HUE056852T2 - Sejtpopuláció felszaporítására szolgáló eljárások, készletek és berendezés - Google Patents
Sejtpopuláció felszaporítására szolgáló eljárások, készletek és berendezésInfo
- Publication number
- HUE056852T2 HUE056852T2 HUE15720620A HUE15720620A HUE056852T2 HU E056852 T2 HUE056852 T2 HU E056852T2 HU E15720620 A HUE15720620 A HU E15720620A HU E15720620 A HUE15720620 A HU E15720620A HU E056852 T2 HUE056852 T2 HU E056852T2
- Authority
- HU
- Hungary
- Prior art keywords
- kits
- population
- expanding
- cells
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/12—Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/52—CD40, CD40-ligand (CD154)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2537/00—Supports and/or coatings for cell culture characterised by physical or chemical treatment
- C12N2537/10—Cross-linking
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Sustainable Development (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Computer Hardware Design (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Physics & Mathematics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461980506P | 2014-04-16 | 2014-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE056852T2 true HUE056852T2 (hu) | 2022-03-28 |
Family
ID=53052805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE15720620A HUE056852T2 (hu) | 2014-04-16 | 2015-04-16 | Sejtpopuláció felszaporítására szolgáló eljárások, készletek és berendezés |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US11274278B2 (https=) |
| EP (2) | EP3988920A1 (https=) |
| JP (4) | JP6696969B2 (https=) |
| KR (2) | KR102714469B1 (https=) |
| CN (3) | CN106414724A (https=) |
| AU (2) | AU2015248786B2 (https=) |
| BR (1) | BR112016024072B1 (https=) |
| CA (2) | CA3176848A1 (https=) |
| CY (1) | CY1124717T1 (https=) |
| DK (1) | DK3132247T3 (https=) |
| ES (1) | ES2892927T3 (https=) |
| HR (1) | HRP20211430T1 (https=) |
| HU (1) | HUE056852T2 (https=) |
| IL (3) | IL280738B (https=) |
| LT (1) | LT3132247T (https=) |
| MX (2) | MX380519B (https=) |
| MY (1) | MY184699A (https=) |
| PH (2) | PH12016502017A1 (https=) |
| PL (1) | PL3132247T3 (https=) |
| PT (1) | PT3132247T (https=) |
| RS (1) | RS62471B1 (https=) |
| RU (2) | RU2735640C9 (https=) |
| SA (3) | SA521421882B1 (https=) |
| SG (2) | SG10201808491UA (https=) |
| SI (1) | SI3132247T1 (https=) |
| SM (1) | SMT202100600T1 (https=) |
| WO (1) | WO2015158868A2 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2746407C1 (ru) | 2012-02-23 | 2021-04-13 | Стейдж Селл Терапеутикс Гмбх | Хроматографическое выделение клеток и других сложных биологических материалов |
| BR112016024072B1 (pt) | 2014-04-16 | 2021-02-09 | Juno Therapeutics Gmbh | método in vitro de estimular uma população de células |
| RU2763795C2 (ru) | 2014-04-23 | 2022-01-11 | Джуно Терапьютикс, Инк. | Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии |
| JP7194020B2 (ja) | 2015-10-22 | 2022-12-21 | ジュノ セラピューティクス ゲーエムベーハー | 細胞の培養方法ならびにそのためのキットおよび装置 |
| US11248238B2 (en) * | 2015-10-22 | 2022-02-15 | Juno Therapeutics Gmbh | Methods, kits, agents and apparatuses for transduction |
| SG11201803330WA (en) * | 2015-10-22 | 2018-05-30 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| EP3192810A1 (en) | 2016-01-14 | 2017-07-19 | Deutsches Krebsforschungszentrum | Psma binding antibody and uses thereof |
| CN107129988A (zh) * | 2016-02-29 | 2017-09-05 | 广西医科大学 | 一种特异性结合cd3的核酸适配体及其筛选方法和应用 |
| WO2017210607A1 (en) * | 2016-06-02 | 2017-12-07 | Klotho Therapeutics, Inc. | Therapeutic recombinant klotho proteins and compositions and methods involving the same |
| US20240018268A1 (en) | 2016-07-29 | 2024-01-18 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies against anti-cd19 antibodies |
| US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
| AU2017370644A1 (en) * | 2016-12-05 | 2019-06-13 | Juno Therapeutics, Inc. | Production of engineered cells for adoptive cell therapy |
| US12234441B2 (en) * | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| CN117247899A (zh) * | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
| US11624046B2 (en) * | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| JP7339160B2 (ja) * | 2017-04-27 | 2023-09-05 | ジュノ セラピューティクス ゲーエムベーハー | オリゴマー粒子試薬およびその使用方法 |
| EP3704230B1 (en) | 2017-11-01 | 2024-10-23 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| WO2019113557A1 (en) | 2017-12-08 | 2019-06-13 | Juno Therapeutics, Inc. | Process for producing a composition of engineered t cells |
| JP7433230B2 (ja) | 2017-12-08 | 2024-02-19 | ジュノー セラピューティクス インコーポレイテッド | 細胞を培養するための無血清培地配合物およびその使用の方法 |
| MX2020006297A (es) * | 2017-12-15 | 2020-12-07 | Aleta Biotherapeutics Inc | Variantes de cd19. |
| CN107904278B (zh) * | 2017-12-25 | 2021-07-20 | 北昊干细胞与再生医学研究院有限公司 | 检测药物对细胞增殖影响的方法 |
| US11149244B2 (en) * | 2018-04-04 | 2021-10-19 | Southwest Research Institute | Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy |
| EP3790958A1 (en) * | 2018-05-08 | 2021-03-17 | Life Technologies Corporation | Compositions and methods for culturing and expanding cells |
| CN112912103B (zh) * | 2018-05-21 | 2025-08-29 | 广州邦定生物技术有限公司 | 多价蛋白质复合物 |
| CN113474450A (zh) | 2018-08-09 | 2021-10-01 | 朱诺治疗学股份有限公司 | 产生工程化细胞的方法以及所述工程化细胞的组合物 |
| CN113056486B (zh) | 2018-09-11 | 2025-06-17 | 德国肿瘤研究中心 | 改善的抗flt3抗原结合蛋白 |
| EP3623383A1 (en) | 2018-09-11 | 2020-03-18 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Improved bispecific flt3xcd3 antigen binding proteins |
| SG11202102986XA (en) * | 2018-09-24 | 2021-04-29 | Southwest Res Inst | Three-dimensional bioreactors |
| EP3874024A1 (en) * | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
| KR20200132147A (ko) * | 2019-05-15 | 2020-11-25 | 의료법인 성광의료재단 | 자연 살해 세포의 배양용 조성물 및 이를 이용한 방법 |
| WO2020241999A1 (ko) * | 2019-05-24 | 2020-12-03 | 고려대학교 세종산학협력단 | 스위치 성 부착반응을 이용한 친화 분리 시스템 및 방법 |
| MX2021015125A (es) * | 2019-06-07 | 2022-04-06 | Juno Therapeutics Inc | Cultivo automatizado de celulas t. |
| WO2021084050A1 (en) | 2019-10-30 | 2021-05-06 | Juno Therapeutics Gmbh | Cell selection and/or stimulation devices and methods of use |
| EP3822288A1 (en) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof |
| KR20220122656A (ko) | 2019-12-06 | 2022-09-02 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ｇｐｒｃ5ｄ-표적화 결합 도메인에 대한 항-이디오타입 항체 및 관련 조성물 및 방법 |
| CN115916817A (zh) | 2019-12-06 | 2023-04-04 | 朱诺治疗学股份有限公司 | 针对bcma靶向结合结构域的抗独特型抗体及相关组合物和方法 |
| WO2021152178A1 (en) | 2020-01-31 | 2021-08-05 | Cell.Copedia GmbH | Methods of isolating a biological entity |
| IL295381B1 (en) | 2020-02-12 | 2026-04-01 | Juno Therapeutics Inc | BCMA-directed chimeric T-cell antigen receptor compounds and methods and uses thereof |
| IL295384B1 (en) | 2020-02-12 | 2026-04-01 | Juno Therapeutics Inc | T-cell preparations with chimeric antigen receptor directed against CD19 and methods and uses thereof |
| US12378521B2 (en) | 2020-04-15 | 2025-08-05 | Amgen Inc. | Method for enhancing production of genetically engineered autologous T cells |
| US12241086B2 (en) | 2020-04-15 | 2025-03-04 | Amgen Inc. | Process for generating genetically engineered autologous T cells |
| WO2022029660A1 (en) | 2020-08-05 | 2022-02-10 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to ror1-targeted binding domains and related compositions and methods |
| JP2023549780A (ja) | 2020-11-04 | 2023-11-29 | ジュノー セラピューティクス インコーポレイテッド | 改変されたインバリアントｃｄ３免疫グロブリンスーパーファミリー鎖遺伝子座からキメラ受容体を発現する細胞ならびに関連するポリヌクレオチドおよび方法 |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| KR20230159851A (ko) | 2021-03-22 | 2023-11-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 치료 세포 조성물의 효력을 결정하는 방법 |
| US20250283037A1 (en) | 2021-05-06 | 2025-09-11 | Juno Therapeutics Gmbh | Methods for stimulating and transducing t cells |
| CN117957313A (zh) | 2021-07-19 | 2024-04-30 | 修复免疫股份有限公司 | 从多能干细胞生产免疫细胞群的方法 |
| CN116286659A (zh) * | 2021-10-25 | 2023-06-23 | 黄�俊 | 多聚体在car表达细胞检测和细胞制备中的应用 |
| WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| EP4615960A1 (en) | 2022-11-09 | 2025-09-17 | C3S2 GmbH | Methods for manufacturing engineered immune cells |
| CN121100267A (zh) | 2022-12-09 | 2025-12-09 | 朱诺治疗学股份有限公司 | 使用全息成像预测细胞表型的机器学习方法 |
| CN121002052A (zh) | 2023-02-03 | 2025-11-21 | C3S2 有限公司 | 用于非病毒生产工程化免疫细胞的方法 |
| KR20260005874A (ko) | 2023-02-28 | 2026-01-12 | 주노 쎄러퓨티크스 인코퍼레이티드 | 전신 자가면역 질환을 치료하기 위한 세포 요법 |
| KR20250169631A (ko) | 2023-04-18 | 2025-12-03 | 주노 쎄러퓨티크스 인코퍼레이티드 | 치료 세포 조성물의 효력을 평가하기 위한 세포독성 검정 |
| CN121464348A (zh) | 2023-05-23 | 2026-02-03 | 朱诺治疗学股份有限公司 | T细胞的激活标记物和评估t细胞激活的方法 |
| CN117448255B (zh) * | 2023-09-28 | 2024-12-31 | 深圳市龙华区人民医院 | S2饲养细胞、制备方法及其应用 |
| WO2025109111A1 (en) * | 2023-11-22 | 2025-05-30 | Immudex Aps | Immune cell activating multimers |
| KR102824339B1 (ko) * | 2024-07-01 | 2025-06-26 | 현대자동차주식회사 | 배터리 제어 장치 및 그 방법 |
| WO2026020055A2 (en) | 2024-07-18 | 2026-01-22 | Juno Therapeutics, Inc. | Methods for assessing exosomes in a cell composition and related uses |
| WO2026050426A2 (en) | 2024-08-28 | 2026-03-05 | Juno Therapeutics, Inc. | Cd19-directed chimeric antigen receptor cell therapy for treating autoimmune and neurological diseases |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4361549A (en) | 1979-04-26 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
| WO1986002077A1 (en) | 1984-10-02 | 1986-04-10 | Meade Harry M | Production of streptavidin-like polypeptides |
| US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| DE4237113B4 (de) | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| EP0700430B1 (en) | 1993-06-04 | 2005-04-20 | The United States of America as Represented by the Secretary of the Navy | Methods for selectively stimulating proliferation of t cells |
| AU5132096A (en) | 1995-01-30 | 1996-08-21 | Terrapin Technologies, Inc. | Glubodies - multiplicities of proteins capable of binding a variety of small molecules |
| CA2211951A1 (en) | 1995-02-09 | 1996-08-15 | University Of Washington | Modified-affinity streptavidin |
| WO1997011183A1 (en) | 1995-04-11 | 1997-03-27 | Trustees Of Boston University | Streptavidin mutants |
| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| AU6701498A (en) | 1997-03-14 | 1998-09-29 | Trustees Of Boston University | Multiflavor streptavidin |
| US5985658A (en) | 1997-11-14 | 1999-11-16 | Health Research Incorporated | Calmodulin-based cell separation technique |
| WO2000043551A1 (en) | 1999-01-26 | 2000-07-27 | Cornell Research Foundation, Inc. | Determining viral load in double negative t cells |
| DK1149114T3 (da) * | 1999-02-03 | 2014-06-23 | Amgen Inc | Polypeptider, der er involveret ved et immunrespons |
| BR0009403A (pt) | 1999-02-04 | 2001-11-27 | Technion Res & Dev Foundation | Método de expansão/conservação das células detronco hemopoiéticas indiferenciadas ou dascélulas progenitoras, método de preparação deum meio condicionado de célula estomacal útil naexpansão/conservação das células de troncohemopoiéticas indiferenciadas ou das célulasprogenitoras, método de transplante de célulasde tronco hemopoiéticas indiferenciadas ou decélulas progenitoras em um recipiente, tampão debiorreator e biorreator |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US20030235908A1 (en) * | 2000-02-24 | 2003-12-25 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| EP1227321A1 (en) | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Reversible MHC multimer staining for functional purification of antigen-specific T cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| ATE370159T1 (de) | 2002-03-01 | 2007-09-15 | Volker A Erdmann | Streptavidin-bindungspeptid |
| US7754155B2 (en) | 2002-03-15 | 2010-07-13 | Ross Amelia A | Devices and methods for isolating target cells |
| WO2003090781A1 (en) | 2002-04-23 | 2003-11-06 | Meir Strahilevitz | Methods and devices for targeting a site in a mammal and for removing species from a mammal |
| FR2841905B1 (fr) | 2002-07-05 | 2004-09-03 | Centre Nat Rech Scient | Fragments fab mutants de l'anticorps anti-cd4 chimere 13b8.2 et leurs applications |
| CA2500392C (en) | 2002-09-27 | 2012-11-27 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
| CA2565581C (en) | 2003-05-02 | 2014-07-08 | Insception Bioscience, Inc. | Apparatus and methods for amplification of blood stem cell numbers |
| EP1623017B1 (en) | 2003-05-08 | 2010-09-15 | Life Technologies Corporation | Generation and isolation of antigen-specific t cells |
| US20080050795A1 (en) | 2003-11-20 | 2008-02-28 | Biosensor Applications Sweden Ab | Mixture Of At Least Two Different Antibodies Specific For Predetermined Antigens And Use Of The Mixture |
| SE0400181D0 (sv) | 2004-01-29 | 2004-01-29 | Gyros Ab | Segmented porous and preloaded microscale devices |
| US7776583B2 (en) | 2004-06-03 | 2010-08-17 | Meso Scale Technologies, Llc | Methods and apparatuses for conducting assays |
| US20110098184A1 (en) | 2004-10-15 | 2011-04-28 | Day Anthony G | Competitve differntial screeing |
| WO2006058226A2 (en) * | 2004-11-24 | 2006-06-01 | The Trustees Of Boston University | Modified dimeric streptavidins and uses thereof |
| US20060252087A1 (en) | 2005-01-18 | 2006-11-09 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
| US7704708B2 (en) * | 2006-02-13 | 2010-04-27 | Uti Limited Partnership | Monomeric streptavidin muteins |
| US7855057B2 (en) | 2006-03-23 | 2010-12-21 | Millipore Corporation | Protein splice variant/isoform discrimination and quantitative measurements thereof |
| US20090208471A1 (en) | 2006-04-07 | 2009-08-20 | Yun Theodore J | Isolation and Use of Human Regulatory T Cells |
| US20070238169A1 (en) * | 2006-04-11 | 2007-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Cell sorter and culture system |
| US20080085532A1 (en) | 2006-09-18 | 2008-04-10 | Jorn Gorlach | Method for determining the immune status of a subject |
| DK2091965T3 (da) | 2006-10-17 | 2013-08-05 | Oncotherapy Science Inc | Peptidvacciner mod cancere, der udtrykker MPHOSPH1- eller DEPDC1-polypeptider |
| JP5557450B2 (ja) | 2006-11-02 | 2014-07-23 | 協和メデックス株式会社 | 測定対象成分の免疫測定法 |
| AU2007353319A1 (en) | 2006-11-15 | 2008-11-20 | Invitrogen Dynal As | Methods for reversibly binding a biotin compound to a support |
| US20080131415A1 (en) | 2006-11-30 | 2008-06-05 | Riddell Stanley R | Adoptive transfer of cd8 + t cell clones derived from central memory cells |
| CN101226118B (zh) | 2007-01-19 | 2010-06-16 | 中国医学科学院肿瘤研究所 | 一种兼容免疫荧光分析的细胞化学染色方法及其用途 |
| WO2008118476A2 (en) * | 2007-03-26 | 2008-10-02 | Codon Devices, Inc. | Cell surface display, screening and production of proteins of interest |
| EP3620465B1 (en) | 2007-07-03 | 2025-02-19 | Dako Denmark A/S | Improved methods for generation, labeling and use of mhc multimers |
| DK2193199T3 (da) | 2007-08-20 | 2014-01-13 | Nextera As | Pvii fag-display |
| WO2009072003A2 (en) | 2007-12-07 | 2009-06-11 | Miltenyi Biotec Gmbh | Sample processing system and methods |
| DK2240781T3 (en) | 2008-01-18 | 2018-03-26 | Harvard College | METHODS FOR DETECTING DISEASE OR STATE SIGNATURES IN BODY FLUIDS |
| CA2713462C (en) | 2008-01-29 | 2020-04-14 | Fred Hutchinson Cancer Research Center | Identification of cd8+ t cells that are cd161hi and/or il18r(alpha)hi and have rapid drug efflux capacity |
| CN101446576B (zh) | 2008-12-29 | 2011-06-22 | 江苏省苏微微生物研究有限公司 | 一种微囊藻毒素-lr单抗免疫亲和柱的制备和使用方法 |
| WO2010080032A2 (en) | 2009-01-09 | 2010-07-15 | Stichting Het Nederlands Kanker Instituut | Bead-assisted viral transduction |
| US20110070581A1 (en) | 2009-04-27 | 2011-03-24 | Amit Gupta | Separation of Leukocytes |
| US20120214187A1 (en) * | 2009-11-02 | 2012-08-23 | Ffina Biolutions, Llc | Method for Enhancing the Sensitivity of Antibody Based Assays |
| US20120321665A1 (en) * | 2009-12-14 | 2012-12-20 | Benaroya Research Institute At Virginia Mason | Compositions and methods for treating airway inflammatory diseases |
| EP2363501A1 (en) | 2010-03-02 | 2011-09-07 | Universitätsklinikum Hamburg-Eppendorf | Method for isolating target cells |
| EP2601521B1 (en) | 2010-08-06 | 2018-05-02 | Ludwig-Maximilians-Universität München | Identification of t cell target antigens |
| WO2012058627A2 (en) | 2010-10-29 | 2012-05-03 | Miqin Zhang | Pre-targeted nanoparticle system and method for labeling biological particles |
| CN110200997A (zh) | 2011-03-23 | 2019-09-06 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
| TR201811128T4 (tr) * | 2011-07-18 | 2018-08-27 | Iba Gmbh | Bir hedef hücrenin tersinir şekilde boyama yöntemi. |
| WO2013038272A2 (en) | 2011-09-13 | 2013-03-21 | Uti Limited Partnership | Streptavidin mutein exhibiting reversible binding for biotin and streptavidin binding peptide tagged proteins |
| RU2746407C1 (ru) * | 2012-02-23 | 2021-04-13 | Стейдж Селл Терапеутикс Гмбх | Хроматографическое выделение клеток и других сложных биологических материалов |
| UA114108C2 (uk) * | 2012-07-10 | 2017-04-25 | Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем | Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання |
| AU2013289979A1 (en) | 2012-07-13 | 2015-01-22 | The Trustees Of The University Of Pennsylvania | Methods of assessing the suitability of transduced T cells for administration |
| CA2881981A1 (en) | 2012-08-20 | 2014-02-27 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
| WO2014076277A1 (en) | 2012-11-16 | 2014-05-22 | Iba Gmbh | Streptavidin muteins and methods of using them |
| CN103305464B (zh) | 2013-06-05 | 2015-04-15 | 南昌大学 | 直接分离cd4+和cd8+淋巴细胞的方法 |
| US9698876B2 (en) | 2013-07-23 | 2017-07-04 | Telefonaktiebolaget Lm Ericsson (Publ) | Transmission mode allocation in LTE networks |
| CN113354744A (zh) | 2013-12-20 | 2021-09-07 | 弗雷德哈钦森癌症研究中心 | 带标签的嵌合效应分子及其受体 |
| AU2015244039B2 (en) | 2014-04-07 | 2021-10-21 | Novartis Ag | Treatment of cancer using anti-CD19 chimeric antigen receptor |
| BR112016024072B1 (pt) | 2014-04-16 | 2021-02-09 | Juno Therapeutics Gmbh | método in vitro de estimular uma população de células |
| RU2763795C2 (ru) | 2014-04-23 | 2022-01-11 | Джуно Терапьютикс, Инк. | Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии |
| JP6661544B2 (ja) | 2014-04-24 | 2020-03-11 | ミルテニイ バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 遺伝子改変したｔ細胞の自動生成法 |
| NZ725201A (en) | 2014-04-25 | 2018-05-25 | Bluebird Bio Inc | Improved methods for manufacturing adoptive cell therapies |
| CA2945414C (en) * | 2014-04-30 | 2023-05-09 | Iba Gmbh | Method of isolating a target cell |
| MX2017012939A (es) | 2015-04-08 | 2018-05-22 | Novartis Ag | Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19. |
| WO2016166568A1 (en) | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| JP7194020B2 (ja) | 2015-10-22 | 2022-12-21 | ジュノ セラピューティクス ゲーエムベーハー | 細胞の培養方法ならびにそのためのキットおよび装置 |
| US11248238B2 (en) | 2015-10-22 | 2022-02-15 | Juno Therapeutics Gmbh | Methods, kits, agents and apparatuses for transduction |
| SG11201803330WA (en) | 2015-10-22 | 2018-05-30 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| CN108884140B (zh) | 2015-12-03 | 2022-10-25 | 朱诺治疗学股份有限公司 | 修饰的嵌合受体及相关组合物和方法 |
| JP7339160B2 (ja) | 2017-04-27 | 2023-09-05 | ジュノ セラピューティクス ゲーエムベーハー | オリゴマー粒子試薬およびその使用方法 |
| CN113474450A (zh) | 2018-08-09 | 2021-10-01 | 朱诺治疗学股份有限公司 | 产生工程化细胞的方法以及所述工程化细胞的组合物 |
| EP3874024A1 (en) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
-
2015
- 2015-04-16 BR BR112016024072-3A patent/BR112016024072B1/pt active IP Right Grant
- 2015-04-16 MY MYPI2016703777A patent/MY184699A/en unknown
- 2015-04-16 CA CA3176848A patent/CA3176848A1/en active Pending
- 2015-04-16 KR KR1020227036837A patent/KR102714469B1/ko active Active
- 2015-04-16 JP JP2017505717A patent/JP6696969B2/ja active Active
- 2015-04-16 EP EP21191440.3A patent/EP3988920A1/en active Pending
- 2015-04-16 RU RU2016144724A patent/RU2735640C9/ru active
- 2015-04-16 ES ES15720620T patent/ES2892927T3/es active Active
- 2015-04-16 LT LTEPPCT/EP2015/058339T patent/LT3132247T/lt unknown
- 2015-04-16 WO PCT/EP2015/058339 patent/WO2015158868A2/en not_active Ceased
- 2015-04-16 EP EP15720620.2A patent/EP3132247B1/en active Active
- 2015-04-16 DK DK15720620.2T patent/DK3132247T3/da active
- 2015-04-16 HR HRP20211430TT patent/HRP20211430T1/hr unknown
- 2015-04-16 CN CN201580032543.4A patent/CN106414724A/zh active Pending
- 2015-04-16 SG SG10201808491UA patent/SG10201808491UA/en unknown
- 2015-04-16 CN CN202310417528.8A patent/CN116656605A/zh active Pending
- 2015-04-16 US US15/304,045 patent/US11274278B2/en active Active
- 2015-04-16 HU HUE15720620A patent/HUE056852T2/hu unknown
- 2015-04-16 SI SI201531727T patent/SI3132247T1/sl unknown
- 2015-04-16 SG SG11201608557UA patent/SG11201608557UA/en unknown
- 2015-04-16 PT PT157206202T patent/PT3132247T/pt unknown
- 2015-04-16 IL IL280738A patent/IL280738B/en unknown
- 2015-04-16 RU RU2020133435A patent/RU2020133435A/ru unknown
- 2015-04-16 AU AU2015248786A patent/AU2015248786B2/en active Active
- 2015-04-16 CA CA2945889A patent/CA2945889C/en active Active
- 2015-04-16 SM SM20210600T patent/SMT202100600T1/it unknown
- 2015-04-16 KR KR1020167031915A patent/KR102459384B1/ko active Active
- 2015-04-16 IL IL293587A patent/IL293587B2/en unknown
- 2015-04-16 CN CN202010423347.2A patent/CN111961647A/zh active Pending
- 2015-04-16 PL PL15720620T patent/PL3132247T3/pl unknown
- 2015-04-16 RS RS20211143A patent/RS62471B1/sr unknown
- 2015-04-16 MX MX2016013493A patent/MX380519B/es unknown
-
2016
- 2016-10-11 PH PH12016502017A patent/PH12016502017A1/en unknown
- 2016-10-13 MX MX2020014089A patent/MX2020014089A/es unknown
- 2016-10-13 IL IL248360A patent/IL248360B/en active IP Right Grant
- 2016-10-16 SA SA521421882A patent/SA521421882B1/ar unknown
- 2016-10-16 SA SA520412247A patent/SA520412247B1/ar unknown
- 2016-10-16 SA SA516380090A patent/SA516380090B1/ar unknown
-
2020
- 2020-04-23 JP JP2020076705A patent/JP7762499B2/ja active Active
- 2020-07-01 PH PH12020551028A patent/PH12020551028A1/en unknown
-
2021
- 2021-11-02 CY CY20211100943T patent/CY1124717T1/el unknown
-
2022
- 2022-01-27 AU AU2022200527A patent/AU2022200527B9/en active Active
- 2022-03-11 US US17/693,292 patent/US20220195388A1/en active Pending
-
2023
- 2023-02-20 JP JP2023024443A patent/JP2023062124A/ja active Pending
-
2024
- 2024-12-20 JP JP2024225388A patent/JP2025060756A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL280738A (en) | Methods, kits and device for increasing cell populations | |
| SG11201803330WA (en) | Methods for culturing cells and kits and apparatus for same | |
| IL251261B (en) | Reagents and methods for the identification, enrichment and/or expansion of antigen-specific T-cells | |
| EP3163849A4 (en) | Method and apparatus for selecting main microphone | |
| PL3172567T3 (pl) | Sposoby i zestawy do monitorowania nefropatii błoniastej | |
| EP3114793A4 (en) | Methods and apparatus for migrating keys | |
| EP3140833A4 (en) | Apparatuses and methods for performing multiple memory operations | |
| EP3091786A4 (en) | Apparatus, method and system for cell selection | |
| EP3105315A4 (en) | Kits and methods for reprograming non-hepatocyte cells into hepatocyte cells | |
| EP3244656A4 (en) | Cell selection method and apparatus | |
| EP3196292A4 (en) | Cell culture apparatus and method | |
| SG11201701562WA (en) | Cell trapping method, method for producing specific cell-trapping device, and method for producing specific cell-containing solution | |
| EP3107996A4 (en) | Tscm cells and methods for use | |
| GB201405130D0 (en) | Electrochemical method and apparatus | |
| EP3238744A4 (en) | Method for modifying t cell population | |
| EP3229515A4 (en) | Method and apparatus for indicating cell splitting pattern | |
| EP3192295A4 (en) | Method and arrangement for cell combination | |
| EP3156080A4 (en) | Cell structure and method for producing cell structure | |
| EP3154290A4 (en) | Resource optimization method and apparatus | |
| IL248805A0 (en) | A method for growing mature stem cells from whole blood | |
| EP3165602A4 (en) | Method for producing b cell population | |
| EP3304961A4 (en) | Method and apparatus for cell configuration | |
| EP3155085A4 (en) | Method and apparatus for making soap | |
| GB201417372D0 (en) | Methods and kits | |
| GB201418382D0 (en) | Device and method for separating cells |