ATE513812T1 - Verfahren zur produktion von terfenadin- und carebastinderivaten mit mikroorganismen - Google Patents
Verfahren zur produktion von terfenadin- und carebastinderivaten mit mikroorganismenInfo
- Publication number
- ATE513812T1 ATE513812T1 AT08005953T AT08005953T ATE513812T1 AT E513812 T1 ATE513812 T1 AT E513812T1 AT 08005953 T AT08005953 T AT 08005953T AT 08005953 T AT08005953 T AT 08005953T AT E513812 T1 ATE513812 T1 AT E513812T1
- Authority
- AT
- Austria
- Prior art keywords
- streptomyces
- microorganism
- structure according
- formulae
- carebastine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70895900A | 2000-11-08 | 2000-11-08 | |
US09/754,786 US6613907B2 (en) | 2000-11-08 | 2001-01-04 | Process for the production of piperidine derivatives with microorganisms |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE513812T1 true ATE513812T1 (de) | 2011-07-15 |
Family
ID=24847879
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08005953T ATE513812T1 (de) | 2000-11-08 | 2001-11-06 | Verfahren zur produktion von terfenadin- und carebastinderivaten mit mikroorganismen |
AT01273746T ATE419257T1 (de) | 2000-11-08 | 2001-11-06 | Verfahren zur produktion von piperidinderivaten mit mikroorganismen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01273746T ATE419257T1 (de) | 2000-11-08 | 2001-11-06 | Verfahren zur produktion von piperidinderivaten mit mikroorganismen |
Country Status (18)
Country | Link |
---|---|
US (3) | US6613907B2 (de) |
EP (2) | EP1339864B1 (de) |
JP (3) | JP4686112B2 (de) |
KR (1) | KR100886727B1 (de) |
AT (2) | ATE513812T1 (de) |
BR (1) | BR0115191A (de) |
CA (1) | CA2427387C (de) |
CY (2) | CY1110595T1 (de) |
DE (1) | DE60137255D1 (de) |
DK (2) | DK1958935T3 (de) |
ES (2) | ES2395243T3 (de) |
HU (1) | HU230069B1 (de) |
MX (1) | MXPA03004003A (de) |
NO (1) | NO334436B1 (de) |
NZ (1) | NZ526040A (de) |
PT (2) | PT1339864E (de) |
RU (1) | RU2290443C2 (de) |
WO (1) | WO2002083062A2 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6613907B2 (en) * | 2000-11-08 | 2003-09-02 | Amr Technology, Inc. | Process for the production of piperidine derivatives with microorganisms |
JP2005523882A (ja) * | 2001-10-16 | 2005-08-11 | アールエックスキネティックス,インコーポレイテッド | 高濃度タンパク質製剤および製造の方法 |
WO2005016912A1 (en) * | 2003-08-19 | 2005-02-24 | Pfizer Inc. | An efficient microbial preparation of capravirine metabolites m4 and m5 |
WO2009058943A1 (en) * | 2007-10-31 | 2009-05-07 | Montana State University | Gliocladium isolate c-13 and methods of its use for producing volatile compounds and hydrocarbons |
US20090306135A1 (en) | 2008-03-24 | 2009-12-10 | Mukesh Kumar Sharma | Stable amorphous fexofenadine hydrochloride |
WO2011151831A1 (en) * | 2010-06-03 | 2011-12-08 | Carmel-Haifa University Economic Corporation Ltd | Extracts of cyathus striatus mushrooms, pharmaceutical compositions comprising them and a new cyathus striatus strain |
KR101987639B1 (ko) * | 2017-05-11 | 2019-06-12 | 코스맥스 주식회사 | 신규 후시디움 코씨네움 균주 및 그 균주 배양액을 포함하는 피부미용 개선용 조성물 |
GB201807815D0 (en) | 2018-05-14 | 2018-06-27 | Hypha Discovery Ltd | Hydroxylation techniques |
GB201819209D0 (en) * | 2018-11-26 | 2019-01-09 | Hypha Discovery Ltd | Biocatalytic techniques |
CN116496205A (zh) * | 2022-05-06 | 2023-07-28 | 成都施贝康生物医药科技有限公司 | 一种卡瑞斯汀的盐及其用途 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3419469A (en) * | 1965-12-08 | 1968-12-31 | Sun Oil Co | Production of carboxylic acids by microbiological oxidation of hydrocarbons |
GB1242169A (en) | 1969-04-09 | 1971-08-11 | Ucb Sa | Piperidine derivatives |
US3649453A (en) * | 1970-01-21 | 1972-03-14 | Upjohn Co | Process for microbiologically oxygenating 1-amidoadamantanes |
US3965257A (en) | 1972-01-28 | 1976-06-22 | Richardson-Merrell Inc. | Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions |
US3878217A (en) | 1972-01-28 | 1975-04-15 | Richardson Merrell Inc | Alpha-aryl-4-substituted piperidinoalkanol derivatives |
BE794596A (fr) | 1972-01-28 | 1973-05-16 | Richardson Merrell Inc | Piperidinoalcanone-oximes substituees et leur procede de preparation |
BE794598A (fr) | 1972-01-28 | 1973-05-16 | Richardson Merrell Inc | Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation |
US3806526A (en) | 1972-01-28 | 1974-04-23 | Richardson Merrell Inc | 1-aroylalkyl-4-diphenylmethyl piperidines |
DE2360091A1 (de) * | 1972-12-06 | 1974-07-04 | Erap | Verfahren zur herstellung von zitronensaeure durch fermentation |
US3931197A (en) | 1974-02-08 | 1976-01-06 | Richardson-Merrell Inc. | Substituted piperidine derivatives |
US3941795A (en) | 1974-02-08 | 1976-03-02 | Richardson-Merrell Inc. | α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES |
US3946022A (en) | 1974-03-04 | 1976-03-23 | Richardson-Merrell Inc. | Piperidine derivatives |
US3956296A (en) | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
US3922276A (en) | 1974-12-11 | 1975-11-25 | Robins Co Inc A H | 1-Substituted-4-benzylidenepiperidines |
US4285957A (en) | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof |
US4254129A (en) | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
US4285958A (en) | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof |
US4254130A (en) | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
US4564594A (en) * | 1983-06-30 | 1986-01-14 | E. I. Du Pont De Nemours And Company | Fermentation process for production of carboxylic acids |
GB8321157D0 (en) | 1983-08-05 | 1983-09-07 | Fordonal Sa | Piperidine derivatives |
US4742175A (en) | 1986-05-07 | 1988-05-03 | Merrell Dow Pharmaceuticals Inc. | Preparation of polymorphically pure terfenadine |
NL8603073A (nl) * | 1986-12-02 | 1988-07-01 | Rijksuniversiteit | Werkwijze voor het bereiden van polyesters door fermentatie; werkwijze voor het bereiden van optisch actieve carbonzuren en esters; polyester omvattende voortbrengselen. |
US5032513A (en) * | 1988-06-01 | 1991-07-16 | Basf Corporation | Process for the preparation of gamma and delta lactones |
DE4034218A1 (de) * | 1990-10-27 | 1992-04-30 | Merck Patent Gmbh | Verfahren zur herstellung von carebastin |
RO116043B1 (ro) | 1992-08-03 | 2000-10-30 | Sepracor Inc | Compozitie farmaceutica |
GB9312669D0 (en) | 1993-06-18 | 1993-08-04 | Orion Yhtymae Oy | New opticla isomers |
WO1995000482A1 (en) | 1993-06-24 | 1995-01-05 | Albany Molecular Research, Inc. | Piperidine derivatives and process for their production |
CN1159277C (zh) | 1993-06-25 | 2004-07-28 | 默里尔药物公司 | 用于制备抗组胺哌啶衍生物的新中间体 |
PT864653E (pt) * | 1997-03-11 | 2004-08-31 | Aventis Pharma Inc | Processo para preparacao de acido 4-(4-(4-(hidroxidifenil)-1-piperidinil)-1-hidroxibutil)-alfa,alfa-dimetilfenilacetico e derivados fosforilados |
FR2776302B1 (fr) | 1998-03-19 | 2002-04-12 | Hoechst Marion Roussel Inc | Nouveau procede de preparation de la fexofenadine |
US6613907B2 (en) * | 2000-11-08 | 2003-09-02 | Amr Technology, Inc. | Process for the production of piperidine derivatives with microorganisms |
-
2001
- 2001-01-04 US US09/754,786 patent/US6613907B2/en not_active Expired - Lifetime
- 2001-11-06 PT PT01273746T patent/PT1339864E/pt unknown
- 2001-11-06 MX MXPA03004003A patent/MXPA03004003A/es active IP Right Grant
- 2001-11-06 CA CA2427387A patent/CA2427387C/en not_active Expired - Fee Related
- 2001-11-06 ES ES08005953T patent/ES2395243T3/es not_active Expired - Lifetime
- 2001-11-06 AT AT08005953T patent/ATE513812T1/de active
- 2001-11-06 AT AT01273746T patent/ATE419257T1/de active
- 2001-11-06 EP EP01273746A patent/EP1339864B1/de not_active Expired - Lifetime
- 2001-11-06 ES ES01273746T patent/ES2321805T3/es not_active Expired - Lifetime
- 2001-11-06 DK DK08005953.8T patent/DK1958935T3/da active
- 2001-11-06 WO PCT/US2001/043714 patent/WO2002083062A2/en active IP Right Grant
- 2001-11-06 HU HU0301652A patent/HU230069B1/hu not_active IP Right Cessation
- 2001-11-06 EP EP08005953A patent/EP1958935B1/de not_active Expired - Lifetime
- 2001-11-06 JP JP2002580867A patent/JP4686112B2/ja not_active Expired - Fee Related
- 2001-11-06 PT PT08005953T patent/PT1958935E/pt unknown
- 2001-11-06 DE DE60137255T patent/DE60137255D1/de not_active Expired - Lifetime
- 2001-11-06 BR BR0115191-6A patent/BR0115191A/pt not_active Application Discontinuation
- 2001-11-06 KR KR1020037006233A patent/KR100886727B1/ko active IP Right Grant
- 2001-11-06 RU RU2003117021/13A patent/RU2290443C2/ru not_active IP Right Cessation
- 2001-11-06 DK DK01273746T patent/DK1339864T3/da active
- 2001-11-06 NZ NZ526040A patent/NZ526040A/en not_active IP Right Cessation
-
2003
- 2003-04-30 NO NO20031974A patent/NO334436B1/no not_active IP Right Cessation
- 2003-08-11 US US10/638,841 patent/US7232908B2/en not_active Expired - Lifetime
-
2007
- 2007-01-17 US US11/624,096 patent/US7691615B2/en not_active Expired - Fee Related
- 2007-06-22 JP JP2007164640A patent/JP4842215B2/ja not_active Expired - Fee Related
-
2008
- 2008-09-17 JP JP2008237991A patent/JP4966276B2/ja not_active Expired - Lifetime
-
2009
- 2009-03-31 CY CY20091100375T patent/CY1110595T1/el unknown
-
2011
- 2011-07-20 CY CY20111100712T patent/CY1112344T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1112344T1 (el) | Μεθοδος για την παραγωγη παραγωγων τερφεναδινης και καρεβαστινης με μικροοργανισμους | |
ATE121091T1 (de) | Phospholipase a2-inhibitor, mikroorganismen, die diesen inhibitor erzeugen und mehrere verfahren zu seiner herstellung. | |
FI864218A0 (fi) | Verkkoutunut selluloosa, sen valmistusmenetelmä, sitä tuottavat mikro-organismit sekä sen käyttö arkkien muodostamiseen | |
WO2000047758A3 (en) | Methods of making compounds | |
ATE109797T1 (de) | Verfahren zur herstellung von verzweigten fructo- oligosacchariden. | |
US4474881A (en) | Process for preparing polyprenyl carboxylic acid derivatives | |
JP2769194B2 (ja) | 酵素分解方法 | |
WO2002095044A2 (en) | Lipase catalyzed esterification, transesterification, and hydrolysis of arylthiols and aryl-thioesters | |
KR0137134B1 (ko) | (+)-호모필로핀산 및 그 염의 제조방법 | |
AU2001282002A1 (en) | Method for the enantioselective reduction of 8-chloro-6-oxo-octanoic acid alkyl esters | |
JP2005528919A5 (de) | ||
WO2002061094A3 (de) | Mikrobiologisches verfahren zur herstellung von l-carnitin | |
KR890003955A (ko) | 광학 활성 인-함유 작용성 아세트산 유도체의 효소적 제조방밥 | |
EP0264429A1 (de) | ENZYMATISCHES VERFAHREN ZUR HERSTELLUNG OPTISCH AKTIVER 1,2-DIHYDRO-3H-PYRROLO-[1,2a]PYRROLE-1-CARBONSÄURE-DERIVATE | |
ATE144794T1 (de) | Verfahren zur enzymatischen herstellung von 7- amino-cephalosporansäure | |
KR900000481A (ko) | 3-메르캡토-2-알킬-프로피온산의 라세미 에스테르 유도체들의 광학 이성질체의 효소 분리방법 | |
ATE389026T1 (de) | Verfahren für die herstellung von inhibitoren der hmg-coa-reduktase. | |
US5128263A (en) | Enzymatic resolution process hydrolyzing thio-ester | |
AU4188800A (en) | Pseudomycin production by (pseudomonas syringae) | |
EP0148272A1 (de) | Verfahren zur herstellung optisch aktiven benzylalkohols | |
WO2002022849A3 (en) | Enzymatic resolution of aryl- and thio-substituted acids | |
EP0751223A3 (de) | Verfahren zur Herstellung von Derivaten des Dimethylolcarbonsäure | |
RU2001105315A (ru) | Микробиологический способ получения оптически активных 3-гидроксипирролидиновых производных | |
KR960023071A (ko) | 발효에 의한 l-로이신의 제조방법 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1958935 Country of ref document: EP |