HUP0303622A2 - Terápiás hatóanyagok gyulladásos bélbetegségek kezelésére - Google Patents
Terápiás hatóanyagok gyulladásos bélbetegségek kezeléséreInfo
- Publication number
- HUP0303622A2 HUP0303622A2 HU0303622A HUP0303622A HUP0303622A2 HU P0303622 A2 HUP0303622 A2 HU P0303622A2 HU 0303622 A HU0303622 A HU 0303622A HU P0303622 A HUP0303622 A HU P0303622A HU P0303622 A2 HUP0303622 A2 HU P0303622A2
- Authority
- HU
- Hungary
- Prior art keywords
- ailim
- activity
- inflammatory bowel
- modulating
- subject
- Prior art date
Links
- 208000022559 Inflammatory bowel disease Diseases 0.000 title abstract 2
- 230000000694 effects Effects 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 206010057248 Cell death Diseases 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 208000004262 Food Hypersensitivity Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000030833 cell death Effects 0.000 abstract 1
- 206010009887 colitis Diseases 0.000 abstract 1
- 230000016396 cytokine production Effects 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000020932 food allergy Nutrition 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000017307 interleukin-4 production Effects 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Abstract
A találmány tárgyát olyan anyagot tartalmazó gyógyászati készítményekképezik, amely <aktiválással indukálható limfocita-immunmodulátormolekula< (AILIM),[amely <indukálható kostimulátor< (ICOS) névenszintén ismert] biológiai aktivitását modulálni képes aktivitással,közelebbről AILIM-mediált jelátvitelt modulálni képes aktivitássalrendelkezik. A találmány tárgyát közelebbről olyan anyagot tartalmazógyógyászati készítmények képezik, amely AILIM-et expresszáló sejtekproliferációját, sejtpusztulást (vagy apoptózist) vagy immun-citolízist szabályzó (például gátló) aktivitással rendelkezik, vagyAILIM-et expresszáló sejtek citokintermelését (például interferon-g-,interleukin-4-termelését) modulálni (például gátolni) képesaktivitással rendelkezik. A találmány szerinti gyógyászatikészítmények alkalmasak a béltraktus abnormális immunitását kísérőbetegségek[például gyulladásos bélbetegségek, példáulvastagbélgyulladás (kifekélyesedő vastagbélgyulladás és hasonlók), ésCrohn-betegség, valamint ételallergiák] szuppresszálására, kezelésérevagy prevenciójára. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001089158 | 2001-03-27 | ||
| JP2002019291A JP4210454B2 (ja) | 2001-03-27 | 2002-01-29 | 炎症性腸疾患治療剤 |
| PCT/JP2002/001361 WO2002076504A1 (fr) | 2001-03-27 | 2002-02-18 | Remedes contre les affections intestinales inflammatoires |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0303622A2 true HUP0303622A2 (hu) | 2004-01-28 |
| HUP0303622A3 HUP0303622A3 (en) | 2008-11-28 |
| HU229378B1 HU229378B1 (en) | 2013-11-28 |
Family
ID=26612136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0303622A HU229378B1 (en) | 2001-03-27 | 2002-02-18 | Remedies for inflammatory bowel diseases |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7465444B2 (hu) |
| EP (1) | EP1374902B1 (hu) |
| JP (1) | JP4210454B2 (hu) |
| KR (1) | KR100602940B1 (hu) |
| CN (1) | CN1291757C (hu) |
| AT (1) | ATE510562T1 (hu) |
| AU (1) | AU2002232222B8 (hu) |
| BR (1) | BR0208446A (hu) |
| CA (1) | CA2441577C (hu) |
| CZ (1) | CZ20032692A3 (hu) |
| HU (1) | HU229378B1 (hu) |
| IL (2) | IL158088A0 (hu) |
| MX (1) | MXPA03008760A (hu) |
| NO (1) | NO332316B1 (hu) |
| NZ (1) | NZ528554A (hu) |
| RU (1) | RU2281118C2 (hu) |
| SK (1) | SK288036B6 (hu) |
| WO (1) | WO2002076504A1 (hu) |
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| JP3521382B2 (ja) | 1997-02-27 | 2004-04-19 | 日本たばこ産業株式会社 | 細胞間接着及びシグナル伝達を媒介する細胞表面分子 |
| US7112655B1 (en) | 1997-02-27 | 2006-09-26 | Japan Tobacco, Inc. | JTT-1 protein and methods of inhibiting lymphocyte activation |
| DE19821060A1 (de) * | 1997-09-23 | 1999-04-15 | Bundesrepublik Deutschland Let | Ko-stimulierendes Polypeptid von T-Zellen, monoklonale Antikörper sowie die Herstellung und deren Verwendung |
| JP3871503B2 (ja) | 1999-08-30 | 2007-01-24 | 日本たばこ産業株式会社 | 免疫性疾患治療剤 |
| JP4210454B2 (ja) | 2001-03-27 | 2009-01-21 | 日本たばこ産業株式会社 | 炎症性腸疾患治療剤 |
| JP3597140B2 (ja) | 2000-05-18 | 2004-12-02 | 日本たばこ産業株式会社 | 副刺激伝達分子ａｉｌｉｍに対するヒトモノクローナル抗体及びその医薬用途 |
| JP4212278B2 (ja) | 2001-03-01 | 2009-01-21 | 日本たばこ産業株式会社 | 移植片拒絶反応抑制剤 |
| US8017113B2 (en) | 2003-03-12 | 2011-09-13 | Rappaport Family Institute For Research In The Medical Sciences | Compositions and methods for diagnosing and treating an inflammation |
| US7749714B2 (en) * | 2003-03-12 | 2010-07-06 | Rappaport Family Institute For Research In The Medical Sciences | Compositions and methods for diagnosing and treating prostate cancer |
| WO2005103086A1 (en) * | 2004-04-23 | 2005-11-03 | Bundesrepublik Deutschland letztvertreten durch das Robert-Koch-Institut vertreten durch seinen Präsidenten | Method for the treatment of t cell mediated conditions by depletion of icos-positive cells in vivo |
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| MD480Z (en) * | 2011-07-07 | 2012-09-30 | Elvira Andon | Method for treating acute ulcerative nonspecific colitis |
| JOP20140087B1 (ar) | 2013-03-13 | 2021-08-17 | Amgen Inc | بروتينات مخصصة ل baff و b7rp1 وإستخداماتها |
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| UA118750C2 (uk) | 2013-03-15 | 2019-03-11 | Ґлаксосмітклайн Інтеллектуал Проперті Дивелопмент Лімітед | Антитіло до lag-3 |
| MA41414A (fr) | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | Protéines de liaison agonistes d' icos |
| SG10201913864RA (en) | 2015-09-02 | 2020-03-30 | Immutep Sas | Anti-LAG-3 Antibodies |
| EP3366691A1 (en) | 2015-12-03 | 2018-08-29 | GlaxoSmithKline Intellectual Property Development Limited | Cyclic purine dinucleotides as modulators of sting |
| WO2017098421A1 (en) | 2015-12-08 | 2017-06-15 | Glaxosmithkline Intellectual Property Development Limited | Benzothiadiazine compounds |
| WO2017153952A1 (en) | 2016-03-10 | 2017-09-14 | Glaxosmithkline Intellectual Property Development Limited | 5-sulfamoyl-2-hydroxybenzamide derivatives |
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| BR112019025913A2 (pt) | 2017-06-09 | 2020-06-30 | Glaxosmithkline Intellectual Property Development Limited | métodos para tratar câncer em um paciente em necesssidade do mesmo e para produzir um anticorpo, anticorpo anti-icos ou fragmento de ligação ao antígeno do mesmo e um anticorpo anti-ox40 ou fragmento de ligação ao antígeno do mesmo, uso de um anticorpo anti-icos ou porção de ligação ao antígeno do mesmo e um anticorpo anti-ox40 ou porção de ligação ao antígeno do mesmo na fabricação de um medicamento, polinucleotídeo que codifica um anticorpo, vetor, e, célula hospedeira. |
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| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| CN112469416A (zh) | 2018-05-31 | 2021-03-09 | 葛兰素史克知识产权开发有限公司 | 用于治疗癌症的ii型蛋白质精氨酸甲基转移酶抑制剂和icos结合蛋白的组合 |
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| MX2021004603A (es) | 2018-10-22 | 2021-09-08 | Glaxosmithkline Ip Dev Ltd | Dosificacion. |
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