ES2163038T3 - Procedimiento para la preparacion de clavulanato de potasio. - Google Patents

Procedimiento para la preparacion de clavulanato de potasio.

Info

Publication number
ES2163038T3
ES2163038T3 ES96927643T ES96927643T ES2163038T3 ES 2163038 T3 ES2163038 T3 ES 2163038T3 ES 96927643 T ES96927643 T ES 96927643T ES 96927643 T ES96927643 T ES 96927643T ES 2163038 T3 ES2163038 T3 ES 2163038T3
Authority
ES
Spain
Prior art keywords
preparation
potassium clavulanate
procedure
potassium
clavulanic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96927643T
Other languages
English (en)
Inventor
Michael Allen Cook
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of ES2163038T3 publication Critical patent/ES2163038T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE CLAVULANATO POTASICO DE CALIDAD FARMACEUTICAMENTE ACEPTABLE POR PRECIPITACION DIRECTA DEL ACIDO CLAVULANICO COMO SAL POTASICA QUE NO HA SIDO PREPURIFICADA POR LA FORMACION DE UNA SAL AMINO INTERMEDIA CON LA ESTIPULACION DE QUE SE EXCLUYE EL ASUNTO QUE SE TRATA EN PCT/GB/95/00191.
ES96927643T 1995-08-02 1996-07-30 Procedimiento para la preparacion de clavulanato de potasio. Expired - Lifetime ES2163038T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9515809.3A GB9515809D0 (en) 1995-08-02 1995-08-02 Process

Publications (1)

Publication Number Publication Date
ES2163038T3 true ES2163038T3 (es) 2002-01-16

Family

ID=10778623

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96927643T Expired - Lifetime ES2163038T3 (es) 1995-08-02 1996-07-30 Procedimiento para la preparacion de clavulanato de potasio.

Country Status (10)

Country Link
EP (2) EP0843680B1 (es)
JP (2) JP2002515022A (es)
AT (1) ATE205498T1 (es)
AU (1) AU6740296A (es)
DE (1) DE69615204T2 (es)
DK (1) DK0843680T3 (es)
ES (1) ES2163038T3 (es)
GB (1) GB9515809D0 (es)
PT (1) PT843680E (es)
WO (1) WO1997005142A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
EP0867515B1 (en) * 1997-03-24 1999-12-08 CIPAN-Companhia Industrial Produtora De Antibioticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DZ2456A1 (fr) 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
WO2001087891A1 (en) * 2000-05-13 2001-11-22 Smithkline Beecham P.L.C. Process for the purification of a salt of clavulanic acid
CN103833774A (zh) * 2014-03-21 2014-06-04 山东新时代药业有限公司 一种从克拉维酸钾混粉中回收有效成分的方法
CN117534683B (zh) * 2023-11-13 2024-08-16 山西双雁药业有限公司 克拉维酸钾的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
US4255332A (en) * 1977-09-01 1981-03-10 Beecham Group Limited Process for the preparation of potassium clavulanate from lithium clavulanate
GB2003863B (en) * 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
EP0026044B1 (en) * 1979-08-24 1983-06-08 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
AU600655B2 (en) * 1984-10-27 1990-08-23 Beecham Group Plc Preparation of clavulanic acid and its salts and esters
GB8521516D0 (en) * 1985-08-29 1985-10-02 Beecham Group Plc Compounds
NZ223316A (en) * 1987-01-29 1989-10-27 Beecham Group Plc Crystalline potassium clavulanate and pharmaceutical compositions
DE3730868A1 (de) * 1987-09-15 1989-03-23 Henkel Kgaa Verfahren zur abtrennung von biotechnisch hergestellten wertstoffen aus einer fermenterbruehe durch querstrom-mikro- und/oder ultrafiltration
IT1259423B (it) * 1991-12-04 1996-03-18 Giorgio Cassani Antibiotico ab-041 dotato di attivita' erbicida, ottenuto dallo streptomyces sp., e processo per la sua produzione
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9401969D0 (en) * 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
AT400846B (de) * 1994-02-25 1996-03-25 Fermic S A De C V Verfahren zur gewinnung und reinigung von alkalimetallsalzen der clavulansäure
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법

Also Published As

Publication number Publication date
AU6740296A (en) 1997-02-26
DE69615204D1 (de) 2001-10-18
WO1997005142A1 (en) 1997-02-13
PT843680E (pt) 2002-01-30
DE69615204T2 (de) 2002-06-13
DK0843680T3 (da) 2002-01-21
EP0843680B1 (en) 2001-09-12
JP2010013458A (ja) 2010-01-21
GB9515809D0 (en) 1995-10-04
EP1088826A1 (en) 2001-04-04
JP5184465B2 (ja) 2013-04-17
ATE205498T1 (de) 2001-09-15
EP0843680A1 (en) 1998-05-27
JP2002515022A (ja) 2002-05-21

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