KR910009932A - (+)-호모 필로핀 산(hoopilopic acid) 및 그 염의 제조방법 - Google Patents

(+)-호모 필로핀 산(hoopilopic acid) 및 그 염의 제조방법 Download PDF

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KR910009932A
KR910009932A KR1019900018915A KR900018915A KR910009932A KR 910009932 A KR910009932 A KR 910009932A KR 1019900018915 A KR1019900018915 A KR 1019900018915A KR 900018915 A KR900018915 A KR 900018915A KR 910009932 A KR910009932 A KR 910009932A
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acid
general formula
acid ester
mixture
philo
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KR1019900018915A
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KR0137134B1 (ko
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쇼이찌 기세
마끼오 하야시다
아이이찌로 오리
준조우 히라쯔까
히데아끼 야마다
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다께바야시 쇼오고
미쓰이 세끼유 가가꾸 고오교오 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C12P7/38—Cyclopentanone- or cyclopentadione-containing products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
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    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/839—Bacillus subtilis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/84—Brevibacterium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/939—Rhizopus

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

(+)-호모 필로핀 산(HOOPILOPIC ACID) 및 그 염의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실시예 37의 생성물 메틸에스테르를 CDCI3중 0.5당량 Eu(hfc)3존재하에서 측정한 NMR 스펙트럼도

Claims (3)

  1. 아스로박터속, 아스퍼질러스속, 어세리키아속, 커닝가멜라속, 크산토모나스속, 칸디다속, 슈도모나스속, 세라챠속, 셀롤로모나스속, 노카디아속, 바실러스속, 브레비박테륨속, 후라보박테륨속, 미코박테륨속, 리조무코르속, 로도토툴라속 또는 로도코쿠스속 등에 속하는 미생물의 균체 또는 그의 처리물 존재하에, 하기 일반식[Ⅰ]로 표시되는 (+)-호모필로핀산 에스테르와 하기 일반식[Ⅱ]로 표시되는 (-)-호모필로핀산 에스테르의 혼합물(식 중, R1, R2는 각각 C1~C10의 직쇄 또는 분기상 탄화수소기를 나타낸다)를 가수분해함을 특징으로 하는 (+)-호모필로핀산 및 그 염의 제조방법
  2. 리파아제, 에스테라아제, 콜레스테롤에스테라아제, 리포프로테인 리파아제들 중 적어도 1종류의 효소를 사용하여 상기 제1항의 일반식[Ⅰ]로 표시되는 (+)-호모필로핀산 에스테르의 혼합물(식 중, R1, R2는 각각 C1~C10의 직쇄 또는 분기상 탄화수소기를 나타낸다)을 가수분해함을 특징으로 하는 (+)-호모필로핀산 및 그 염의 제조방법
  3. 리파아제, 에스테라아제, 콜레스테롤에스테라아제 등으로 이루어지는 그룹에서 선택된 가수분해효소 또는 브레비박테륨속, 에세리키아속 또는 로도토룰라속에 속하는 미생물 또는 그의 처리물 중 임의의 1종류를 사용하여 상기 제1항의 일반식[Ⅰ]의 (+)-호모필로핀산 에스테르와 일반식[Ⅱ]로 표시되는 (-)-호모필로핀산 에스테르 (식 중, R1, R2는 각각 C1~C10의 직쇄 또는 분기상 탄화수소기를 나타낸다) 혼합물을 가수분해 한 미반응의 (+)-호모필로핀산 에스테르를 회수하고, 외수한 미반응(+)-호모필로핀산, 에스트를 리파아제, 에스테라아제 등의 효소 또는 아스퍼질러스속, 에세리키아속, 크산토모나스속, 칸디다속, 슈도모나스속, 세라챠속, 셀루로모나스속, 노카디아속, 바실러스속, 후라보박테륨속, 미코박테륨속, 리조무코르속, 로도코쿠스속에 속하는 미생물 또는 그의 처리물 중 임의의 하나를 사용하여 가수분해함을 특징으로 하는 (+)-호모필로핀산 및 그 염의 제조방법
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900018915A 1989-11-22 1990-11-22 (+)-호모필로핀산 및 그 염의 제조방법 KR0137134B1 (ko)

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Application Number Priority Date Filing Date Title
JP1-302273 1989-11-22
JP1302273A JP2880204B2 (ja) 1989-11-22 1989-11-22 （＋）‐ホモピロピン酸の製造法

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KR910009932A true KR910009932A (ko) 1991-06-28
KR0137134B1 KR0137134B1 (ko) 1998-04-25

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US (1) US5182198A (ko)
EP (1) EP0430555B1 (ko)
JP (1) JP2880204B2 (ko)
KR (1) KR0137134B1 (ko)
AT (1) ATE121137T1 (ko)
CA (1) CA2030218C (ko)
DE (1) DE69018576T2 (ko)
HU (1) HU212279B (ko)

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US5529929A (en) * 1995-06-07 1996-06-25 Seprachem, Inc. Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens
US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use
US20070087061A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components
JP2007166908A (ja) * 2005-12-19 2007-07-05 Sumitomo Chemical Co Ltd 光学活性な３−（３−ヒドロキシフェニル）−２−アルコキシプロパン酸又は３−（３−ヒドロキシフェニル）−２−アルコキシプロパン酸エステルの製法

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* Cited by examiner, † Cited by third party
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US5037747A (en) * 1988-01-26 1991-08-06 Hoffmann-La Roche Inc. Production of benzopyran-2-carboxylic acids and esters by enzymatic hydrolysis

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HUT61292A (en) 1992-12-28
JPH03198796A (ja) 1991-08-29
US5182198A (en) 1993-01-26
CA2030218A1 (en) 1991-05-23
ATE121137T1 (de) 1995-04-15
EP0430555A1 (en) 1991-06-05
KR0137134B1 (ko) 1998-04-25
CA2030218C (en) 1998-12-08
EP0430555B1 (en) 1995-04-12
JP2880204B2 (ja) 1999-04-05
HU212279B (en) 1996-04-29
DE69018576D1 (de) 1995-05-18
HU907244D0 (en) 1991-05-28
DE69018576T2 (de) 1995-08-17

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