HUE046617T2 - Pirazol-aminopirimidin-származékok mint LRRK2 modulátorok - Google Patents
Pirazol-aminopirimidin-származékok mint LRRK2 modulátorokInfo
- Publication number
- HUE046617T2 HUE046617T2 HUE16180927A HUE16180927A HUE046617T2 HU E046617 T2 HUE046617 T2 HU E046617T2 HU E16180927 A HUE16180927 A HU E16180927A HU E16180927 A HUE16180927 A HU E16180927A HU E046617 T2 HUE046617 T2 HU E046617T2
- Authority
- HU
- Hungary
- Prior art keywords
- aminopyrimidine derivatives
- pyrazole
- lrrk2 modulators
- lrrk2
- modulators
- Prior art date
Links
- JOOFEGKZJOFZKJ-UHFFFAOYSA-N 1h-pyrazole;pyrimidin-2-amine Chemical class C=1C=NNC=1.NC1=NC=CC=N1 JOOFEGKZJOFZKJ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41227310P | 2010-11-10 | 2010-11-10 | |
| US201161546613P | 2011-10-13 | 2011-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE046617T2 true HUE046617T2 (hu) | 2020-03-30 |
Family
ID=44983512
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE11782588A HUE037844T2 (hu) | 2010-11-10 | 2011-11-09 | Pirazol-aminopirimidin-származékok mint LRRK2 modulátorok |
| HUE16180927A HUE046617T2 (hu) | 2010-11-10 | 2011-11-09 | Pirazol-aminopirimidin-származékok mint LRRK2 modulátorok |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE11782588A HUE037844T2 (hu) | 2010-11-10 | 2011-11-09 | Pirazol-aminopirimidin-származékok mint LRRK2 modulátorok |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US8815882B2 (hu) |
| EP (3) | EP3590933B1 (hu) |
| JP (3) | JP5986094B2 (hu) |
| KR (1) | KR101566091B1 (hu) |
| CN (1) | CN103313978B (hu) |
| AR (1) | AR083813A1 (hu) |
| AU (1) | AU2011328139A1 (hu) |
| BR (1) | BR112013011600B1 (hu) |
| CA (2) | CA2812669C (hu) |
| CY (1) | CY1120073T1 (hu) |
| DK (2) | DK3124483T3 (hu) |
| EC (1) | ECSP13012611A (hu) |
| ES (2) | ES2746134T3 (hu) |
| HK (1) | HK1187605A1 (hu) |
| HR (2) | HRP20172006T1 (hu) |
| HU (2) | HUE037844T2 (hu) |
| IL (1) | IL225234A0 (hu) |
| LT (2) | LT3124483T (hu) |
| MA (1) | MA34644B1 (hu) |
| MX (1) | MX2013005199A (hu) |
| NO (1) | NO2638031T3 (hu) |
| PL (2) | PL2638031T3 (hu) |
| PT (2) | PT2638031T (hu) |
| RS (2) | RS56583B1 (hu) |
| SG (1) | SG189043A1 (hu) |
| SI (2) | SI3124483T1 (hu) |
| TW (1) | TW201302733A (hu) |
| WO (1) | WO2012062783A1 (hu) |
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| US20140228384A1 (en) * | 2011-11-29 | 2014-08-14 | Genentech, Inc. | Assays and biomarkers for lrrk2 |
| PT2785711T (pt) * | 2011-11-29 | 2016-09-30 | Hoffmann La Roche | Derivados de 2-(fenil ou pirid-3- il)aminopiridinacomo moduladores de lrrk2 quinase, para o tratamento da doença de parkinson |
| KR101996699B1 (ko) | 2011-11-30 | 2019-07-04 | 제넨테크, 인크. | Lrrk2에 대해 양전자 방사 단층촬영(pet) 이미징을 위한 불소-18 및 탄소-11 표지된 방사선 리간드 |
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| CN110627810B (zh) * | 2019-06-05 | 2024-05-10 | 中国医学科学院药用植物研究所 | 一种三氟甲基吡唑衍生物的制备方法 |
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