HUP0201712A3 - Clot associated coagulation factors inhibiting heparin compositions - Google Patents

Clot associated coagulation factors inhibiting heparin compositions

Info

Publication number
HUP0201712A3
HUP0201712A3 HU0201712A HUP0201712A HUP0201712A3 HU P0201712 A3 HUP0201712 A3 HU P0201712A3 HU 0201712 A HU0201712 A HU 0201712A HU P0201712 A HUP0201712 A HU P0201712A HU P0201712 A3 HUP0201712 A3 HU P0201712A3
Authority
HU
Hungary
Prior art keywords
coagulation factors
associated coagulation
factors inhibiting
heparin compositions
clot associated
Prior art date
Application number
HU0201712A
Other languages
English (en)
Original Assignee
Weitz Jeffrey I Ancaster
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Weitz Jeffrey I Ancaster filed Critical Weitz Jeffrey I Ancaster
Publication of HUP0201712A2 publication Critical patent/HUP0201712A2/hu
Publication of HUP0201712A3 publication Critical patent/HUP0201712A3/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078Degradation products
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
HU0201712A 1999-06-30 2000-06-29 Clot associated coagulation factors inhibiting heparin compositions HUP0201712A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14186599P 1999-06-30 1999-06-30
US15474499P 1999-09-17 1999-09-17

Publications (2)

Publication Number Publication Date
HUP0201712A2 HUP0201712A2 (en) 2002-10-28
HUP0201712A3 true HUP0201712A3 (en) 2003-03-28

Family

ID=26839527

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0201712A HUP0201712A3 (en) 1999-06-30 2000-06-29 Clot associated coagulation factors inhibiting heparin compositions

Country Status (16)

Country Link
US (1) US20080119438A1 (hu)
EP (1) EP1192187A1 (hu)
JP (1) JP2003504428A (hu)
KR (1) KR20020032444A (hu)
CN (1) CN1371391A (hu)
AU (1) AU782661B2 (hu)
BR (1) BR0012202A (hu)
CA (1) CA2377734A1 (hu)
CZ (1) CZ20014665A3 (hu)
HK (1) HK1045532A1 (hu)
HU (1) HUP0201712A3 (hu)
IL (1) IL147318A0 (hu)
MX (1) MXPA02000142A (hu)
NZ (1) NZ516229A (hu)
PL (1) PL353335A1 (hu)
WO (1) WO2001002443A1 (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES512091A0 (es) * 1981-05-12 1984-07-16 Common Sense Products Pty Ltd Perfeccionamientos introducidos en recintos resistentes a la intemperie para aparatos electricos utilizados en aparcamientos puertos, viviendas y similares.
RU2322245C2 (ru) * 2000-01-10 2008-04-20 Дитер ВЕЛЬЦЕЛЬ Гепарин со средней молекулярной массой
JP2005505537A (ja) * 2001-08-28 2005-02-24 レオ・ファーマ・アクティーゼルスカブ 低分子量ヘパリンと低分子量デルマタン硫酸とを含む抗血栓組成物
AU2003303301B2 (en) 2002-05-03 2008-08-07 Massachusetts Institute Of Technology Delta4,5 glycuronidase and uses thereof
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
RU2451515C2 (ru) * 2006-05-25 2012-05-27 Момента Фармасьютикал, Инк. Композиции гепарина низкой молекулярной массы и их применение
CA2652205A1 (en) * 2006-05-25 2007-12-06 Mallik Sundaram Low molecular weight heparin composition and uses thereof
DE102006036326A1 (de) * 2006-08-03 2008-02-07 Charité - Universitätsmedizin Berlin Dendritische Polyglycerolsulfate und -sulfonate und deren Verwendung bei entzündlichen Erkrankungen
EP2256137A1 (en) * 2009-05-05 2010-12-01 Sanofi-Aventis Novel sulfated octasaccharide and its use as antithrombotic agent
EP2256136A1 (en) * 2009-05-05 2010-12-01 Sanofi-Aventis Novel acylated decasaccharides and their use as antithrombotic agents
KR100971551B1 (ko) * 2010-04-29 2010-07-21 (주)안세기술 항공 및 해상 교통관제시스템 운용에 최적화된 다용도 스트립 프린터
CN104144950B (zh) * 2011-12-19 2017-09-05 迪乐方有限责任公司 含有重复的二糖单元的非抗凝的葡糖胺聚糖及其医药用途
WO2013095215A1 (en) * 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
EP3348270A1 (en) * 2017-01-11 2018-07-18 Fytagoras B.V. Medium molecular weight heparin
CN108424474B (zh) * 2017-02-15 2023-07-25 清华大学 去抗凝肝素衍生物及其用于炎症性肠病的治疗
EP3581189A1 (en) * 2018-06-14 2019-12-18 Fytagoras B.V. Medium molecular weight heparin for treatment and secondary prevention of ischemic stroke
GB202106972D0 (en) * 2021-05-14 2021-06-30 Bhogal Pervinder Singh Medium molecular weight heparin

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766167A (en) * 1971-03-26 1973-10-16 Research Corp Orally active anticoagulant
US4500519A (en) * 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
US4692435A (en) * 1978-11-06 1987-09-08 Choay, S.A. Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4826827A (en) * 1979-10-05 1989-05-02 Choay S.A. Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
DE3265781D1 (en) * 1981-05-21 1985-10-03 Akzo Nv New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
US4396762A (en) * 1981-08-24 1983-08-02 Massachusetts Institute Of Technology Heparinase derived anticoagulants
CA1195322A (en) * 1982-07-19 1985-10-15 Eduardo Amaya Process for manufacturing low molecular weight heparins by depolymerization of normal heparin
FR2538404B1 (hu) * 1982-12-28 1985-08-23 Anic Spa
US4948881A (en) * 1982-12-28 1990-08-14 Sanofi Process for the depolymerization and sulfation of polysaccharides
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
US4687765A (en) * 1983-07-25 1987-08-18 Choay S.A. Method and composition for thrombolytic treatment
FR2568774B2 (fr) * 1984-05-30 1989-05-19 Choay Sa Medicaments favorisant les proprietes d'ecoulement du sang et leur utilisation en therapeutique
IT1208509B (it) * 1985-03-13 1989-07-10 Mediolanum Farmaceutici Srl Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.
US4916219A (en) * 1985-03-28 1990-04-10 University Of Iowa Research Foundation Oligosaccharide heparin fragments as inhibitors of complement cascade
IT1214609B (it) * 1985-05-17 1990-01-18 Opocrin Spa Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
US5106734A (en) * 1986-04-30 1992-04-21 Novo Nordisk A/S Process of using light absorption to control enzymatic depolymerization of heparin to produce low molecular weight heparin
DK196886D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
US4745107A (en) * 1986-08-20 1988-05-17 Foley Kevin M Heparin derivatives with improved permeability
US4745106A (en) * 1986-08-20 1988-05-17 Griffin Charles C Heparin derivatives having improved anti-Xa specificity
US4745105A (en) * 1986-08-20 1988-05-17 Griffin Charles C Low molecular weight heparin derivatives with improved permeability
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
EP0300099A1 (en) * 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US4981955A (en) * 1988-06-28 1991-01-01 Lopez Lorenzo L Depolymerization method of heparin
GB8826448D0 (en) * 1988-11-11 1988-12-14 Thrombosis Res Inst Improvements in/relating to organic compounds
US5380716A (en) * 1988-12-15 1995-01-10 Glycomed, Inc. Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation
US5382570A (en) * 1990-04-23 1995-01-17 Akzo, N.V. Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type
US5378829A (en) * 1990-04-23 1995-01-03 Akzo N.V. Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
IT1245761B (it) * 1991-01-30 1994-10-14 Alfa Wassermann Spa Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.
US5280016A (en) * 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
US5250519A (en) * 1991-03-29 1993-10-05 Glycomed Incorporated Non-anticoagulant heparin derivatives
SE9101155D0 (sv) * 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
SK120193A3 (en) * 1991-05-02 1994-07-06 Yeda Res & Dev Pharmaceutical composition for the prevention and/or treatment of pathological processes
IT1245907B (it) * 1991-05-17 1994-10-25 Alfa Wassermann Spa Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica.
US5849721A (en) * 1992-02-07 1998-12-15 Rhone-Poulenc Rorer S.A. Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
IT1264530B (it) * 1992-07-31 1996-10-02 Crinos Industria Farmaco Impiego dei polisaccaridi nelle neuropatie atrofico degenerative
SE9302135D0 (sv) * 1993-06-18 1993-06-18 Kabi Pharmacia Ab New pharmaceutical composition
IT1264709B1 (it) * 1993-07-12 1996-10-04 Italfarmaco Spa Derivati eparinici ad attivita' antimetastatica
US5583121A (en) * 1994-01-12 1996-12-10 Michigan State University Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
US6127347A (en) * 1994-01-12 2000-10-03 Univ Michigan Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
FR2718849B1 (fr) * 1994-04-14 1996-06-14 Pasteur Sanofi Diagnostics Procédé d'immunodosage de l'antithrombine III activée par un glycosaminoglycane, anticorps monoclonaux correspondants et leur procédé d'obtention.
US5681733A (en) * 1994-06-10 1997-10-28 Ibex Technologies Nucleic acid sequences and expression systems for heparinase II and heparinase III derived from Flavobacterium heparinum
US5639469A (en) * 1994-06-15 1997-06-17 Minnesota Mining And Manufacturing Company Transmucosal delivery system
IL114955A (en) * 1994-08-17 1999-12-22 Novo Nordisk As N-substituted naphthofused lactams and pharmaceutical compositions containing them
IT1274351B (it) * 1994-10-06 1997-07-17 Alfa Wassermann Spa Uso di alcuni glicosaminoglicani nella dialisi peritoneale.
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5922690A (en) * 1996-04-25 1999-07-13 Van Gorp; Cornelius L. Dermatan disulfate, an inhibitor of thrombin generation and activation
IL120722A (en) * 1996-05-08 1999-07-14 Akzo Nobel Nv Polysulfated tetrasaccharide derivatives and pharmaceutical compositions containing them
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
US5741881A (en) * 1996-11-25 1998-04-21 Meadox Medicals, Inc. Process for preparing covalently bound-heparin containing polyurethane-peo-heparin coating compositions
HUP9903496A3 (en) * 1996-11-27 2001-03-28 Aventis Pharmaceuticals Inc Co Pharmaceutical composition comprising a compound having anti-xa activity and a platelet aggregation antagonist compound
US6075013A (en) * 1997-06-06 2000-06-13 Hamilton Civic Hospitals Research Development Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors

Also Published As

Publication number Publication date
MXPA02000142A (es) 2003-07-21
CN1371391A (zh) 2002-09-25
IL147318A0 (en) 2002-08-14
HK1045532A1 (zh) 2002-11-29
BR0012202A (pt) 2002-04-02
CZ20014665A3 (cs) 2002-05-15
JP2003504428A (ja) 2003-02-04
CA2377734A1 (en) 2001-01-11
HUP0201712A2 (en) 2002-10-28
KR20020032444A (ko) 2002-05-03
NZ516229A (en) 2004-08-27
EP1192187A1 (en) 2002-04-03
AU782661B2 (en) 2005-08-18
PL353335A1 (en) 2003-11-17
AU5668200A (en) 2001-01-22
WO2001002443A1 (en) 2001-01-11
US20080119438A1 (en) 2008-05-22

Similar Documents

Publication Publication Date Title
HUP0201712A3 (en) Clot associated coagulation factors inhibiting heparin compositions
HUP0202797A3 (en) Compositions having improved stability
GB9908302D0 (en) Organosiloxane compositions
GB2352103B (en) Amplitude calculation circuit
HUP0105279A3 (en) Compositions having improved stability
GB2342357B (en) Amphiphilic heparin derivatives
GB9904049D0 (en) Rapidly-soluble compositions
DE29901601U1 (de) Schaltschrank
GB9915345D0 (en) Detergent compositions or components
GB0029012D0 (en) Dishwasher
PL343095A1 (en) Paroxetine compositions
GB9904939D0 (en) Polymer compositions
DE29901776U1 (de) Schaltschrank
GB9915442D0 (en) Molecular sieve compositions
DE29810323U1 (de) Schaltschrank
ZA200110525B (en) Heparin compositions that inhibit clot associated coagulation factors.
EP1185278A4 (en) FIBRINPOLYMERSTRUKTUR
GB2356131B (en) Dishwasher
DE29805235U1 (de) Schaltschrank
EP1189618A4 (en) thrombin
DE29823349U1 (de) Schaltschrank
GB9903924D0 (en) Cosmectic compositions
GB9904931D0 (en) Compositions
GB9905474D0 (en) Detergent compositions or components
DE29821865U1 (de) Schaltschrank

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees