HUP0300627A2 - Terápiára alkalmas szintetikus oligonukleotidok - Google Patents

Terápiára alkalmas szintetikus oligonukleotidok

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Publication number
HUP0300627A2
HUP0300627A2 HU0300627A HUP0300627A HUP0300627A2 HU P0300627 A2 HUP0300627 A2 HU P0300627A2 HU 0300627 A HU0300627 A HU 0300627A HU P0300627 A HUP0300627 A HU P0300627A HU P0300627 A2 HUP0300627 A2 HU P0300627A2
Authority
HU
Hungary
Prior art keywords
synthetic oligonucleotides
gxty
tygx
therapeutically useful
useful synthetic
Prior art date
Application number
HU0300627A
Other languages
English (en)
Inventor
Mario C. Filion
Nigel C. Phillips
Original Assignee
Bioniche Life Sciences Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioniche Life Sciences Inc. filed Critical Bioniche Life Sciences Inc.
Publication of HUP0300627A2 publication Critical patent/HUP0300627A2/hu
Publication of HUP0300627A3 publication Critical patent/HUP0300627A3/hu

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3513—Protein; Peptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgyát 2--20 bázis méretű 3'-OH, 5'-OH szintetikusoligonukleotidokat (szekvenciákat) tartalmazó készítmények éseljárások képezik, amelyekben a szintetikus oligonukleotidok lehetnek(GxTy)n (I), (TyGx) n (II), a (GxTy)n, (III), (GxTy)nb (IV), (TyGx)nb(V), a(GxTy)nb (VI), a(TyGx)nb (VII) összetételűek, ahol a képletekbenx és y értéke 1-7, bármely egész szám, n értéke 1-12. bármely egészszám, továbbá a és b jelentése egy vagy több A, C, G vagy T, és amelyszekvenciák a sejtciklus megállítását, sejtosztódás gátlását,kaszpázok aktiválását, rákos sejtekben az apoptózist vagy azimmunrendszer sejtjeiben citokinek előállítását indukálják. Ó
HU0300627A 1999-12-13 2000-12-12 Therapeutically useful synthetic oligonucleotides HUP0300627A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17032599P 1999-12-13 1999-12-13
US22892500P 2000-08-29 2000-08-29
PCT/CA2000/001467 WO2001044465A2 (en) 1999-12-13 2000-12-12 Therapeutically useful synthetic oligonucleotides

Publications (2)

Publication Number Publication Date
HUP0300627A2 true HUP0300627A2 (hu) 2004-06-28
HUP0300627A3 HUP0300627A3 (en) 2005-11-28

Family

ID=26865979

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300627A HUP0300627A3 (en) 1999-12-13 2000-12-12 Therapeutically useful synthetic oligonucleotides

Country Status (18)

Country Link
US (2) US7157436B2 (hu)
EP (2) EP1238070B1 (hu)
JP (1) JP4772245B2 (hu)
KR (1) KR100829646B1 (hu)
CN (2) CN101491536B (hu)
AT (2) ATE370231T1 (hu)
AU (1) AU785212B2 (hu)
CA (1) CA2393808A1 (hu)
CZ (1) CZ20022372A3 (hu)
DE (2) DE60036019T2 (hu)
DK (2) DK1867718T3 (hu)
ES (2) ES2340807T3 (hu)
HU (1) HUP0300627A3 (hu)
IL (2) IL150196A0 (hu)
MX (1) MXPA02005842A (hu)
NO (1) NO330508B1 (hu)
PT (1) PT1238070E (hu)
WO (1) WO2001044465A2 (hu)

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Also Published As

Publication number Publication date
CA2393808A1 (en) 2001-06-21
WO2001044465A2 (en) 2001-06-21
JP4772245B2 (ja) 2011-09-14
PT1238070E (pt) 2007-11-06
AU1847901A (en) 2001-06-25
DE60036019D1 (de) 2007-09-27
EP1867718A3 (en) 2008-04-02
WO2001044465A3 (en) 2001-11-29
DK1238070T3 (da) 2007-12-03
NO330508B1 (no) 2011-05-09
NO20022820D0 (no) 2002-06-13
US20070213291A1 (en) 2007-09-13
IL150196A (en) 2009-06-15
HUP0300627A3 (en) 2005-11-28
DE60043759D1 (de) 2010-03-11
US7157436B2 (en) 2007-01-02
DE60036019T2 (de) 2008-05-29
CN101491536A (zh) 2009-07-29
KR20020079752A (ko) 2002-10-19
ES2340807T3 (es) 2010-06-09
MXPA02005842A (es) 2003-10-14
JP2003517041A (ja) 2003-05-20
CN1433469A (zh) 2003-07-30
US20010041681A1 (en) 2001-11-15
CZ20022372A3 (cs) 2002-11-13
ATE370231T1 (de) 2007-09-15
NO20022820L (no) 2002-08-08
ES2288883T3 (es) 2008-02-01
CN100445380C (zh) 2008-12-24
KR100829646B1 (ko) 2008-05-16
IL150196A0 (en) 2002-12-01
EP1238070A2 (en) 2002-09-11
EP1867718A2 (en) 2007-12-19
CN101491536B (zh) 2012-07-04
AU785212B2 (en) 2006-11-09
ATE455851T1 (de) 2010-02-15
DK1867718T3 (da) 2010-04-12
EP1867718B1 (en) 2010-01-20
EP1238070B1 (en) 2007-08-15

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