HUP9700926A2 - D3-vitamin-analógok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

D3-vitamin-analógok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9700926A2
HUP9700926A2 HU9700926A HUP9700926A HUP9700926A2 HU P9700926 A2 HUP9700926 A2 HU P9700926A2 HU 9700926 A HU9700926 A HU 9700926A HU P9700926 A HUP9700926 A HU P9700926A HU P9700926 A2 HUP9700926 A2 HU P9700926A2
Authority
HU
Hungary
Prior art keywords
atom
hydrogen atom
vitamine
analogues
producing
Prior art date
Application number
HU9700926A
Other languages
English (en)
Inventor
Andrew David Batcho
Graeme Findlay Bryce
Bernard Michael Hennessy
Jerome Anthony Iacobelli
Milan Radoje Uskokovic
Original Assignee
F.Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of HU9700926D0 publication Critical patent/HU9700926D0/hu
Publication of HUP9700926A2 publication Critical patent/HUP9700926A2/hu
Publication of HUP9700926A3 publication Critical patent/HUP9700926A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Az (I) általánős képletű vegyületek(mely képletbenRjelentése hidrőgénatőm, flűőratőm vagy hidrőxilcsőpőrt,R2jelentése hidrőgénatőm, kis szénaőtmszámú alkilcsőpőrt vagyhalőgénatőm,Xjeletnése =CH2, vagy amennyiben R hidrőxilcsőpőrtőt képvisel, úgy Xjelentése (H,H) vagy =CH2, ésAjelentése -CC-,, képletű csőpőrt vagy -CH2-CH2-csőpőrt,azzal a feltételellel, hőgy amennyibenAjelentése -CH2-CH2-csőpőrt, úgy R2 hidrőgénatőmőt vagy kisszénatőmszámú alkilcsőpőrtőt képvisel)hiperbűrjánzó bőrrendellenességek, neőpláziás betegségek,faggyúmirigy-betegségek és főtőkárősődőtt bőrrel összefüggő állapőtőkkezelésére alkalmazhatók.ŕ
HU9700926A 1996-05-23 1997-05-21 Vitamine d3 analogues, process for producing them and pharmaceutial compositions containing the same HUP9700926A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1815396P 1996-05-23 1996-05-23
US1818696P 1996-05-23 1996-05-23
US3990097P 1997-03-19 1997-03-19

Publications (3)

Publication Number Publication Date
HU9700926D0 HU9700926D0 (en) 1997-07-28
HUP9700926A2 true HUP9700926A2 (hu) 1998-01-28
HUP9700926A3 HUP9700926A3 (en) 1999-05-28

Family

ID=27360973

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700926A HUP9700926A3 (en) 1996-05-23 1997-05-21 Vitamine d3 analogues, process for producing them and pharmaceutial compositions containing the same

Country Status (29)

Country Link
EP (2) EP1464640A3 (hu)
JP (1) JP2859247B2 (hu)
KR (1) KR100783856B1 (hu)
CN (1) CN1176072C (hu)
AR (1) AR007241A1 (hu)
AT (1) ATE277008T1 (hu)
AU (1) AU723929B2 (hu)
BR (1) BR9703384A (hu)
CA (1) CA2205275C (hu)
CO (1) CO4950531A1 (hu)
CZ (1) CZ157897A3 (hu)
DE (1) DE69730774T2 (hu)
DK (1) DK0808833T3 (hu)
ES (1) ES2227635T3 (hu)
HR (1) HRP970273A2 (hu)
HU (1) HUP9700926A3 (hu)
IL (1) IL120843A0 (hu)
MA (1) MA24251A1 (hu)
NO (1) NO972304L (hu)
NZ (1) NZ314839A (hu)
PE (1) PE70198A1 (hu)
PL (1) PL320132A1 (hu)
PT (1) PT808833E (hu)
SG (1) SG70009A1 (hu)
TR (1) TR199700415A2 (hu)
TW (1) TW445252B (hu)
UY (1) UY24561A1 (hu)
YU (1) YU20197A (hu)
ZA (1) ZA974336B (hu)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
CA2281944C (en) * 1997-02-25 2007-05-15 The Regents Of The University Of Michigan Methods and compositions for preventing and treating chronological aging in human skin
WO1998051678A1 (en) * 1997-05-16 1998-11-19 Women & Infants Hospital CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF
ATE322477T1 (de) * 1997-05-16 2006-04-15 Woman & Infants Hospital 3-epi-vitamin d2 verbindungen und ihre anwendungen
EP0957098A1 (en) * 1998-05-14 1999-11-17 F. Hoffmann-La Roche Ag Intermediates for the synthesis of 3-epi vitamin D3 metabolites and analogs
US6603030B1 (en) * 1999-04-22 2003-08-05 Hoffman-La Roche Inc. Process for producing phosphineoxide vitamin D precursors
PT1178808E (pt) * 1999-04-23 2012-08-16 Leo Pharma As Composição farmacêutica não aquosa para utilização dérmica para o tratamento da psoríase compreendendo uma vitamina d, um corticosteróide e de um componente solvente
US6255501B1 (en) * 1999-04-26 2001-07-03 Hoffman-La Roche Inc. Process for preparing antiosteoporotic agents
WO2001040177A2 (en) * 1999-12-02 2001-06-07 Women And Infants Hospital Esters of vitamin d3 and uses thereof
AU2004203436A1 (en) 2003-09-24 2005-04-14 Bioxell Spa Compound and use in treatment
CH698144B1 (fr) * 2003-09-24 2009-05-29 Bioxell Spa Analogue de la vitamine D3
GB2407499B (en) * 2003-11-03 2008-02-27 Bioxell Spa Vitamin D3 analogue for use in the treatment of BPH
CA2557809A1 (en) 2004-03-01 2005-09-09 Bioxell Spa Treatment of interstitial cystitis with vitamin d compounds
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
CA2605815A1 (en) * 2005-04-25 2006-11-02 Cytochroma Inc. Low-calcemic 16,23-diene 25-oxime analogs of 1alpha,25-dihydroxy vitamin d3
US20090137828A1 (en) * 2005-08-18 2009-05-28 Bioxell S.P.A. Synthesis of 1A-Fluoro-25-Hydroxy-16-23E-Diene-26,27-Bishomo-20-Epi-Cholecalciferol
TW200838544A (en) * 2007-01-25 2008-10-01 Bioxell Spa Synthesis of 1 α-fluoro-25-hydroxy-16-23E-diene-26, 27-bishomo-20-epi-cholecalciferol
WO2008146130A1 (en) 2007-05-30 2008-12-04 Cytochroma Inc. Process for producing phosphine oxide vitamin d precursors
ES2366077B2 (es) * 2010-03-30 2012-06-25 Universidade De Vigo Compuestos quirales, procedimientos de obtención y uso.
ES2541719T3 (es) * 2010-10-25 2015-07-24 Teijin Pharma Limited Derivado de 23-ino-vitamina D3
CN105348164B (zh) * 2015-10-29 2017-03-29 无锡福祈制药有限公司 一种1α‑羟基维生素D2的制备方法
CN106748942B (zh) * 2016-11-28 2018-06-29 无锡福祈制药有限公司 度骨化醇类似物wxfq-65及其合成方法
ES2731558B2 (es) * 2018-05-15 2020-03-18 Univ Santiago Compostela Compuestos de interés farmacéutico
CN109738252B (zh) * 2019-01-23 2021-03-09 深圳天辰医疗科技有限公司 25-羟基-维生素d解离液
CN109696435B (zh) * 2019-01-25 2021-03-09 深圳天辰医疗科技有限公司 维生素d的测定方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
GB9206648D0 (en) * 1992-03-26 1992-05-06 Leo Pharm Prod Ltd Chemical compounds
ES2091515T3 (es) * 1992-05-20 1996-11-01 Hoffmann La Roche Analogos fluorados de la vitamina d3.
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
JP3228488B2 (ja) * 1993-12-24 2001-11-12 株式会社クラレ ２０−エピステロイド誘導体およびその製造方法

Also Published As

Publication number Publication date
EP1464640A3 (en) 2005-01-12
CA2205275A1 (en) 1997-11-23
HU9700926D0 (en) 1997-07-28
EP0808833A3 (en) 1998-11-25
MA24251A1 (fr) 1998-04-01
PE70198A1 (es) 1998-11-26
NO972304L (no) 1997-11-24
TW445252B (en) 2001-07-11
DK0808833T3 (da) 2005-01-31
EP1464640A2 (en) 2004-10-06
DE69730774T2 (de) 2005-09-29
CN1175573A (zh) 1998-03-11
ZA974336B (en) 1997-11-24
PT808833E (pt) 2004-11-30
AU2357797A (en) 1997-11-27
AR007241A1 (es) 1999-10-27
EP0808833A2 (en) 1997-11-26
NZ314839A (en) 2000-01-28
CZ157897A3 (en) 1997-12-17
MX9703774A (es) 1998-06-30
TR199700415A3 (tr) 1997-12-21
JPH1045713A (ja) 1998-02-17
NO972304D0 (no) 1997-05-21
CN1176072C (zh) 2004-11-17
SG70009A1 (en) 2000-01-25
PL320132A1 (en) 1997-11-24
HUP9700926A3 (en) 1999-05-28
DE69730774D1 (de) 2004-10-28
BR9703384A (pt) 1998-09-15
ES2227635T3 (es) 2005-04-01
CA2205275C (en) 2007-04-03
KR100783856B1 (ko) 2008-05-09
KR970074765A (ko) 1997-12-10
UY24561A1 (es) 2000-12-29
EP0808833B1 (en) 2004-09-22
JP2859247B2 (ja) 1999-02-17
HRP970273A2 (en) 1998-04-30
ATE277008T1 (de) 2004-10-15
AU723929B2 (en) 2000-09-07
YU20197A (sh) 1999-09-27
CO4950531A1 (es) 2000-09-01
TR199700415A2 (xx) 1997-12-21
IL120843A0 (en) 1997-09-30

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