HUP0002265A2 - Eljárás plazmafehérjét tartalmazó gyógyszer előállítására - Google Patents
Eljárás plazmafehérjét tartalmazó gyógyszer előállításáraInfo
- Publication number
- HUP0002265A2 HUP0002265A2 HU0002265A HUP0002265A HUP0002265A2 HU P0002265 A2 HUP0002265 A2 HU P0002265A2 HU 0002265 A HU0002265 A HU 0002265A HU P0002265 A HUP0002265 A HU P0002265A HU P0002265 A2 HUP0002265 A2 HU P0002265A2
- Authority
- HU
- Hungary
- Prior art keywords
- plasma protein
- citrate
- plasma
- producing
- containing medicament
- Prior art date
Links
- 102000004506 Blood Proteins Human genes 0.000 title abstract 5
- 108010017384 Blood Proteins Proteins 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 3
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 150000002739 metals Chemical class 0.000 abstract 2
- 150000001860 citric acid derivatives Chemical class 0.000 abstract 1
- 150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000002763 monocarboxylic acids Chemical class 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Marine Sciences & Fisheries (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány tárgya eljárás plazmafehérjét tartalmazó, nemkívánatosfémektől lényegében mentes gyógyszer citrátplazmából vagycitráttartalmú plazmafrakcióból történő előállítására, amely akövetkező lépéseket tartalmazza: - plazmafehérjét tartalmazó oldatban lévő citrátok és adott esetbencitráthoz kötött fémek kicserélése vízoldható mono- vagydikarboxilátokra, illetve szerves mono- vagy dikarbonsavakra,csapadékképződést elő nem idéző körülmények között, - a plazmafehérje vagy a plazmafehérjék kinyerése és - a gyógyszer elkészítése. Ó
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0163396A AT403989B (de) | 1996-09-16 | 1996-09-16 | Verfahren zur herstellung eines plasmaprotein-hältigen arzneimittels |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0002265A2 true HUP0002265A2 (hu) | 2000-11-28 |
HUP0002265A3 HUP0002265A3 (en) | 2003-01-28 |
Family
ID=3517640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0002265A HUP0002265A3 (en) | 1996-09-16 | 1997-09-10 | Process for producing a plasma protein-containing medicament |
Country Status (24)
Country | Link |
---|---|
US (3) | US20020034809A1 (hu) |
EP (1) | EP0927195B1 (hu) |
JP (1) | JP2001500867A (hu) |
KR (1) | KR20000036002A (hu) |
CN (1) | CN1230967A (hu) |
AR (1) | AR009582A1 (hu) |
AT (2) | AT403989B (hu) |
AU (1) | AU732519B2 (hu) |
BR (1) | BR9712044A (hu) |
CA (1) | CA2265936C (hu) |
CZ (1) | CZ91199A3 (hu) |
DE (1) | DE59710700D1 (hu) |
DK (1) | DK0927195T3 (hu) |
ES (1) | ES2206701T3 (hu) |
HU (1) | HUP0002265A3 (hu) |
ID (1) | ID21224A (hu) |
IL (1) | IL128770A0 (hu) |
IN (1) | IN187314B (hu) |
MX (1) | MXPA99002144A (hu) |
NO (1) | NO991198L (hu) |
PL (1) | PL332159A1 (hu) |
PT (1) | PT927195E (hu) |
SK (1) | SK32899A3 (hu) |
WO (1) | WO1998012225A2 (hu) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2103236B1 (es) * | 1996-01-30 | 1998-04-16 | Grifols Grupo Sa | Albumina humana terapeutica con baja capacidad para la fijacion de aluminio. |
AT407484B (de) * | 1997-11-12 | 2001-03-26 | Bio Prod & Bio Eng Ag | Arzneimittel zur förderung der wundheilung |
AT408946B (de) * | 1999-02-18 | 2002-04-25 | Immuno Ag | Verwendung von orosomucoid zur herstellung einer pharmazeutischen präparation |
JP2003040798A (ja) * | 2001-07-26 | 2003-02-13 | Nihon Pharmaceutical Co Ltd | 低アルミニウム含有アルブミン製剤およびその製造法 |
EP1458408B1 (en) | 2001-12-21 | 2009-04-15 | Novo Nordisk Health Care AG | Liquid composition of factor vii polypeptides |
AT501088A2 (de) * | 2002-12-18 | 2006-06-15 | Bio Prod & Bio Eng Ag | Stabile therapeutische proteine |
US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
WO2004103398A1 (en) * | 2003-05-23 | 2004-12-02 | Novo Nordisk Health Care Ag | Protein stabilization in solution |
KR20120104619A (ko) | 2003-08-14 | 2012-09-21 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 인자 vii 폴리펩티드의 액상 수성 약학적 조성물 |
ES2294976B1 (es) * | 2007-11-12 | 2008-12-16 | Grifols, S.A. | "procedimiento de obtencion de albumina humana de alta eficacia para su uso en terapia de detoxificacion". |
KR20210134808A (ko) | 2011-12-05 | 2021-11-10 | 팩터 바이오사이언스 인크. | 세포를 형질감염시키는 방법들 및 생성물들 |
ES2381828B1 (es) * | 2012-03-20 | 2012-11-16 | Grifols, S.A. | PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO |
EP3668985B1 (en) | 2017-08-17 | 2021-06-16 | Just-Evotec Biologics, Inc. | Method of purifying glycosylated protein from host cell galectins and other contaminants |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE384134C (de) * | 1921-05-07 | 1923-10-25 | Chemisch Pharmazeutische Werke | Verfahren zur Herstellung eines Kamillenextraktes |
DE2331854A1 (de) * | 1973-06-22 | 1975-01-16 | Greither Salus Haus Dr Otto | Verfahren zur herstellung standardisierter arzneimittel aus kamillenblueten |
FR2630115B1 (fr) | 1988-04-14 | 1994-10-28 | Merieux Inst | Procede de stabilisation des solutions d'albumine humaine et solution obtenue |
SE500110C2 (sv) * | 1989-06-27 | 1994-04-18 | Kabi Pharmacia Ab | Sätt att rena ett protein från därtill bundna flervärda metalljoner |
US5250663A (en) * | 1990-04-19 | 1993-10-05 | Miles Inc. | Preparing essentially monomeric normal human serum albumin |
JP2949846B2 (ja) | 1990-11-30 | 1999-09-20 | 吉富製薬株式会社 | アルブミン製剤の保存方法 |
US5561115A (en) | 1994-08-10 | 1996-10-01 | Bayer Corporation | Low temperature albumin fractionation using sodium caprylate as a partitioning agent |
ES2103236B1 (es) | 1996-01-30 | 1998-04-16 | Grifols Grupo Sa | Albumina humana terapeutica con baja capacidad para la fijacion de aluminio. |
US5744586A (en) * | 1996-06-26 | 1998-04-28 | Alpha Therapeutic Corporation | Manufacturing process for the production of purified transferrin |
US5886154A (en) | 1997-06-20 | 1999-03-23 | Lebing; Wytold R. | Chromatographic method for high yield purification and viral inactivation of antibodies |
-
1996
- 1996-09-16 AT AT0163396A patent/AT403989B/de not_active IP Right Cessation
-
1997
- 1997-09-10 ID IDW990038A patent/ID21224A/id unknown
- 1997-09-10 BR BR9712044A patent/BR9712044A/pt not_active IP Right Cessation
- 1997-09-10 JP JP10514063A patent/JP2001500867A/ja not_active Ceased
- 1997-09-10 KR KR1019997001958A patent/KR20000036002A/ko not_active Application Discontinuation
- 1997-09-10 MX MXPA99002144A patent/MXPA99002144A/es not_active Application Discontinuation
- 1997-09-10 EP EP97918834A patent/EP0927195B1/de not_active Expired - Lifetime
- 1997-09-10 PL PL97332159A patent/PL332159A1/xx unknown
- 1997-09-10 US US09/254,288 patent/US20020034809A1/en not_active Abandoned
- 1997-09-10 DK DK97918834T patent/DK0927195T3/da active
- 1997-09-10 AU AU42899/97A patent/AU732519B2/en not_active Expired
- 1997-09-10 CZ CZ99911A patent/CZ91199A3/cs unknown
- 1997-09-10 WO PCT/AT1997/000197 patent/WO1998012225A2/de not_active Application Discontinuation
- 1997-09-10 SK SK328-99A patent/SK32899A3/sk unknown
- 1997-09-10 ES ES97918834T patent/ES2206701T3/es not_active Expired - Lifetime
- 1997-09-10 CA CA002265936A patent/CA2265936C/en not_active Expired - Fee Related
- 1997-09-10 CN CN97197989A patent/CN1230967A/zh active Pending
- 1997-09-10 AT AT97918834T patent/ATE248857T1/de active
- 1997-09-10 HU HU0002265A patent/HUP0002265A3/hu unknown
- 1997-09-10 DE DE59710700T patent/DE59710700D1/de not_active Expired - Lifetime
- 1997-09-10 IL IL12877097A patent/IL128770A0/xx unknown
- 1997-09-10 PT PT97918834T patent/PT927195E/pt unknown
- 1997-09-15 IN IN2622DE1997 patent/IN187314B/en unknown
- 1997-09-16 AR ARP970104234A patent/AR009582A1/es unknown
-
1999
- 1999-03-11 NO NO991198A patent/NO991198L/no not_active Application Discontinuation
-
2005
- 2005-06-14 US US11/151,295 patent/US8709492B2/en not_active Expired - Lifetime
-
2014
- 2014-04-29 US US14/264,369 patent/US20140234292A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2265936A1 (en) | 1998-03-26 |
NO991198L (no) | 1999-05-14 |
DE59710700D1 (de) | 2003-10-09 |
ES2206701T3 (es) | 2004-05-16 |
EP0927195B1 (de) | 2003-09-03 |
EP0927195A2 (de) | 1999-07-07 |
ATA163396A (de) | 1997-12-15 |
CA2265936C (en) | 2008-04-22 |
ATE248857T1 (de) | 2003-09-15 |
BR9712044A (pt) | 1999-08-24 |
HUP0002265A3 (en) | 2003-01-28 |
US8709492B2 (en) | 2014-04-29 |
IL128770A0 (en) | 2000-01-31 |
KR20000036002A (ko) | 2000-06-26 |
PT927195E (pt) | 2004-01-30 |
US20050249815A1 (en) | 2005-11-10 |
MXPA99002144A (es) | 2005-04-28 |
CN1230967A (zh) | 1999-10-06 |
NO991198D0 (no) | 1999-03-11 |
US20020034809A1 (en) | 2002-03-21 |
IN187314B (hu) | 2002-03-23 |
JP2001500867A (ja) | 2001-01-23 |
AU4289997A (en) | 1998-04-14 |
SK32899A3 (en) | 1999-08-06 |
CZ91199A3 (cs) | 1999-06-16 |
PL332159A1 (en) | 1999-08-30 |
AR009582A1 (es) | 2000-04-26 |
ID21224A (id) | 1999-05-06 |
WO1998012225A2 (de) | 1998-03-26 |
US20140234292A1 (en) | 2014-08-21 |
AU732519B2 (en) | 2001-04-26 |
AT403989B (de) | 1998-07-27 |
WO1998012225A3 (de) | 1998-04-23 |
DK0927195T3 (da) | 2003-11-24 |
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