CY1106545T1 - Ετεροκυκλικες ενωσεις, μεθοδος παρασκευης τους και φαρμακευτικες συνθεσεις που τις περιεχουν - Google Patents

Ετεροκυκλικες ενωσεις, μεθοδος παρασκευης τους και φαρμακευτικες συνθεσεις που τις περιεχουν

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Publication number
CY1106545T1
CY1106545T1 CY20071100565T CY071100565T CY1106545T1 CY 1106545 T1 CY1106545 T1 CY 1106545T1 CY 20071100565 T CY20071100565 T CY 20071100565T CY 071100565 T CY071100565 T CY 071100565T CY 1106545 T1 CY1106545 T1 CY 1106545T1
Authority
CY
Cyprus
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
heterocyclic compounds
description
Prior art date
Application number
CY20071100565T
Other languages
English (en)
Inventor
Gérald Guillaumet
Marie-Claude Viaud
Ahmed Mamai
Isabelle Charton
Pierre Renard
Caroline Bennejean
Beatrice Guardiola
Philippe Daubos
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of CY1106545T1 publication Critical patent/CY1106545T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings

Abstract

Η εφεύρεση αφορά τις ενώσεις του τύπου (I), στον οποίο: τα R1, R2 και R3 είναι τέτοια όπως ορίσθηκαν στην περιγραφή, το Χ είναι τέτοιο όπως ορίστηκε στην περιγραφή, το Υ παριστάνει άτομο οξυγόνου, άτομο θείου, ομάδα CHq, SO ή SO2, το n ισούται με 0 έως 5, το Α παριστάνει ομάδα NR5R6 ή CZNR8R9. Φάρμακα.
CY20071100565T 1997-05-16 2007-04-26 Ετεροκυκλικες ενωσεις, μεθοδος παρασκευης τους και φαρμακευτικες συνθεσεις που τις περιεχουν CY1106545T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9706019A FR2763335B1 (fr) 1997-05-16 1997-05-16 Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1998/000954 WO1998052935A1 (fr) 1997-05-16 1998-05-14 Composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
CY1106545T1 true CY1106545T1 (el) 2012-01-25

Family

ID=9506957

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100565T CY1106545T1 (el) 1997-05-16 2007-04-26 Ετεροκυκλικες ενωσεις, μεθοδος παρασκευης τους και φαρμακευτικες συνθεσεις που τις περιεχουν

Country Status (21)

Country Link
US (2) US6313160B1 (el)
EP (1) EP0998471B1 (el)
JP (1) JP2002510290A (el)
CN (1) CN1139584C (el)
AT (1) ATE356814T1 (el)
AU (1) AU741753B2 (el)
BR (1) BR9809643A (el)
CA (1) CA2289599C (el)
CY (1) CY1106545T1 (el)
DE (1) DE69837334T2 (el)
DK (1) DK0998471T3 (el)
ES (1) ES2285775T3 (el)
FR (1) FR2763335B1 (el)
HK (1) HK1028028A1 (el)
HU (1) HUP0003127A3 (el)
NO (1) NO324562B1 (el)
NZ (1) NZ500952A (el)
PL (1) PL197156B1 (el)
PT (1) PT998471E (el)
WO (1) WO1998052935A1 (el)
ZA (1) ZA984114B (el)

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CA2605587A1 (en) * 2005-04-22 2006-11-02 Wyeth Chromane and chromene derivatives and uses thereof
CN1891687B (zh) * 2005-07-08 2011-08-03 中国医学科学院医药生物技术研究所 微生物来源的炎症因子受体拮抗活性化合物及其应用
ES2391326T3 (es) * 2008-05-23 2012-11-23 Novaera S.R.L. Formulaciones de endipaleno en el tratamiento de la psoriasis
CA3042107C (en) * 2009-11-03 2023-03-07 Fosun Orinove Pharmatech, Inc. Ire-1.alpha. inhibitors
KR102022154B1 (ko) * 2016-11-24 2019-09-18 한양대학교 산학협력단 MBD2-p66α(GATAD2A)의 상호작용을 억제하는 화합물을 포함하는 암 전이 억제 및 암 질환 예방 및 치료용 조성물
US10052326B1 (en) 2017-10-12 2018-08-21 King Saud University Antihepatotoxic agents
CN111960970B (zh) * 2018-08-08 2021-08-20 中国人民解放军总医院 抗肿瘤化合物

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Also Published As

Publication number Publication date
AU7772398A (en) 1998-12-11
ES2285775T3 (es) 2007-11-16
NO995594D0 (no) 1999-11-15
PT998471E (pt) 2007-06-05
CN1139584C (zh) 2004-02-25
CA2289599A1 (fr) 1998-11-26
PL197156B1 (pl) 2008-03-31
CN1260789A (zh) 2000-07-19
NO324562B1 (no) 2007-11-19
EP0998471B1 (fr) 2007-03-14
FR2763335B1 (fr) 2000-11-24
JP2002510290A (ja) 2002-04-02
HK1028028A1 (en) 2001-02-02
US6602903B2 (en) 2003-08-05
US6313160B1 (en) 2001-11-06
WO1998052935A1 (fr) 1998-11-26
FR2763335A1 (fr) 1998-11-20
AU741753B2 (en) 2001-12-06
DK0998471T3 (da) 2007-07-02
DE69837334D1 (de) 2007-04-26
EP0998471A1 (fr) 2000-05-10
NO995594L (no) 2000-01-14
US20020052400A1 (en) 2002-05-02
ATE356814T1 (de) 2007-04-15
CA2289599C (fr) 2005-12-06
HUP0003127A2 (hu) 2002-05-29
PL336857A1 (en) 2000-07-17
NZ500952A (en) 2002-03-01
HUP0003127A3 (en) 2002-12-28
BR9809643A (pt) 2000-10-03
ZA984114B (en) 1998-11-24
DE69837334T2 (de) 2008-01-10

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