HUP0301991A2 - IL-18-inhibitorok alkalmazása atheroszklerózis kezelésére és/vagy megelżzésére - Google Patents
IL-18-inhibitorok alkalmazása atheroszklerózis kezelésére és/vagy megelżzéséreInfo
- Publication number
- HUP0301991A2 HUP0301991A2 HU0301991A HUP0301991A HUP0301991A2 HU P0301991 A2 HUP0301991 A2 HU P0301991A2 HU 0301991 A HU0301991 A HU 0301991A HU P0301991 A HUP0301991 A HU P0301991A HU P0301991 A2 HUP0301991 A2 HU P0301991A2
- Authority
- HU
- Hungary
- Prior art keywords
- atherosclerosis
- inhibitors
- prevention
- treatment
- subject
- Prior art date
Links
- 201000001320 Atherosclerosis Diseases 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A találmány szerinti megoldás a vaszkuláris betegségek tárgykörébetartozik. A találmány tárgya közelebbről IL-18-inhibitorok alkalmazásaatheroszklerózis kezelésére és/vagy megelőzésére. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00109606 | 2000-05-05 | ||
PCT/EP2001/004843 WO2001085201A2 (en) | 2000-05-05 | 2001-04-30 | Use of il-18 inhibitors for the treatment and/or prevention of atherosclerosis |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0301991A2 true HUP0301991A2 (hu) | 2003-09-29 |
HUP0301991A3 HUP0301991A3 (en) | 2006-11-28 |
HU229375B1 HU229375B1 (en) | 2013-11-28 |
Family
ID=8168631
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301991A HU229375B1 (en) | 2000-05-05 | 2001-04-30 | Use of il-18 inhibitors for the treatment and/or prevention of atherosclerosis |
Country Status (33)
Country | Link |
---|---|
US (1) | US20040076628A1 (hu) |
EP (1) | EP1278540B1 (hu) |
JP (1) | JP5122053B2 (hu) |
KR (2) | KR100798545B1 (hu) |
CN (2) | CN1841066B (hu) |
AR (1) | AR035640A1 (hu) |
AT (1) | ATE395075T1 (hu) |
AU (2) | AU6739001A (hu) |
BG (1) | BG65881B1 (hu) |
BR (1) | BRPI0110506B8 (hu) |
CA (1) | CA2407895C (hu) |
CY (1) | CY1110385T1 (hu) |
CZ (1) | CZ300792B6 (hu) |
DE (1) | DE60134009D1 (hu) |
DK (1) | DK1278540T3 (hu) |
EA (2) | EA005410B1 (hu) |
EE (1) | EE05056B1 (hu) |
ES (1) | ES2305082T3 (hu) |
HK (2) | HK1055681A1 (hu) |
HR (1) | HRP20020828A2 (hu) |
HU (1) | HU229375B1 (hu) |
IL (2) | IL152567A0 (hu) |
ME (1) | ME00554B (hu) |
MX (1) | MXPA02010895A (hu) |
NO (1) | NO329821B1 (hu) |
PL (1) | PL209371B1 (hu) |
PT (1) | PT1278540E (hu) |
RS (1) | RS50926B (hu) |
SI (1) | SI1278540T1 (hu) |
SK (1) | SK287761B6 (hu) |
UA (2) | UA87658C2 (hu) |
WO (1) | WO2001085201A2 (hu) |
ZA (1) | ZA200208228B (hu) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL356836A1 (en) * | 2000-02-10 | 2004-07-12 | Abbott Laboratories | Antibodies that bind human interleukin-18 and methods of making and using |
CA2435466C (en) * | 2001-01-29 | 2012-04-03 | Applied Research Systems Ars Holding N.V. | Use of il-18 inhibitors for the treatment and/or prevention of heart disease |
PL216228B1 (pl) * | 2001-05-25 | 2014-03-31 | Ares Trading Sa | Zastosowanie białka wiążącego IL-18 |
US6797727B2 (en) | 2001-07-16 | 2004-09-28 | Transition Therapeutics Inc. | Use of rhein or diacerhein compounds for the treatment or prevention of vascular diseases |
GB0210212D0 (en) * | 2002-05-03 | 2002-06-12 | Univ Southampton | Effects of dietary N-3 and N-6 pufa intake on atheromatous plaque stability |
US8729124B2 (en) | 2002-03-05 | 2014-05-20 | Pronova Biopharma Norge As | Use of EPA and DHA in secondary prevention |
UA80275C2 (en) | 2002-03-22 | 2007-09-10 | Applied Research Systems | Use of il-18 inhibitors for the treatment and/or prevention of peripheral vascular diseases (variants) |
CA2516157C (en) * | 2003-03-11 | 2012-09-18 | Applied Research Systems Ars Holding N.V. | Expression vectors comprising the mcmv ie2 promoter |
JP5074030B2 (ja) | 2003-05-13 | 2012-11-14 | メルク セローノ ソシエテ アノニム | Il−18結合タンパク質の活性変異体とその医学的応用 |
US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
AU2005232436C1 (en) * | 2004-04-15 | 2010-08-26 | Athera Biotechnologies Ab | Annexin V for preventing atherothrombosis and plaque rupture |
CN101219208B (zh) * | 2005-01-04 | 2010-08-11 | 健能隆医药技术(上海)有限公司 | 白介素-22的医药用途 |
ATE557038T1 (de) | 2005-06-03 | 2012-05-15 | Ares Trading Sa | Herstellung von rekombinantem il-18 bindendem protein |
ATE529433T1 (de) | 2005-06-10 | 2011-11-15 | Ares Trading Sa | Verfahren zur reinigung eines il-18-bindenden proteins |
TW201215405A (en) | 2010-08-25 | 2012-04-16 | Hoffmann La Roche | Antibodies against IL-18R1 and uses thereof |
JOP20200308A1 (ar) | 2012-09-07 | 2017-06-16 | Novartis Ag | جزيئات إرتباط il-18 |
MD707Z (ro) * | 2013-01-18 | 2014-07-31 | Институт Зоологии Академии Наук Молдовы | Metodă de identificare a secvenţelor polimorfe 4a/4b ale genei sintetazei endoteliale a oxidului nitric |
PL3041864T3 (pl) | 2013-09-05 | 2021-12-20 | Ab2 Bio Sa | Białko wiążące il-18 (il-18bp) w chorobach zapalnych |
MY194040A (en) | 2015-03-05 | 2022-11-09 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases |
CN110273591B (zh) | 2019-08-13 | 2023-12-12 | 上海杉脉电子科技发展有限公司 | 一种单动力微型智能锁 |
TW202233675A (zh) | 2020-10-29 | 2022-09-01 | 瑞士商諾華公司 | Il-18拮抗劑用於治療和/或預防異位性皮炎或相關病症之用途 |
CN112972655A (zh) * | 2021-04-16 | 2021-06-18 | 武汉大学 | 白细胞介素12在制备预防、缓解和/或治疗主动脉瘤药物中的应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5985863A (en) * | 1996-09-12 | 1999-11-16 | Vertex Pharmaceuticals, Inc. | Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor |
US5877197A (en) * | 1996-12-16 | 1999-03-02 | Karanewsky; Donald S. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
EP0987552A3 (en) * | 1998-08-31 | 2000-06-07 | Pfizer Products Inc. | Diarylsulfonylurea binding proteins |
WO2000012555A1 (fr) * | 1998-09-01 | 2000-03-09 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Proteine de liaison de l'interleukine 18 |
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2001
- 2001-04-30 CN CN2006100092901A patent/CN1841066B/zh not_active Expired - Lifetime
- 2001-04-30 AT AT01945064T patent/ATE395075T1/de active
- 2001-04-30 DE DE60134009T patent/DE60134009D1/de not_active Expired - Lifetime
- 2001-04-30 ME MEP-2008-640A patent/ME00554B/me unknown
- 2001-04-30 SK SK1556-2002A patent/SK287761B6/sk not_active IP Right Cessation
- 2001-04-30 AU AU6739001A patent/AU6739001A/xx active Pending
- 2001-04-30 UA UAA200507913A patent/UA87658C2/uk unknown
- 2001-04-30 EP EP01945064A patent/EP1278540B1/en not_active Expired - Lifetime
- 2001-04-30 CZ CZ20023644A patent/CZ300792B6/cs not_active IP Right Cessation
- 2001-04-30 AU AU2001267390A patent/AU2001267390B2/en not_active Expired
- 2001-04-30 JP JP2001581854A patent/JP5122053B2/ja not_active Expired - Lifetime
- 2001-04-30 CA CA2407895A patent/CA2407895C/en not_active Expired - Lifetime
- 2001-04-30 EE EEP200200620A patent/EE05056B1/xx unknown
- 2001-04-30 MX MXPA02010895A patent/MXPA02010895A/es active IP Right Grant
- 2001-04-30 HU HU0301991A patent/HU229375B1/hu unknown
- 2001-04-30 ES ES01945064T patent/ES2305082T3/es not_active Expired - Lifetime
- 2001-04-30 US US10/275,341 patent/US20040076628A1/en not_active Abandoned
- 2001-04-30 KR KR1020077014038A patent/KR100798545B1/ko active IP Right Grant
- 2001-04-30 PL PL365697A patent/PL209371B1/pl unknown
- 2001-04-30 DK DK01945064T patent/DK1278540T3/da active
- 2001-04-30 PT PT01945064T patent/PT1278540E/pt unknown
- 2001-04-30 UA UA2002129704A patent/UA78492C2/uk unknown
- 2001-04-30 WO PCT/EP2001/004843 patent/WO2001085201A2/en active IP Right Grant
- 2001-04-30 CN CNB018090540A patent/CN1250286C/zh not_active Expired - Lifetime
- 2001-04-30 BR BRPI0110506A patent/BRPI0110506B8/pt not_active IP Right Cessation
- 2001-04-30 SI SI200130832T patent/SI1278540T1/sl unknown
- 2001-04-30 EA EA200201175A patent/EA005410B1/ru not_active IP Right Cessation
- 2001-04-30 EA EA200401183A patent/EA007014B1/ru not_active IP Right Cessation
- 2001-04-30 KR KR1020027014755A patent/KR20030016254A/ko not_active Application Discontinuation
- 2001-04-30 RS YUP-826/02A patent/RS50926B/sr unknown
- 2001-04-30 IL IL15256701A patent/IL152567A0/xx unknown
- 2001-05-04 AR ARP010102129A patent/AR035640A1/es unknown
-
2002
- 2002-10-11 ZA ZA2002/08228A patent/ZA200208228B/en unknown
- 2002-10-16 HR HRP20020828 patent/HRP20020828A2/hr not_active Application Discontinuation
- 2002-10-24 BG BG107218A patent/BG65881B1/bg unknown
- 2002-10-31 IL IL152567A patent/IL152567A/en active IP Right Grant
- 2002-11-05 NO NO20025307A patent/NO329821B1/no not_active IP Right Cessation
-
2003
- 2003-11-05 HK HK03107981A patent/HK1055681A1/xx not_active IP Right Cessation
-
2007
- 2007-03-02 HK HK07102380.7A patent/HK1094909A1/xx not_active IP Right Cessation
-
2008
- 2008-06-30 CY CY20081100684T patent/CY1110385T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB9A | Succession in title |
Owner name: MERCK SERONO SA, CH Free format text: FORMER OWNER(S): APPLIED RESEARCH SYSTEMS ARS HOLDING N.V., NL Owner name: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERC, FR Free format text: FORMER OWNER(S): APPLIED RESEARCH SYSTEMS ARS HOLDING N.V., NL |