ATE264107T1 - Cyclooxygenaseinhibitor und salze von amidinderivaten, verfahren zu deren herstellung, deren verwendung als arzneiwirkstoffe sowie diese salze enthaltende arzneimittel - Google Patents

Cyclooxygenaseinhibitor und salze von amidinderivaten, verfahren zu deren herstellung, deren verwendung als arzneiwirkstoffe sowie diese salze enthaltende arzneimittel

Info

Publication number
ATE264107T1
ATE264107T1 AT96925786T AT96925786T ATE264107T1 AT E264107 T1 ATE264107 T1 AT E264107T1 AT 96925786 T AT96925786 T AT 96925786T AT 96925786 T AT96925786 T AT 96925786T AT E264107 T1 ATE264107 T1 AT E264107T1
Authority
AT
Austria
Prior art keywords
salts
medicinal
amideine
hibitor
cyclooxygenase
Prior art date
Application number
AT96925786T
Other languages
English (en)
Inventor
De Lassauniere Pierre Chabrier
Colette Broquet
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Application granted granted Critical
Publication of ATE264107T1 publication Critical patent/ATE264107T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/606—Salicylic acid; Derivatives thereof having amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Surgery (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96925786T 1995-07-15 1996-07-15 Cyclooxygenaseinhibitor und salze von amidinderivaten, verfahren zu deren herstellung, deren verwendung als arzneiwirkstoffe sowie diese salze enthaltende arzneimittel ATE264107T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9514518.1A GB9514518D0 (en) 1995-07-15 1995-07-15 Guanidine salt inhibitors of NO synthase and cyclooxygenase
PCT/FR1996/001095 WO1997003678A1 (fr) 1995-07-15 1996-07-15 Sels de derives d'amidine et d'inhibiteur de cyclooxygenase, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
ATE264107T1 true ATE264107T1 (de) 2004-04-15

Family

ID=10777740

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96925786T ATE264107T1 (de) 1995-07-15 1996-07-15 Cyclooxygenaseinhibitor und salze von amidinderivaten, verfahren zu deren herstellung, deren verwendung als arzneiwirkstoffe sowie diese salze enthaltende arzneimittel

Country Status (24)

Country Link
US (1) US6063807A (de)
EP (1) EP0839041B1 (de)
JP (1) JPH11509540A (de)
CN (1) CN1187056C (de)
AT (1) ATE264107T1 (de)
AU (1) AU704373B2 (de)
CA (1) CA2227034A1 (de)
CZ (1) CZ293676B6 (de)
DE (1) DE69632193T2 (de)
DK (1) DK0839041T3 (de)
ES (1) ES2219690T3 (de)
GB (1) GB9514518D0 (de)
HU (1) HUP9901331A3 (de)
IL (1) IL122737A (de)
MX (1) MX9800408A (de)
NO (1) NO980178D0 (de)
NZ (1) NZ313654A (de)
PL (1) PL185375B1 (de)
PT (1) PT839041E (de)
RU (1) RU2167856C2 (de)
TW (1) TW474908B (de)
UA (1) UA53624C2 (de)
WO (1) WO1997003678A1 (de)
ZA (1) ZA965969B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925351A (en) 1995-07-21 1999-07-20 Biogen, Inc. Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US7255854B1 (en) 1996-10-25 2007-08-14 Biogen, Inc. Use of lymphotoxin-β receptor blocking agents for the treatment of antibody mediated immunological diseases
CO5261556A1 (es) * 1999-12-08 2003-03-31 Pharmacia Corp Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico
US20020147216A1 (en) * 2000-01-31 2002-10-10 Yuhong Zhou Mucin synthesis inhibitors
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
WO2002007721A2 (en) * 2000-07-20 2002-01-31 Lauras As Use of cox-2 inhibitors for preventing immunodeficiency
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
MY137736A (en) 2001-04-03 2009-03-31 Pharmacia Corp Reconstitutable parenteral composition
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
MXPA04010186A (es) * 2002-04-18 2005-02-03 Pharmacia Corp Monoterapia para el tratamiento de la enfermedad de parkinson con inhibidor (es) de la ciclooxigenasa-2 (cox 2).
MXPA04009352A (es) * 2002-04-18 2005-01-25 Pharmacia Corp Terapia de combinacion para el tratamiento de la enfermedad de parkinson con inhibidores de ciclooxigenasa-2 (cox2).
RU2237658C1 (ru) * 2003-07-10 2004-10-10 Общество с ограниченной ответственностью "Международный институт эколого-технологических проблем" Гидрохлорид п-гуанидиносалицилата натрия
EP1663960B1 (de) * 2003-09-25 2011-08-24 Dompe' S.P.A. Amidine und derivate davon und pharmazeutische zusammensetzungen, die diese enthalten
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
JP2010506955A (ja) 2006-10-20 2010-03-04 バイオジェン・アイデック・エムエイ・インコーポレイテッド 可溶性リンホトキシンβレセプターによる脱髄障害の処置
US20090155430A1 (en) * 2007-12-14 2009-06-18 E.I. Du Pont De Nemours And Company Films comprising liquid smoke and flavorants
RU2478618C2 (ru) * 2010-03-15 2013-04-10 Закрытое Акционерное Общество "Инфарма" Новое биологически активное соединение n-[3-(4-нитрофениламино)-индол-2-илметилен] аминогуанидина гидрохлорид с противовоспалительной активностью
RU2480452C1 (ru) * 2012-01-11 2013-04-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СПХФА Минздрава России) Способ получения n-4-нитрофенилбензамидина
RU2684117C1 (ru) * 2018-10-29 2019-04-04 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) Способ получения N-(нафталин-2-ил)бензамидина
CN109678715B (zh) * 2018-11-28 2019-11-12 中国药科大学 2-(1-酰氧正戊基)苯甲酸与碱性氨基酸或氨基胍形成的盐、其制备方法及用途
RU2694263C1 (ru) * 2019-02-14 2019-07-11 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) Анальгезирующее и противовоспалительное средство с противомикробной активностью

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56147761A (en) * 1980-04-15 1981-11-16 Banyu Pharmaceut Co Ltd Salt compound consisting of acetylsalicylic acid and diguanidine, its preparation and agent containing the same as active constitutent
US4324801A (en) * 1981-04-21 1982-04-13 Banyu Pharmaceutical Co. Ltd. Phenylguanidine acetylsalicylate compounds, process for production thereof, and pharmaceutical composition thereof
JPS61143320A (ja) * 1985-11-08 1986-07-01 Banyu Pharmaceut Co Ltd 微小循環器系改善剤
GB9200114D0 (en) * 1992-01-04 1992-02-26 Scras Dual inhibitors of no synthase and cyclooxygenase

Also Published As

Publication number Publication date
RU2167856C2 (ru) 2001-05-27
CZ7398A3 (cs) 1998-06-17
CN1187056C (zh) 2005-02-02
DK0839041T3 (da) 2004-08-09
GB9514518D0 (en) 1995-09-13
MX9800408A (es) 1998-04-30
EP0839041A1 (de) 1998-05-06
NZ313654A (en) 1999-10-28
AU6617596A (en) 1997-02-18
CZ293676B6 (cs) 2004-06-16
DE69632193T2 (de) 2005-05-04
ZA965969B (en) 1997-10-31
CA2227034A1 (fr) 1997-02-06
CN1190890A (zh) 1998-08-19
AU704373B2 (en) 1999-04-22
PL324490A1 (en) 1998-05-25
EP0839041B1 (de) 2004-04-14
JPH11509540A (ja) 1999-08-24
HUP9901331A3 (en) 1999-11-29
WO1997003678A1 (fr) 1997-02-06
NO980178L (no) 1998-01-14
IL122737A (en) 2003-01-12
IL122737A0 (en) 1998-08-16
PL185375B1 (pl) 2003-04-30
TW474908B (en) 2002-02-01
NO980178D0 (no) 1998-01-14
HUP9901331A2 (hu) 1999-08-30
ES2219690T3 (es) 2004-12-01
DE69632193D1 (de) 2004-05-19
PT839041E (pt) 2004-09-30
US6063807A (en) 2000-05-16
UA53624C2 (uk) 2003-02-17

Similar Documents

Publication Publication Date Title
ATE264107T1 (de) Cyclooxygenaseinhibitor und salze von amidinderivaten, verfahren zu deren herstellung, deren verwendung als arzneiwirkstoffe sowie diese salze enthaltende arzneimittel
DE59401924D1 (de) Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
NO973479L (no) Substituerte heterosykliske forbindelser, fremgangsmåte for fremstilling og farmasöytiske blandinger inneholdende samme
DE69723869D1 (de) Heterozyklische verbindungen, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen die diese enthalten und ihre anwendung in der behandlung von diabetis und verwandten krankheiten
ES2102475T3 (es) Nuevas alquil-amidas heterociclicas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
DE69632194D1 (de) Galanthamin-derivate, verfahren zu ihrer herstellung, ihre verwendung als arzmittel und diese enthaltende pharmazeutische zusammensetzung
ATE302778T1 (de) N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE259369T1 (de) Neue geranylgeranylderivate, verfahren zu deren herstellung und entsprechende pharmazeutische zusammensetzungen
ATE282615T1 (de) Neue beta-amyloid inhibitoren, verfahren zu deren herstellung und deren verwendung als arzneimittel
DE59610175D1 (de) Hydantoinderivate als zwischenprodukte für pharmazeutische wirkstoffe
DE59404786D1 (de) Verwendung von cumarinen als pla 2-inhibitoren, neue cumarine, verfahren zu ihrer herstellung und arzneimittel
NO306400B1 (no) N-substituerte azabicykloheptan-derivater, anvendelse derav og farmasöytisk preparat
DE69837045D1 (de) Dreiringige verbindungen, verfahren zu ihrer herstellung und zwischenprodukte dieses verfahren, ihre anwendung als arzneimittel und sie enthaltende pharmazeutische zusammensetzungen
DE59607683D1 (de) Neue borneolderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
ATE182886T1 (de) Neue pyridin- bzw. pyridazinderivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
ATE195529T1 (de) 17beta-(2-oxo-tetrahydrofuran-4-yl)-thio- androstane derivate (17beta-(gamma-buttersäure- lacton)-thio derivate) zur behandlung von entzündungen, pharmazeutische präparate davon und ein verfahren zu ihrer herstellung
DE69943259D1 (de) Neue 2-Halogen-Derivate von 5-O-Desosaminylerythronolid A, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
DE59402079D1 (de) Benzo[f]chinoxalindionderivative, deren herstellung und verwendung in arzneimitteln
DE69215511D1 (de) Gem-diphosphonsäure-nitrosocarbamoylderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zubereitungen
DE59206968D1 (de) Leukotrien-b 4?-derivative, verfahren zu ihrer herstellung und arzneimittel
ATE170527T1 (de) Phosphonobernsteinsäurederivate und ihre verwendung als arzneimittel
FI953360A7 (fi) Substituoituja 1-(7-kloorikinol-4-yyli)pyratsoli-3-karboksiamidi-H-oksidijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
ATE221068T1 (de) Anellierte beta-carboline

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0839041

Country of ref document: EP

REN Ceased due to non-payment of the annual fee