- 1996-07-12 ZA ZA965969A patent/ZA965969B/xx unknown
- 1996-07-15 WO PCT/FR1996/001095 patent/WO1997003678A1/fr active IP Right Grant
- 1996-07-15 ES ES96925786T patent/ES2219690T3/es not_active Expired - Lifetime
- 1996-07-15 MX MX9800408A patent/MX9800408A/es not_active IP Right Cessation
- 1996-07-15 RU RU98102777/04A patent/RU2167856C2/ru not_active IP Right Cessation
- 1996-07-15 PL PL96324490A patent/PL185375B1/pl not_active IP Right Cessation
- 1996-07-15 DK DK96925786T patent/DK0839041T3/da active
- 1996-07-15 PT PT96925786T patent/PT839041E/pt unknown
- 1996-07-15 AT AT96925786T patent/ATE264107T1/de not_active IP Right Cessation
- 1996-07-15 IL IL12273796A patent/IL122737A/xx not_active IP Right Cessation
- 1996-07-15 CA CA002227034A patent/CA2227034A1/fr not_active Abandoned
- 1996-07-15 CZ CZ199873A patent/CZ293676B6/cs not_active IP Right Cessation
- 1996-07-15 AU AU66175/96A patent/AU704373B2/en not_active Ceased
- 1996-07-15 NZ NZ313654A patent/NZ313654A/en unknown
- 1996-07-15 CN CNB961955627A patent/CN1187056C/zh not_active Expired - Fee Related
- 1996-07-15 JP JP9506344A patent/JPH11509540A/ja active Pending
- 1996-07-15 UA UA98010194A patent/UA53624C2/uk unknown
- 1996-07-15 US US08/981,682 patent/US6063807A/en not_active Expired - Fee Related
- 1996-07-15 DE DE69632193T patent/DE69632193T2/de not_active Expired - Fee Related
- 1996-07-15 EP EP96925786A patent/EP0839041B1/fr not_active Expired - Lifetime
- 1996-07-15 HU HU9901331A patent/HUP9901331A3/hu unknown
- 1996-07-30 TW TW085109268A patent/TW474908B/zh not_active IP Right Cessation
-
1998
- 1998-01-14 NO NO980178A patent/NO980178L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1190890A (zh) | 1998-08-19 |
| CA2227034A1 (fr) | 1997-02-06 |
| PT839041E (pt) | 2004-09-30 |
| NO980178D0 (no) | 1998-01-14 |
| PL185375B1 (pl) | 2003-04-30 |
| CZ293676B6 (cs) | 2004-06-16 |
| DE69632193T2 (de) | 2005-05-04 |
| CN1187056C (zh) | 2005-02-02 |
| EP0839041A1 (fr) | 1998-05-06 |
| ZA965969B (en) | 1997-10-31 |
| ES2219690T3 (es) | 2004-12-01 |
| JPH11509540A (ja) | 1999-08-24 |
| US6063807A (en) | 2000-05-16 |
| CZ7398A3 (cs) | 1998-06-17 |
| AU704373B2 (en) | 1999-04-22 |
| IL122737A0 (en) | 1998-08-16 |
| DE69632193D1 (de) | 2004-05-19 |
| NO980178L (no) | 1998-01-14 |
| HUP9901331A3 (en) | 1999-11-29 |
| ATE264107T1 (de) | 2004-04-15 |
| RU2167856C2 (ru) | 2001-05-27 |
| NZ313654A (en) | 1999-10-28 |
| EP0839041B1 (fr) | 2004-04-14 |
| IL122737A (en) | 2003-01-12 |
| MX9800408A (es) | 1998-04-30 |
| UA53624C2 (uk) | 2003-02-17 |
| WO1997003678A1 (fr) | 1997-02-06 |
| TW474908B (en) | 2002-02-01 |
| GB9514518D0 (en) | 1995-09-13 |
| AU6617596A (en) | 1997-02-18 |
| DK0839041T3 (da) | 2004-08-09 |
| PL324490A1 (en) | 1998-05-25 |
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