DE69615204T2 - Verfahren zur herstellung von kaliumclavulanat - Google Patents

Verfahren zur herstellung von kaliumclavulanat

Info

Publication number
DE69615204T2
DE69615204T2 DE69615204T DE69615204T DE69615204T2 DE 69615204 T2 DE69615204 T2 DE 69615204T2 DE 69615204 T DE69615204 T DE 69615204T DE 69615204 T DE69615204 T DE 69615204T DE 69615204 T2 DE69615204 T2 DE 69615204T2
Authority
DE
Germany
Prior art keywords
potassium clavulanate
producing potassium
clavulanic acid
potassium salt
potassium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69615204T
Other languages
English (en)
Other versions
DE69615204D1 (de
Inventor
Michael Allen Cook
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE69615204D1 publication Critical patent/DE69615204D1/de
Application granted granted Critical
Publication of DE69615204T2 publication Critical patent/DE69615204T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Saccharide Compounds (AREA)
DE69615204T 1995-08-02 1996-07-30 Verfahren zur herstellung von kaliumclavulanat Expired - Lifetime DE69615204T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9515809.3A GB9515809D0 (en) 1995-08-02 1995-08-02 Process
PCT/EP1996/003375 WO1997005142A1 (en) 1995-08-02 1996-07-30 Process for the preparation of potassium clavulanate

Publications (2)

Publication Number Publication Date
DE69615204D1 DE69615204D1 (de) 2001-10-18
DE69615204T2 true DE69615204T2 (de) 2002-06-13

Family

ID=10778623

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69615204T Expired - Lifetime DE69615204T2 (de) 1995-08-02 1996-07-30 Verfahren zur herstellung von kaliumclavulanat

Country Status (10)

Country Link
EP (2) EP0843680B1 (de)
JP (2) JP2002515022A (de)
AT (1) ATE205498T1 (de)
AU (1) AU6740296A (de)
DE (1) DE69615204T2 (de)
DK (1) DK0843680T3 (de)
ES (1) ES2163038T3 (de)
GB (1) GB9515809D0 (de)
PT (1) PT843680E (de)
WO (1) WO1997005142A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DK0867515T3 (da) * 1997-03-24 2000-06-13 Cipan Comp Ind Prod Fremgangsmåde til isolering af et farmaceutisk acceptabelt alkalimetalsalt af clavulansyre
DZ2456A1 (fr) * 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
IL152643A0 (en) * 2000-05-13 2003-06-24 Smithkline Beecham Plc Process for the purification of a salt of clavulanic acid
CN103833774A (zh) * 2014-03-21 2014-06-04 山东新时代药业有限公司 一种从克拉维酸钾混粉中回收有效成分的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
GB2003863B (en) * 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
US4255332A (en) * 1977-09-01 1981-03-10 Beecham Group Limited Process for the preparation of potassium clavulanate from lithium clavulanate
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
MX7417E (es) * 1984-10-27 1988-10-14 Antibioticos Sa Metodo para la preparacion de acido clavulanico y sus derivados
GB8521516D0 (en) * 1985-08-29 1985-10-02 Beecham Group Plc Compounds
EP0277008B1 (de) * 1987-01-29 1995-06-14 Beecham Group Plc Verfahren zur Kristallisation von Kalium-Clavulanat
DE3730868A1 (de) * 1987-09-15 1989-03-23 Henkel Kgaa Verfahren zur abtrennung von biotechnisch hergestellten wertstoffen aus einer fermenterbruehe durch querstrom-mikro- und/oder ultrafiltration
IT1259423B (it) * 1991-12-04 1996-03-18 Giorgio Cassani Antibiotico ab-041 dotato di attivita' erbicida, ottenuto dallo streptomyces sp., e processo per la sua produzione
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9401969D0 (en) * 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
AT400846B (de) * 1994-02-25 1996-03-25 Fermic S A De C V Verfahren zur gewinnung und reinigung von alkalimetallsalzen der clavulansäure
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법

Also Published As

Publication number Publication date
AU6740296A (en) 1997-02-26
EP1088826A1 (de) 2001-04-04
PT843680E (pt) 2002-01-30
GB9515809D0 (en) 1995-10-04
EP0843680B1 (de) 2001-09-12
DE69615204D1 (de) 2001-10-18
JP2010013458A (ja) 2010-01-21
WO1997005142A1 (en) 1997-02-13
ES2163038T3 (es) 2002-01-16
ATE205498T1 (de) 2001-09-15
DK0843680T3 (da) 2002-01-21
JP2002515022A (ja) 2002-05-21
JP5184465B2 (ja) 2013-04-17
EP0843680A1 (de) 1998-05-27

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Legal Events

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