HUP0204083A3 - 2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors, process for their preparation and pharmaceutical compositions containing them - Google Patents
2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors, process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- HUP0204083A3 HUP0204083A3 HU0204083A HUP0204083A HUP0204083A3 HU P0204083 A3 HUP0204083 A3 HU P0204083A3 HU 0204083 A HU0204083 A HU 0204083A HU P0204083 A HUP0204083 A HU P0204083A HU P0204083 A3 HUP0204083 A3 HU P0204083A3
- Authority
- HU
- Hungary
- Prior art keywords
- vegf
- amino
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- HTPCDVLWYUXWQR-UHFFFAOYSA-N 2-aminopyridine-3-carboxamide Chemical class NC(=O)C1=CC=CN=C1N HTPCDVLWYUXWQR-UHFFFAOYSA-N 0.000 title 1
- 229940127361 Receptor Tyrosine Kinase Inhibitors Drugs 0.000 title 1
- 108091008605 VEGF receptors Proteins 0.000 title 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0001930.7A GB0001930D0 (en) | 2000-01-27 | 2000-01-27 | Organic compounds |
PCT/EP2001/000835 WO2001055114A1 (en) | 2000-01-27 | 2001-01-25 | 2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0204083A2 HUP0204083A2 (hu) | 2003-03-28 |
HUP0204083A3 true HUP0204083A3 (en) | 2005-03-29 |
Family
ID=9884488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0204083A HUP0204083A3 (en) | 2000-01-27 | 2001-01-25 | 2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors, process for their preparation and pharmaceutical compositions containing them |
Country Status (25)
Country | Link |
---|---|
US (1) | US6624174B2 (hu) |
EP (2) | EP1259487B8 (hu) |
JP (1) | JP3894793B2 (hu) |
KR (1) | KR100554988B1 (hu) |
CN (1) | CN1216867C (hu) |
AT (1) | ATE452880T1 (hu) |
AU (1) | AU771626B2 (hu) |
BR (1) | BR0107805A (hu) |
CA (1) | CA2396590C (hu) |
CZ (1) | CZ20022582A3 (hu) |
DE (1) | DE60140860D1 (hu) |
ES (2) | ES2490191T3 (hu) |
GB (1) | GB0001930D0 (hu) |
HK (1) | HK1050895A1 (hu) |
HU (1) | HUP0204083A3 (hu) |
IL (2) | IL150481A0 (hu) |
MX (1) | MXPA02007319A (hu) |
NO (1) | NO323826B1 (hu) |
NZ (1) | NZ520005A (hu) |
PL (1) | PL356307A1 (hu) |
PT (2) | PT2168948E (hu) |
RU (1) | RU2296124C2 (hu) |
SK (1) | SK287426B6 (hu) |
WO (1) | WO2001055114A1 (hu) |
ZA (1) | ZA200205988B (hu) |
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WO1998057957A1 (fr) | 1997-06-18 | 1998-12-23 | Nissan Chemical Industries, Ltd. | Composes pyridiniques et herbicides associes |
AR013693A1 (es) | 1997-10-23 | 2001-01-10 | Uriach & Cia Sa J | Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria |
JP2002516909A (ja) * | 1998-06-05 | 2002-06-11 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 置換1−(4−アミノフェニル)ピラゾール及び抗炎症剤としてのそれらの使用 |
ES2263294T3 (es) | 1998-12-23 | 2006-12-01 | Eli Lilly And Company | Amidas antitromboticas. |
EP3222619A1 (en) * | 1999-04-15 | 2017-09-27 | Bristol-Myers Squibb Holdings Ireland | Cyclic protein tyrosine kinase inhibitors |
JP2003520854A (ja) | 2000-01-27 | 2003-07-08 | サイトビア インコーポレイテッド | カスパーゼのアクチベーターおよびアポトーシスのインデューサーとしての置換ニコチンアミドおよび類似物およびそれらの使用 |
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2000
- 2000-01-27 GB GBGB0001930.7A patent/GB0001930D0/en not_active Ceased
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2001
- 2001-01-25 PL PL01356307A patent/PL356307A1/xx not_active Application Discontinuation
- 2001-01-25 SK SK1085-2002A patent/SK287426B6/sk not_active IP Right Cessation
- 2001-01-25 CZ CZ20022582A patent/CZ20022582A3/cs unknown
- 2001-01-25 CA CA2396590A patent/CA2396590C/en not_active Expired - Lifetime
- 2001-01-25 KR KR1020027009671A patent/KR100554988B1/ko not_active IP Right Cessation
- 2001-01-25 RU RU2002121645/15A patent/RU2296124C2/ru not_active IP Right Cessation
- 2001-01-25 NZ NZ520005A patent/NZ520005A/en not_active IP Right Cessation
- 2001-01-25 PT PT91790642T patent/PT2168948E/pt unknown
- 2001-01-25 JP JP2001555056A patent/JP3894793B2/ja not_active Expired - Lifetime
- 2001-01-25 DE DE60140860T patent/DE60140860D1/de not_active Expired - Lifetime
- 2001-01-25 HU HU0204083A patent/HUP0204083A3/hu unknown
- 2001-01-25 EP EP01946854.5A patent/EP1259487B8/en not_active Expired - Lifetime
- 2001-01-25 US US10/181,005 patent/US6624174B2/en not_active Expired - Lifetime
- 2001-01-25 WO PCT/EP2001/000835 patent/WO2001055114A1/en active IP Right Grant
- 2001-01-25 EP EP09179064.2A patent/EP2168948B1/en not_active Expired - Lifetime
- 2001-01-25 BR BR0107805-4A patent/BR0107805A/pt not_active Application Discontinuation
- 2001-01-25 CN CN018042333A patent/CN1216867C/zh not_active Expired - Fee Related
- 2001-01-25 ES ES09179064.2T patent/ES2490191T3/es not_active Expired - Lifetime
- 2001-01-25 PT PT01946854T patent/PT1259487E/pt unknown
- 2001-01-25 MX MXPA02007319A patent/MXPA02007319A/es active IP Right Grant
- 2001-01-25 AU AU28499/01A patent/AU771626B2/en not_active Ceased
- 2001-01-25 IL IL15048101A patent/IL150481A0/xx unknown
- 2001-01-25 ES ES01946854T patent/ES2338407T3/es not_active Expired - Lifetime
- 2001-01-25 AT AT01946854T patent/ATE452880T1/de active
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2002
- 2002-06-27 IL IL150481A patent/IL150481A/en not_active IP Right Cessation
- 2002-07-02 NO NO20023218A patent/NO323826B1/no not_active IP Right Cessation
- 2002-07-26 ZA ZA200205988A patent/ZA200205988B/en unknown
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2003
- 2003-04-29 HK HK03103030A patent/HK1050895A1/xx not_active IP Right Cessation
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FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |