HUP0301652A2 - Piperidinszármazékok mikroorganizmusokkal való előállítására szolgáló eljárás - Google Patents
Piperidinszármazékok mikroorganizmusokkal való előállítására szolgáló eljárásInfo
- Publication number
- HUP0301652A2 HUP0301652A2 HU0301652A HUP0301652A HUP0301652A2 HU P0301652 A2 HUP0301652 A2 HU P0301652A2 HU 0301652 A HU0301652 A HU 0301652A HU P0301652 A HUP0301652 A HU P0301652A HU P0301652 A2 HUP0301652 A2 HU P0301652A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- general formula
- microorganism
- hydrogen atom
- production
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000003053 piperidines Chemical class 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 241000228212 Aspergillus Species 0.000 abstract 1
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- 241001465180 Botrytis Species 0.000 abstract 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 abstract 1
- 241000010215 Cunninghamella bainieri Species 0.000 abstract 1
- 241000959617 Cyathus Species 0.000 abstract 1
- 241001149562 Gelasinospora Species 0.000 abstract 1
- 241000896533 Gliocladium Species 0.000 abstract 1
- 241001450823 Helicostylum Species 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 241000235395 Mucor Species 0.000 abstract 1
- 241000186359 Mycobacterium Species 0.000 abstract 1
- 241000228143 Penicillium Species 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 241000235527 Rhizopus Species 0.000 abstract 1
- 241000223252 Rhodotorula Species 0.000 abstract 1
- 241000371621 Stemphylium Species 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A jelen találmány az (IA) és/vagy az (IB) általános képletű vegyületelőállításával kapcsolatos, ahol az említett általános képletben njelentése 0 vagy 1; R1 csoport jelentése hidrogénatom vagyhidroxicsoport; R2 csoport jelentése hidrogénatom; vagy ha n jelentése0; akkor R1 és R2 csoportok együttesen az R1 csoporttal és R2csoporttal rendelkező szénatomok közötti második kémiai kötésbőlszármaznak, feltéve, hogy ha n jelentése 1, akkor R1 és R2 csoportokjelentése hidrogénatom; R3 csoport jelentése -COOH csoport, vagy -COOR4 csoport; R4 csoport jelentése alkilcsoport vagy arilcsoport; A,B és D gyűrűik szubsztituensei, melyek mindegyike lehet azonos vagyeltérő, és jelentésük vagy hidrogénatom, vagy halogénatom, vagyalkilcsoport, vagy hidroxicsoport, vagy alkoxicsoport. Ez az eljárásmagába foglalja a (IIA) és/vagy a (IIB) általános képletű kiindulásivegyület - ahol az említett általános képletben R3 jelentése -CH3-csoport, és R1, R2, A, B és D jelentése a fentiek szerinti - egymikroorganizmus jelenlétében a vegyület előállításához hatékonykörülmények között történő inkubálását. A mikroorganizmus jelenthetStreptomyces-t, Stemphylium-ot, Gliocladium-ot, Bacillus-t, Botrytis-tCyathus-t, Rhizopus-t, Pycnidiosphora-t, Pseudomonas-t, Helicostylum-ot, Aspergillust, Mucor-t, Gelasinospora-t, Rhodotorula-t, Candida-t,Mycobacterium-ot vagy Penicillium-ot. Alternatív lehetőségként amikroorganizmus lehet Cunninghamella bainieri. Ó
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70895900A | 2000-11-08 | 2000-11-08 | |
| US09/708,959 | 2000-11-08 | ||
| US09/754,786 US6613907B2 (en) | 2000-11-08 | 2001-01-04 | Process for the production of piperidine derivatives with microorganisms |
| US09/754,786 | 2001-01-04 | ||
| PCT/US2001/043714 WO2002083062A2 (en) | 2000-11-08 | 2001-11-06 | Process for the production of piperidine derivatives with microorganisms |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0301652A2 true HUP0301652A2 (hu) | 2003-10-28 |
| HUP0301652A3 HUP0301652A3 (en) | 2012-09-28 |
| HU230069B1 HU230069B1 (hu) | 2015-06-29 |
Family
ID=24847879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0301652A HU230069B1 (hu) | 2000-11-08 | 2001-11-06 | Piperidin származékok Stemphylium consortiale mikroorganizmussal való előállítására szolgáló eljárás |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6613907B2 (hu) |
| EP (2) | EP1339864B1 (hu) |
| JP (3) | JP4686112B2 (hu) |
| KR (1) | KR100886727B1 (hu) |
| AT (2) | ATE513812T1 (hu) |
| BR (1) | BR0115191A (hu) |
| CA (1) | CA2427387C (hu) |
| CY (2) | CY1110595T1 (hu) |
| DE (1) | DE60137255D1 (hu) |
| DK (2) | DK1958935T3 (hu) |
| ES (2) | ES2321805T3 (hu) |
| HU (1) | HU230069B1 (hu) |
| MX (1) | MXPA03004003A (hu) |
| NO (1) | NO334436B1 (hu) |
| NZ (1) | NZ526040A (hu) |
| PT (2) | PT1339864E (hu) |
| RU (1) | RU2290443C2 (hu) |
| WO (1) | WO2002083062A2 (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6613907B2 (en) * | 2000-11-08 | 2003-09-02 | Amr Technology, Inc. | Process for the production of piperidine derivatives with microorganisms |
| JP2005523882A (ja) * | 2001-10-16 | 2005-08-11 | アールエックスキネティックス，インコーポレイテッド | 高濃度タンパク質製剤および製造の方法 |
| WO2005016912A1 (en) * | 2003-08-19 | 2005-02-24 | Pfizer Inc. | An efficient microbial preparation of capravirine metabolites m4 and m5 |
| WO2009058943A1 (en) * | 2007-10-31 | 2009-05-07 | Montana State University | Gliocladium isolate c-13 and methods of its use for producing volatile compounds and hydrocarbons |
| EP2105134A1 (en) | 2008-03-24 | 2009-09-30 | Ranbaxy Laboratories Limited | Stable amorphous fexofenadine hydrochloride |
| EP2576761B1 (en) * | 2010-06-03 | 2017-02-08 | Carmel-Haifa University Economic Corporation Ltd | Extracts of cyathus striatus mushrooms, pharmaceutical compositions comprising them and a new cyathus striatus strain |
| KR101987639B1 (ko) * | 2017-05-11 | 2019-06-12 | 코스맥스 주식회사 | 신규 후시디움 코씨네움 균주 및 그 균주 배양액을 포함하는 피부미용 개선용 조성물 |
| GB201807815D0 (en) | 2018-05-14 | 2018-06-27 | Hypha Discovery Ltd | Hydroxylation techniques |
| GB201819209D0 (en) * | 2018-11-26 | 2019-01-09 | Hypha Discovery Ltd | Biocatalytic techniques |
| CN116496205A (zh) * | 2022-05-06 | 2023-07-28 | 成都施贝康生物医药科技有限公司 | 一种卡瑞斯汀的盐及其用途 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3419469A (en) * | 1965-12-08 | 1968-12-31 | Sun Oil Co | Production of carboxylic acids by microbiological oxidation of hydrocarbons |
| GB1242169A (en) | 1969-04-09 | 1971-08-11 | Ucb Sa | Piperidine derivatives |
| US3649453A (en) * | 1970-01-21 | 1972-03-14 | Upjohn Co | Process for microbiologically oxygenating 1-amidoadamantanes |
| US3878217A (en) | 1972-01-28 | 1975-04-15 | Richardson Merrell Inc | Alpha-aryl-4-substituted piperidinoalkanol derivatives |
| BE794598A (fr) | 1972-01-28 | 1973-05-16 | Richardson Merrell Inc | Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation |
| US3806526A (en) | 1972-01-28 | 1974-04-23 | Richardson Merrell Inc | 1-aroylalkyl-4-diphenylmethyl piperidines |
| US3965257A (en) | 1972-01-28 | 1976-06-22 | Richardson-Merrell Inc. | Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions |
| BE794596A (fr) | 1972-01-28 | 1973-05-16 | Richardson Merrell Inc | Piperidinoalcanone-oximes substituees et leur procede de preparation |
| DE2360091A1 (de) * | 1972-12-06 | 1974-07-04 | Erap | Verfahren zur herstellung von zitronensaeure durch fermentation |
| US3931197A (en) | 1974-02-08 | 1976-01-06 | Richardson-Merrell Inc. | Substituted piperidine derivatives |
| US3941795A (en) | 1974-02-08 | 1976-03-02 | Richardson-Merrell Inc. | α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES |
| US3946022A (en) | 1974-03-04 | 1976-03-23 | Richardson-Merrell Inc. | Piperidine derivatives |
| US3922276A (en) | 1974-12-11 | 1975-11-25 | Robins Co Inc A H | 1-Substituted-4-benzylidenepiperidines |
| US3956296A (en) | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
| US4285957A (en) | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof |
| US4254130A (en) | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| US4254129A (en) | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| US4285958A (en) | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof |
| US4564594A (en) * | 1983-06-30 | 1986-01-14 | E. I. Du Pont De Nemours And Company | Fermentation process for production of carboxylic acids |
| GB8321157D0 (en) | 1983-08-05 | 1983-09-07 | Fordonal Sa | Piperidine derivatives |
| US4742175A (en) | 1986-05-07 | 1988-05-03 | Merrell Dow Pharmaceuticals Inc. | Preparation of polymorphically pure terfenadine |
| NL8603073A (nl) * | 1986-12-02 | 1988-07-01 | Rijksuniversiteit | Werkwijze voor het bereiden van polyesters door fermentatie; werkwijze voor het bereiden van optisch actieve carbonzuren en esters; polyester omvattende voortbrengselen. |
| US5032513A (en) * | 1988-06-01 | 1991-07-16 | Basf Corporation | Process for the preparation of gamma and delta lactones |
| DE4034218A1 (de) * | 1990-10-27 | 1992-04-30 | Merck Patent Gmbh | Verfahren zur herstellung von carebastin |
| ES2284740T3 (es) | 1992-08-03 | 2007-11-16 | Sepracor Inc. | Carboxilato de terfenadina y el tratamiento de la irritacion cutanea. |
| GB9312669D0 (en) | 1993-06-18 | 1993-08-04 | Orion Yhtymae Oy | New opticla isomers |
| HU226559B1 (en) | 1993-06-24 | 2009-03-30 | Amr Technology | Process for the production of piperidine derivatives |
| CN1275916C (zh) | 1993-06-25 | 2006-09-20 | 阿温蒂斯公司 | 用于制备抗组胺哌啶衍生物的新中间体 |
| DE59810863D1 (de) * | 1997-03-11 | 2004-04-08 | Aventis Pharma Inc | Verfahren zur Herstellung von 4-(4-(4-(Hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)-alpha,alpha-dimenthylphenylessigsäure und phosphorylierter Derivate |
| FR2776302B1 (fr) | 1998-03-19 | 2002-04-12 | Hoechst Marion Roussel Inc | Nouveau procede de preparation de la fexofenadine |
| US6613907B2 (en) * | 2000-11-08 | 2003-09-02 | Amr Technology, Inc. | Process for the production of piperidine derivatives with microorganisms |
-
2001
- 2001-01-04 US US09/754,786 patent/US6613907B2/en not_active Expired - Lifetime
- 2001-11-06 AT AT08005953T patent/ATE513812T1/de active
- 2001-11-06 WO PCT/US2001/043714 patent/WO2002083062A2/en active IP Right Grant
- 2001-11-06 ES ES01273746T patent/ES2321805T3/es not_active Expired - Lifetime
- 2001-11-06 DK DK08005953.8T patent/DK1958935T3/da active
- 2001-11-06 EP EP01273746A patent/EP1339864B1/en not_active Expired - Lifetime
- 2001-11-06 EP EP08005953A patent/EP1958935B1/en not_active Expired - Lifetime
- 2001-11-06 ES ES08005953T patent/ES2395243T3/es not_active Expired - Lifetime
- 2001-11-06 PT PT01273746T patent/PT1339864E/pt unknown
- 2001-11-06 KR KR1020037006233A patent/KR100886727B1/ko active IP Right Grant
- 2001-11-06 HU HU0301652A patent/HU230069B1/hu not_active IP Right Cessation
- 2001-11-06 JP JP2002580867A patent/JP4686112B2/ja not_active Expired - Fee Related
- 2001-11-06 DE DE60137255T patent/DE60137255D1/de not_active Expired - Lifetime
- 2001-11-06 CA CA2427387A patent/CA2427387C/en not_active Expired - Fee Related
- 2001-11-06 MX MXPA03004003A patent/MXPA03004003A/es active IP Right Grant
- 2001-11-06 AT AT01273746T patent/ATE419257T1/de active
- 2001-11-06 RU RU2003117021/13A patent/RU2290443C2/ru not_active IP Right Cessation
- 2001-11-06 BR BR0115191-6A patent/BR0115191A/pt not_active Application Discontinuation
- 2001-11-06 DK DK01273746T patent/DK1339864T3/da active
- 2001-11-06 NZ NZ526040A patent/NZ526040A/en not_active IP Right Cessation
- 2001-11-06 PT PT08005953T patent/PT1958935E/pt unknown
-
2003
- 2003-04-30 NO NO20031974A patent/NO334436B1/no not_active IP Right Cessation
- 2003-08-11 US US10/638,841 patent/US7232908B2/en not_active Expired - Lifetime
-
2007
- 2007-01-17 US US11/624,096 patent/US7691615B2/en not_active Expired - Fee Related
- 2007-06-22 JP JP2007164640A patent/JP4842215B2/ja not_active Expired - Fee Related
-
2008
- 2008-09-17 JP JP2008237991A patent/JP4966276B2/ja not_active Expired - Lifetime
-
2009
- 2009-03-31 CY CY20091100375T patent/CY1110595T1/el unknown
-
2011
- 2011-07-20 CY CY20111100712T patent/CY1112344T1/el unknown
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