HUP0000572A2 - Nukleotid analógot tartalmazó gyógyszerkészítmények és eljárás előállításukra - Google Patents

Nukleotid analógot tartalmazó gyógyszerkészítmények és eljárás előállításukra

Info

Publication number
HUP0000572A2
HUP0000572A2 HU0000572A HUP0000572A HUP0000572A2 HU P0000572 A2 HUP0000572 A2 HU P0000572A2 HU 0000572 A HU0000572 A HU 0000572A HU P0000572 A HUP0000572 A HU P0000572A HU P0000572 A2 HUP0000572 A2 HU P0000572A2
Authority
HU
Hungary
Prior art keywords
preparing
pharmaceutical compositions
compositions containing
nucleotide analogs
containing nucleotide
Prior art date
Application number
HU0000572A
Other languages
English (en)
Inventor
Chris Bland
Gerald Steele
Original Assignee
Astra Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharmaceuticals Ltd. filed Critical Astra Pharmaceuticals Ltd.
Publication of HUP0000572A2 publication Critical patent/HUP0000572A2/hu
Publication of HUP0000572A3 publication Critical patent/HUP0000572A3/hu
Publication of HU226616B1 publication Critical patent/HU226616B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A találmány tárgyát fagyasztva szárításra alkalmasgyógyszerkészítmény, amelynek összetevői egy általános képletű nukleotid analóg - ahol R1 és R2 hidrogén- vagyhalogénatom, R3 és R4 fenil- vagy adott esetben szubsztituáltalkilcsoport; és X egy savas tulajdonságú csoport - és mannit, valamint módosító adalékanyagként nátrium-klorid vagy egypoliol, továbbá az előállítására szolgáló eljárás képezi. Ó
HU0000572A 1996-12-20 1997-12-11 Pharmaceutical compositions suitable fer freeze drying comprising nucleotide analogs and process for preparing them HU226616B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9604795A SE9604795D0 (sv) 1996-12-20 1996-12-20 New pharmaceutical formulation
PCT/SE1997/002068 WO1998028009A1 (en) 1996-12-20 1997-12-11 Pharmaceutical compositions for freeze drying

Publications (3)

Publication Number Publication Date
HUP0000572A2 true HUP0000572A2 (hu) 2001-05-28
HUP0000572A3 HUP0000572A3 (en) 2002-10-28
HU226616B1 HU226616B1 (en) 2009-04-28

Family

ID=20405148

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000572A HU226616B1 (en) 1996-12-20 1997-12-11 Pharmaceutical compositions suitable fer freeze drying comprising nucleotide analogs and process for preparing them

Country Status (36)

Country Link
US (1) US6114313A (hu)
EP (1) EP1007094B1 (hu)
JP (1) JP4488538B2 (hu)
KR (1) KR100552880B1 (hu)
CN (1) CN1121875C (hu)
AR (1) AR010377A1 (hu)
AT (1) ATE221787T1 (hu)
AU (1) AU758857B2 (hu)
BR (1) BR9713974B1 (hu)
CA (1) CA2275153C (hu)
CZ (1) CZ300635B6 (hu)
DE (1) DE69714616T2 (hu)
DK (1) DK1007094T3 (hu)
EE (1) EE03857B1 (hu)
ES (1) ES2182133T3 (hu)
FR (1) FR15C0060I2 (hu)
HK (1) HK1026366A1 (hu)
HU (1) HU226616B1 (hu)
ID (1) ID21635A (hu)
IL (1) IL130449A0 (hu)
IS (1) IS1897B (hu)
MY (1) MY121982A (hu)
NO (1) NO327142B1 (hu)
NZ (1) NZ336027A (hu)
PL (1) PL190493B1 (hu)
PT (1) PT1007094E (hu)
RU (1) RU2205012C2 (hu)
SA (1) SA97180719B1 (hu)
SE (1) SE9604795D0 (hu)
SI (1) SI1007094T1 (hu)
SK (1) SK283137B6 (hu)
TR (1) TR199901412T2 (hu)
TW (1) TW522015B (hu)
UA (1) UA66779C2 (hu)
WO (1) WO1998028009A1 (hu)
ZA (1) ZA9711055B (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9702680D0 (sv) * 1997-07-11 1997-07-11 Astra Pharma Prod New formulation
WO2009140092A1 (en) 2008-05-13 2009-11-19 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US8759316B2 (en) 2008-05-13 2014-06-24 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US9427448B2 (en) 2009-11-11 2016-08-30 The Medicines Company Methods of treating, reducing the incidence of, and/or preventing ischemic events
US20120141468A1 (en) 2008-05-13 2012-06-07 Lisa Ruderman Chen Maintenance of platelet inhibition during antiplatelet therapy
US20130303477A1 (en) 2008-05-13 2013-11-14 The Medicines Company Maintenance of Platelet Inhibition During Antiplatelet Therapy
US10376532B2 (en) 2009-11-11 2019-08-13 Chiesi Farmaceutici, S.P.A. Methods of treating, reducing the incidence of, and/or preventing ischemic events
CA2778880C (en) 2009-11-11 2018-02-13 The Medicines Company Methods of treating or preventing stent thrombosis
EP2672975B1 (en) 2011-02-09 2016-04-20 The Medicines Company Methods for treating pulmonary hypertension
ES2904256T3 (es) 2013-03-09 2022-04-04 Chiesi Farm Spa Métodos para tratar, reducir la incidencia de y/o prevenir eventos isquémicos
CN103772461A (zh) * 2014-01-06 2014-05-07 南京正科制药有限公司 一种坎格雷洛晶型ⅰ
KR102440847B1 (ko) 2015-01-14 2022-09-06 키에시 파르마슈티시 엣스. 피. 에이. 고순도의 칸그렐러를 포함하는 약제학적 제제, 및 이들의 제조 및 사용 방법
BR112019022676A2 (pt) 2017-06-23 2020-05-19 Chiesi Farm Spa método de prevenção de trombose de derivação da artéria sistêmica-para-pulmonar

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5637967B2 (hu) * 1973-05-17 1981-09-03
JPH01228915A (ja) * 1988-03-09 1989-09-12 Dai Ichi Seiyaku Co Ltd Ａｔｐ凍結乾燥製剤
GB8903593D0 (en) * 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
CZ281415B6 (cs) * 1989-11-09 1996-09-11 Masarykova Nemocnice S Poliklinikou Iii. Typu Způsob přípravy přenosového faktoru z buffy coatu savčí krve
GB9010742D0 (en) * 1990-05-14 1990-07-04 Quadrant Bioresources Ltd Stabilization of biological macromolecular substances
AU659645B2 (en) * 1991-06-26 1995-05-25 Inhale Therapeutic Systems Storage of materials
EP0619119B1 (en) * 1991-12-09 1999-03-31 Asahi Kasei Kogyo Kabushiki Kaisha Stabilized parathyroid hormone composition

Also Published As

Publication number Publication date
FR15C0060I1 (hu) 2015-10-23
EP1007094A1 (en) 2000-06-14
JP2001507022A (ja) 2001-05-29
ATE221787T1 (de) 2002-08-15
CZ220199A3 (cs) 1999-11-17
BR9713974A (pt) 2000-04-11
KR100552880B1 (ko) 2006-02-20
SK76499A3 (en) 1999-11-08
SE9604795D0 (sv) 1996-12-20
PL334006A1 (en) 2000-01-31
NZ336027A (en) 2001-03-30
CZ300635B6 (cs) 2009-07-08
PT1007094E (pt) 2002-12-31
CN1240362A (zh) 2000-01-05
SK283137B6 (sk) 2003-03-04
EE9900260A (et) 2000-02-15
RU2205012C2 (ru) 2003-05-27
UA66779C2 (uk) 2004-06-15
ID21635A (id) 1999-07-08
ES2182133T3 (es) 2003-03-01
AU5351598A (en) 1998-07-17
DE69714616D1 (de) 2002-09-12
NO327142B1 (no) 2009-05-04
TR199901412T2 (xx) 1999-08-23
SI1007094T1 (en) 2003-02-28
IS5064A (is) 1999-06-03
EE03857B1 (et) 2002-10-15
AR010377A1 (es) 2000-06-07
MY121982A (en) 2006-03-31
HK1026366A1 (en) 2000-12-15
SA97180719B1 (ar) 2006-05-13
KR20000069598A (ko) 2000-11-25
AU758857B2 (en) 2003-04-03
ZA9711055B (en) 1998-07-08
IS1897B (is) 2003-10-20
DE69714616T2 (de) 2003-04-03
EP1007094B1 (en) 2002-08-07
WO1998028009A1 (en) 1998-07-02
PL190493B1 (pl) 2005-12-30
NO993067D0 (no) 1999-06-21
BR9713974B1 (pt) 2010-02-23
HUP0000572A3 (en) 2002-10-28
IL130449A0 (en) 2000-06-01
FR15C0060I2 (fr) 2016-04-22
TW522015B (en) 2003-03-01
JP4488538B2 (ja) 2010-06-23
CA2275153A1 (en) 1998-07-02
US6114313A (en) 2000-09-05
NO993067L (no) 1999-08-09
CA2275153C (en) 2008-03-25
DK1007094T3 (da) 2002-10-28
CN1121875C (zh) 2003-09-24
HU226616B1 (en) 2009-04-28

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Legal Events

Date Code Title Description
FH91 Appointment of a representative

Free format text: FORMER REPRESENTATIVE(S): RATHONYI ZOLTAN, S.B.G. & K. BUDAPESTI NEMZETKOEZI SZABADALMI IRODA, HU

Representative=s name: RATHONYI ZOLTAN, S.B.G. & K. BUDAPESTI NEMZETK, HU

FH92 Termination of representative

Representative=s name: RATHONYI ZOLTAN, S.B.G. & K. BUDAPESTI NEMZETK, HU

GB9A Succession in title

Owner name: ASTRAZENECA UK LIMITED, GB

Free format text: FORMER OWNER(S): ASTRA PHARMACEUTICALS LTD., GB