JPS56147761A - Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutent - Google Patents

Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutent

Info

Publication number
JPS56147761A
JPS56147761A JP4872580A JP4872580A JPS56147761A JP S56147761 A JPS56147761 A JP S56147761A JP 4872580 A JP4872580 A JP 4872580A JP 4872580 A JP4872580 A JP 4872580A JP S56147761 A JPS56147761 A JP S56147761A
Authority
JP
Japan
Prior art keywords
acetylsalicylic acid
diguanidine
formula
compound consisting
salt compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4872580A
Other languages
Japanese (ja)
Inventor
Akinori Matsuzaki
Hiroshi Okabe
Takao Takiguchi
Midori Nakayanagi
Masaru Nishikibe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Priority to JP4872580A priority Critical patent/JPS56147761A/en
Publication of JPS56147761A publication Critical patent/JPS56147761A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A salt compound consisting of acetylsalicylic acid and diguanidine of formula I (n is 0 or 1; R is phenylene, pyridinediyl, alkylene, etc.).
EXAMPLE: 1,4-Diguanidobenzenediacetylsalicylate.
USE: An antipyretic and analgesic agent, anti-inflammatory agent, a blood platelet agglutination inhibitor, prostaglandin formation inhibitor and an ameliorant for the microcirculatory system. Higher solubility in water and higher activity than acetylsalicylic acid, and capable of preparing a solution sufficiently injectable even into blood vessels and muscles. The aqueous hydrogen ion concentration is near neutral and has much less side effects on the stomach and the intestines than those of the acetylsalicylic acid.
PROCESS: A salt of diguanidine expressed by formula II (HX is hydrogen halide, etc.) is reacted with acetylsalicylic acid to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP4872580A 1980-04-15 1980-04-15 Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutent Pending JPS56147761A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4872580A JPS56147761A (en) 1980-04-15 1980-04-15 Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4872580A JPS56147761A (en) 1980-04-15 1980-04-15 Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutent

Publications (1)

Publication Number Publication Date
JPS56147761A true JPS56147761A (en) 1981-11-16

Family

ID=12811263

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4872580A Pending JPS56147761A (en) 1980-04-15 1980-04-15 Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutent

Country Status (1)

Country Link
JP (1) JPS56147761A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0308750B1 (en) * 1987-09-09 1995-12-13 Fuji Photo Film Co., Ltd. Base precursor and light-sensitive material containing base precursor
WO1997003678A1 (en) * 1995-07-15 1997-02-06 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Cyclo-oxygenase inhibitor and amidine derivative salts, preparation method therefor, use thereof as drugs, and pharmaceutical compositions containing said salts

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0308750B1 (en) * 1987-09-09 1995-12-13 Fuji Photo Film Co., Ltd. Base precursor and light-sensitive material containing base precursor
WO1997003678A1 (en) * 1995-07-15 1997-02-06 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Cyclo-oxygenase inhibitor and amidine derivative salts, preparation method therefor, use thereof as drugs, and pharmaceutical compositions containing said salts

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