JPS56147761A - Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutent - Google Patents
Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutentInfo
- Publication number
- JPS56147761A JPS56147761A JP4872580A JP4872580A JPS56147761A JP S56147761 A JPS56147761 A JP S56147761A JP 4872580 A JP4872580 A JP 4872580A JP 4872580 A JP4872580 A JP 4872580A JP S56147761 A JPS56147761 A JP S56147761A
- Authority
- JP
- Japan
- Prior art keywords
- acetylsalicylic acid
- diguanidine
- formula
- compound consisting
- salt compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A salt compound consisting of acetylsalicylic acid and diguanidine of formula I (n is 0 or 1; R is phenylene, pyridinediyl, alkylene, etc.).
EXAMPLE: 1,4-Diguanidobenzenediacetylsalicylate.
USE: An antipyretic and analgesic agent, anti-inflammatory agent, a blood platelet agglutination inhibitor, prostaglandin formation inhibitor and an ameliorant for the microcirculatory system. Higher solubility in water and higher activity than acetylsalicylic acid, and capable of preparing a solution sufficiently injectable even into blood vessels and muscles. The aqueous hydrogen ion concentration is near neutral and has much less side effects on the stomach and the intestines than those of the acetylsalicylic acid.
PROCESS: A salt of diguanidine expressed by formula II (HX is hydrogen halide, etc.) is reacted with acetylsalicylic acid to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4872580A JPS56147761A (en) | 1980-04-15 | 1980-04-15 | Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4872580A JPS56147761A (en) | 1980-04-15 | 1980-04-15 | Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutent |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56147761A true JPS56147761A (en) | 1981-11-16 |
Family
ID=12811263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4872580A Pending JPS56147761A (en) | 1980-04-15 | 1980-04-15 | Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56147761A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0308750B1 (en) * | 1987-09-09 | 1995-12-13 | Fuji Photo Film Co., Ltd. | Base precursor and light-sensitive material containing base precursor |
WO1997003678A1 (en) * | 1995-07-15 | 1997-02-06 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Cyclo-oxygenase inhibitor and amidine derivative salts, preparation method therefor, use thereof as drugs, and pharmaceutical compositions containing said salts |
-
1980
- 1980-04-15 JP JP4872580A patent/JPS56147761A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0308750B1 (en) * | 1987-09-09 | 1995-12-13 | Fuji Photo Film Co., Ltd. | Base precursor and light-sensitive material containing base precursor |
WO1997003678A1 (en) * | 1995-07-15 | 1997-02-06 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Cyclo-oxygenase inhibitor and amidine derivative salts, preparation method therefor, use thereof as drugs, and pharmaceutical compositions containing said salts |
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