AU2001232032A1 - Benzooxazole derivatives as tnf and pde iv inhibitors - Google Patents
Benzooxazole derivatives as tnf and pde iv inhibitorsInfo
- Publication number
- AU2001232032A1 AU2001232032A1 AU2001232032A AU3203201A AU2001232032A1 AU 2001232032 A1 AU2001232032 A1 AU 2001232032A1 AU 2001232032 A AU2001232032 A AU 2001232032A AU 3203201 A AU3203201 A AU 3203201A AU 2001232032 A1 AU2001232032 A1 AU 2001232032A1
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- pde
- tnf
- inhibitors
- nr4r5
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Dermatology (AREA)
- AIDS & HIV (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
Abstract
A compound of the formulawhereinR1 is C1-3 alkyl optionally substituted with one or more fluorines;R2 is C1-6 alkyl, cycloalkyl or NR4R5;R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C)NR4R5 is a nitrogen-containing heterocyclic ring;R6 is C1-3 alkyl; andR7 and R8, which are the same or different, each represents C1-3 alkyl, halogen, CF3 or CN;or a pharmaceutically-acceptable salt thereof.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0003256.5A GB0003256D0 (en) | 2000-02-11 | 2000-02-11 | Heterocyclic compounds and their therapeutic use |
GB0003256 | 2000-02-11 | ||
PCT/GB2001/000507 WO2001058896A1 (en) | 2000-02-11 | 2001-02-08 | Benzoxazole derivatives as tnf and pde iv inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001232032A1 true AU2001232032A1 (en) | 2001-08-20 |
Family
ID=9885479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001232032A Abandoned AU2001232032A1 (en) | 2000-02-11 | 2001-02-08 | Benzooxazole derivatives as tnf and pde iv inhibitors |
Country Status (9)
Country | Link |
---|---|
US (1) | US6403791B1 (en) |
EP (1) | EP1261605B1 (en) |
JP (1) | JP2003522771A (en) |
AT (1) | ATE282037T1 (en) |
AU (1) | AU2001232032A1 (en) |
DE (1) | DE60107056T2 (en) |
ES (1) | ES2231439T3 (en) |
GB (1) | GB0003256D0 (en) |
WO (1) | WO2001058896A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001232340A1 (en) * | 2000-02-18 | 2001-08-27 | Kirin Beer Kabushiki Kaisha | Novel isoxazole and thiazole compounds and use thereof as drugs |
NZ560969A (en) * | 2005-02-17 | 2010-08-27 | Albany Molecular Res Inc | Benzoxazole carboxamides for treating chemotherapy-induced vomiting and irritable bowel syndrome |
GB0602768D0 (en) * | 2006-02-10 | 2006-03-22 | Vastox Plc | Treatment of muscular dystrophy |
NZ570625A (en) | 2006-02-10 | 2011-10-28 | Biomarin Iga Ltd | Treatment of duchenne muscular dystrophy |
WO2008019363A2 (en) * | 2006-08-07 | 2008-02-14 | Albany Molecular Research, Inc. | 2-alkylbenzoxazole carboxamides as 5ht3 modulators |
EP2061460A2 (en) * | 2006-08-07 | 2009-05-27 | Albany Molecular Research, Inc. | 2-aminobenzoxazole carboxamides as 5ht3 modulators |
CN101077866B (en) * | 2007-05-15 | 2012-07-11 | 中国人民解放军第二军医大学 | Substituted benzoxazoles antifungal compounds and preparation method thereof |
BRPI0811317A2 (en) | 2007-08-03 | 2015-01-27 | Summit Corp Plc | COMBINATION, PHARMACEUTICAL PACKAGING, KIT OR PACKAGING FOR A PATIENT AGENT, AUXILIARY AGENT, COMPOSITE, USES OF AN AUXILIARY AGENT AND COMPOUND, AND PROCESS FOR PRODUCTION OF A COMBINATION |
GB0715939D0 (en) * | 2007-08-15 | 2007-09-26 | Vastox Plc | Method of treatment of duchenne muscular dystrophy |
EP2247600A4 (en) * | 2008-02-06 | 2011-09-14 | Biomarin Pharm Inc | Benzoxazole carboxamide inhibitors of poly(adp-ribose)polymerase (parp) |
WO2015005429A1 (en) * | 2013-07-10 | 2015-01-15 | Meiji Seikaファルマ株式会社 | Novel pde4 inhibitor |
CN110114358B (en) * | 2016-12-26 | 2021-12-03 | 明治制果药业株式会社 | Novel compound and pharmacologically acceptable salt thereof |
JP6815566B2 (en) * | 2018-06-27 | 2021-01-20 | Meiji Seikaファルマ株式会社 | Therapeutic agents for inflammatory, autoimmune, fibrotic, and cancerous diseases |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2802706B2 (en) * | 1992-09-28 | 1998-09-24 | 富士写真フイルム株式会社 | Method for producing heterocyclic compound |
RU2170730C2 (en) * | 1996-05-20 | 2001-07-20 | Дарвин Дискавери Лимитед | Quinoline carboxamides and pharmaceutical composition based on thereof |
ATE242234T1 (en) * | 1996-11-15 | 2003-06-15 | Darwin Discovery Ltd | BICYCLIC ARYLCARBOXAMIDES AND THEIR THERAPEUTIC USE |
TW555759B (en) * | 1998-06-08 | 2003-10-01 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
-
2000
- 2000-02-11 GB GBGB0003256.5A patent/GB0003256D0/en not_active Ceased
-
2001
- 2001-02-08 JP JP2001558446A patent/JP2003522771A/en active Pending
- 2001-02-08 ES ES01904113T patent/ES2231439T3/en not_active Expired - Lifetime
- 2001-02-08 DE DE60107056T patent/DE60107056T2/en not_active Expired - Fee Related
- 2001-02-08 WO PCT/GB2001/000507 patent/WO2001058896A1/en active IP Right Grant
- 2001-02-08 EP EP01904113A patent/EP1261605B1/en not_active Expired - Lifetime
- 2001-02-08 AU AU2001232032A patent/AU2001232032A1/en not_active Abandoned
- 2001-02-08 AT AT01904113T patent/ATE282037T1/en not_active IP Right Cessation
- 2001-02-09 US US09/779,963 patent/US6403791B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1261605B1 (en) | 2004-11-10 |
DE60107056D1 (en) | 2004-12-16 |
GB0003256D0 (en) | 2000-04-05 |
EP1261605A1 (en) | 2002-12-04 |
WO2001058896A8 (en) | 2001-12-20 |
ATE282037T1 (en) | 2004-11-15 |
WO2001058896A1 (en) | 2001-08-16 |
JP2003522771A (en) | 2003-07-29 |
US6403791B1 (en) | 2002-06-11 |
ES2231439T3 (en) | 2005-05-16 |
DE60107056T2 (en) | 2005-11-10 |
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