HUP0402370A2 - Ciklooxigenáz-2 inhibitor és hiszton deacetiláz inhibitor keverékét tartalmazó gyógyszerkészítmények - Google Patents

Ciklooxigenáz-2 inhibitor és hiszton deacetiláz inhibitor keverékét tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0402370A2
HUP0402370A2 HU0402370A HUP0402370A HUP0402370A2 HU P0402370 A2 HUP0402370 A2 HU P0402370A2 HU 0402370 A HU0402370 A HU 0402370A HU P0402370 A HUP0402370 A HU P0402370A HU P0402370 A2 HUP0402370 A2 HU P0402370A2
Authority
HU
Hungary
Prior art keywords
inhibitor
pharmaceutical compositions
compositions containing
histone deacetylase
cyclooxigenase
Prior art date
Application number
HU0402370A
Other languages
English (en)
Inventor
Ying-Nan Pan Chen
Peter Lassota
Alexander Wallace Wood
Original Assignee
Novartis Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag. filed Critical Novartis Ag.
Publication of HUP0402370A2 publication Critical patent/HUP0402370A2/hu
Publication of HUP0402370A3 publication Critical patent/HUP0402370A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

A találmány tárgyát egy olyan keverék képezi, amely (a) egyciklooxigenáz-2 inhibitort (<COX-2 inhibitor<) és (b) egy hisztondeacetiláz inhibitort (<HDAI<) tartalmaz. A találmány szerinti keverékszimultán, párhuzamos, szeparált vagy szekvenciális használatraalkalmazható, emlősök különösen emberek rosszindulatú stádium előttibélsérüléseinek vagy bélrákjának, vagy más rosszindulatú betegségeinekkezelésére. A találmány tárgyát képezik továbbá gyógyszerészetikészítmények, amelyek a fent említett keverékeket tartalmazzák,valamint eljárás emlősök, különösen emberek rosszindulatú stádiumelőtti bélsérüléseinek (például polipjainak) és bélrákjának, valamintmás rosszindulatú betegségeinek ilyen keverékkel való kezelésére. Ó
HU0402370A 2001-11-06 2002-11-05 Pharmaceutical compositions containing cyclooxigenase-2 inhibitor and histone deacetylase inhibitor combination HUP0402370A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33301601P 2001-11-06 2001-11-06
US41931402P 2002-10-17 2002-10-17
PCT/EP2002/012343 WO2003039599A1 (en) 2001-11-06 2002-11-05 Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination

Publications (2)

Publication Number Publication Date
HUP0402370A2 true HUP0402370A2 (hu) 2005-02-28
HUP0402370A3 HUP0402370A3 (en) 2008-04-28

Family

ID=26988512

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402370A HUP0402370A3 (en) 2001-11-06 2002-11-05 Pharmaceutical compositions containing cyclooxigenase-2 inhibitor and histone deacetylase inhibitor combination

Country Status (22)

Country Link
US (3) US7402603B2 (hu)
EP (1) EP1443967B1 (hu)
JP (1) JP4413614B2 (hu)
KR (1) KR100937064B1 (hu)
CN (1) CN100457183C (hu)
AT (1) ATE352319T1 (hu)
AU (1) AU2002351844B2 (hu)
BR (1) BR0213932A (hu)
CA (1) CA2461373A1 (hu)
CY (1) CY1106508T1 (hu)
DE (1) DE60217895T2 (hu)
DK (1) DK1443967T3 (hu)
ES (1) ES2280597T3 (hu)
HU (1) HUP0402370A3 (hu)
IL (2) IL160970A0 (hu)
MX (1) MXPA04004312A (hu)
NO (1) NO20042148L (hu)
NZ (1) NZ544689A (hu)
PL (1) PL205853B1 (hu)
PT (1) PT1443967E (hu)
RU (1) RU2311200C2 (hu)
WO (1) WO2003039599A1 (hu)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1608628A2 (en) * 2003-03-17 2005-12-28 Takeda San Diego, Inc. Histone deacetylase inhibitors
AR043850A1 (es) * 2003-04-17 2005-08-17 Bayer Pharmaceuticals Corp Acidos hidroxamicos utiles en el tratamiento de trastornos hiperproliferativos
WO2004103358A2 (en) * 2003-05-21 2004-12-02 Novartis Ag Combination of histone deacetylase inhibitors with chemotherapeutic agents
EP1491188A1 (en) * 2003-06-25 2004-12-29 G2M Cancer Drugs AG Topical use of valproic acid for the prevention or treatment of skin disorders
US20050159470A1 (en) * 2003-12-19 2005-07-21 Syrrx, Inc. Histone deacetylase inhibitors
WO2005066151A2 (en) * 2003-12-19 2005-07-21 Takeda San Diego, Inc. Histone deacetylase inhibitors
EP1780210A4 (en) * 2004-08-11 2009-06-10 Kyorin Seiyaku Kk NEW CYCLIC AMINOBENOIC ACID DERIVATIVE
US7642275B2 (en) * 2004-12-16 2010-01-05 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7786330B2 (en) 2005-02-28 2010-08-31 Asahi Glass Company, Limited Process for producing 1,2-dialkoxy-3-fluorobenzene
EP1896436A2 (en) * 2005-05-11 2008-03-12 Takeda San Diego, Inc. Histone deacetylase inhibitors
AU2006270322A1 (en) * 2005-07-14 2007-01-25 Takeda San Diego, Inc. Histone deacetylase inhibitors
EP1743654A1 (en) * 2005-07-15 2007-01-17 TopoTarget Germany AG Use of inhibitors of histone deacetylases in combination with NSAID for the therapy of cancer and/or inflammatory diseases
WO2007016136A2 (en) * 2005-07-28 2007-02-08 Nitromed, Inc. Organic nitric oxide enhancing salts of cyclooxygenase-2 selective inhibitors, compositons and methods of use
JP2009525955A (ja) * 2006-01-13 2009-07-16 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
CN102584673B (zh) * 2006-06-12 2014-08-06 诺华股份有限公司 N-羟基-3-[4-[[[2-(2-甲基-1h-吲哚-3-基)乙基]氨基]甲基]苯基]-2e-2-丙烯酰胺的多晶型物
EP2394991B1 (en) 2006-06-12 2015-09-23 Novartis AG Process for making starting materials for N-hydroxy-3-[4-[2-(2-methyl-1 H-indol-3-yl)-ethylaminomethyl]-phenyl]-2E-2-propenamide
BRPI0713653A2 (pt) * 2006-06-12 2012-10-23 Novartis Ag processo para a preparação de sais de n-hidróxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil ]fenil]-2e-2propenamida
WO2008002634A1 (en) * 2006-06-28 2008-01-03 Novartis Ag Use of hdac inhibitors for the treatment of lymphomas
EP2055692A4 (en) * 2006-08-25 2010-07-07 Asahi Glass Co Ltd PROCESS FOR PRODUCING 1,2-DIALCOXY-3-FLUOROBENZENE
AU2008214299B2 (en) 2007-02-06 2014-01-09 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
EP2491923A3 (en) * 2007-02-15 2012-12-26 Novartis AG Combinations of therapeutic agents for treating cancer
EA018618B1 (ru) 2007-10-01 2013-09-30 Ликсте Байотекнолоджи, Инк. Ингибиторы hdac
WO2010147612A1 (en) 2009-06-18 2010-12-23 Lixte Biotechnology, Inc. Methods of modulating cell regulation by inhibiting p53
CA2730148C (en) 2008-08-01 2018-04-03 Lixte Biotechnology, Inc. Neuroprotective agents for the prevention and treatment of neurodegenerative diseases
US8227473B2 (en) 2008-08-01 2012-07-24 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
RU2640416C2 (ru) * 2012-04-16 2018-01-09 Тоа Эйо Лтд. Бициклическое соединение
EA201591931A1 (ru) 2013-04-09 2016-05-31 Ликсте Байотекнолоджи, Инк. Композиции оксабициклогептанов и оксабициклогептенов
US9745253B2 (en) 2015-03-13 2017-08-29 Forma Therapeutics, Inc. Alpha-cinnamide compounds and compositions as HDAC8 inhibitors
CN115108926B (zh) * 2022-04-02 2023-06-20 上海工程技术大学 一种用于制备厄达替尼的中间体化合物及制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO4960662A1 (es) * 1997-08-28 2000-09-25 Novartis Ag Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)

Also Published As

Publication number Publication date
PL205853B1 (pl) 2010-06-30
NZ544689A (en) 2007-08-31
RU2004117170A (ru) 2005-04-20
DK1443967T3 (da) 2007-04-16
AU2002351844B2 (en) 2006-12-21
IL160970A (en) 2010-06-30
DE60217895D1 (en) 2007-03-15
BR0213932A (pt) 2004-08-31
US20080227845A1 (en) 2008-09-18
JP4413614B2 (ja) 2010-02-10
IL160970A0 (en) 2004-08-31
EP1443967A1 (en) 2004-08-11
PL368539A1 (en) 2005-04-04
PT1443967E (pt) 2007-04-30
US20090192211A1 (en) 2009-07-30
JP2005510517A (ja) 2005-04-21
RU2311200C2 (ru) 2007-11-27
NO20042148L (no) 2004-08-04
DE60217895T2 (de) 2007-07-05
ATE352319T1 (de) 2007-02-15
WO2003039599A1 (en) 2003-05-15
KR100937064B1 (ko) 2010-01-15
KR20050043744A (ko) 2005-05-11
US20050032899A1 (en) 2005-02-10
EP1443967B1 (en) 2007-01-24
US7402603B2 (en) 2008-07-22
CN1578674A (zh) 2005-02-09
CY1106508T1 (el) 2012-01-25
CN100457183C (zh) 2009-02-04
ES2280597T3 (es) 2007-09-16
CA2461373A1 (en) 2003-05-15
MXPA04004312A (es) 2005-05-16
HUP0402370A3 (en) 2008-04-28

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees