HK1200820A1 - 作為 調節劑的吡唑氨基嘧啶衍生物 - Google Patents
作為 調節劑的吡唑氨基嘧啶衍生物Info
- Publication number
- HK1200820A1 HK1200820A1 HK15101249.0A HK15101249A HK1200820A1 HK 1200820 A1 HK1200820 A1 HK 1200820A1 HK 15101249 A HK15101249 A HK 15101249A HK 1200820 A1 HK1200820 A1 HK 1200820A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- lrrk2
- modulators
- aminopyrimidine derivatives
- pyrazole
- pyrazole aminopyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261642019P | 2012-05-03 | 2012-05-03 | |
| PCT/EP2013/058939 WO2013164321A1 (en) | 2012-05-03 | 2013-04-30 | Pyrazole aminopyrimidine derivatives as lrrk2 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1200820A1 true HK1200820A1 (zh) | 2015-08-14 |
Family
ID=48325675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15101249.0A HK1200820A1 (zh) | 2012-05-03 | 2015-02-05 | 作為 調節劑的吡唑氨基嘧啶衍生物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9212173B2 (zh) |
| EP (1) | EP2844652B1 (zh) |
| JP (1) | JP6218808B2 (zh) |
| KR (1) | KR102091894B1 (zh) |
| CN (2) | CN106220615A (zh) |
| BR (1) | BR112014026952B1 (zh) |
| CA (1) | CA2870049C (zh) |
| HK (1) | HK1200820A1 (zh) |
| MX (1) | MX363118B (zh) |
| RU (1) | RU2637947C2 (zh) |
| WO (1) | WO2013164321A1 (zh) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2871375C (en) * | 2012-05-03 | 2020-10-27 | F. Hoffmann-La Roche Ag | Pyrazole aminopyrimidine derivatives as lrrk2 modulators for use in the treatment of parkinson's disease |
| CN105732639A (zh) | 2012-06-29 | 2016-07-06 | 辉瑞大药厂 | 作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类 |
| EP3083618B1 (en) | 2013-12-17 | 2018-02-21 | Pfizer Inc | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
| AU2014369031A1 (en) | 2013-12-20 | 2016-07-07 | Signal Pharmaceuticals, Llc | Substituted Diaminopyrimidyl Compounds, compositions thereof, and methods of treatment therewith |
| EA029774B1 (ru) | 2014-01-29 | 2018-05-31 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Соединения |
| JP6474826B2 (ja) | 2014-01-29 | 2019-02-27 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | 化合物 |
| US20170226081A1 (en) * | 2014-07-24 | 2017-08-10 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
| JP6873980B2 (ja) | 2015-09-14 | 2021-05-19 | ファイザー・インク | ＬＲＲＫ２阻害薬としての新規のイミダゾ［４，５−ｃ］キノリンおよびイミダゾ［４，５−ｃ］［１，５］ナフチリジン誘導体 |
| WO2017087905A1 (en) * | 2015-11-20 | 2017-05-26 | Denali Therapeutics Inc. | Compound, compositions, and methods |
| CN108934162A (zh) | 2015-12-16 | 2018-12-04 | 南方研究所 | 吡咯并嘧啶化合物、作为激酶lrrk2抑制剂的用途及其制备方法 |
| US11028080B2 (en) | 2016-03-11 | 2021-06-08 | Denali Therapeutics Inc. | Substituted pyrimidines as LRKK2 inhibitors |
| HUE056678T2 (hu) | 2016-06-16 | 2022-02-28 | Denali Therapeutics Inc | Pirimidin-2-ilamino-1H-pirazolok mint LRRK2 inhibitorok neurodegeneratív rendellenességek kezelésére való alkalmazásra |
| CN106588884B (zh) * | 2016-11-10 | 2019-04-09 | 浙江大学 | 2-多取代芳环-嘧啶类衍生物及制备和医药用途 |
| KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| BR112019028205A2 (pt) * | 2017-06-30 | 2020-10-06 | Amgen Inc. | síntese de omecamtiv mecarbil |
| MA51222A (fr) | 2017-11-21 | 2020-10-07 | Denali Therapeutics Inc | Polymorphes et formes solides d'un composé de pyrimidinylamino-pyrazole, et procédés de production |
| CA3086182A1 (en) | 2017-12-20 | 2019-06-27 | Denali Therapeutics Inc. | Process for the preparation of pyrimidinyl-4-aminopyrazole compounds |
| JP7364841B2 (ja) * | 2018-02-14 | 2023-10-19 | 智彦 大和田 | 酸ハロゲン化物による化合物の製造方法 |
| WO2019159248A1 (ja) | 2018-02-14 | 2019-08-22 | 大阪有機化学工業株式会社 | 耐熱性且つ易剥離性の硬化樹脂膜を形成するための硬化性樹脂組成物及びその製造方法 |
| KR20210082454A (ko) * | 2018-09-25 | 2021-07-05 | 카듀리온 파마슈티칼스, 인크. | 아미노피리미딘 화합물 |
| WO2020068846A1 (en) * | 2018-09-25 | 2020-04-02 | Heterocyclic Compound | Heterocyclic compound |
| WO2020187292A1 (zh) * | 2019-03-19 | 2020-09-24 | 北京赛特明强医药科技有限公司 | 2-取代吡唑氨基-4-取代氨基-5-嘧啶甲酰胺类化合物、组合物及其应用 |
| CN116685325A (zh) | 2020-10-20 | 2023-09-01 | 豪夫迈·罗氏有限公司 | Pd-1轴结合拮抗剂和lrrk2抑制剂的组合疗法 |
| WO2023076404A1 (en) | 2021-10-27 | 2023-05-04 | Aria Pharmaceuticals, Inc. | Methods for treating systemic lupus erythematosus |
| WO2024097394A1 (en) | 2022-11-03 | 2024-05-10 | Denali Therapeutics Inc. | Solid and co-crystal forms of a pyrimidine triazole compound |
| WO2024112746A1 (en) | 2022-11-22 | 2024-05-30 | Denali Therapeutics Inc. | Processes and intermediates for the preparation of a pyrimidine aminopyrazole compound |
| CN115819405A (zh) * | 2022-12-20 | 2023-03-21 | 沪渝人工智能研究院 | 嘧啶氨基吡唑衍生物及其作为富亮氨酸重复激酶2抑制剂的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100876069B1 (ko) * | 2000-09-15 | 2008-12-26 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제 억제제로서 유용한 피라졸 화합물 및 이를 포함하는 약제학적 조성물 |
| RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
| AU2005322855B2 (en) * | 2004-12-30 | 2012-09-20 | Exelixis, Inc. | Pyrimidine derivatives as kinase modulators and method of use |
| WO2009145814A2 (en) * | 2008-03-10 | 2009-12-03 | Vertex Pharmaceuticals Incorporated | Pyrimidines and pyridines useful as inhibitors of protein kinases |
| EP2440548A1 (en) * | 2009-06-10 | 2012-04-18 | Abbott Laboratories | 2- ( lh-pyrazol-4 -ylamino ) -pyrimidine as kinase inhibitors |
| CN105837519A (zh) * | 2010-06-04 | 2016-08-10 | 霍夫曼-拉罗奇有限公司 | 作为lrrk2调节剂的氨基嘧啶衍生物 |
| WO2012031004A1 (en) * | 2010-09-01 | 2012-03-08 | Gilead Connecticut, Inc. | Pyridinones/pyrazinones, method of making, and method of use thereof |
| RS56583B1 (sr) * | 2010-11-10 | 2018-02-28 | Genentech Inc | Derivati pirazol aminopirimidina kao lrrk2 modulatori |
| US8637537B2 (en) * | 2011-08-25 | 2014-01-28 | Genentech, Inc. | Serine/threonine kinase inhibitors |
| CA2853967A1 (en) * | 2011-11-03 | 2013-05-10 | F. Hoffmann-La Roche Ag | 8-fluorophthalazin-1 (2h) -one compounds as inhibitors of btk activity |
| SI3321262T1 (sl) * | 2012-03-01 | 2021-04-30 | Array Biopharma, Inc. | Inhibitorji serin/treonin kinaze |
| DK2900657T3 (da) * | 2012-09-26 | 2020-05-04 | Hoffmann La Roche | Cykliske etherpyrazol-4-yl-heterocyclyl-carboxamidforbindelser og fremgangsmåder til anvendelse |
| KR102002265B1 (ko) * | 2013-05-01 | 2019-07-19 | 에프. 호프만-라 로슈 아게 | 바이헤테로아릴 화합물 및 이의 용도 |
-
2013
- 2013-04-30 CN CN201610580911.5A patent/CN106220615A/zh active Pending
- 2013-04-30 KR KR1020147033695A patent/KR102091894B1/ko active IP Right Grant
- 2013-04-30 EP EP13720901.1A patent/EP2844652B1/en active Active
- 2013-04-30 CA CA2870049A patent/CA2870049C/en active Active
- 2013-04-30 WO PCT/EP2013/058939 patent/WO2013164321A1/en active Application Filing
- 2013-04-30 BR BR112014026952-1A patent/BR112014026952B1/pt active IP Right Grant
- 2013-04-30 CN CN201380023403.1A patent/CN104271569B/zh active Active
- 2013-04-30 RU RU2014147381A patent/RU2637947C2/ru active
- 2013-04-30 JP JP2015509410A patent/JP6218808B2/ja active Active
- 2013-04-30 MX MX2014012945A patent/MX363118B/es unknown
-
2014
- 2014-11-03 US US14/531,271 patent/US9212173B2/en active Active
-
2015
- 2015-02-05 HK HK15101249.0A patent/HK1200820A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150016532A (ko) | 2015-02-12 |
| EP2844652A1 (en) | 2015-03-11 |
| CN106220615A (zh) | 2016-12-14 |
| JP2015515966A (ja) | 2015-06-04 |
| US9212173B2 (en) | 2015-12-15 |
| MX2014012945A (es) | 2015-02-10 |
| EP2844652B1 (en) | 2019-03-13 |
| BR112014026952A2 (pt) | 2017-06-27 |
| KR102091894B1 (ko) | 2020-03-20 |
| CA2870049A1 (en) | 2013-11-07 |
| US20150051238A1 (en) | 2015-02-19 |
| WO2013164321A1 (en) | 2013-11-07 |
| BR112014026952A8 (pt) | 2021-06-15 |
| RU2014147381A (ru) | 2016-06-27 |
| CN104271569A (zh) | 2015-01-07 |
| BR112014026952B1 (pt) | 2022-03-15 |
| CA2870049C (en) | 2020-12-29 |
| JP6218808B2 (ja) | 2017-10-25 |
| CN104271569B (zh) | 2016-08-24 |
| MX363118B (es) | 2019-03-11 |
| RU2637947C2 (ru) | 2017-12-08 |
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