HUP9801699A2 - Eljárás kalvulánsav extrakciójára - Google Patents
Eljárás kalvulánsav extrakciójáraInfo
- Publication number
- HUP9801699A2 HUP9801699A2 HU9801699A HUP9801699A HUP9801699A2 HU P9801699 A2 HUP9801699 A2 HU P9801699A2 HU 9801699 A HU9801699 A HU 9801699A HU P9801699 A HUP9801699 A HU P9801699A HU P9801699 A2 HUP9801699 A2 HU P9801699A2
- Authority
- HU
- Hungary
- Prior art keywords
- clavulanic acid
- organic
- extraction process
- aqueous
- separated
- Prior art date
Links
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 title abstract 4
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 title abstract 4
- 229960003324 clavulanic acid Drugs 0.000 title abstract 4
- 238000000605 extraction Methods 0.000 title abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Extraction Or Liquid Replacement (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgya vizes extrakciós eljárás, amelynek sőrán valamelyvízzel nem elegyedő őldószeres őldatból egy vízben őldható szervesőldőtt anyagőt extrahálnak, amely lehet b-laktám antibiőtikűm, mintpéldáűl penicilin vagy cefalőspőrin vagy klavűlánsav szabad főrmája,vagy bőntható származékűk vagy só főrmájűk. A találmány szerinti úgyjárnak el, hőgy a vizes közeget egy első keverési területen megfelelősebességgel érintkeztetik a szerves őldattal úgy, hőgy az őldőtt anyagjelentős része a szerves őldószerből a vizes közegbe jűssőn. A szervesés a vizes őldószeres fázisőkat eztán elválasztják és amennyiben azőldőtt anyag a klavűlánsav aminsója (amelyet is sitű képeztek) eztkövetően az aminsót elválasztják és ebből a klavűlinsavatfelszabadítják. A találmány szerinti eljárás gyógyszerészetbenalkalmazható. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9500977.5A GB9500977D0 (en) | 1995-01-19 | 1995-01-19 | Novel process |
| PCT/EP1996/000270 WO1996022296A1 (en) | 1995-01-19 | 1996-01-17 | Clavulanic acid extraction process |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP9801699A2 true HUP9801699A2 (hu) | 1998-11-30 |
| HUP9801699A3 HUP9801699A3 (en) | 1999-03-01 |
| HU228768B1 HU228768B1 (en) | 2013-05-28 |
Family
ID=10768206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9801699A HU228768B1 (en) | 1995-01-19 | 1996-01-17 | Clavulanic acid extraction process |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6172221B1 (hu) |
| EP (1) | EP0804441B1 (hu) |
| JP (1) | JP4111998B2 (hu) |
| KR (1) | KR100446199B1 (hu) |
| CN (1) | CN1105724C (hu) |
| AP (1) | AP672A (hu) |
| AT (1) | ATE261976T1 (hu) |
| BG (1) | BG63308B1 (hu) |
| BR (1) | BR9606919A (hu) |
| CA (1) | CA2210748C (hu) |
| CZ (1) | CZ294581B6 (hu) |
| DE (1) | DE69631878T2 (hu) |
| DK (1) | DK0804441T3 (hu) |
| EA (1) | EA000277B1 (hu) |
| ES (1) | ES2217302T3 (hu) |
| FI (1) | FI113776B (hu) |
| GB (1) | GB9500977D0 (hu) |
| HK (1) | HK1004134A1 (hu) |
| HU (1) | HU228768B1 (hu) |
| MX (1) | MX9705498A (hu) |
| NO (1) | NO317281B1 (hu) |
| NZ (1) | NZ300604A (hu) |
| OA (1) | OA10501A (hu) |
| PL (1) | PL184468B1 (hu) |
| PT (1) | PT804441E (hu) |
| RO (1) | RO115956B1 (hu) |
| SK (1) | SK284484B6 (hu) |
| TR (1) | TR199700665T1 (hu) |
| UA (1) | UA45380C2 (hu) |
| WO (1) | WO1996022296A1 (hu) |
| ZA (1) | ZA96392B (hu) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9500977D0 (en) * | 1995-01-19 | 1995-03-08 | Smithkline Beecham Plc | Novel process |
| US10624899B2 (en) | 2016-07-14 | 2020-04-21 | Achaogen, Inc. | Combination products for the treatment of bacterial infections and methods of producing or dosing of same |
| WO2020176806A1 (en) * | 2019-02-27 | 2020-09-03 | 3-Delta, Inc. | Compositions that contain lipophilic plant material and surfactant, and related methods |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4110165A (en) * | 1974-04-20 | 1978-08-29 | Beecham Group Limited | Process for the production of clavulanic acid |
| EP0026044B1 (en) | 1979-08-24 | 1983-06-08 | Beecham Group Plc | Amine salt of clavulanic acid, its preparation and use |
| GB8404749D0 (en) * | 1984-02-23 | 1984-03-28 | Atomic Energy Authority Uk | Fluidic contactor |
| GB9401969D0 (en) | 1994-02-02 | 1994-03-30 | Smithkline Beecham Plc | Process |
| SI9400107A (en) * | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
| GB9500977D0 (en) * | 1995-01-19 | 1995-03-08 | Smithkline Beecham Plc | Novel process |
-
1995
- 1995-01-19 GB GBGB9500977.5A patent/GB9500977D0/en active Pending
-
1996
- 1996-01-17 DE DE69631878T patent/DE69631878T2/de not_active Expired - Lifetime
- 1996-01-17 RO RO97-01321A patent/RO115956B1/ro unknown
- 1996-01-17 WO PCT/EP1996/000270 patent/WO1996022296A1/en active IP Right Grant
- 1996-01-17 SK SK963-97A patent/SK284484B6/sk not_active IP Right Cessation
- 1996-01-17 PT PT96901326T patent/PT804441E/pt unknown
- 1996-01-17 TR TR97/00665T patent/TR199700665T1/xx unknown
- 1996-01-17 HU HU9801699A patent/HU228768B1/hu unknown
- 1996-01-17 CN CN96192663A patent/CN1105724C/zh not_active Expired - Lifetime
- 1996-01-17 CA CA002210748A patent/CA2210748C/en not_active Expired - Lifetime
- 1996-01-17 DK DK96901326T patent/DK0804441T3/da active
- 1996-01-17 US US08/875,240 patent/US6172221B1/en not_active Expired - Lifetime
- 1996-01-17 MX MX9705498A patent/MX9705498A/es unknown
- 1996-01-17 KR KR1019970704876A patent/KR100446199B1/ko not_active IP Right Cessation
- 1996-01-17 PL PL96321381A patent/PL184468B1/pl unknown
- 1996-01-17 ES ES96901326T patent/ES2217302T3/es not_active Expired - Lifetime
- 1996-01-17 EA EA199700121A patent/EA000277B1/ru not_active IP Right Cessation
- 1996-01-17 JP JP52205796A patent/JP4111998B2/ja not_active Expired - Lifetime
- 1996-01-17 UA UA97073840A patent/UA45380C2/uk unknown
- 1996-01-17 AT AT96901326T patent/ATE261976T1/de active
- 1996-01-17 NZ NZ300604A patent/NZ300604A/en not_active IP Right Cessation
- 1996-01-17 BR BR9606919A patent/BR9606919A/pt not_active Application Discontinuation
- 1996-01-17 EP EP96901326A patent/EP0804441B1/en not_active Expired - Lifetime
- 1996-01-17 CZ CZ19972252A patent/CZ294581B6/cs not_active IP Right Cessation
- 1996-01-17 AP APAP/P/1997/001022A patent/AP672A/en active
- 1996-01-18 ZA ZA96392A patent/ZA96392B/xx unknown
-
1997
- 1997-07-07 BG BG101768A patent/BG63308B1/bg unknown
- 1997-07-18 OA OA70054A patent/OA10501A/en unknown
- 1997-07-18 FI FI973057A patent/FI113776B/fi not_active IP Right Cessation
- 1997-07-18 NO NO19973328A patent/NO317281B1/no not_active IP Right Cessation
-
1998
- 1998-04-27 HK HK98103538A patent/HK1004134A1/xx not_active IP Right Cessation
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