HUP9900911A1 - Gyógyászatilag hatásos zsírsavszármazékok, eljárás ezek előállítására és ezeket tartalmazó gyógyászati készítmények - Google Patents

Gyógyászatilag hatásos zsírsavszármazékok, eljárás ezek előállítására és ezeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9900911A1
HUP9900911A1 HU9900911A HUP9900911A HUP9900911A1 HU P9900911 A1 HUP9900911 A1 HU P9900911A1 HU 9900911 A HU9900911 A HU 9900911A HU P9900911 A HUP9900911 A HU P9900911A HU P9900911 A1 HUP9900911 A1 HU P9900911A1
Authority
HU
Hungary
Prior art keywords
ring
powder
general formula
chain alkyl
acyl
Prior art date
Application number
HU9900911A
Other languages
English (en)
Inventor
Naoki Fukami
Keisuke Imai
Seiji Yoshimura
Keiji néhai Hemmi
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515162.7A external-priority patent/GB9515162D0/en
Priority claimed from AUPN9835A external-priority patent/AUPN983596A0/en
Application filed by Fujisawa Pharmaceutical Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Publication of HUP9900911A1 publication Critical patent/HUP9900911A1/hu
Publication of HUP9900911A3 publication Critical patent/HUP9900911A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgyát az (I) általánős képletű vegyületek és ezekgyógyászatilag megfelelő sói képezik, ahől a képletben R1 jelentéseacilcsőpőrt, R2 jelentése acil-(rövid szénláncú alkil)-csőpőrt, R3jelentése hidrőgénatőm, aril-(rövid szénláncú alkil)-csőpőrt éshasőnló csőpőrtők, R4 jelentése acil-(rövid szénláncú alkil)-csőpőrt, és R5 Xjelentése -O-, -NH- vagy -N- általánős képletű csőpőrt, ahől aképletben R6 jelentése rövid szénláncú alkilcsőpőrt és hasőnlócsőpőrtők. Az (I) általánős képletű vegyületek kedvező gyógyászatihatásűk következtében gyógyszerek hatóanyagát képezhetik. A találmánytárgyáhőz tartőzik az (I) általánős képletű zsírsavszármazékők és ezeksóinak előállítására szőlgáló eljárás is. A találmány szerintigyógyászati készítmények hatóanyagként valamely (I) általánős képletűzsírsavszármazékőt vagy ennek gyógyászatilag megfelelő sóját, tővábbágyógyászatilag megfelelő vivő- és/vagy segédanyagőt tartalmaznak. ŕ
HU9900911A 1995-07-24 1996-07-18 Esters and amides as pla2 inhibitors HUP9900911A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9515162.7A GB9515162D0 (en) 1995-07-24 1995-07-24 New compound
AUPN9835A AUPN983596A0 (en) 1996-05-14 1996-05-14 New compound

Publications (2)

Publication Number Publication Date
HUP9900911A1 true HUP9900911A1 (hu) 1999-07-28
HUP9900911A3 HUP9900911A3 (en) 2000-06-28

Family

ID=25645172

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900911A HUP9900911A3 (en) 1995-07-24 1996-07-18 Esters and amides as pla2 inhibitors

Country Status (14)

Country Link
US (3) US20020019416A1 (hu)
EP (1) EP0854863B1 (hu)
JP (1) JP3353301B2 (hu)
KR (1) KR19990035780A (hu)
CN (1) CN1056602C (hu)
AT (1) ATE226934T1 (hu)
CA (1) CA2227466A1 (hu)
DE (1) DE69624582T2 (hu)
EA (1) EA199800155A1 (hu)
ES (1) ES2181901T3 (hu)
HU (1) HUP9900911A3 (hu)
IL (1) IL122664A (hu)
MX (1) MX9800704A (hu)
WO (1) WO1997003951A1 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001501980A (ja) * 1998-06-29 2001-02-13 藤沢薬品工業株式会社 医薬組成物
DE19952146A1 (de) * 1999-10-29 2001-06-07 Boehringer Ingelheim Pharma Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JP2004503604A (ja) 2000-07-24 2004-02-05 ザ・ユニバーシティ・オブ・クイーンズランド 化合物およびホスホリパーゼ阻害剤
AU2001272234B2 (en) * 2000-07-24 2006-06-01 The University Of Queensland Compounds and inhibitors of phospholipases
WO2003076389A1 (en) * 2002-03-07 2003-09-18 The Regents Of The University Of California Compositions and methods for inhibition of phospholipase a2 mediated inflammation
US8138383B2 (en) * 2002-03-11 2012-03-20 Arrowhead Madison Inc. Membrane active heteropolymers
US7531569B2 (en) * 2003-12-02 2009-05-12 Sanofi-Aventis Deutschland Gmbh Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives
EP1902014A2 (en) 2005-07-11 2008-03-26 Wyeth Glutamate aggrecanase inhibitors
WO2007044100A1 (en) 2005-10-13 2007-04-19 Wyeth Methods for preparing glutamic acid derivatives
FR2893873B1 (fr) * 2005-11-25 2008-12-12 Air Liquide Procede de coupage avec un laser a fibre d'acier inoxydable
JP5584518B2 (ja) * 2009-05-28 2014-09-03 石原産業株式会社 ジアミノトリフルオロメチルピリジン誘導体を含有する抗ショック剤
JP6326825B2 (ja) * 2013-02-18 2018-05-23 住友化学株式会社 塩、レジスト組成物及びレジストパターンの製造方法
EP3189033B1 (en) * 2014-06-19 2020-08-05 Rafael Pharmaceuticals, Inc. Pharmaceutical compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128A (en) * 1847-05-22 Brick-press
US4792555A (en) * 1987-03-20 1988-12-20 American Home Products Corporation Phospholipase A2 inhibitors
US5128346A (en) * 1987-09-21 1992-07-07 Abbott Laboratories Derivatives of D-glutamic acid and D-aspartic acid
ES2044781B1 (es) * 1992-04-14 1994-10-01 Menarini Lab Procedimiento para la preparacion de nuevas amidas con accion inhibidora de la fosfolipasa a2
ATE184593T1 (de) * 1994-01-24 1999-10-15 Fujisawa Pharmaceutical Co Aminosäurederivate und ihre verwendung als phospholipase-a2-inhibitoren

Also Published As

Publication number Publication date
CN1056602C (zh) 2000-09-20
US20020169326A1 (en) 2002-11-14
EA199800155A1 (ru) 1999-02-25
US20020019416A1 (en) 2002-02-14
MX9800704A (es) 1998-04-30
DE69624582T2 (de) 2003-03-20
US20040063959A1 (en) 2004-04-01
IL122664A (en) 2000-12-06
EP0854863A1 (en) 1998-07-29
JP3353301B2 (ja) 2002-12-03
CN1197450A (zh) 1998-10-28
EP0854863B1 (en) 2002-10-30
CA2227466A1 (en) 1997-02-06
HUP9900911A3 (en) 2000-06-28
ES2181901T3 (es) 2003-03-01
JPH11509548A (ja) 1999-08-24
DE69624582D1 (de) 2002-12-05
IL122664A0 (en) 1998-08-16
ATE226934T1 (de) 2002-11-15
KR19990035780A (ko) 1999-05-25
WO1997003951A1 (en) 1997-02-06

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