ATE389026T1 - Verfahren für die herstellung von inhibitoren der hmg-coa-reduktase. - Google Patents
Verfahren für die herstellung von inhibitoren der hmg-coa-reduktase.Info
- Publication number
- ATE389026T1 ATE389026T1 AT98935282T AT98935282T ATE389026T1 AT E389026 T1 ATE389026 T1 AT E389026T1 AT 98935282 T AT98935282 T AT 98935282T AT 98935282 T AT98935282 T AT 98935282T AT E389026 T1 ATE389026 T1 AT E389026T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- ähereinafter
- substituted
- referred
- unsubstituted alkyl
- Prior art date
Links
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 16
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 239000011541 reaction mixture Substances 0.000 abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 150000001340 alkali metals Chemical class 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000686 lactone group Chemical group 0.000 abstract 2
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/07—Bacillus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21363697 | 1997-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE389026T1 true ATE389026T1 (de) | 2008-03-15 |
Family
ID=16642443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98935282T ATE389026T1 (de) | 1997-08-07 | 1998-07-30 | Verfahren für die herstellung von inhibitoren der hmg-coa-reduktase. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6245535B1 (de) |
| EP (1) | EP1020530B1 (de) |
| JP (1) | JP4162848B2 (de) |
| KR (1) | KR100433888B1 (de) |
| CN (1) | CN1159448C (de) |
| AT (1) | ATE389026T1 (de) |
| AU (1) | AU8460698A (de) |
| CA (1) | CA2299634C (de) |
| DE (1) | DE69839248T2 (de) |
| WO (1) | WO1999007872A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6946270B1 (en) | 1999-01-20 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing HMG-CoA reductase inhibitors |
| US7049111B1 (en) * | 1999-01-29 | 2006-05-23 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing HMG-CoA reductase inhibitor |
| CN101351551A (zh) * | 2005-11-29 | 2009-01-21 | 协和发酵工业株式会社 | 新型蛋白质和编码该蛋白质的dna |
| EP2094841B1 (de) * | 2006-12-13 | 2012-03-14 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Verfahren zur herstellung von pravastatin |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX7065E (es) | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
| US6043064A (en) | 1993-10-22 | 2000-03-28 | Bristol-Myers Squibb Company | Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof |
| US5942423A (en) * | 1995-06-07 | 1999-08-24 | Massachusetts Institute Of Technology | Conversion of compactin to pravastatin by actinomadura |
| CZ291991B6 (cs) * | 1995-11-29 | 2003-07-16 | Sankyo Company Limited | Aktinomycetový promotor |
| KR100186758B1 (ko) * | 1996-08-09 | 1999-04-01 | 영진약품공업 주식회사 | 프라바스타틴(pravastatin)전구체의제조방법 |
-
1998
- 1998-07-30 CN CNB988079003A patent/CN1159448C/zh not_active Expired - Fee Related
- 1998-07-30 EP EP98935282A patent/EP1020530B1/de not_active Expired - Lifetime
- 1998-07-30 CA CA002299634A patent/CA2299634C/en not_active Expired - Fee Related
- 1998-07-30 KR KR10-2000-7000988A patent/KR100433888B1/ko not_active Expired - Fee Related
- 1998-07-30 AT AT98935282T patent/ATE389026T1/de not_active IP Right Cessation
- 1998-07-30 WO PCT/JP1998/003396 patent/WO1999007872A1/ja not_active Ceased
- 1998-07-30 AU AU84606/98A patent/AU8460698A/en not_active Abandoned
- 1998-07-30 US US09/463,912 patent/US6245535B1/en not_active Expired - Lifetime
- 1998-07-30 DE DE69839248T patent/DE69839248T2/de not_active Expired - Lifetime
- 1998-07-30 JP JP2000506355A patent/JP4162848B2/ja not_active Expired - Lifetime
-
2001
- 2001-04-10 US US09/829,080 patent/US6468780B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20010053542A1 (en) | 2001-12-20 |
| DE69839248D1 (de) | 2008-04-24 |
| JP4162848B2 (ja) | 2008-10-08 |
| EP1020530A4 (de) | 2003-04-16 |
| US6245535B1 (en) | 2001-06-12 |
| WO1999007872A9 (en) | 2003-06-26 |
| CN1159448C (zh) | 2004-07-28 |
| AU8460698A (en) | 1999-03-01 |
| CN1265705A (zh) | 2000-09-06 |
| EP1020530A1 (de) | 2000-07-19 |
| WO1999007872A1 (en) | 1999-02-18 |
| CA2299634C (en) | 2007-10-16 |
| CA2299634A1 (en) | 1999-02-18 |
| KR100433888B1 (ko) | 2004-06-04 |
| DE69839248T2 (de) | 2009-04-02 |
| KR20010022408A (ko) | 2001-03-15 |
| US6468780B2 (en) | 2002-10-22 |
| EP1020530B1 (de) | 2008-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |