HUP0202749A3 - Pharmaceutical solutions of levosimendan - Google Patents

Pharmaceutical solutions of levosimendan

Info

Publication number
HUP0202749A3
HUP0202749A3 HU0202749A HUP0202749A HUP0202749A3 HU P0202749 A3 HUP0202749 A3 HU P0202749A3 HU 0202749 A HU0202749 A HU 0202749A HU P0202749 A HUP0202749 A HU P0202749A HU P0202749 A3 HUP0202749 A3 HU P0202749A3
Authority
HU
Hungary
Prior art keywords
levosimendan
pharmaceutical solutions
pharmaceutical
solutions
Prior art date
Application number
HU0202749A
Other languages
English (en)
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8555263&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0202749(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orion Corp filed Critical Orion Corp
Publication of HUP0202749A2 publication Critical patent/HUP0202749A2/hu
Publication of HUP0202749A3 publication Critical patent/HUP0202749A3/hu
Publication of HU228340B1 publication Critical patent/HU228340B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
HU0202749A 1999-09-10 2000-09-08 Pharmaceutical solutions of levosimendan HU228340B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI991925A FI109659B (fi) 1999-09-10 1999-09-10 Levosimendaanin farmaseuttisia liuoksia
PCT/FI2000/000761 WO2001019334A2 (en) 1999-09-10 2000-09-08 Pharmaceutical solutions of levosimendan

Publications (3)

Publication Number Publication Date
HUP0202749A2 HUP0202749A2 (hu) 2003-02-28
HUP0202749A3 true HUP0202749A3 (en) 2003-03-28
HU228340B1 HU228340B1 (en) 2013-03-28

Family

ID=8555263

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202749A HU228340B1 (en) 1999-09-10 2000-09-08 Pharmaceutical solutions of levosimendan

Country Status (39)

Country Link
US (2) US6730673B1 (hu)
EP (1) EP1210085B1 (hu)
JP (1) JP4708648B2 (hu)
KR (1) KR100869752B1 (hu)
CN (1) CN1203855C (hu)
AR (1) AR025449A1 (hu)
AT (1) ATE315937T1 (hu)
AU (1) AU771027B2 (hu)
BG (1) BG65827B1 (hu)
BR (1) BRPI0013924B8 (hu)
CA (1) CA2382013C (hu)
CO (1) CO5180582A1 (hu)
CZ (1) CZ303095B6 (hu)
DE (1) DE60025627T2 (hu)
DK (1) DK1210085T3 (hu)
EA (1) EA005067B1 (hu)
EE (1) EE05375B1 (hu)
ES (1) ES2256034T3 (hu)
FI (1) FI109659B (hu)
HK (1) HK1049282B (hu)
HR (1) HRP20020298B1 (hu)
HU (1) HU228340B1 (hu)
IL (2) IL148379A0 (hu)
IS (1) IS2244B (hu)
ME (1) ME00523B (hu)
MX (1) MXPA02002423A (hu)
MY (1) MY125984A (hu)
NO (1) NO331989B1 (hu)
NZ (1) NZ517605A (hu)
PL (1) PL202356B1 (hu)
PT (1) PT1210085E (hu)
RS (1) RS50445B (hu)
SI (1) SI1210085T1 (hu)
SK (1) SK287154B6 (hu)
TR (1) TR200200620T2 (hu)
TW (1) TWI242434B (hu)
UA (1) UA73954C2 (hu)
WO (1) WO2001019334A2 (hu)
ZA (1) ZA200201828B (hu)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI109659B (fi) * 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia
FI20010233A0 (fi) * 2001-02-08 2001-02-08 Orion Corp Menetelmä sydämen vajaatoiminnan hoitoon
CN100428937C (zh) * 2003-10-30 2008-10-29 北京海合天科技开发有限公司 左西孟旦冷冻干燥组合物
CN100367964C (zh) * 2004-04-29 2008-02-13 王思清 左西孟旦-β环糊精包含物制剂
US20070010518A1 (en) * 2005-02-18 2007-01-11 Matti Kivikko Method for administering levosimendan
WO2008082871A1 (en) * 2006-12-28 2008-07-10 Orion Corporation Formulations of levosimendan for parenteral administration
US10046081B2 (en) 2008-04-11 2018-08-14 The Henry M Jackson Foundation For The Advancement Of Military Medicine, Inc. Electrospun dextran fibers and devices formed therefrom
WO2012093404A2 (en) 2011-01-03 2012-07-12 Gufic Biosciences Limited Parenteral formulations of levosimendan
US20130096479A1 (en) * 2011-10-18 2013-04-18 St. Teresa Medical, Inc. Method of forming hemostatic products
CN104619345A (zh) * 2012-05-18 2015-05-13 罗达制药有限公司 液体制剂
CN105106113B (zh) * 2015-09-30 2019-07-26 济南康和医药科技有限公司 一种左西孟旦注射液及其制备方法
PT3370693T (pt) * 2015-11-06 2020-04-08 Carinopharm Gmbh Formulações melhoradas de levossimendano para administração intravenosa como infusão ou injeção e de concentrado de infusão
WO2017083050A1 (en) 2015-11-12 2017-05-18 St. Teresa Medical, Inc. A method of sealing a durotomy
CN108261398A (zh) * 2016-12-30 2018-07-10 齐鲁制药有限公司 一种含有左西孟旦的供注射用药物制剂及其制备方法
WO2019089717A1 (en) 2017-11-02 2019-05-09 St. Teresa Medical, Inc. Fibrin sealant products
CN111474289A (zh) * 2019-10-31 2020-07-31 武汉嘉诺康医药技术有限公司 一种利用反相色谱分离分析左西孟旦中右西孟旦的方法
JP2023507626A (ja) 2019-12-16 2023-02-24 テナックス・セラピューティクス，インコーポレイテッド 駆出率が保たれた心不全を伴う肺高血圧症（ＰＨ－ＨＦ－ｐＥＦ）を治療するためのレボシメンダン
CN111514147B (zh) * 2020-05-12 2021-09-17 成都欣捷高新技术开发股份有限公司 用于急性失代偿心力衰竭症状的左西孟旦钠药用组合物及制备方法
US11760730B2 (en) 2021-01-11 2023-09-19 Navinta, Llc Process for the preparation of high purity Levosimendan
TR2021013305A2 (tr) * 2021-08-23 2023-03-21 Tuem Ekip Ilac Anonim Sirketi Li̇yofi̇li̇ze levosi̇mendan formülasyonlari
CN115518037A (zh) * 2022-10-14 2022-12-27 上药东英（江苏）药业有限公司 一种安全质量稳定的左西孟旦注射剂组合物及其制备方法
CN116473930B (zh) * 2023-05-17 2023-12-15 山东泰合医药科技有限公司 一种注射用左西孟旦及其制备方法
CN117919246A (zh) * 2024-01-26 2024-04-26 重庆东得医药科技有限公司 一种以左西孟旦为活性成分的组合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2251615B (en) 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
GB9606474D0 (en) 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en) * 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
FI980902A7 (fi) * 1998-04-23 1999-10-24 Orion Yhtymae Oyj Levosimendaanin stabiileja koostumuksia
FI109659B (fi) * 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia

Also Published As

Publication number Publication date
TR200200620T2 (tr) 2002-09-23
FI19991925L (fi) 2001-03-10
MXPA02002423A (es) 2002-08-12
RS50445B (sr) 2010-03-02
ES2256034T3 (es) 2006-07-16
BR0013924A (pt) 2002-05-21
HU228340B1 (en) 2013-03-28
UA73954C2 (uk) 2005-10-17
US6730673B1 (en) 2004-05-04
ME00523B (me) 2011-10-10
NO331989B1 (no) 2012-05-21
IL148379A (en) 2006-12-10
AU771027B2 (en) 2004-03-11
DE60025627T2 (de) 2006-11-16
YU16902A (sh) 2004-09-03
IL148379A0 (en) 2002-09-12
HK1049282B (zh) 2005-12-30
SI1210085T1 (sl) 2006-04-30
US20040106617A1 (en) 2004-06-03
HK1049282A1 (en) 2003-05-09
EA200200348A1 (ru) 2002-08-29
JP2003509351A (ja) 2003-03-11
CA2382013A1 (en) 2001-03-22
MY125984A (en) 2006-09-29
AU7004400A (en) 2001-04-17
CN1373665A (zh) 2002-10-09
IS2244B (is) 2007-05-15
PT1210085E (pt) 2006-05-31
WO2001019334A2 (en) 2001-03-22
AR025449A1 (es) 2002-11-27
PL354028A1 (pl) 2003-12-15
NO20021090D0 (no) 2002-03-05
ZA200201828B (en) 2003-08-27
DK1210085T3 (da) 2006-05-08
CA2382013C (en) 2009-08-11
DE60025627D1 (de) 2006-04-06
EP1210085A2 (en) 2002-06-05
JP4708648B2 (ja) 2011-06-22
IS6296A (is) 2002-03-06
CO5180582A1 (es) 2002-07-30
TWI242434B (en) 2005-11-01
US6943164B2 (en) 2005-09-13
KR20020048400A (ko) 2002-06-22
BG106589A (bg) 2002-11-29
SK287154B6 (sk) 2010-01-07
BR0013924B1 (pt) 2013-09-24
FI109659B (fi) 2002-09-30
KR100869752B1 (ko) 2008-11-21
SK3272002A3 (en) 2002-12-03
NZ517605A (en) 2003-08-29
BRPI0013924B8 (pt) 2021-05-25
HUP0202749A2 (hu) 2003-02-28
HRP20020298B1 (hr) 2007-02-28
CZ303095B6 (cs) 2012-03-28
ATE315937T1 (de) 2006-02-15
CN1203855C (zh) 2005-06-01
EE05375B1 (et) 2011-02-15
EA005067B1 (ru) 2004-10-28
CZ2002788A3 (cs) 2002-11-13
HRP20020298A2 (en) 2003-06-30
NO20021090L (no) 2002-03-05
PL202356B1 (pl) 2009-06-30
EE200200129A (et) 2003-04-15
BG65827B1 (bg) 2010-02-26
EP1210085B1 (en) 2006-01-18
WO2001019334A3 (en) 2001-11-15

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: ORION CORPORATION ID NO.1999212-6, FI

Free format text: FORMER OWNER(S): ORION CORP., FI