HUP9802308A2 - Bioaktív zsírsavészterek és eljárás a vegyületeket tartalmazó gyógyszerkészítmények előállítására - Google Patents

Bioaktív zsírsavészterek és eljárás a vegyületeket tartalmazó gyógyszerkészítmények előállítására

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Publication number
HUP9802308A2
HUP9802308A2 HU9802308A HUP9802308A HUP9802308A2 HU P9802308 A2 HUP9802308 A2 HU P9802308A2 HU 9802308 A HU9802308 A HU 9802308A HU P9802308 A HUP9802308 A HU P9802308A HU P9802308 A2 HUP9802308 A2 HU P9802308A2
Authority
HU
Hungary
Prior art keywords
fatty acid
acid
contg
acid esters
compounds
Prior art date
Application number
HU9802308A
Other languages
English (en)
Inventor
David Frederick Horrobin
Phillip Knowles
Mehar Manku
Austin Mcmordie
Andrea Pitt
Peter Redden
Original Assignee
Scotia Holdings Plc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9508823.3A external-priority patent/GB9508823D0/en
Priority claimed from GBGB9517107.0A external-priority patent/GB9517107D0/en
Priority claimed from GBGB9605440.8A external-priority patent/GB9605440D0/en
Application filed by Scotia Holdings Plc. filed Critical Scotia Holdings Plc.
Publication of HUP9802308A2 publication Critical patent/HUP9802308A2/hu
Publication of HUP9802308A3 publication Critical patent/HUP9802308A3/hu

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
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    • C07D233/91—Nitro radicals
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Abstract

-1 = (57) A találmány tárgyát az (I) általánős képletű vegyületekképezik, melyek terápiás célra használhatók - a képletben R1 jelentése két vagy több cisz vagy transz kettős kötést tartalmazó C16-30 zsírsavból származó acilcsőpőrt, előnyösen egy n-6 vagy n-3sőrőzatbeli esszenciális zsírsav vagy kőnjűgált linőlsav, vagykőlűmbinsav vagy parinarinsav, és R2 jelentése vagy R1-gyel azőnős vagy attól eltérően bármely mástápanyag, gyógyszer vagy más biőaktív származék, ami a szervezetbenszabadűl fel aktív anyagként, és R3 jelentése hidrőgénatőm, tiszta szénhidrőgén vagy őlyan, amelyheterőatőmőkat tartalmaz. A találmány tárgyát képezi a vegyületeket tartalmazógyógyszerkészítmények előállítása is. A találmány szerinti vegyülettela biőaktív anyag könnyen átjűt a szervezet lipidgátján. ŕ
HU9802308A 1995-05-01 1996-05-01 Fatty acid esters as bioactive compounds and process for preparing pharmaceutical compns. contg. them HUP9802308A3 (en)

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